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In this work, chiral UCNPs\/Cu<jats:sub>x<\/jats:sub>OS@ZIF nanoprobes are prepared by encapsulating upconversion nanoparticles (UCNPs) and Cu<jats:sub>x<\/jats:sub>OS nanoparticles (NPs) into zeolitic imidazolate framework-8 (ZIF-8). The novel excited-state energy distribution-modulated upconversion nanostructure (NaYbF<jats:sub>4<\/jats:sub>@NaYF<jats:sub>4<\/jats:sub>: Yb, Er) is selected as the fluorescence source and energy donor for highly efficient fluorescence resonance energy transfer (FRET). Cu<jats:sub>x<\/jats:sub>OS NP is employed as chiral source and energy acceptor to quench upconversion luminescence (UCL) and provide circular dichroism (CD) signal. Utilizing the natural adsorption and sorting advantages of ZIF-8, the designed nanoprobe can isolate the influence of other common disruptors, thus achieve ultra-sensitive and highly selective UCL\/CD dual-mode quantification of H<jats:sub>2<\/jats:sub>S in aqueous solution and in living cells. Notably, the nanoprobe is also capable of in vivo intra-tumoral H<jats:sub>2<\/jats:sub>S tracking. Our work highlights the multifunctional properties of chiral nanocomposites in sensing and opens a new vision and idea for the preparation and application of chiral nanomaterials in biomedical and biological analysis.<\/jats:p>","DOI":"10.1038\/s41377-024-01539-6","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T07:08:07Z","timestamp":1722496087000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Upconversion-based chiral nanoprobe for highly selective dual-mode sensing and bioimaging of hydrogen sulfide in vitro and in vivo"],"prefix":"10.1038","volume":"13","author":[{"given":"Yang","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqian","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4186-9637","authenticated-orcid":false,"given":"Xiaomin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geyu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"key":"1539_CR1","doi-asserted-by":"publisher","first-page":"12782","DOI":"10.1039\/D2CC04420J","volume":"58","author":"AH Qu","year":"2022","unstructured":"Qu, A. 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