{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:20:03Z","timestamp":1792808403317,"version":"4.5.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["CA204231"],"award-info":[{"award-number":["CA204231"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["CA236322"],"award-info":[{"award-number":["CA236322"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL149620"],"award-info":[{"award-number":["HL149620"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK134064"],"award-info":[{"award-number":["DK134064"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1038\/s41375-026-03070-6","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T09:57:51Z","timestamp":1785146271000},"page":"2244-2255","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cohesin haploinsufficiency and inv(16) cooperate to reinforce Fli1 gene transcriptional programs during acute myeloid leukemia initiation and maintenance"],"prefix":"10.1038","volume":"40","author":[{"given":"Alison E.","family":"Meyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn E.","family":"Heimbruch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-8493","authenticated-orcid":false,"given":"Kirthi","family":"Pulakanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cary","family":"Stelloh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataly","family":"Cruz-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3651-6036","authenticated-orcid":false,"given":"Josiah","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6799-7697","authenticated-orcid":false,"given":"Lisa","family":"Latzko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8464-1483","authenticated-orcid":false,"given":"Sebastian","family":"Vosberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp A.","family":"Greif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7450-758X","authenticated-orcid":false,"given":"Lucio H.","family":"Castilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Pulikkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramaniam","family":"Malarkannan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2688-9541","authenticated-orcid":false,"given":"Sridhar","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"3070_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1329529","volume":"11","author":"P Chen","year":"2024","unstructured":"Chen P, Liu X, Zhao Y, Hu Y, Guo J, Wang H. Global, national, and regional burden of acute myeloid leukemia among 60\u201389\u2009years-old individuals: insights from a study covering the period 1990 to 2019. Front Public Health. 2024;11:1329529.","journal-title":"Front Public Health"},{"key":"3070_CR2","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1056\/NEJMoa1112304","volume":"366","author":"JP Patel","year":"2012","unstructured":"Patel JP, G\u00f6nen M, Figueroa ME, Fernandez H, Sun Z, Racevskis J, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med. 2012;366:1079\u201389.","journal-title":"N Engl J Med"},{"key":"3070_CR3","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1056\/NEJMoa1516192","volume":"374","author":"E Papaemmanuil","year":"2016","unstructured":"Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, et al. Genomic classification and prognosis in acute myeloid leukemia. N Engl J Med. 2016;374:2209\u201321.","journal-title":"N Engl J Med"},{"key":"3070_CR4","doi-asserted-by":"crossref","unstructured":"Network TCGAR. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med. 2013;368:2059\u201374.","DOI":"10.1056\/NEJMoa1301689"},{"key":"3070_CR5","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/s41586-018-0623-z","volume":"562","author":"JW Tyner","year":"2018","unstructured":"Tyner JW, Tognon CE, Bottomly D, Wilmot B, Kurtz SE, Savage SL, et al. Functional genomic landscape of acute myeloid leukaemia. Nature. 2018;562:526\u201331.","journal-title":"Nature"},{"key":"3070_CR6","doi-asserted-by":"publisher","first-page":"438","DOI":"10.3390\/cancers15020438","volume":"15","author":"C Sargas","year":"2023","unstructured":"Sargas C, Ayala R, Larrayoz MJ, Chillon MC, Carrillo-Cruz E, Bilbao-Sieyro C, et al. Molecular landscape and validation of new genomic classification in 2668 adult AML patients: real- life data from the PETHEMA registry. Cancers. 2023;15:438.","journal-title":"Cancers"},{"key":"3070_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00503-6","volume":"11","author":"G Borthakur","year":"2021","unstructured":"Borthakur G, Kantarjian H. Core binding factor acute myelogenous leukemia-2021 treatment algorithm. Blood Cancer J. 2021;11:114.","journal-title":"Blood Cancer J"},{"key":"3070_CR8","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3892\/mco.2020.2052","volume":"13","author":"X Quan","year":"2020","unstructured":"Quan X, Deng J. Core binding factor acute myeloid leukemia: advances in the heterogeneity of KIT, FLT3, and RAS mutations (Review). Mol Clin Oncol. 2020;13:95\u2013100.","journal-title":"Mol Clin Oncol"},{"key":"3070_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2023.101117","volume":"62","author":"C Darwish","year":"2023","unstructured":"Darwish C, Farina K, Tremblay D. The core concepts of core binding factor acute myeloid leukemia: current considerations for prognosis and treatment. Blood Rev. 2023;62:101117.","journal-title":"Blood Rev"},{"key":"3070_CR10","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.3390\/cancers11121973","volume":"11","author":"A Beghini","year":"2019","unstructured":"Beghini A. Core binding factor leukemia: chromatin remodeling moves towards oncogenic transcription. Cancers. 2019;11:1973.","journal-title":"Cancers"},{"key":"3070_CR11","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.1182\/blood.2020009933","volume":"137","author":"S Surapally","year":"2021","unstructured":"Surapally S, Tenen DG, Pulikkan JA. Emerging therapies for inv(16) AML. Blood. 2021;137:2579\u201384.","journal-title":"Blood"},{"key":"3070_CR12","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1182\/blood-2013-12-541730","volume":"124","author":"L Xue","year":"2014","unstructured":"Xue L, Pulikkan JA, Valk PJM, Castilla LH. NrasG12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbf\u03b2-SMMHC via activation of MEK\/ERK axis. Blood. 2014;124:426\u201336.","journal-title":"Blood"},{"key":"3070_CR13","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/S0092-8674(00)81388-4","volume":"87","author":"LH Castilla","year":"1996","unstructured":"Castilla LH, Wijmenga C, Wang Q, Stacy T, Speck NA, Eckhaus M, et al. Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygousfor a knocked-in leukemia gene CBFB\u2013MYH11. Cell. 1996;87:687\u201396.","journal-title":"Cell"},{"key":"3070_CR14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI176311","volume":"134","author":"RB Day","year":"2024","unstructured":"Day RB, Hickman JA, Xu Z, Katerndahl CDS, Ferraro F, Ramakrishnan SM, et al. Proteogenomic analysis reveals cytoplasmic sequestration of RUNX1 by the acute myeloid leukemia\u2013initiating CBFB::MYH11 oncofusion protein. J Clin Investig. 2024;134:e176311.","journal-title":"J Clin Investig"},{"key":"3070_CR15","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1038\/ng.3709","volume":"48","author":"ZJ Faber","year":"2016","unstructured":"Faber ZJ, Chen X, Gedman AL, Boggs K, Cheng J, Ma J, et al. The genomic landscape of core-binding factor acute myeloid leukemias. Nat Genet. 2016;48:1551\u20136.","journal-title":"Nat Genet"},{"key":"3070_CR16","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1038\/s41375-019-0697-0","volume":"34","author":"S Opatz","year":"2020","unstructured":"Opatz S, Bamopoulos SA, Metzeler KH, Herold T, Ksienzyk B, Braundl K, et al. The clinical mutatome of core binding factor leukemia. Leukemia. 2020;34:1553\u201362.","journal-title":"Leukemia"},{"key":"3070_CR17","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.1182\/blood-2015-12-688705","volume":"127","author":"N Duployez","year":"2016","unstructured":"Duployez N, Marceau-Renaut A, Boissel N, Petit A, Bucci M, Geffroy S, et al. Comprehensive mutational profiling of core binding factor acute myeloid leukemia. Blood. 2016;127:2451\u20139.","journal-title":"Blood"},{"key":"3070_CR18","doi-asserted-by":"publisher","first-page":"6342","DOI":"10.1182\/bloodadvances.2020002673","volume":"4","author":"N Jahn","year":"2020","unstructured":"Jahn N, Terzer T, Strang E, Dolnik A, Cocciardi S, Panina E, et al. Genomic heterogeneity in core-binding factor acute myeloid leukemia and its clinical implications. Blood Adv. 2020;4:6342\u201352.","journal-title":"Blood Adv"},{"key":"3070_CR19","first-page":"84","volume":"39","author":"W Qin","year":"2022","unstructured":"Qin W, Chen X, Shen HJ, Wang Z, Cai X, Jiang N, et al. Comprehensive mutation profile in acute myeloid leukemia patients with RUNX1-RUNX1T1 or CBFB-MYH11 fusions. Turk J Haematol. 2022;39:84\u201393.","journal-title":"Turk J Haematol"},{"key":"3070_CR20","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1128\/MCB.01503-13","volume":"34","author":"X Kong","year":"2014","unstructured":"Kong X, Ball AR Jr., Pham HX, Zeng W, Chen HY, Schmiesing JA, et al. Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair. Mol Cell Biol. 2014;34:685\u201398.","journal-title":"Mol Cell Biol"},{"key":"3070_CR21","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.neo.2021.01.003","volume":"23","author":"KE Heimbruch","year":"2021","unstructured":"Heimbruch KE, Meyer AE, Agrawal P, Viny AD, Rao S. A cohesive look at leukemogenesis: the cohesin complex and other driving mutations in AML. Neoplasia. 2021;23:337\u201347.","journal-title":"Neoplasia"},{"key":"3070_CR22","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1182\/blood-2013-07-518746","volume":"123","author":"F Thol","year":"2014","unstructured":"Thol F, Bollin R, Gehlhaar M, Walter C, Dugas M, Suchanek KJ, et al. Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications. Blood. 2014;123:914\u201320.","journal-title":"Blood"},{"key":"3070_CR23","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1182\/blood-2014-04-567057","volume":"124","author":"S Thota","year":"2014","unstructured":"Thota S, Viny AD, Makishima H, Spitzer B, Radivoyevitch T, Przychodzen B, et al. Genetic alterations of the cohesin complex genes in myeloid malignancies. Blood. 2014;124:1790\u20138.","journal-title":"Blood"},{"key":"3070_CR24","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1038\/ng.2731","volume":"45","author":"A Kon","year":"2013","unstructured":"Kon A, Shih LY, Minamino M, Sanada M, Shiraishi Y, Nagata Y, et al. Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms. Nat Genet. 2013;45:1232\u20137.","journal-title":"Nat Genet"},{"key":"3070_CR25","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/leu.2016.240","volume":"31","author":"JB Fisher","year":"2017","unstructured":"Fisher JB, Peterson J, Reimer M, Stelloh C, Pulakanti K, Gerbec ZJ, et al. The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of Hoxa7 and Hoxa9. Leukemia. 2017;31:712\u20139.","journal-title":"Leukemia"},{"key":"3070_CR26","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1084\/jem.20151317","volume":"212","author":"AD Viny","year":"2015","unstructured":"Viny AD, Ott CJ, Spitzer B, Rivas M, Meydan C, Papalexi E, et al. Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis. J Exp Med. 2015;212:1819\u201332.","journal-title":"J Exp Med"},{"key":"3070_CR27","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1084\/jem.20151323","volume":"212","author":"J Mullenders","year":"2015","unstructured":"Mullenders J, Aranda-Orgilles B, Lhoumaud P, Keller M, Pae J, Wang K, et al. Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms. J Exp Med. 2015;212:1833\u201350.","journal-title":"J Exp Med"},{"key":"3070_CR28","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.stem.2015.09.017","volume":"17","author":"C Mazumdar","year":"2015","unstructured":"Mazumdar C, Shen Y, Xavy S, Zhao F, Reinisch A, Li R, et al. Leukemia-associated cohesin mutants dominantly enforce stem cell programs and impair human hematopoietic progenitor differentiation. Cell Stem Cell. 2015;17:675\u201388.","journal-title":"Cell Stem Cell"},{"key":"3070_CR29","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ccr.2005.12.014","volume":"9","author":"Y-H Kuo","year":"2006","unstructured":"Kuo Y-H, Landrette SF, Heilman SA, Perrat PN, Garrett L, Liu PP, et al. Cbf\u03b2-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia. Cancer Cell. 2006;9:57\u201368.","journal-title":"Cancer Cell"},{"key":"3070_CR30","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1038\/s41375-022-01632-y","volume":"36","author":"AE Meyer","year":"2022","unstructured":"Meyer AE, Stelloh C, Pulakanti K, Burns R, Fisher JB, Heimbruch KE, et al. Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1; cohesin-mutated AML. Leukemia. 2022;36:2032\u201341.","journal-title":"Leukemia"},{"key":"3070_CR31","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.stem.2019.08.003","volume":"25","author":"AD Viny","year":"2019","unstructured":"Viny AD, Bowman RL, Liu Y, Lavallee VP, Eisman SE, Xiao W, et al. Cohesin members Stag1 and Stag2 display distinct roles in chromatin accessibility and topological control of HSC self-renewal and differentiation. Cell Stem Cell. 2019;25:682\u201396 e8.","journal-title":"Cell Stem Cell"},{"key":"3070_CR32","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1038\/leu.2013.257","volume":"28","author":"A Mandoli","year":"2014","unstructured":"Mandoli A, Singh AA, Jansen PW, Wierenga AT, Riahi H, Franci G, et al. CBFB-MYH11\/RUNX1 together with a compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupies self-renewal genes in inv(16) acute myeloid leukemia. Leukemia. 2014;28:770\u20138.","journal-title":"Leukemia"},{"key":"3070_CR33","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1038\/sj.onc.1202444","volume":"18","author":"V Laudet","year":"1999","unstructured":"Laudet V, Hanni C, Stehelin D, Duterque-Coquillaud M. Molecular phylogeny of the ETS gene family. Oncogene. 1999;18:1351\u20139.","journal-title":"Oncogene"},{"key":"3070_CR34","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.ccr.2010.03.022","volume":"17","author":"Y Kamikubo","year":"2010","unstructured":"Kamikubo Y, Zhao L, Wunderlich M, Corpora T, Hyde RK, Paul TA, et al. Accelerated leukemogenesis by truncated CBF\u03b2-SMMHC defective in high-affinity binding with RUNX1. Cancer Cell. 2010;17:455\u201368.","journal-title":"Cancer Cell"},{"key":"3070_CR35","doi-asserted-by":"publisher","first-page":"e1268241","DOI":"10.1080\/23723556.2016.1268241","volume":"4","author":"M Czeh","year":"2017","unstructured":"Czeh M, Rosenbauer F. Uncovering a new cellular origin for acute myeloid leukemia with lineage plasticity. Mol Cell Oncol. 2017;4:e1268241.","journal-title":"Mol Cell Oncol"},{"key":"3070_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-01193-0","volume":"8","author":"Y Chen","year":"2022","unstructured":"Chen Y, Li J, Xu L, G\u0103man M-A, Zou Z. The genesis and evolution of acute myeloid leukemia stem cells in the microenvironment: from biology to therapeutic targeting. Cell Death Discov. 2022;8:397.","journal-title":"Cell Death Discov"},{"key":"3070_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12166","volume":"7","author":"J George","year":"2016","unstructured":"George J, Uyar A, Young K, Kuffler L, Waldron-Francis K, Marquez E, et al. Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells. Nat Commun. 2016;7:12166.","journal-title":"Nat Commun"},{"key":"3070_CR38","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/cyto.a.22093","volume":"83A","author":"A Mayle","year":"2013","unstructured":"Mayle A, Luo M, Jeong M, Goodell MA. Flow cytometry analysis of murine hematopoietic stem cells. Cytom Part A. 2013;83A:27\u201337.","journal-title":"Cytom Part A"},{"key":"3070_CR39","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1002\/cyto.a.20674","volume":"75A","author":"GA Challen","year":"2009","unstructured":"Challen GA, Boles N, Lin KYK, Goodell MA. Mouse hematopoietic stem cell identification and analysis. Cytom Part A. 2009;75A:14\u201324.","journal-title":"Cytom Part A"},{"key":"3070_CR40","first-page":"397","volume":"2","author":"L Shao","year":"2013","unstructured":"Shao L, Wang Y, Chang J, Luo Y, Meng A, Zhou D. Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury. Transl Cancer Res. 2013;2:397\u2013411.","journal-title":"Transl Cancer Res"},{"key":"3070_CR41","doi-asserted-by":"publisher","first-page":"D780","DOI":"10.1093\/nar\/gky1020","volume":"47","author":"J Choi","year":"2019","unstructured":"Choi J, Baldwin TM, Wong M, Bolden JE, Fairfax KA, Lucas EC, et al. Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans. Nucleic Acids Res. 2019;47:D780\u2013D785.","journal-title":"Nucleic Acids Res"},{"key":"3070_CR42","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3389\/fonc.2018.00129","volume":"8","author":"JA Pulikkan","year":"2018","unstructured":"Pulikkan JA, Castilla LH. Preleukemia and leukemia-initiating cell activity in inv(16) acute myeloid leukemia. Front Oncol. 2018;8:129.","journal-title":"Front Oncol"},{"key":"3070_CR43","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1038\/s41596-020-0336-2","volume":"15","author":"B Van de Sande","year":"2020","unstructured":"Van de Sande B, Flerin C, Davie K, De Waegeneer M, Hulselmans G, Aibar S, et al. A scalable SCENIC workflow for single-cell gene regulatory network analysis. Nat Protoc. 2020;15:2247\u201376.","journal-title":"Nat Protoc"},{"key":"3070_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2025.105287","volume":"153","author":"SE Conneely","year":"2026","unstructured":"Conneely SE, Quezada A, Kurtz KJ, Zhang N, Fuente J, Mercer N, et al. Cohesin haploinsufficiency is tolerated in Cbfb: MYH11-driven murine acute myeloid leukemia. Exp Hematol. 2026;153:105287.","journal-title":"Exp Hematol"},{"key":"3070_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-01054-2","volume":"14","author":"D Alawieh","year":"2024","unstructured":"Alawieh D, Cysique-Foinlan L, Willekens C, Renneville A. RAS mutations in myeloid malignancies: revisiting old questions with novel insights and therapeutic perspectives. Blood Cancer J. 2024;14:72.","journal-title":"Blood Cancer J"},{"key":"3070_CR46","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1182\/blood.2020009707","volume":"138","author":"JAI Thoms","year":"2021","unstructured":"Thoms JAI, Truong P, Subramanian S, Knezevic K, Harvey G, Huang Y, et al. Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells. Blood. 2021;138:1441\u201355.","journal-title":"Blood"},{"key":"3070_CR47","doi-asserted-by":"publisher","first-page":"11434","DOI":"10.3390\/ijms222111434","volume":"22","author":"S Nagel","year":"2021","unstructured":"Nagel S, Pommerenke C, Meyer C, Macleod RAF. NKL homeobox genes NKX2-3 and NKX2-4 deregulate megakaryocytic-erythroid cell differentiation in AML. Int J Mol Sci. 2021;22:11434.","journal-title":"Int J Mol Sci"},{"key":"3070_CR48","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1038\/s41375-022-01602-4","volume":"36","author":"P Xiang","year":"2022","unstructured":"Xiang P, Yang X, Escano L, Dhillon I, Schneider E, Clemans-Gibbon J, et al. Elucidating the importance and regulation of key enhancers for human MEIS1 expression. Leukemia. 2022;36:1980\u20139.","journal-title":"Leukemia"},{"key":"3070_CR49","doi-asserted-by":"publisher","first-page":"5604","DOI":"10.1182\/blood-2011-04-348052","volume":"118","author":"SM Kornblau","year":"2011","unstructured":"Kornblau SM, Qiu YH, Zhang N, Singh N, Faderl S, Ferrajoli A, et al. Abnormal expression of FLI1 protein is an adverse prognostic factor in acute myeloid leukemia. Blood. 2011;118:5604\u201312.","journal-title":"Blood"},{"key":"3070_CR50","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1158\/2159-8290.CD-19-0982","volume":"10","author":"Y Ochi","year":"2020","unstructured":"Ochi Y, Kon A, Sakata T, Nakagawa MM, Nakazawa N, Kakuta M, et al. Combined cohesin\u2013RUNX1 deficiency synergistically perturbs chromatin looping and causes myelodysplastic syndromes. Cancer Discov. 2020;10:836\u201353.","journal-title":"Cancer Discov"},{"key":"3070_CR51","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.ccell.2021.05.007","volume":"39","author":"B Adane","year":"2021","unstructured":"Adane B, Alexe G, Seong BKA, Lu D, Hwang EE, Hnisz D, et al. STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma. Cancer Cell. 2021;39:827\u201344.e10.","journal-title":"Cancer Cell"},{"key":"3070_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24005-x","volume":"8","author":"Y Cai","year":"2018","unstructured":"Cai Y, Lin J-R, Zhang Q, O\u2019Brien K, Montagna C, Zhang ZD. Epigenetic alterations to Polycomb targets precede malignant transition in a mouse model of breast cancer. Sci Rep. 2018;8:5535.","journal-title":"Sci Rep"},{"key":"3070_CR53","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s00018-022-04160-1","volume":"79","author":"Y Ben-David","year":"2022","unstructured":"Ben-David Y, Gajendran B, Sample KM, Zacksenhaus E. Current insights into the role of Fli-1 in hematopoiesis and malignant transformation. Cell Mol Life Sci. 2022;79:163.","journal-title":"Cell Mol Life Sci"},{"key":"3070_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1363-1","volume":"10","author":"T Liu","year":"2019","unstructured":"Liu T, Xia L, Yao Y, Yan C, Fan Y, Gajendran B, et al. Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis. Cell Death Dis. 2019;10:117.","journal-title":"Cell Death Dis"},{"key":"3070_CR55","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2011.52","volume":"2","author":"YJ Li","year":"2012","unstructured":"Li YJ, Zhao X, Vecchiarelli-Federico LM, Li Y, Datti A, Cheng Y, et al. Drug-mediated inhibition of Fli-1 for the treatment of leukemia. Blood Cancer J. 2012;2:e54.","journal-title":"Blood Cancer J"},{"key":"3070_CR56","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1593\/neo.101202","volume":"13","author":"PJ Grohar","year":"2011","unstructured":"Grohar PJ, Griffin LB, Yeung C, Chen QR, Pommier Y, Khanna C, et al. Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells. Neoplasia. 2011;13:145\u201353.","journal-title":"Neoplasia"},{"key":"3070_CR57","doi-asserted-by":"publisher","first-page":"3725","DOI":"10.1200\/JCO.24.00020","volume":"42","author":"PA Meyers","year":"2024","unstructured":"Meyers PA, Federman N, Daw N, Anderson PM, Davis LE, Kim A, et al. Open-label, multicenter, phase I\/II, first-in-human trial of TK216: a first-generation EWS::FLI1 fusion protein antagonist in Ewing sarcoma. J Clin Oncol. 2024;42:3725\u201334.","journal-title":"J Clin Oncol"},{"key":"3070_CR58","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1002\/gcc.20948","volume":"51","author":"P Paulo","year":"2012","unstructured":"Paulo P, Barros-Silva JD, Ribeiro FR, Ramalho-Carvalho J, Jer\u00f3nimo C, Henrique R, et al. FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer. Genes, Chromosomes, Cancer. 2012;51:240\u20139.","journal-title":"Genes, Chromosomes, Cancer"},{"key":"3070_CR59","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-61","volume":"13","author":"N Selvaraj","year":"2014","unstructured":"Selvaraj N, Budka JA, Ferris MW, Jerde TJ, Hollenhorst PC. Prostate cancer ETS rearrangements switch a cell migration gene expression program from RAS\/ERK to PI3K\/AKT regulation. Mol Cancer. 2014;13:61.","journal-title":"Mol Cancer"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41375-026-03070-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-026-03070-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-026-03070-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:43:23Z","timestamp":1790250203000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41375-026-03070-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":59,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["3070"],"URL":"https:\/\/doi.org\/10.1038\/s41375-026-03070-6","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]},"assertion":[{"value":"3 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}