{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:47:17Z","timestamp":1791654437881,"version":"4.3.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K12519"],"award-info":[{"award-number":["15K12519"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K22969"],"award-info":[{"award-number":["19K22969"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H01847"],"award-info":[{"award-number":["21H01847"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H00303"],"award-info":[{"award-number":["22H00303"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K12519"],"award-info":[{"award-number":["15K12519"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K12519"],"award-info":[{"award-number":["15K12519"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009023","name":"MEXT | JST | Precursory Research for Embryonic Science and Technology","doi-asserted-by":"publisher","award":["JPMJPR17PC"],"award-info":[{"award-number":["JPMJPR17PC"]}],"id":[{"id":"10.13039\/501100009023","id-type":"DOI","asserted-by":"publisher"}]},{"name":"A research grant from the Research Clusters Program of Tokushima University is a research budget allocated competitively within Tokushima University."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Light Sci Appl"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We demonstrate long-range enhancement of fluorescence and Raman scattering using a dense random array of Ag nanoislands (AgNIs) coated with column-structured silica (CSS) overlayer of over 100\u2009nm thickness, namely, remote plasmonic-like enhancement (RPE). The CSS layer provides physical and chemical protection, reducing the impact between analyte molecules and metal nanostructures. RPE plates are fabricated with high productivity using sputtering and chemical immersion in gold(I)\/halide solution. The RPE plate significantly enhances Raman scattering and fluorescence, even without proximity between analyte molecules and metal nanostructures. The maximum enhancement factors are 10<jats:sup>7<\/jats:sup>-fold for Raman scattering and 10<jats:sup>2<\/jats:sup>-fold for fluorescence. RPE is successfully applied to enhance fluorescence biosensing of intracellular signalling dynamics in HeLa cells and Raman histological imaging of oesophagus tissues. Our findings present an interesting deviation from the conventional near-field enhancement theory, as they cannot be readily explained within its framework. However, based on the phenomenological aspects we have demonstrated, the observed enhancement is likely associated with the remote resonant coupling between the localised surface plasmon of AgNIs and the molecular transition dipole of the analyte, facilitated through the CSS structure. Although further investigation is warranted to fully understand the underlying mechanisms, the RPE plate offers practical advantages, such as high productivity and biocompatibility, making it a valuable tool for biosensing and biomolecular analysis in chemistry, biology, and medicine. We anticipate that RPE will advance as a versatile analytical tool for enhanced biosensing using Raman and fluorescence analysis in various biological contexts.<\/jats:p>","DOI":"10.1038\/s41377-024-01655-3","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T08:42:45Z","timestamp":1730104965000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer"],"prefix":"10.1038","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3528-7163","authenticated-orcid":false,"given":"Takeo","family":"Minamikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8450-721X","authenticated-orcid":false,"given":"Reiko","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5942-130X","authenticated-orcid":false,"given":"Yoshinori","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Tanioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sota","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideharu","family":"Hase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Takamatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7951-110X","authenticated-orcid":false,"given":"Yu","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuo","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"1655_CR1","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1038\/nmeth817","volume":"2","author":"JW Lichtman","year":"2005","unstructured":"Lichtman, J. W. & Conchello, J. A. Fluorescence microscopy. Nat. Methods 2, 910\u2013919 (2005).","journal-title":"Nat. Methods"},{"key":"1655_CR2","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1126\/science.1137395","volume":"316","author":"SW Hell","year":"2007","unstructured":"Hell, S. W. Far-field optical nanoscopy. Science 316, 1153\u20131158 (2007).","journal-title":"Science"},{"key":"1655_CR3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s43586-021-00069-4","volume":"1","author":"EHK Stelzer","year":"2021","unstructured":"Stelzer, E. H. K. et al. Light sheet fluorescence microscopy. Nat. Rev. Methods Prim. 1, 73 (2021).","journal-title":"Nat. Rev. Methods Prim."},{"key":"1655_CR4","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1080\/05704920701551530","volume":"42","author":"Z Movasaghi","year":"2007","unstructured":"Movasaghi, Z., Rehman, S. & Rehman, I. U. Raman spectroscopy of biological tissues. Appl. Spectrosc. Rev. 42, 493\u2013541 (2007).","journal-title":"Appl. Spectrosc. Rev."},{"key":"1655_CR5","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1002\/jrs.4335","volume":"44","author":"A Rygula","year":"2013","unstructured":"Rygula, A. et al. Raman spectroscopy of proteins: a review. J. Raman Spectrosc. 44, 1061\u20131076 (2013).","journal-title":"J. Raman Spectrosc."},{"key":"1655_CR6","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/nprot.2013.030","volume":"8","author":"AF Palonpon","year":"2013","unstructured":"Palonpon, A. F. et al. Raman and SERS microscopy for molecular imaging of live cells. Nat. Protoc. 8, 677\u2013692 (2013).","journal-title":"Nat. Protoc."},{"key":"1655_CR7","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0009-2614(99)01451-7","volume":"318","author":"RM St\u00f6ckle","year":"2000","unstructured":"St\u00f6ckle, R. M. et al. Nanoscale chemical analysis by tip-enhanced Raman spectroscopy. Chem. Phys. Lett. 318, 131\u2013136 (2000).","journal-title":"Chem. Phys. Lett."},{"key":"1655_CR8","doi-asserted-by":"publisher","DOI":"10.1063\/5.0009766","volume":"153","author":"S Mahapatra","year":"2020","unstructured":"Mahapatra, S. et al. Tip-enhanced Raman spectroscopy: Chemical analysis with nanoscale to angstrom scale resolution. J. Chem. Phys. 153, 010902 (2020).","journal-title":"J. Chem. Phys."},{"key":"1655_CR9","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1111\/j.1462-5822.2009.01283.x","volume":"11","author":"AD Hoppe","year":"2009","unstructured":"Hoppe, A. D., Seveau, S. & Swanson, J. A. Live cell fluorescence microscopy to study microbial pathogenesis. Cell. Microbiol. 11, 540\u2013550 (2009).","journal-title":"Cell. Microbiol."},{"key":"1655_CR10","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3390\/bios5020337","volume":"5","author":"Y Suzuki","year":"2015","unstructured":"Suzuki, Y. & Yokoyama, K. Development of functional fluorescent molecular probes for the detection of biological substances. Biosensors 5, 337\u2013363 (2015).","journal-title":"Biosensors"},{"key":"1655_CR11","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.molcel.2015.03.002","volume":"58","author":"A Miyawaki","year":"2015","unstructured":"Miyawaki, A. & Niino, Y. Molecular spies for bioimaging \u2013 fluorescent protein-based probes. Mol. Cell 58, 632\u2013643 (2015).","journal-title":"Mol. Cell"},{"key":"1655_CR12","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1038\/nrm976","volume":"3","author":"J Zhang","year":"2002","unstructured":"Zhang, J. et al. Creating new fluorescent probes for cell biology. Nat. Rev. Mol. Cell Biol. 3, 906\u2013918 (2002).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"1655_CR13","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1366\/000370207781269747","volume":"61","author":"Y Hattori","year":"2007","unstructured":"Hattori, Y. et al. In vivo Raman study of the living rat esophagus and stomach using a micro-Raman probe under an endoscope. Appl. Spectrosc. 61, 579\u2013584 (2007).","journal-title":"Appl. Spectrosc."},{"key":"1655_CR14","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1126\/science.1165758","volume":"322","author":"CW Freudiger","year":"2008","unstructured":"Freudiger, C. W. et al. Label-free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy. Science 322, 1857\u20131861 (2008).","journal-title":"Science"},{"key":"1655_CR15","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/nphoton.2012.263","volume":"6","author":"Y Ozeki","year":"2012","unstructured":"Ozeki, Y. et al. High-speed molecular spectral imaging of tissue with stimulated Raman scattering. Nat. Photonics 6, 844\u2013850 (2012).","journal-title":"Nat. Photonics"},{"key":"1655_CR16","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.addr.2015.03.009","volume":"89","author":"K Kong","year":"2015","unstructured":"Kong, K. et al. Raman spectroscopy for medical diagnostics \u2013 From in-vitro biofluid assays to in-vivo cancer detection. Adv. Drug Deliv. Rev. 89, 121\u2013134 (2015).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"1655_CR17","doi-asserted-by":"publisher","first-page":"3892","DOI":"10.1364\/BOE.6.003892","volume":"6","author":"A Papour","year":"2015","unstructured":"Papour, A. et al. Wide-field Raman imaging for bone detection in tissue. Biomed. Opt. Express 6, 3892\u20133897 (2015).","journal-title":"Biomed. Opt. Express"},{"key":"1655_CR18","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1039\/C7AN01760J","volume":"143","author":"L Frame","year":"2018","unstructured":"Frame, L. et al. Development of a label-free Raman imaging technique for differentiation of malaria parasite infected from non-infected tissue. Analyst 143, 157\u2013163 (2018).","journal-title":"Analyst"},{"key":"1655_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33025-6","volume":"8","author":"T Yamamoto","year":"2018","unstructured":"Yamamoto, T. et al. Label-free evaluation of myocardial infarct in surgically excised ventricular myocardium by Raman spectroscopy. Sci. Rep. 8, 14671 (2018).","journal-title":"Sci. Rep."},{"key":"1655_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75604-6","volume":"10","author":"T Minamikawa","year":"2020","unstructured":"Minamikawa, T. et al. Molecular imaging analysis of microvesicular and macrovesicular lipid droplets in non-alcoholic fatty liver disease by Raman microscopy. Sci. Rep. 10, 18548 (2020).","journal-title":"Sci. Rep."},{"key":"1655_CR21","doi-asserted-by":"publisher","first-page":"013001","DOI":"10.1088\/0022-3727\/41\/1\/013001","volume":"41","author":"E Fort","year":"2008","unstructured":"Fort, E. & Gr\u00e9sillon, S. Surface enhanced fluorescence. J. Phys. D: Appl. Phys. 41, 013001 (2008).","journal-title":"J. Phys. D: Appl. Phys."},{"key":"1655_CR22","first-page":"R597","volume":"14","author":"K Kneipp","year":"2002","unstructured":"Kneipp, K. et al. Surface-enhanced Raman scattering and biophysics. J. Phys.: Condens. Matter 14, R597\u2013R624 (2002).","journal-title":"J. Phys.: Condens. Matter"},{"key":"1655_CR23","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1146\/annurev.anchem.1.031207.112814","volume":"1","author":"PL Stiles","year":"2008","unstructured":"Stiles, P. L. et al. Surface-enhanced Raman spectroscopy. Annu. Rev. Anal. Chem. 1, 601\u2013626 (2008).","journal-title":"Annu. Rev. Anal. Chem."},{"key":"1655_CR24","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1002\/jrs.1378","volume":"36","author":"ZQ Tian","year":"2005","unstructured":"Tian, Z. Q. Surface-enhanced Raman spectroscopy: advancements and applications. J. Raman Spectrosc. 36, 466\u2013470 (2005).","journal-title":"J. Raman Spectrosc."},{"key":"1655_CR25","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s11468-005-9002-3","volume":"1","author":"JR Lakowicz","year":"2006","unstructured":"Lakowicz, J. R. Plasmonics in biology and plasmon-controlled fluorescence. Plasmonics 1, 5\u201333 (2006).","journal-title":"Plasmonics"},{"key":"1655_CR26","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/nbt1377","volume":"26","author":"X Qian","year":"2008","unstructured":"Qian, X. et al. In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags. Nat. Biotechnol. 26, 83\u201390 (2008).","journal-title":"Nat. Biotechnol."},{"key":"1655_CR27","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1002\/adma.200803464","volume":"21","author":"G von Maltzahn","year":"2009","unstructured":"von Maltzahn, G. et al. SERS-coded gold nanorods as a multifunctional platform for densely multiplexed near-infrared imaging and photothermal heating. Adv. Mater. 21, 3175\u20133180 (2009).","journal-title":"Adv. Mater."},{"key":"1655_CR28","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1016\/j.biomaterials.2010.10.058","volume":"32","author":"J Qian","year":"2011","unstructured":"Qian, J. et al. Fluorescence-surface enhanced Raman scattering co-functionalized gold nanorods as near-infrared probes for purely optical in vivo imaging. Biomaterials 32, 1601\u20131610 (2011).","journal-title":"Biomaterials"},{"key":"1655_CR29","doi-asserted-by":"publisher","first-page":"13620","DOI":"10.1073\/pnas.1003926107","volume":"107","author":"AK Kodali","year":"2010","unstructured":"Kodali, A. K., Llora, X. & Bhargava, R. Optimally designed nanolayered metal-dielectric particles as probes for massively multiplexed and ultrasensitive molecular assays. Proc. Natl Acad. Sci. USA 107, 13620\u201313625 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1655_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1546","volume":"2","author":"TY Liu","year":"2011","unstructured":"Liu, T. Y. et al. Functionalized arrays of Raman-enhancing nanoparticles for capture and culture-free analysis of bacteria in human blood. Nat. Commun. 2, 538 (2011).","journal-title":"Nat. Commun."},{"key":"1655_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20413-8","volume":"12","author":"W Lee","year":"2021","unstructured":"Lee, W. et al. Spread spectrum SERS allows label-free detection of attomolar neurotransmitters. Nat. Commun. 12, 159 (2021).","journal-title":"Nat. Commun."},{"key":"1655_CR32","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202200902","volume":"35","author":"D Zheng","year":"2023","unstructured":"Zheng, D. et al. Toward plasmonic neural probes: SERS detection of neurotransmitters through gold-nanoislands-decorated tapered optical fibers with sub-10 nm gaps. Adv. Mater. 35, 2200902 (2023).","journal-title":"Adv. Mater."},{"key":"1655_CR33","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1021\/acssensors.0c00784","volume":"5","author":"X Zhao","year":"2020","unstructured":"Zhao, X. et al. Branched Au nanoparticles on nanofibers for surface-enhanced Raman scattering sensing of intracellular pH and extracellular pH gradients. ACS Sens. 5, 2155\u20132167 (2020).","journal-title":"ACS Sens."},{"key":"1655_CR34","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202200975","volume":"18","author":"L Collard","year":"2022","unstructured":"Collard, L. et al. Holographic manipulation of nanostructured fiber optics enables spatially-resolved, reconfigurable optical control of plasmonic local field enhancement and SERS. Small 18, 2200975 (2022).","journal-title":"Small"},{"key":"1655_CR35","doi-asserted-by":"publisher","first-page":"7065","DOI":"10.1021\/acsnano.1c00188","volume":"15","author":"K Tapio","year":"2021","unstructured":"Tapio, K. et al. A versatile DNA origami-based plasmonic nanoantenna for label-free single-molecule surface-enhanced Raman spectroscopy. ACS Nano 15, 7065\u20137077 (2021).","journal-title":"ACS Nano"},{"key":"1655_CR36","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.molcata.2010.12.001","volume":"335","author":"N Gupta","year":"2011","unstructured":"Gupta, N., Singh, H. P. & Sharma, R. K. Metal nanoparticles with high catalytic activity in degradation of methyl orange: An electron relay effect. J. Mol. Catal. A: Chem. 335, 248\u2013252 (2011).","journal-title":"J. Mol. Catal. A: Chem."},{"key":"1655_CR37","doi-asserted-by":"publisher","first-page":"448","DOI":"10.3390\/bios11110448","volume":"11","author":"A Skvortsov","year":"2021","unstructured":"Skvortsov, A. et al. Stable in biocompatible buffers silver nanoisland films for SERS. Biosensors 11, 448 (2021).","journal-title":"Biosensors"},{"key":"1655_CR38","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-023-15958-4","volume":"23","author":"EA Kumah","year":"2023","unstructured":"Kumah, E. A. et al. Human and environmental impacts of nanoparticles: a scoping review of the current literature. BMC Public Health 23, 1059 (2023).","journal-title":"BMC Public Health"},{"key":"1655_CR39","doi-asserted-by":"publisher","first-page":"18301","DOI":"10.1021\/acsami.1c01834","volume":"13","author":"X Luo","year":"2021","unstructured":"Luo, X. et al. Boosting long-range surface-enhanced Raman scattering on plasmonic nanohole arrays for ultrasensitive detection of MiRNA. ACS Appl. Mater. Interfaces 13, 18301\u201318313 (2021).","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"1655_CR40","doi-asserted-by":"publisher","first-page":"24126","DOI":"10.1039\/C7CP04564F","volume":"19","author":"C Hou","year":"2017","unstructured":"Hou, C. et al. Long-range surface plasmon resonance and surface-enhanced Raman scattering on X-shaped gold plasmonic nanohole arrays. Phys. Chem. Chem. Phys. 19, 24126\u201324134 (2017).","journal-title":"Phys. Chem. Chem. Phys."},{"key":"1655_CR41","doi-asserted-by":"publisher","first-page":"17541","DOI":"10.1021\/acs.analchem.2c03846","volume":"94","author":"P Wu","year":"2022","unstructured":"Wu, P. et al. Long-range SERS detection of the SARS-CoV-2 antigen on a well-ordered gold hexagonal nanoplate film. Anal. Chem. 94, 17541\u201317550 (2022).","journal-title":"Anal. Chem."},{"key":"1655_CR42","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1351\/PAC-REP-10-09-31","volume":"83","author":"AM Brouwer","year":"2011","unstructured":"Brouwer, A. M. Standards for photoluminescence quantum yield measurements in solution (IUPAC Technical Report). Pure Appl. Chem. 83, 2213\u20132228 (2011).","journal-title":"Pure Appl. Chem."},{"key":"1655_CR43","doi-asserted-by":"publisher","first-page":"8171","DOI":"10.1016\/S0021-9258(18)83165-9","volume":"264","author":"A Minta","year":"1989","unstructured":"Minta, A., Kao, J. P. & Tsien, R. Y. Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores. J. Biol. Chem. 264, 8171\u20138178 (1989).","journal-title":"J. Biol. Chem."},{"key":"1655_CR44","doi-asserted-by":"publisher","first-page":"326","DOI":"10.2307\/3583604","volume":"2","author":"T F\u00f6rster","year":"1960","unstructured":"F\u00f6rster, T. Transfer mechanisms of electronic excitation energy. Radiat. Res. Suppl. 2, 326\u2013339 (1960).","journal-title":"Radiat. Res. Suppl."},{"key":"1655_CR45","doi-asserted-by":"publisher","first-page":"17254","DOI":"10.1021\/jp053167t","volume":"109","author":"M Kawasaki","year":"2005","unstructured":"Kawasaki, M. & Mine, S. Enhanced molecular fluorescence near thick Ag island film of large pseudotabular nanoparticles. J. Phys. Chem. B 109, 17254\u201317261 (2005).","journal-title":"J. Phys. Chem. B"}],"container-title":["Light: Science &amp; Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41377-024-01655-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41377-024-01655-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41377-024-01655-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T08:43:19Z","timestamp":1730104999000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41377-024-01655-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1655"],"URL":"https:\/\/doi.org\/10.1038\/s41377-024-01655-3","relation":{},"ISSN":["2047-7538"],"issn-type":[{"value":"2047-7538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"12 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"T.M., R.S., Y.H., H.T., S.I., H.H., Ya.M., and T.T. declare no competing financial interests. Y.Y. and Yu.M. were employees of Ushio Inc. during this project. Mi.K., Yu.M., Ma.K. and Y.Y have filed patents related to this work.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"299"}}