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Lensless HT (LHT) offers a promising alternative for large-volume examination, however existing approaches fail to accurately reconstruct highly scattering samples over extended depths, which remains a critical challenge in optical imaging field. Here, we introduce a gigavoxel-scale, multiple-scattering-aware LHT with a large FOV (surpassing 0.6\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    ), millimeter-scale axial range, and pixel level (~2.4\u2009\u00b5m) resolution. Our approach leverages a multi-wavelength, oblique-illumination hologram reconstruction and a robust, automatic illumination angle calibration, which are necessary for precise large-volume 3D holographic reconstruction. Moreover, we propose optimization-driven multi-slice tomographic framework to accurately capture multiple scattering effects outperforming first order Born\/Rytov-based inversions. To rigorously validate our method, we reconstruct bespoke multi-layer two-photon polymerized test structure over a 1.7\u2009mm imaging depth and 25\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    FOV, yielding an unprecedented 3D space-bandwidth product exceeding a gigavoxel level. Furthermore, we demonstrate for the first time on-chip label-free imaging of entire 500-\u00b5m-thick tissue slice of optically cleared mouse brain. With the proposed method, we aim to unlock powerful new capabilities for large-scale, quantitative, label-free 3D imaging across biomedicine, neuroscience, material sciences and beyond.\n                  <\/jats:p>","DOI":"10.1038\/s41377-026-02416-0","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:41:57Z","timestamp":1789526517000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gigavoxel-scale multiple-scattering-aware lensless holotomography"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4829-8128","authenticated-orcid":false,"given":"Miko\u0142aj","family":"Rogalski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1922-3856","authenticated-orcid":false,"given":"Julianna","family":"Winnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7943-9157","authenticated-orcid":false,"given":"Julia","family":"Dudek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9412-5610","authenticated-orcid":false,"given":"Piotr","family":"Arcab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3691-9671","authenticated-orcid":false,"given":"Emilia","family":"Wdowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3191-510X","authenticated-orcid":false,"given":"Pawe\u0142","family":"Matryba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4725-8909","authenticated-orcid":false,"given":"Marzena","family":"Stefaniuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3526-3233","authenticated-orcid":false,"given":"Piotr","family":"Zda\u0144kowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5907-0105","authenticated-orcid":false,"given":"Maciej","family":"Trusiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"2416_CR1","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1038\/s41566-023-01299-6","volume":"17","author":"NT Shaked","year":"2023","unstructured":"Shaked, N. 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