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FB: institutional research funds from ADC Therapeutics, Bayer AG, BeiGene, Floratek Pharma, Helsinn, HTG Molecular Diagnostics, Ideogen AG, Idorsia Pharmaceuticals Ltd., Immagene, ImmunoGen, Menarini Ricerche, Nordic Nanovector ASA, Oncternal Therapeutics, Spexis AG; consultancy fee from BIMINI Biotech, Floratek Pharma, Helsinn, Immagene, Menarini, Vrise Therapeutics; advisory board fees to institution from Novartis; expert statements provided to HTG Molecular Diagnostics; travel grants from Amgen, Astra Zeneca, iOnctura. SF is a consultant for Janssen, EUSA Pharma, Abbvie and Sandoz; is on the advisory board of Janssen, EUSA Pharma, Recordati, Incyte, Roche, Astra Zeneca and Italfarmaco; received speaker\u2019s honoraria from Janssen, EUSA Pharma, Recordati, Lilly, Beigene, Gilead and Gentili; and received research funding from Gilead, Beigene and Morphosys. ML has relationship in terms of consultancy, participation to advisory boards, invitation to scientific meetings, institutional research support and contracts with: AbbVie, Acerta, Amgen, ADC Therapeutics, BeiGene, Celgene\/BMS, Eusapharma, GSKI, Gentili, Gilead\/Kite, Novartis, Incyte J&J, Jazz, Lilly, Regeneron, Roche, Sandoz; he has non-financial interests as PI or strategic investigator in studies supported by: Celgene, J&J, BeiGene, ADC Therapeutics. GG has been consulting in Advisory Boards for Abbvie, AstraZeneca, Beigene, Incyte, Johnson & Johnson, and Lilly, and received speaker\u2019s honoraria from Abbvie, AstraZeneca, Beigene, Hikma, Incyte, Johnson & Johnson, and Lilly. The remaining authors have no conflicts of interest to declare.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All study methods were performed in accordance with relevant guidelines and regulations. 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