{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:00:45Z","timestamp":1780473645204,"version":"3.54.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1038\/s41375-026-02935-0","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:36:06Z","timestamp":1774877766000},"page":"1214-1226","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PRMT1 facilitates the tumorigenesis of chronic lymphocytic leukemia by regulating methylation of MAST1"],"prefix":"10.1038","volume":"40","author":[{"given":"Zheng","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinting","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0894-4922","authenticated-orcid":false,"given":"Ya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8051-1481","authenticated-orcid":false,"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"2935_CR1","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1001\/jama.2023.1946","volume":"329","author":"M Shadman","year":"2023","unstructured":"Shadman M. Diagnosis and treatment of chronic lymphocytic leukemia: a review. JAMA. 2023;329:918\u201332.","journal-title":"JAMA"},{"key":"2935_CR2","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1182\/blood.2020010029","volume":"138","author":"FK Stevenson","year":"2021","unstructured":"Stevenson FK, Forconi F, Kipps TJ. Exploring the pathways to chronic lymphocytic leukemia. Blood. 2021;138:827\u201335.","journal-title":"Blood"},{"key":"2935_CR3","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13045-023-01469-7","volume":"16","author":"R Bennett","year":"2023","unstructured":"Bennett R, Anderson MA, Seymour JF. Unresolved questions in selection of therapies for treatment-na\u00efve chronic lymphocytic leukemia. J Hematol Oncol. 2023;16:72.","journal-title":"J Hematol Oncol"},{"key":"2935_CR4","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/s41573-021-00159-8","volume":"20","author":"Q Wu","year":"2021","unstructured":"Wu Q, Schapira M, Arrowsmith CH, Barsyte-Lovejoy D. Protein arginine methylation: from enigmatic functions to therapeutic targeting. Nat Rev Drug Discov. 2021;20:509\u201330.","journal-title":"Nat Rev Drug Discov"},{"key":"2935_CR5","doi-asserted-by":"publisher","first-page":"4357","DOI":"10.1016\/j.molcel.2021.09.011","volume":"81","author":"J Xu","year":"2021","unstructured":"Xu J, Richard S. Cellular pathways influenced by protein arginine methylation: implications for cancer. Mol Cell. 2021;81:4357\u201368.","journal-title":"Mol Cell"},{"key":"2935_CR6","doi-asserted-by":"publisher","first-page":"3023","DOI":"10.1158\/0008-5472.CAN-23-3829","volume":"84","author":"WJ Hsu","year":"2024","unstructured":"Hsu WJ, Chiang MC, Chao YC, Chang YC, Hsu MC, Chung CH, et al. Arginine methylation of DDX3 by PRMT1 mediates mitochondrial homeostasis to promote breast cancer metastasis. Cancer Res. 2024;84:3023\u201343.","journal-title":"Cancer Res"},{"key":"2935_CR7","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.it.2020.08.007","volume":"41","author":"S Sengupta","year":"2020","unstructured":"Sengupta S, Kennemer A, Patrick K, Tsichlis P, Guerau-de-Arellano M. Protein arginine methyltransferase 5 in T lymphocyte biology. Trends Immunol. 2020;41:918\u201331.","journal-title":"Trends Immunol"},{"key":"2935_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2023.101016","volume":"72","author":"Y Zhu","year":"2024","unstructured":"Zhu Y, Xia T, Chen DQ, Xiong X, Shi L, Zuo Y, et al. Promising role of protein arginine methyltransferases in overcoming anti-cancer drug resistance. Drug Resist Updates. 2024;72:101016.","journal-title":"Drug Resist Updates"},{"key":"2935_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01602-z","volume":"21","author":"C Nicot","year":"2022","unstructured":"Nicot C. PRMT7: a survive-or-die switch in cancer stem cells. Mol Cancer. 2022;21:127.","journal-title":"Mol Cancer"},{"key":"2935_CR10","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.ccell.2019.07.003","volume":"36","author":"JY Fong","year":"2019","unstructured":"Fong JY, Pignata L, Goy PA, Kawabata KC, Lee SCW, Koh CM, et al. Therapeutic targeting of RNA splicing catalysis through inhibition of protein arginine methylation. Cancer Cell. 2019;36:194\u2013209.e9.","journal-title":"Cancer Cell"},{"key":"2935_CR11","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/s41580-019-0155-x","volume":"20","author":"E Guccione","year":"2019","unstructured":"Guccione E, Richard S. The regulation, functions and clinical relevance of arginine methylation. Nat Rev Mol Cell Biol. 2019;20:642\u201357.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2935_CR12","doi-asserted-by":"publisher","first-page":"554","DOI":"10.7150\/ijbs.89958","volume":"20","author":"Z Peng","year":"2024","unstructured":"Peng Z, Bao L, Shi B, Shi YB. Protein arginine methyltransferase 1 is required for the maintenance of adult small intestinal and colonic epithelial cell homeostasis. Int J Biol Sci. 2024;20:554\u201368.","journal-title":"Int J Biol Sci"},{"key":"2935_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-021-00871-5","volume":"13","author":"B Yao","year":"2021","unstructured":"Yao B, Gui T, Zeng X, Deng Y, Wang Z, Wang Y, et al. PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling. Genome Med. 2021;13:58.","journal-title":"Genome Med"},{"key":"2935_CR14","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.3390\/life11111147","volume":"11","author":"C Thiebaut","year":"2021","unstructured":"Thiebaut C, Eve L, Poulard C, Le Romancer M. Structure, activity, and function of PRMT1. Life. 2021;11:1147.","journal-title":"Life"},{"key":"2935_CR15","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1158\/0008-5472.CAN-23-1082","volume":"84","author":"H Tao","year":"2024","unstructured":"Tao H, Jin C, Zhou L, Deng Z, Li X, Dang W, et al. PRMT1 inhibition activates the interferon pathway to potentiate antitumor immunity and enhance checkpoint blockade efficacy in melanoma. Cancer Res. 2024;84:419\u201333.","journal-title":"Cancer Res"},{"key":"2935_CR16","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s00018-023-04987-2","volume":"80","author":"S Cai","year":"2023","unstructured":"Cai S, Chang J, Su M, Wei Y, Sun H, Chen C, et al. miR-455-5p promotes pathological cardiac remodeling via suppression of PRMT1-mediated Notch signaling pathway. Cell Mol Life Sci. 2023;80:359.","journal-title":"Cell Mol Life Sci"},{"key":"2935_CR17","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/cmdc.200800301","volume":"4","author":"R Heinke","year":"2009","unstructured":"Heinke R, Spannhoff A, Meier R, Trojer P, Bauer I, Jung M, et al. Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors. ChemMedChem. 2009;4:69\u201377.","journal-title":"ChemMedChem"},{"key":"2935_CR18","doi-asserted-by":"publisher","first-page":"3717","DOI":"10.1016\/j.bmc.2011.02.032","volume":"19","author":"EM Bissinger","year":"2011","unstructured":"Bissinger EM, Heinke R, Spannhoff A, Eberlin A, Metzger E, Cura V, et al. Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem. 2011;19:3717\u201331.","journal-title":"Bioorg Med Chem"},{"key":"2935_CR19","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1038\/s41388-020-01617-0","volume":"40","author":"XK Yin","year":"2021","unstructured":"Yin XK, Wang YL, Wang F, Feng WX, Bai SM, Zhao WW, et al. PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer. Oncogene. 2021;40:1375\u201389.","journal-title":"Oncogene"},{"key":"2935_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06036-z","volume":"14","author":"Y Jia","year":"2023","unstructured":"Jia Y, Yu X, Liu R, Shi L, Jin H, Yang D, et al. PRMT1 methylation of WTAP promotes multiple myeloma tumorigenesis by activating oxidative phosphorylation via m6A modification of NDUFS6. Cell Death Dis. 2023;14:512.","journal-title":"Cell Death Dis"},{"key":"2935_CR21","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.3390\/jpm11101009","volume":"11","author":"WJ Hsu","year":"2021","unstructured":"Hsu WJ, Chen CH, Chang YC, Cheng CH, TsaI YH, Lin CW. PRMT1 confers resistance to olaparib via modulating MYC signaling in triple-negative breast cancer. J Pers Med. 2021;11:1009.","journal-title":"J Pers Med"},{"key":"2935_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24845-8","volume":"12","author":"C Pan","year":"2021","unstructured":"Pan C, Kang J, Hwang JS, Li J, Boese AC, Wang X, et al. Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1. Nat Commun. 2021;12:4960.","journal-title":"Nat Commun"},{"key":"2935_CR23","doi-asserted-by":"publisher","first-page":"5949","DOI":"10.7150\/thno.72826","volume":"12","author":"A Tyagi","year":"2022","unstructured":"Tyagi A, Kaushal K, Chandrasekaran AP, Sarodaya N, Das S, Park CH, et al. CRISPR\/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells. Theranostics. 2022;12:5949\u201370.","journal-title":"Theranostics"},{"key":"2935_CR24","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1002\/2211-5463.12860","volume":"10","author":"T Jing","year":"2020","unstructured":"Jing T, Ma J, Zhao H, Zhang J, Jiang N, Ma D. MAST1 modulates neuronal differentiation and cell cycle exit via P27 in neuroblastoma cells. FEBS Open Bio. 2020;10:1104\u201314.","journal-title":"FEBS Open Bio"},{"key":"2935_CR25","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.neuron.2018.10.044","volume":"100","author":"R Tripathy","year":"2018","unstructured":"Tripathy R, Leca I, van Dijk T, Weiss J, van Bon BW, Sergaki MC, et al. Mutations in MAST1 cause mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Neuron. 2018;100:1354\u201368.e5.","journal-title":"Neuron"},{"key":"2935_CR26","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.ccell.2018.06.012","volume":"34","author":"L Jin","year":"2018","unstructured":"Jin L, Chun J, Pan C, Li D, Lin R, Alesi GN, et al. MAST1 Drives cisplatin resistance in human cancers by rewiring cRaf-independent MEK activation. Cancer Cell. 2018;34:315\u201330.e7.","journal-title":"Cancer Cell"},{"key":"2935_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112913","volume":"409","author":"W Ding","year":"2021","unstructured":"Ding W, Lu Y, Zhou A, Chen Y, Wang Z, Wang L, et al. Mast1 mediates radiation-induced gastric injury via the P38 MAPK pathway. Exp Cell Res. 2021;409:112913.","journal-title":"Exp Cell Res"},{"key":"2935_CR28","doi-asserted-by":"publisher","first-page":"5520","DOI":"10.1038\/s41388-018-0333-x","volume":"37","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Zhou X, Li Y, Xu Y, Lu K, Li P, et al. Inhibition of maternal embryonic leucine zipper kinase with OTSSP167 displays potent anti-leukemic effects in chronic lymphocytic leukemia. Oncogene. 2018;37:5520\u201333.","journal-title":"Oncogene"},{"key":"2935_CR29","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1038\/s41375-025-02673-9","volume":"39","author":"M Wang","year":"2025","unstructured":"Wang M, Zhu R, Small D, Lin L, Li L, Ma S, et al. SIRT5 inhibition impairs mitochondrial metabolism and enhances venetoclax-induced elimination of acute myeloid leukemia cells. Leukemia. 2025;39:1871\u201382.","journal-title":"Leukemia"},{"key":"2935_CR30","doi-asserted-by":"publisher","first-page":"2842","DOI":"10.1038\/s41388-021-01692-x","volume":"40","author":"C Cheng","year":"2021","unstructured":"Cheng C, Pei X, Li SW, Yang J, Li C, Tang J, et al. CRISPR\/Cas9 library screening uncovered methylated PKP2 as a critical driver of lung cancer radioresistance by stabilizing \u03b2-catenin. Oncogene. 2021;40:2842\u201357.","journal-title":"Oncogene"},{"key":"2935_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38443-3","volume":"14","author":"J Liu","year":"2023","unstructured":"Liu J, Bu X, Chu C, Dai X, Asara JM, Sicinski P, et al. PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity. Nat Commun. 2023;14:2806.","journal-title":"Nat Commun"},{"key":"2935_CR32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24798-y","volume":"12","author":"V Giuliani","year":"2021","unstructured":"Giuliani V, Miller MA, Liu CY, Hartono SR, Class CA, Bristow CA, et al. PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma. Nat Commun. 2021;12:4626.","journal-title":"Nat Commun"},{"key":"2935_CR33","doi-asserted-by":"publisher","first-page":"2865","DOI":"10.1158\/0008-5472.CAN-18-3211","volume":"79","author":"LM Liu","year":"2019","unstructured":"Liu LM, Sun WZ, Fan XZ, Xu YL, Cheng MB, Zhang Y. Methylation of C\/EBP\u03b1 by PRMT1 inhibits its tumor-suppressive function in breast cancer. Cancer Res. 2019;79:2865\u201377.","journal-title":"Cancer Res"},{"key":"2935_CR34","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36708-5","volume":"14","author":"K Wang","year":"2023","unstructured":"Wang K, Luo L, Fu S, Wang M, Wang Z, Dong L, et al. PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma. Nat Commun. 2023;14:1011.","journal-title":"Nat Commun"},{"key":"2935_CR35","doi-asserted-by":"publisher","first-page":"5387","DOI":"10.7150\/thno.42345","volume":"11","author":"J Wang","year":"2021","unstructured":"Wang J, Wang C, Xu P, Li X, Lu Y, Jin D, et al. PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Theranostics. 2021;11:5387\u2013403.","journal-title":"Theranostics"},{"key":"2935_CR36","doi-asserted-by":"publisher","first-page":"3226","DOI":"10.1038\/s41418-020-00615-9","volume":"27","author":"Z Li","year":"2020","unstructured":"Li Z, Wang D, Lu J, Huang B, Wang Y, Dong M, et al. Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis. Cell Death Differ. 2020;27:3226\u201342.","journal-title":"Cell Death Differ"},{"key":"2935_CR37","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1182\/blood.2019001282","volume":"134","author":"X He","year":"2019","unstructured":"He X, Zhu Y, Lin YC, Li M, Du J, Dong H, et al. PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ acute myeloid leukemia. Blood. 2019;134:548\u201360.","journal-title":"Blood"},{"key":"2935_CR38","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1182\/blood.2019002457","volume":"134","author":"Y Zhu","year":"2019","unstructured":"Zhu Y, He X, Lin YC, Dong H, Zhang L, Chen X, et al. Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia. Blood. 2019;134:1257\u201368.","journal-title":"Blood"},{"key":"2935_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01009-1","volume":"8","author":"S Infantino","year":"2017","unstructured":"Infantino S, Light A, O\u2019Donnell K, Bryant V, Avery DT, Elliott M, et al. Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation. Nat Commun. 2017;8:891.","journal-title":"Nat Commun"},{"key":"2935_CR40","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220381","volume":"220","author":"LC Litzler","year":"2023","unstructured":"Litzler LC, Zahn A, Dionne KL, Sprumont A, Ferreira SR, Slattery MRF, et al. Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice. J Exp Med. 2023;220:e20220381.","journal-title":"J Exp Med"},{"key":"2935_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-025-02028-3","volume":"27","author":"N Deng","year":"2025","unstructured":"Deng N, Kang W, Du J, Rong X, Han Q. Microtubule associated serine\/threonine kinase-3 inhibits the malignant phenotype of breast cancer by promoting phosphorylation-mediated ubiquitination degradation of yes-associated protein. Breast Cancer Res. 2025;27:63.","journal-title":"Breast Cancer Res"},{"key":"2935_CR42","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s13045-020-00949-4","volume":"13","author":"J Yuan","year":"2020","unstructured":"Yuan J, Dong X, Yap J, Hu J. The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy. J Hematol Oncol. 2020;13:113.","journal-title":"J Hematol Oncol"},{"key":"2935_CR43","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2760899","volume":"2022","author":"B Tan","year":"2022","unstructured":"Tan B, Zhang J, Wang W, Ma H, Yang Y. E3 ubiquitin ligase CHIP inhibits the interaction between Hsp90\u03b2 and MAST1 to repress radiation resistance in non-small-cell lung cancer stem cells. Stem Cells Int. 2022;2022:2760899.","journal-title":"Stem Cells Int"},{"key":"2935_CR44","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1182\/blood-2011-07-370403","volume":"119","author":"S Krysov","year":"2012","unstructured":"Krysov S, Dias S, Paterson A, Mockridge CI, Potter KN, Smith KA, et al. Surface IgM stimulation induces MEK1\/2-dependent MYC expression in chronic lymphocytic leukemia cells. Blood. 2012;119:170\u20139.","journal-title":"Blood"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41375-026-02935-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-026-02935-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-026-02935-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:03:40Z","timestamp":1780470220000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41375-026-02935-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["2935"],"URL":"https:\/\/doi.org\/10.1038\/s41375-026-02935-0","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]},"assertion":[{"value":"9 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}