{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:54:21Z","timestamp":1793426061864,"version":"4.5.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010661","name":"EC | Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["101124542; 757339; PoC DeAlarmin; 953407"],"award-info":[{"award-number":["101124542; 757339; PoC DeAlarmin; 953407"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"EC | Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["INTERCEPT-MDS ITN 953407"],"award-info":[{"award-number":["INTERCEPT-MDS ITN 953407"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["09150172110021"],"award-info":[{"award-number":["09150172110021"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["DJCLS 01 R\/2021; 2021-20250"],"award-info":[{"award-number":["DJCLS 01 R\/2021; 2021-20250"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["PI 23\/0007"],"award-info":[{"award-number":["PI 23\/0007"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["504777725; 417911533; 514007497"],"award-info":[{"award-number":["504777725; 417911533; 514007497"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 222\/1598-1 FUGG Projekt 566187929"],"award-info":[{"award-number":["INST 222\/1598-1 FUGG Projekt 566187929"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["417911533"],"award-info":[{"award-number":["417911533"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"EC | European Regional Development Fund","doi-asserted-by":"publisher","award":["PMP 24\/00025"],"award-info":[{"award-number":["PMP 24\/00025"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2021 SGR 00560"],"award-info":[{"award-number":["2021 SGR 00560"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["CERCA Programme"],"award-info":[{"award-number":["CERCA Programme"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Deletion of chromosome 5q [del(5q)] is the most common cytogenetic abnormality in myelodysplastic neoplasms (MDS) and results in haploinsufficiency of multiple genes, including\n                    <jats:italic>CSNK1A1<\/jats:italic>\n                    . Recurrent\n                    <jats:italic>CSNK1A1<\/jats:italic>\n                    mutations, predominantly affecting the E98 hotspot, occur almost exclusively in del(5q) MDS and are associated with adverse outcomes, yet their impact on CK1\u0251 function remains unclear. Using integrated transcriptomic, (phospho)proteomic, and kinome activity profiling in hematopoietic stem and progenitor cells (HSPCs), combined with in vivo serial transplantation assays, we show that\n                    <jats:italic>Csnk1a1<\/jats:italic>\n                    E98V represents a change-of-function rather than a loss-of-function mutation. Unlike\n                    <jats:italic>Csnk1a1<\/jats:italic>\n                    haploinsufficiency,\n                    <jats:italic>Csnk1a1<\/jats:italic>\n                    E98V preserves long-term hematopoietic reconstitution and does not enhance clonal expansion in vivo. Instead, the mutation induces suppression of kinase signaling networks, leading to coordinated repression of ribosomal gene expression, protein translation, and cell cycle programs. This signaling rewiring is accompanied by metabolic reprogramming characterized by reduced mitochondrial respiration, increased glycolytic flux, and an inability to adapt to metabolic challenges, creating a stress-tolerant but inflexible cellular state. Notably,\n                    <jats:italic>Csnk1a1<\/jats:italic>\n                    E98V cells exhibit impaired megakaryopoiesis and increased vulnerability to iron overload, as well as RSL-3-mediated ferroptosis. Analysis of del(5q) MDS patients confirmed that\n                    <jats:italic>CSNK1A1<\/jats:italic>\n                    mutations are associated with distinct clinical features, including thrombocytopenia, elevated myeloblasts, and reduced bone marrow iron levels. Together, our findings support a two-step model in which del(5q)-associated\n                    <jats:italic>CSNK1A1<\/jats:italic>\n                    haploinsufficiency drives clonal expansion, followed by acquisition of\n                    <jats:italic>CSNK1A1<\/jats:italic>\n                    mutations that promote stress tolerance rather than increased proliferation. This adaptive rewiring exposes metabolic and iron-dependent vulnerabilities that may be therapeutically exploited.\n                  <\/jats:p>","DOI":"10.1038\/s41375-026-03122-x","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:42:10Z","timestamp":1788428530000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Csnk1a1 E98 mutations rewire signaling and metabolism in del(5q) myelodysplastic neoplasms"],"prefix":"10.1038","author":[{"given":"Stephani","family":"Schmitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8155-6534","authenticated-orcid":false,"given":"Juliette E.","family":"Pearce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0074-5726","authenticated-orcid":false,"given":"Sergio","family":"Martinez-H\u00f8yer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerjanne","family":"Vroeg in de wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge A. M.","family":"Snoeren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula S. A.","family":"Stalmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn N. R.","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelien J. F.","family":"Dugourd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5309-5558","authenticated-orcid":false,"given":"Giulia","family":"Franciosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9502-669X","authenticated-orcid":false,"given":"Eric M.","family":"Bindels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5083-9838","authenticated-orcid":false,"given":"Wencke","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0196-2837","authenticated-orcid":false,"given":"Torsten","family":"Haferlach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiel P. C.","family":"van der Vorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2623-2876","authenticated-orcid":false,"given":"Oriol","family":"Calvete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Sol\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-8976","authenticated-orcid":false,"given":"Julio","family":"Saez-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6287-9725","authenticated-orcid":false,"given":"Andreas","family":"Linkermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4747-4938","authenticated-orcid":false,"given":"Jesper","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6138-8916","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne F. E.","family":"Gleitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekka K.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"3122_CR1","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1182\/blood.2022015850","volume":"140","author":"DA Arber","year":"2022","unstructured":"Arber DA, Orazi A, Hasserjian RP, Borowitz MJ, Calvo KR, Kvasnicka H-M, et al. International consensus classification of myeloid neoplasms and acute leukemias: integrating morphologic, clinical, and genomic data. Blood. 2022;140:1200\u201328.","journal-title":"Blood"},{"key":"3122_CR2","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","volume":"36","author":"JD Khoury","year":"2022","unstructured":"Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, et al. The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic\/dendritic neoplasms. Leukemia. 2022;36:1703\u201319.","journal-title":"Leukemia"},{"key":"3122_CR3","doi-asserted-by":"publisher","first-page":"4385","DOI":"10.1182\/blood-2007-03-082404","volume":"110","author":"D Haase","year":"2007","unstructured":"Haase D, Germing U, Schanz J, Pfeilst\u00f6cker M, N\u00f6sslinger T, Hildebrandt B, et al. New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients. Blood. 2007;110:4385\u201395.","journal-title":"Blood"},{"key":"3122_CR4","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1053\/j.seminoncol.2011.04.010","volume":"38","author":"BL Ebert","year":"2011","unstructured":"Ebert BL. Molecular dissection of the 5q deletion in myelodysplastic syndrome. Semin Oncol. 2011;38:621\u20136.","journal-title":"Semin Oncol"},{"key":"3122_CR5","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/S0092-8674(02)00685-2","volume":"108","author":"C Liu","year":"2002","unstructured":"Liu C, Li Y, Semenov M, Han C, Baeg G-H, Tan Y, et al. Control of \u03b2-catenin phosphorylation\/degradation by a dual-kinase mechanism. Cell. 2002;108:837\u201347.","journal-title":"Cell"},{"key":"3122_CR6","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/nature09673","volume":"470","author":"E Elyada","year":"2011","unstructured":"Elyada E, Pribluda A, Goldstein RE, Morgenstern Y, Brachya G, Cojocaru G, et al. CKI\u03b1 ablation highlights a critical role for p53 in invasiveness control. Nature. 2011;470:409\u201313.","journal-title":"Nature"},{"key":"3122_CR7","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature07613","volume":"458","author":"N Bid\u00e8re","year":"2009","unstructured":"Bid\u00e8re N, Ngo VN, Lee J, Collins C, Zheng L, Wan F, et al. Casein kinase 1\u03b1 governs antigen-receptor-induced NF-\u03baB activation and human lymphoma cell survival. Nature. 2009;458:92\u201396.","journal-title":"Nature"},{"key":"3122_CR8","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.ccr.2014.08.001","volume":"26","author":"RK Schneider","year":"2014","unstructured":"Schneider RK, Adem\u00e0 V, Heckl D, J\u00e4r\u00e5s M, Mallo M, Lord AM, et al. Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS. Cancer Cell. 2014;26:509\u201320.","journal-title":"Cancer Cell"},{"key":"3122_CR9","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1182\/bloodadvances.2021006061","volume":"6","author":"USA Stalmann","year":"2022","unstructured":"Stalmann USA, Ticconi F, Snoeren IAM, Li R, Gleitz HFE, Cowley GS, et al. Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for CSNK1A1 in clonal expansion. Blood Adv. 2022;6:1780\u201396.","journal-title":"Blood Adv"},{"key":"3122_CR10","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/nature14610","volume":"523","author":"J Kr\u00f6nke","year":"2015","unstructured":"Kr\u00f6nke J, Fink EC, Hollenbach PW, MacBeth KJ, Hurst SN, Udeshi ND, et al. Lenalidomide induces ubiquitination and degradation of CK1\u03b1 in del(5q) MDS. Nature. 2015;523:183\u20138.","journal-title":"Nature"},{"key":"3122_CR11","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/bjh.13563","volume":"171","author":"E Bello","year":"2015","unstructured":"Bello E, Pellagatti A, Shaw J, Mecucci C, Ku\u0161ec R, Killick S, et al. CSNK1A1 mutations and gene expression analysis in myelodysplastic syndromes with del(5q). Br J Haematol. 2015;171:210\u20134.","journal-title":"Br J Haematol"},{"key":"3122_CR12","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.1038\/leu.2015.49","volume":"29","author":"M Heuser","year":"2015","unstructured":"Heuser M, Meggendorfer M, Cruz MMA, Fabisch J, Klesse S, K\u00f6hler L, et al. Frequency and prognostic impact of casein kinase 1A1 mutations in MDS patients with deletion of chromosome 5q. Leukemia. 2015;29:1942\u20135.","journal-title":"Leukemia"},{"key":"3122_CR13","doi-asserted-by":"publisher","first-page":"e212","DOI":"10.1016\/S2352-3026(15)00050-2","volume":"2","author":"AE Smith","year":"2015","unstructured":"Smith AE, Kulasekararaj AG, Jiang J, Mian S, Mohamedali A, Gaken J, et al. CSNK1A1 mutations and isolated del(5q) abnormality in myelodysplastic syndrome: a retrospective mutational analysis. Lancet Haematol. 2015;2:e212\u2013221.","journal-title":"Lancet Haematol"},{"key":"3122_CR14","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1038\/nmeth.2510","volume":"10","author":"V Redecke","year":"2013","unstructured":"Redecke V, Wu R, Zhou J, Finkelstein D, Chaturvedi V, High AA, et al. Hematopoietic progenitor cell lines with myeloid and lymphoid potential. Nat Methods. 2013;10:795\u2013803.","journal-title":"Nat Methods"},{"key":"3122_CR15","doi-asserted-by":"publisher","first-page":"W304","DOI":"10.1093\/nar\/gkab359","volume":"49","author":"MV Kuleshov","year":"2021","unstructured":"Kuleshov MV, Xie Z, London ABK, Yang J, Evangelista JE, Lachmann A, et al. KEA3: improved kinase enrichment analysis via data integration. Nucleic Acids Res. 2021;49:W304\u2013W316.","journal-title":"Nucleic Acids Res"},{"key":"3122_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-018-0236-z","volume":"16","author":"S Jiang","year":"2018","unstructured":"Jiang S, Zhang M, Sun J, Yang X. Casein kinase 1\u03b1: biological mechanisms and theranostic potential. Cell Commun Signal. 2018;16:23.","journal-title":"Cell Commun Signal"},{"key":"3122_CR17","first-page":"508","volume":"28","author":"U Knippschild","year":"2005","unstructured":"Knippschild U, Wolff S, Giamas G, Brockschmidt C, Wittau M, W\u00fcrl PU, et al. The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development. Onkologie. 2005;28:508\u201314.","journal-title":"Onkologie"},{"key":"3122_CR18","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.biocel.2010.12.004","volume":"43","author":"JK Cheong","year":"2011","unstructured":"Cheong JK, Virshup DM. Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol. 2011;43:465\u20139.","journal-title":"Int J Biochem Cell Biol"},{"key":"3122_CR19","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nature06494","volume":"451","author":"BL Ebert","year":"2008","unstructured":"Ebert BL, Pretz J, Bosco J, Chang CY, Tamayo P, Galili N, et al. Identification of RPS14 as a 5q- syndrome gene by RNA interference screen. Nature. 2008;451:335\u20139.","journal-title":"Nature"},{"key":"3122_CR20","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.cell.2018.02.036","volume":"173","author":"RK Khajuria","year":"2018","unstructured":"Khajuria RK, Munschauer M, Ulirsch JC, Fiorini C, Ludwig LS, McFarland SK, et al. Ribosome levels selectively regulate translation and lineage commitment in human hematopoiesis. Cell. 2018;173:90\u2013103. e19.","journal-title":"Cell"},{"key":"3122_CR21","doi-asserted-by":"publisher","first-page":"766","DOI":"10.4161\/psb.6.5.15438","volume":"6","author":"J Guo","year":"2011","unstructured":"Guo J, Jin Z, Yang X, Li J-F, Chen J-G. Eukaryotic initiation factor 6, an evolutionarily conserved regulator of ribosome biogenesis and protein translation. Plant Signal Behav. 2011;6:766\u201371.","journal-title":"Plant Signal Behav"},{"key":"3122_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21588-4","volume":"12","author":"AL Kennedy","year":"2021","unstructured":"Kennedy AL, Myers KC, Bowman J, Gibson CJ, Camarda ND, Furutani E, et al. Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome. Nat Commun. 2021;12:1334.","journal-title":"Nat Commun"},{"key":"3122_CR23","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.stem.2010.07.011","volume":"7","author":"T Simsek","year":"2010","unstructured":"Simsek T, Kocabas F, Zheng J, DeBerardinis RJ, Mahmoud AI, Olson EN, et al. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell. 2010;7:380\u201390.","journal-title":"Cell Stem Cell"},{"key":"3122_CR24","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1038\/nm.2882","volume":"18","author":"K Ito","year":"2012","unstructured":"Ito K, Carracedo A, Weiss D, Arai F, Ala U, Avigan DE, et al. A PML\u2013PPAR-\u03b4 pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med. 2012;18:1350\u20138.","journal-title":"Nat Med"},{"key":"3122_CR25","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.stem.2012.10.011","volume":"12","author":"K Takubo","year":"2013","unstructured":"Takubo K, Nagamatsu G, Kobayashi CI, Nakamura-Ishizu A, Kobayashi H, Ikeda E, et al. Regulation of glycolysis by PDK functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell. 2013;12:49\u201361.","journal-title":"Cell Stem Cell"},{"key":"3122_CR26","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1182\/blood.2025028460","volume":"146","author":"F Kollotzek","year":"2025","unstructured":"Kollotzek F, Mott K, Fischer M, Findik B, G\u00f6b V, Manke M-C, et al. Casein kinase 1\u03b1 essentially regulates thrombopoiesis by driving megakaryocyte maturation and cytoskeleton organization. Blood. 2025;146:1964\u201378.","journal-title":"Blood"},{"key":"3122_CR27","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1182\/blood.V46.4.519.519","volume":"46","author":"G Sokal","year":"1975","unstructured":"Sokal G, Michaux J, Van Den Berghe H, Cordier A, Rodhain J, Ferrant A, et al. A new hematologic syndrome with a distinct karyotype: the 5 q\u2013 chromosome. Blood. 1975;46:519\u201333.","journal-title":"Blood"},{"key":"3122_CR28","doi-asserted-by":"publisher","first-page":"e222","DOI":"10.1016\/j.leukres.2012.08.002","volume":"36","author":"A Jonasova","year":"2012","unstructured":"Jonasova A, Cermak J, Vondrakova J, Siskova M, Hochova I, Kadlckova E, et al. Thrombocytopenia at diagnosis an important negative prognostic marker in isolated 5q\u2212 MDS (IPSS low and intermediate-1). Leuk Res. 2012;36:e222\u2013e224.","journal-title":"Leuk Res"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41375-026-03122-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-026-03122-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-026-03122-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:42:11Z","timestamp":1788428531000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41375-026-03122-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":28,"alternative-id":["3122"],"URL":"https:\/\/doi.org\/10.1038\/s41375-026-03122-x","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]},"assertion":[{"value":"24 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"JSR reports in the last 3 years funding from GSK and Pfizer & fees\/honoraria from Travere Therapeutics, Stadapharm, Astex Pharmaceuticals, Owkin, Pfizer, Vera Therapeutics, Grunenthal, Tempus, and Moderna. AD reports in the last 3 years fees\/honoraria from Tempus and MONTAI. RKS is a co-founder and shareholder of Sequantrix GmbH and receives research funding from Active Biotech.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}