{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:45:05Z","timestamp":1791942305844,"version":"4.3.4"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1038\/s41375-026-02989-0","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:46:15Z","timestamp":1780919175000},"page":"1532-1534","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Normal life expectancy after all-trans retinoic acid and arsenic trioxide for acute promyelocytic leukemia"],"prefix":"10.1038","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8648-885X","authenticated-orcid":false,"given":"A.","family":"Piciocchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Talone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Messina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"de Fabritiis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Marsili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Sargentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1942-1230","authenticated-orcid":false,"given":"S.","family":"Soddu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Cicconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8293-0663","authenticated-orcid":false,"given":"L.","family":"Guarnera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. D.","family":"Divona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3277-6594","authenticated-orcid":false,"given":"P.","family":"Musto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ferrara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"D\u2019Ardia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Borlenghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Buccisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1163-6162","authenticated-orcid":false,"given":"M.","family":"Breccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5065-5166","authenticated-orcid":false,"given":"F.","family":"Efficace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Fazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0245-0553","authenticated-orcid":false,"given":"A.","family":"Venditti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Lo","family":"Coco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Platzbecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1278-604X","authenticated-orcid":false,"given":"M.","family":"Vignetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-4761","authenticated-orcid":false,"given":"M. T.","family":"Voso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"2989_CR1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/j.0954-6820.1957.tb00124.x","volume":"159","author":"L Hillestad","year":"1957","unstructured":"Hillestad L. Acute promyelocytic leukemia. Acta Med Scand. 1957;159:189\u201394.","journal-title":"Acta Med Scand"},{"key":"2989_CR2","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1182\/blood.V41.4.489.489","volume":"41","author":"J Bernard","year":"1973","unstructured":"Bernard J, Weil M, Boiron M, Jacquillat C, Flandrin G, Gemon MF. Acute promyelocytic leukemia: results of treatment by daunorubicin. Blood. 1973;41:489\u201396.","journal-title":"Blood"},{"key":"2989_CR3","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1182\/blood.V72.2.567.567","volume":"72","author":"ME Huang","year":"1988","unstructured":"Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhao L, et al. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood. 1988;72:567\u201372.","journal-title":"Blood"},{"key":"2989_CR4","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1056\/NEJMoa1300874","volume":"369","author":"F Lo-Coco","year":"2013","unstructured":"Lo-Coco F, Avvisati G, Vignetti M, Thiede C, Orlando SM, Iacobelli S, et al. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med. 2013;369:111\u201321.","journal-title":"N Engl J Med"},{"key":"2989_CR5","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1182\/blood.2024026186","volume":"145","author":"MT Voso","year":"2025","unstructured":"Voso MT, Guarnera L, Lehmann S, D\u00f6hner K, D\u00f6hner H, Platzbecker U, et al. Acute promyelocytic leukemia: long-term outcomes from the HARMONY Project. Blood. 2025;145:234\u201343.","journal-title":"Blood"},{"key":"2989_CR6","doi-asserted-by":"publisher","first-page":"3160","DOI":"10.1200\/JCO-25-00535","volume":"43","author":"U Platzbecker","year":"2025","unstructured":"Platzbecker U, Ad\u00e8s L, Montesinos P, Ammatuna E, Fenaux P, Baldus C, et al. Arsenic trioxide and all-trans retinoic acid combination therapy for the treatment of high-risk acute promyelocytic leukemia: results from the APOLLO trial. J Clin Oncol. 2025;43:3160\u20139.","journal-title":"J Clin Oncol"},{"key":"2989_CR7","doi-asserted-by":"publisher","first-page":"5341","DOI":"10.1007\/s00277-024-06038-7","volume":"103","author":"F Efficace","year":"2024","unstructured":"Efficace F, Sparano F, Breccia M, Greco C, Carluccio P, Borlenghi E, et al. Health-related quality-of-life benefits of arsenic trioxide in patients with non\u2013high-risk acute promyelocytic leukemia are sustained over time: long-term results of the GIMEMA APL0406 trial. Ann Hematol. 2024;103:5341\u20139.","journal-title":"Ann Hematol"},{"key":"2989_CR8","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1038\/s41375-019-0589-3","volume":"34","author":"L Cicconi","year":"2020","unstructured":"Cicconi L, Platzbecker U, Avvisati G, Paoloni F, Thiede C, Vignetti M, et al. Long-term results of all-trans retinoic acid and arsenic trioxide in non\u2013high-risk acute promyelocytic leukemia: update of the APL0406 Italian\u2013German randomized trial. Leukemia. 2020;34:914\u20138.","journal-title":"Leukemia"},{"key":"2989_CR9","unstructured":"Piciocchi A, Talone A, Messina M, Marsili G, Sargentini V, Soddu S, et al. Do APL patients treated with ATO plus ATRA achieve a normal life expectancy? Insights from the long-term follow-up of the GIMEMA APL0406 trial and the real-life APL0618 study. Haematologica. 2025;110:SIE Abstract, oral communication."},{"key":"2989_CR10","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/ahg.12154","volume":"80","author":"H Fang","year":"2016","unstructured":"Fang H, Zhang H, Yang Y. Poisson approximation-based score test for detecting association of rare variants. Ann Hum Genet. 2016;80:221\u201334.","journal-title":"Ann Hum Genet"},{"key":"2989_CR11","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1097\/01.JAA.0000995680.52352.b5","volume":"37","author":"M Becker","year":"2024","unstructured":"Becker M, Farina KA, Mascarenhas J. Acute myeloid leukemia: current understanding and management. JAAPA. 2024;37:34\u20139.","journal-title":"JAAPA"},{"key":"2989_CR12","doi-asserted-by":"publisher","first-page":"4370","DOI":"10.1182\/bloodadvances.2021004649","volume":"5","author":"F Efficace","year":"2021","unstructured":"Efficace F, Platzbecker U, Breccia M, Cottone F, Carluccio P, Salutari P, et al. Long-term quality of life of patients with acute promyelocytic leukemia treated with arsenic trioxide vc chemotherapy. Blood Adv. 2021;5:4370\u20139.","journal-title":"Blood Adv"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41375-026-02989-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-026-02989-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-026-02989-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:57:10Z","timestamp":1782917830000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41375-026-02989-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["2989"],"URL":"https:\/\/doi.org\/10.1038\/s41375-026-02989-0","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"assertion":[{"value":"5 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}