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However, the emerging microneedle (MN) technologies for colorimetric or electrochemical detection of glucose in sampled dermal interstitial fluid (ISF) remain far from practical CGM due to many concerns. Herein, we propose a new disposable solid MN array on a flexible paper substrate, integrated with reusable electronics and a mobile application, for electrochemical glucose sensing in ISF. The paper substrate was prepared by infusing paper with UV-cured flexible gingiva mask resin, ensuring body comfort. The solid MN array was fabricated from a newly developed composite of UV-cured biocompatible surgical guide resin (SGR) and microcrystalline cellulose (MCC), using a simple self-developed fabrication technique, ensuring safe skin interaction. The paper-based composite MN arrays were converted into conductive biosensing electrodes by coating them with graphene ink and additional functional modifiers via airbrushing, and subsequently integrated into a wearable patch for continuous ISF glucose monitoring. The resulting MN array electrodes exhibited excellent analytical performance in monitoring glucose of ex vivo porcine plasma, hydrogel-based artificial skin, and in vivo mice, with high sensitivity, selectivity against interferents, and robust stability. This study provides a simple, cost-effective, and eco-friendly path for the development of wearable electroanalytical devices toward practical CGM.<\/jats:p>","DOI":"10.1038\/s41378-026-01313-1","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:40:36Z","timestamp":1780472436000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A wearable paper-based SGR\/MCC microneedle array sensor for continuous glucose monitoring"],"prefix":"10.1038","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1214-3717","authenticated-orcid":false,"given":"Joseph Benjamin","family":"Holman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talifhani","family":"Mushiana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengdi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2987-7378","authenticated-orcid":false,"given":"Bensheng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0656-8847","authenticated-orcid":false,"given":"Chengpan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3331-1011","authenticated-orcid":false,"given":"Weiping","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"1313_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2023.115103","volume":"225","author":"YY Zou","year":"2023","unstructured":"Zou, Y. 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