{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:29:31Z","timestamp":1786613371273,"version":"build-2736575974"},"reference-count":199,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK133864"],"award-info":[{"award-number":["R01DK133864"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM145960"],"award-info":[{"award-number":["R01GM145960"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK133864"],"award-info":[{"award-number":["R01DK133864"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Microsyst Nanoeng"],"DOI":"10.1038\/s41378-026-01320-2","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T07:38:01Z","timestamp":1786606681000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Noninvasive biophysical modulations of Piezo ion channels"],"prefix":"10.1038","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4845-6464","authenticated-orcid":false,"given":"Yunfan","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1134-0989","authenticated-orcid":false,"given":"Haosheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1436-4054","authenticated-orcid":false,"given":"Luke P.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"1320_CR1","doi-asserted-by":"crossref","unstructured":"Fang, X. Z. et al. Structure, kinetic properties and biological function of mechanosensitive Piezo channels. Cell Biosci. 11, 13 (2021).","DOI":"10.1186\/s13578-020-00522-z"},{"key":"1320_CR2","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1126\/science.1193270","volume":"330","author":"B Coste","year":"2010","unstructured":"Coste, B. et al. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 330, 55\u201360 (2010).","journal-title":"Science"},{"key":"1320_CR3","doi-asserted-by":"crossref","unstructured":"Ge, J. P. et al. Architecture of the mammalian mechanosensitive Piezo1 channel. Nature 527, 64\u201369 (2015).","DOI":"10.1038\/nature15247"},{"key":"1320_CR4","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/nature25743","volume":"554","author":"QC Zhao","year":"2018","unstructured":"Zhao, Q. C. et al. Structure and mechanogating mechanism of the Piezo1 channel. Nature 554, 487\u2013492 (2018).","journal-title":"Nature"},{"key":"1320_CR5","doi-asserted-by":"publisher","first-page":"19","DOI":"10.7554\/eLife.33660","volume":"6","author":"YSR Guo","year":"2017","unstructured":"Guo, Y. S. R. & MacKinnon, R. Structure-based membrane dome mechanism for Piezo mechanosensitivity. eLife 6, 19 (2017).","journal-title":"eLife"},{"key":"1320_CR6","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature25453","volume":"554","author":"K Saotome","year":"2018","unstructured":"Saotome, K. et al. Structure of the mechanically activated ion channel Piezo1. Nature 554, 481\u2013486 (2018).","journal-title":"Nature"},{"key":"1320_CR7","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41586-019-1505-8","volume":"573","author":"L Wang","year":"2019","unstructured":"Wang, L. et al. Structure and mechanogating of the mammalian tactile channel PIEZO2. Nature 573, 225\u2013229 (2019).","journal-title":"Nature"},{"key":"1320_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202509860","volume":"12","author":"LA Ambattu","year":"2025","unstructured":"Ambattu, L. A., del Rosal, B., Ferrai, C. & Yeo, L. Y. Sonoepigenetic modification mechanoprimes early osteogenic commitment in mesenchymal stem cells. Adv. Sci. 12, e09860 (2025).","journal-title":"Adv. Sci."},{"key":"1320_CR9","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1113\/jphysiol.1950.sp004479","volume":"111","author":"B Katz","year":"1950","unstructured":"Katz, B. Depolarization of sensory terminals and the initiation of impulses in the muscle spindle. J. Physiol. 111, 261\u2013282 (1950).","journal-title":"J. Physiol."},{"key":"1320_CR10","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202314079","volume":"34","author":"L Chen","year":"2024","unstructured":"Chen, L. et al. Electroactive biomaterials regulate the electrophysiological microenvironment to promote bone and cartilage tissue regeneration. Adv. Funct. Mater. 34, 2314079 (2024).","journal-title":"Adv. Funct. Mater."},{"key":"1320_CR11","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-018-0059-8","volume":"38","author":"J Jacob","year":"2018","unstructured":"Jacob, J., More, N., Kalia, K. & Kapusetti, G. Piezoelectric smart biomaterials for bone and cartilage tissue engineering. Inflamm. Regen. 38, 2 (2018).","journal-title":"Inflamm. Regen."},{"key":"1320_CR12","doi-asserted-by":"publisher","first-page":"30657","DOI":"10.1039\/D1RA03557F","volume":"11","author":"R Lay","year":"2021","unstructured":"Lay, R., Deijs, G. S. & Malmstr\u00f6m, J. The intrinsic piezoelectric properties of materials\u2014a review with a focus on biological materials. RSC Adv. 11, 30657\u201330673 (2021).","journal-title":"RSC Adv."},{"key":"1320_CR13","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1073\/pnas.84.8.2297","volume":"84","author":"B Martinac","year":"1987","unstructured":"Martinac, B., Buechner, M., Delcour, A. H., Adler, J. & Kung, C. Pressure-sensitive ion channel in Escherichia coli. Proc. Natl. Acad. Sci. USA 84, 2297\u20132301 (1987).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"1320_CR14","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/368265a0","volume":"368","author":"SI Sukharev","year":"1994","unstructured":"Sukharev, S. I., Blount, P., Martinac, B., Blattner, F. R. & Kung, C. A large-conductance mechanosensitive channel in E. coli encoded by mscL alone. Nature 368, 265\u2013268 (1994).","journal-title":"Nature"},{"key":"1320_CR15","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1093\/emboj\/18.7.1730","volume":"18","author":"N Levina","year":"1999","unstructured":"Levina, N. et al. Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity. EMBO J. 18, 1730\u20131737 (1999).","journal-title":"EMBO J."},{"key":"1320_CR16","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1146\/annurev-physiol-021317-121351","volume":"80","author":"CD Cox","year":"2018","unstructured":"Cox, C. D., Bavi, N. & Martinac, B. Bacterial mechanosensors. Annu. Rev. Physiol. 80, 71\u201393 (2018).","journal-title":"Annu. Rev. Physiol."},{"key":"1320_CR17","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/nature10812","volume":"483","author":"B Coste","year":"2012","unstructured":"Coste, B. et al. Piezo proteins are pore-forming subunits of mechanically activated channels. Nature 483, 176\u2013181 (2012).","journal-title":"Nature"},{"key":"1320_CR18","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1016\/j.celrep.2016.10.033","volume":"17","author":"R Syeda","year":"2016","unstructured":"Syeda, R. et al. Piezo1 channels are inherently mechanosensitive. Cell Rep. 17, 1739\u20131746 (2016).","journal-title":"Cell Rep."},{"key":"1320_CR19","first-page":"17","volume":"22","author":"X Xu","year":"2021","unstructured":"Xu, X. et al. Piezo channels: awesome mechanosensitive structures in cellular mechanotransduction and their role in bone. Int. J. Mol. Sci. 22, 17 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"1320_CR20","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/j.neuron.2016.01.046","volume":"89","author":"QC Zhao","year":"2016","unstructured":"Zhao, Q. C. et al. Ion permeation and mechanotransduction mechanisms of mechanosensitive Piezo channels. Neuron 89, 1248\u20131263 (2016).","journal-title":"Neuron"},{"key":"1320_CR21","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.tibs.2021.01.008","volume":"46","author":"Y Jiang","year":"2021","unstructured":"Jiang, Y., Yang, X. Z., Jiang, J. H. & Xiao, B. L. Structural designs and mechanogating mechanisms of the mechanosensitive Piezo channels. Trends Biochem. Sci. 46, 472\u2013488 (2021).","journal-title":"Trends Biochem. Sci."},{"key":"1320_CR22","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/nature15247","volume":"527","author":"J Ge","year":"2015","unstructured":"Ge, J. et al. Architecture of the mammalian mechanosensitive Piezo1 channel. Nature 527, 64\u201369 (2015).","journal-title":"Nature"},{"key":"1320_CR23","doi-asserted-by":"publisher","first-page":"10366","DOI":"10.1038\/ncomms10366","volume":"7","author":"CD Cox","year":"2016","unstructured":"Cox, C. D. et al. Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension. Nat. Commun. 7, 10366 (2016).","journal-title":"Nat. Commun."},{"key":"1320_CR24","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/s41586-022-04574-8","volume":"604","author":"X Yang","year":"2022","unstructured":"Yang, X. et al. Structure deformation and curvature sensing of PIEZO1 in lipid membranes. Nature 604, 377\u2013383 (2022).","journal-title":"Nature"},{"key":"1320_CR25","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1038\/s41467-018-03570-9","volume":"9","author":"YF Wang","year":"2018","unstructured":"Wang, Y. F. et al. A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel. Nat. Commun. 9, 1300 (2018).","journal-title":"Nat. Commun."},{"key":"1320_CR26","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1111\/febs.14711","volume":"286","author":"QC Zhao","year":"2019","unstructured":"Zhao, Q. C., Zhou, H., Li, X. M. & Xiao, B. L. The mechanosensitive Piezo1 channel: a three-bladed propeller-like structure and a lever-like mechanogating mechanism. FEBS J. 286, 2461\u20132470 (2019).","journal-title":"FEBS J."},{"key":"1320_CR27","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/S0076-6879(99)94027-2","volume":"294","author":"P Blount","year":"1999","unstructured":"Blount, P., Sukharev, S. I., Moe, P. C., Martinac, B. & Kung, C. Mechanosensitive channels of bacteria. Methods Enzymol. 294, 458\u2013482 (1999).","journal-title":"Methods Enzymol."},{"key":"1320_CR28","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/nature25743","volume":"554","author":"Q Zhao","year":"2018","unstructured":"Zhao, Q. et al. Structure and mechanogating mechanism of the Piezo1 channel. Nature 554, 487\u2013492 (2018).","journal-title":"Nature"},{"key":"1320_CR29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41413-021-00168-8","volume":"9","author":"L Qin","year":"2021","unstructured":"Qin, L. et al. Roles of mechanosensitive channel Piezo1\/2 proteins in skeleton and other tissues. Bone Res. 9, 17 (2021).","journal-title":"Bone Res."},{"key":"1320_CR30","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1074\/jbc.RA120.015905","volume":"296","author":"ED Nosyreva","year":"2021","unstructured":"Nosyreva, E. D., Thompson, D. & Syeda, R. Identification and functional characterization of the Piezo1 channel pore domain. J. Biol. Chem. 296, 10 (2021).","journal-title":"J. Biol. Chem."},{"key":"1320_CR31","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/s41586-019-1499-2","volume":"573","author":"YC Lin","year":"2019","unstructured":"Lin, Y. C. et al. Force-induced conformational changes in PIEZO1. Nature 573, 230\u2013234 (2019).","journal-title":"Nature"},{"key":"1320_CR32","doi-asserted-by":"publisher","first-page":"29","DOI":"10.7554\/eLife.41968","volume":"7","author":"CA Haselwandter","year":"2018","unstructured":"Haselwandter, C. A. & MacKinnon, R. Piezo\u2019s membrane footprint and its contribution to mechanosensitivity. eLife 7, 29 (2018).","journal-title":"eLife"},{"key":"1320_CR33","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.tibs.2016.09.004","volume":"42","author":"J Wu","year":"2017","unstructured":"Wu, J., Lewis, A. H. & Grandl, J. Touch, tension, and transduction\u2014the function and regulation of Piezo ion channels. Trends Biochem. Sci. 42, 57\u201371 (2017).","journal-title":"Trends Biochem. Sci."},{"key":"1320_CR34","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.neuron.2020.02.010","volume":"106","author":"J Geng","year":"2020","unstructured":"Geng, J. et al. A plug-and-latch mechanism for gating the mechanosensitive piezo channel. Neuron 106, 438 (2020).","journal-title":"Neuron"},{"key":"1320_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07709-6","volume":"10","author":"WM Botello-Smith","year":"2019","unstructured":"Botello-Smith, W. M. et al. A mechanism for the activation of the mechanosensitive Piezo1 channel by the small molecule Yoda1. Nat. Commun. 10, 10 (2019).","journal-title":"Nat. Commun."},{"key":"1320_CR36","doi-asserted-by":"publisher","first-page":"17","DOI":"10.7554\/eLife.12088","volume":"4","author":"AH Lewis","year":"2015","unstructured":"Lewis, A. H. & Grandl, J. Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension. eLife 4, 17 (2015).","journal-title":"eLife"},{"key":"1320_CR37","doi-asserted-by":"crossref","unstructured":"Wang, J. et al. Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-\u03b2-catenin mechanotransduction complex. Cell Rep. 38, 110342 (2022).","DOI":"10.1016\/j.celrep.2022.110342"},{"key":"1320_CR38","doi-asserted-by":"publisher","first-page":"16148","DOI":"10.1073\/pnas.1409802111","volume":"111","author":"MM Pathak","year":"2014","unstructured":"Pathak, M. M. et al. Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells. Proc. Natl. Acad. Sci. USA 111, 16148\u201316153 (2014).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"1320_CR39","doi-asserted-by":"publisher","first-page":"13545","DOI":"10.1021\/acsnano.9b07499","volume":"13","author":"N Bavi","year":"2019","unstructured":"Bavi, N., Richardson, J., Heu, C., Martinac, B. & Poole, K. PIEZO1-mediated currents are modulated by substrate mechanics. ACS Nano 13, 13545\u201313559 (2019).","journal-title":"ACS Nano"},{"key":"1320_CR40","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz6997","volume":"6","author":"L Feld","year":"2020","unstructured":"Feld, L. et al. Cellular contractile forces are nonmechanosensitive. Sci. Adv. 6, eaaz6997 (2020).","journal-title":"Sci. Adv."},{"key":"1320_CR41","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.07369","volume":"4","author":"R Syeda","year":"2015","unstructured":"Syeda, R. et al. Chemical activation of the mechanotransduction channel Piezo1. eLife 4, e07369 (2015).","journal-title":"eLife"},{"key":"1320_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04405-3","volume":"9","author":"JJ Lacroix","year":"2018","unstructured":"Lacroix, J. J., Botello-Smith, W. M. & Luo, Y. Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1. Nat. Commun. 9, 2029 (2018).","journal-title":"Nat. Commun."},{"key":"1320_CR43","doi-asserted-by":"crossref","unstructured":"Xiao, B. Levering mechanically activated Piezo channels for potential pharmacological intervention. Annu. Rev. Pharmacol. Toxicol. 60, 195\u2013218 (2020).","DOI":"10.1146\/annurev-pharmtox-010919-023703"},{"key":"1320_CR44","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1126\/science.adh8190","volume":"381","author":"Z Zhou","year":"2023","unstructured":"Zhou, Z. et al. MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels. Science 381, 799\u2013804 (2023).","journal-title":"Science"},{"key":"1320_CR45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2512426122","volume":"122","author":"AM Habib","year":"2025","unstructured":"Habib, A. M. et al. MDFIC2 is a PIEZO channel modulator that can alleviate mechanical allodynia associated with neuropathic pain. Proc. Natl. Acad. Sci. USA. 122, e2512426122 (2025).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"1320_CR46","doi-asserted-by":"crossref","first-page":"E32","DOI":"10.1055\/a-1687-2445","volume":"147","author":"B M\u00fcller-Oerlinghausen","year":"2022","unstructured":"M\u00fcller-Oerlinghausen, B. et al. Touch medicine\u2014a complementary therapeutic approach exemplified by the treatment of depression. Dtsch. Med. Wochenschr. 147, E32\u2013E40 (2022).","journal-title":"Dtsch. Med. Wochenschr."},{"key":"1320_CR47","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1021\/acs.nanolett.7b00177","volume":"17","author":"BM Gaub","year":"2017","unstructured":"Gaub, B. M. & M\u00fcller, D. J. Mechanical stimulation of Piezo1 receptors depends on extracellular matrix proteins and directionality of force. Nano Lett. 17, 2064\u20132072 (2017).","journal-title":"Nano Lett."},{"key":"1320_CR48","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3390\/jvd2010006","volume":"2","author":"H Penasso","year":"2023","unstructured":"Penasso, H., Petersen, F. & Peternell, G. Vascular and neural response to focal vibration, sensory feedback, and Piezo ion channel signaling. J. Vasc. Dis. 2, 42\u201390 (2023).","journal-title":"J. Vasc. Dis."},{"key":"1320_CR49","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1038\/s41551-021-00724-x","volume":"5","author":"JD Eekhoff","year":"2021","unstructured":"Eekhoff, J. D., Iannucci, L. E. & Lake, S. P. Shear mechanosensing drives tendon adaptation. Nat. Biomed. Eng. 5, 1409\u20131410 (2021).","journal-title":"Nat. Biomed. Eng."},{"key":"1320_CR50","doi-asserted-by":"crossref","unstructured":"Bartel, L. & Mosabbir, A. Possible mechanisms for the effects of sound vibration on human health. Healthcare 9, 597 (2021).","DOI":"10.3390\/healthcare9050597"},{"key":"1320_CR51","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1152\/japplphysiol.91612.2008","volume":"106","author":"A Uryash","year":"2009","unstructured":"Uryash, A. et al. Low-amplitude pulses to the circulation through periodic acceleration induces endothelial-dependent vasodilatation. J. Appl. Physiol. 106, 1840\u20131847 (2009).","journal-title":"J. Appl. Physiol."},{"key":"1320_CR52","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.peptides.2007.10.021","volume":"29","author":"A Mart\u00ednez","year":"2008","unstructured":"Mart\u00ednez, A. et al. Adrenomedullin is increased by pulsatile shear stress on the vascular endothelium via periodic acceleration (pGz). Peptides 29, 73\u201378 (2008).","journal-title":"Peptides"},{"key":"1320_CR53","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1089\/ars.2007.1959","volume":"10","author":"K Chen","year":"2008","unstructured":"Chen, K., Pittman, R. N. & Popel, A.S. Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective. Antioxid. Redox Signal. 10, 1185\u20131198 (2008).","journal-title":"Antioxid. Redox Signal."},{"key":"1320_CR54","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1113\/jphysiol.2003.059899","volume":"555","author":"CR White","year":"2004","unstructured":"White, C. R., Haidekker, M. A., Stevens, H. Y. & Frangos, J. A. Extracellular signal-regulated kinase activation and endothelin-1 production in human endothelial cells exposed to vibration. J. Physiol. 555, 565\u2013572 (2004).","journal-title":"J. Physiol."},{"key":"1320_CR55","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.1172\/JCI123825","volume":"129","author":"A Iring","year":"2019","unstructured":"Iring, A. et al. Shear stress\u2013induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure. J. Clin. Investig. 129, 2775\u20132791 (2019).","journal-title":"J. Clin. Investig."},{"key":"1320_CR56","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1038\/nn.4394","volume":"19","author":"DE Koser","year":"2016","unstructured":"Koser, D. E. et al. Mechanosensing is critical for axon growth in the developing brain. Nat. Neurosci. 19, 1592\u20131598 (2016).","journal-title":"Nat. Neurosci."},{"key":"1320_CR57","doi-asserted-by":"crossref","unstructured":"Yoo, S., Nguyen, M. P., Fukuda, M., Bittner, G. D. & Fishman, H. M. Plasmalemmal sealing of transected mammalian neurites is a gradual process mediated by Ca2+-regulated proteins. J. Neurosci. Res. 74, 541\u2013551 (2003).","DOI":"10.1002\/jnr.10771"},{"key":"1320_CR58","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.cell.2013.10.004","volume":"155","author":"Y Cho","year":"2013","unstructured":"Cho, Y., Sloutsky, R., Naegle, K. M. & Cavalli, V. Injury-induced HDAC5 nuclear export is essential for axon regeneration. Cell 155, 894\u2013908 (2013).","journal-title":"Cell"},{"key":"1320_CR59","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1007\/s00018-005-5097-0","volume":"62","author":"A Czogalla","year":"2005","unstructured":"Czogalla, A. & Sikorski, A. F. Spectrin and calpain: a \u2018target\u2019 and a \u2018sniper\u2019 in the pathology of neuronal cells. Cell. Mol. Life Sci. 62, 1913\u20131924 (2005).","journal-title":"Cell. Mol. Life Sci."},{"key":"1320_CR60","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/0012-1606(84)90202-1","volume":"102","author":"D Bray","year":"1984","unstructured":"Bray, D. Axonal growth in response to experimentally applied mechanical tension. Dev. Biol. 102, 379\u2013389 (1984).","journal-title":"Dev. Biol."},{"key":"1320_CR61","doi-asserted-by":"crossref","unstructured":"Kerstein, P. C., Nichol, R. H. & Gomez, T. M. Mechanochemical regulation of growth cone motility. Front. Cell Neurosci. 9, 244 (2015).","DOI":"10.3389\/fncel.2015.00244"},{"key":"1320_CR62","doi-asserted-by":"crossref","unstructured":"Usoskin, D. et al. En masse in vitro functional profiling of the axonal mechanosensitivity of sensory neurons. Proc. Natl. Acad. Sci. USA. 107, 16336\u201316341 (2010).","DOI":"10.1073\/pnas.0914705107"},{"key":"1320_CR63","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1068\/p7637","volume":"43","author":"M Hollins","year":"2014","unstructured":"Hollins, M., McDermott, K. & Harper, D. How does vibration reduce pain? Perception 43, 70\u201384 (2014).","journal-title":"Perception"},{"key":"1320_CR64","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1126\/science.150.3699.971","volume":"150","author":"R Melzack","year":"1965","unstructured":"Melzack, R. & Wall, P. D. Pain mechanisms: a new theory. Science 150, 971\u2013979 (1965).","journal-title":"Science"},{"key":"1320_CR65","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0304-3959(84)90808-X","volume":"20","author":"T Lundeberg","year":"1984","unstructured":"Lundeberg, T., Nordemar, R. & Ottoson, D. Pain alleviation by vibratory stimulation. Pain 20, 25\u201344 (1984).","journal-title":"Pain"},{"key":"1320_CR66","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/0006-8993(90)90524-F","volume":"507","author":"MW Salter","year":"1990","unstructured":"Salter, M. W. & Henry, J. L. Physiological characteristics of responses of wide dynamic range spinal neurones to cutaneously applied vibration in the cat. Brain Res. 507, 69\u201384 (1990).","journal-title":"Brain Res."},{"key":"1320_CR67","first-page":"8","volume":"30","author":"J Xu","year":"2014","unstructured":"Xu, J., Tany, X. & Guo, Y. Effect of somatosensory music low frequency acoustic wave on 12 main and collateral channels and acupuncture point microcirculation on 30 cases of healthy people. JCAM 30, 8\u201314 (2014).","journal-title":"JCAM"},{"key":"1320_CR68","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1002\/term.1533","volume":"8","author":"G Ceccarelli","year":"2014","unstructured":"Ceccarelli, G. et al. Low-amplitude high frequency vibration down-regulates myostatin and atrogin-1 expression, two components of the atrophy pathway in muscle cells. J. Tissue Eng. Regen. Med. 8, 396\u2013406 (2014).","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"1320_CR69","doi-asserted-by":"publisher","first-page":"4294","DOI":"10.1111\/febs.12253","volume":"280","author":"S Schiaffino","year":"2013","unstructured":"Schiaffino, S., Dyar, K. A., Ciciliot, S., Blaauw, B. & Sandri, M. Mechanisms regulating skeletal muscle growth and atrophy. FEBS J. 280, 4294\u20134314 (2013).","journal-title":"FEBS J."},{"key":"1320_CR70","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14356","volume":"8","author":"TF Corbiere","year":"2020","unstructured":"Corbiere, T. F. & Koh, T. J. Local low-intensity vibration improves healing of muscle injury in mice. Physiol. Rep. 8, e14356 (2020).","journal-title":"Physiol. Rep."},{"key":"1320_CR71","doi-asserted-by":"publisher","first-page":"C73","DOI":"10.1152\/ajpcell.00273.2019","volume":"318","author":"YH Li","year":"2020","unstructured":"Li, Y.H. et al. Primary cilia respond to intermittent low-magnitude, high-frequency vibration and mediate vibration-induced effects in osteoblasts. Am. J. Physiol. Cell Physiol. 318, C73\u2013C82 (2020).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"1320_CR72","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/S1359-6446(01)01872-4","volume":"6","author":"CT Rubin","year":"2001","unstructured":"Rubin, C. T., Sommerfeldt, D. W., Judex, S. & Qin, Y.X. Inhibition of osteopenia by low magnitude, high-frequency mechanical stimuli. Drug Discov. Today 6, 848\u2013858 (2001).","journal-title":"Drug Discov. Today"},{"key":"1320_CR73","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1096\/fj.05-4966.com","volume":"20","author":"RG Bacabac","year":"2006","unstructured":"Bacabac, R. G. et al. Bone cell responses to high-frequency vibration stress: does the nucleus oscillate within the cytoplasm? FASEB J. 20, 858\u2013864 (2006).","journal-title":"FASEB J."},{"key":"1320_CR74","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1006\/bbrc.1998.8175","volume":"243","author":"L Mancini","year":"1998","unstructured":"Mancini, L., Moradi-Bidhendi, N., Brandi, M. L. & MacIntyre, I. Nitric oxide superoxide and peroxynitrite modulate osteoclast activity. Biochem. Biophys. Res. Commun. 243, 785\u2013790 (1998).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"1320_CR75","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/s42254-019-0074-y","volume":"1","author":"E Stride","year":"2019","unstructured":"Stride, E. & Coussios, C. Nucleation, mapping and control of cavitation for drug delivery. Nat. Rev. Phys. 1, 495\u2013509 (2019).","journal-title":"Nat. Rev. Phys."},{"key":"1320_CR76","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27594-w","volume":"13","author":"S Yoo","year":"2022","unstructured":"Yoo, S., Mittelstein, D. R., Hurt, R., Lacroix, J. & Shapiro, M. G. Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification. Nat. Commun. 13, 13 (2022).","journal-title":"Nat. Commun."},{"key":"1320_CR77","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27710-w","volume":"13","author":"J Rufo","year":"2022","unstructured":"Rufo, J., Zhang, P. R., Zhong, R. Y., Lee, L. K. P. & Huang, T. J. A sound approach to advancing healthcare systems: the future of biomedical acoustics. Nat. Commun. 13, 8 (2022).","journal-title":"Nat. Commun."},{"key":"1320_CR78","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/advs.202002489","volume":"8","author":"XY Guo","year":"2021","unstructured":"Guo, X. Y. et al. Controllable cell deformation using acoustic streaming for membrane permeability modulation. Adv. Sci. 8, 11 (2021).","journal-title":"Adv. Sci."},{"key":"1320_CR79","doi-asserted-by":"publisher","first-page":"3258","DOI":"10.1073\/pnas.1015771108","volume":"108","author":"B Krasovitski","year":"2011","unstructured":"Krasovitski, B., Frenkel, V., Shoham, S. & Kimmel, E. Intramembrane cavitation as a unifying mechanism for ultrasound-induced bioeffects. Proc. Natl. Acad. Sci. USA. 108, 3258\u20133263 (2011).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"1320_CR80","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1002\/advs.202101950","volume":"9","author":"A Vasan","year":"2022","unstructured":"Vasan, A. et al. Ultrasound mediated cellular deflection results in cellular depolarization. Adv. Sci. 9, 12 (2022).","journal-title":"Adv. Sci."},{"key":"1320_CR81","doi-asserted-by":"publisher","first-page":"E7039","DOI":"10.1073\/pnas.1518679112","volume":"112","author":"F Yuan","year":"2015","unstructured":"Yuan, F., Yang, C. & Zhong, P. Cell membrane deformation and bioeffects produced by tandem bubble-induced jetting flow. Proc. Natl. Acad. Sci. USA. 112, E7039\u2013E7047 (2015).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"1320_CR82","first-page":"E353","volume":"115","author":"FF Li","year":"2018","unstructured":"Li, F. F. et al. Dynamics and mechanisms of intracellular calcium waves elicited by tandem bubble-induced jetting flow. Proc. Natl. Acad. Sci. USA. 115, E353\u2013E362 (2018).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"1320_CR83","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ultsonch.2021.105494","volume":"73","author":"XL Shen","year":"2021","unstructured":"Shen, X. L., Song, Z. Q., Xu, E. J., Zhou, J. & Yan, F. Sensitization of nerve cells to ultrasound stimulation through Piezo1-targeted microbubbles. Ultrason. Sonochem. 73, 10 (2021).","journal-title":"Ultrason. Sonochem."},{"key":"1320_CR84","doi-asserted-by":"publisher","first-page":"9983","DOI":"10.1073\/pnas.1606915113","volume":"113","author":"B Helfield","year":"2016","unstructured":"Helfield, B., Chen, X. C., Watkins, S. C. & Villanueva, F. S. Biophysical insight into mechanisms of sonoporation. Proc. Natl. Acad. Sci. USA. 113, 9983\u20139988 (2016).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"1320_CR85","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0041-624X(99)00090-6","volume":"38","author":"S Hilgenfeldt","year":"2000","unstructured":"Hilgenfeldt, S. & Lohse, D. The acoustics of diagnostic microbubbles: dissipative effects and heat deposition. Ultrasonics 38, 99\u2013104 (2000).","journal-title":"Ultrasonics"},{"key":"1320_CR86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/neuros\/nyz407","volume":"87","author":"A Franzini","year":"2020","unstructured":"Franzini, A., Moosa, S., Prada, F. & Elias, W. J. Ultrasound ablation in neurosurgery: current clinical applications and future perspectives. Neurosurgery 87, 1\u201310 (2020).","journal-title":"Neurosurgery"},{"key":"1320_CR87","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1080\/17425247.2022.2134853","volume":"19","author":"X Chen","year":"2022","unstructured":"Chen, X., Lei, S., Lin, J. & Huang, P. Stimuli-responsive image-guided nanocarriers as smart drug delivery platforms. Expert Opin. Drug Deliv. 19, 1487\u20131504 (2022).","journal-title":"Expert Opin. Drug Deliv."},{"key":"1320_CR88","doi-asserted-by":"crossref","unstructured":"Wang, S. et al. Ultrasonic neuromodulation and sonogenetics: a new era for neural modulation. Front. Physiol. 11, 787 (2020).","DOI":"10.3389\/fphys.2020.00787"},{"key":"1320_CR89","doi-asserted-by":"crossref","unstructured":"Lee, J. H. et al. On-demand drug release system for in vivo cancer treatment through self-assembled magnetic nanoparticles. Angew. Chem. Int Ed. 52, 4384\u20134388 (2013).","DOI":"10.1002\/anie.201207721"},{"key":"1320_CR90","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.pbiomolbio.2006.07.010","volume":"93","author":"WD O\u2019Brien","year":"2007","unstructured":"O\u2019Brien, W. D. Ultrasound-biophysics mechanisms. Prog. Biophys. Mol. Biol. 93, 212\u2013255 (2007).","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"1320_CR91","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.cell.2016.02.002","volume":"164","author":"M Schewe","year":"2016","unstructured":"Schewe, M. et al. A non-canonical voltage-sensing mechanism controls gating in K2P K+ channels. Cell 164, 937\u2013949 (2016).","journal-title":"Cell"},{"key":"1320_CR92","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1126\/science.1077945","volume":"298","author":"RB Bass","year":"2002","unstructured":"Bass, R. B., Strop, P., Barclay, M. & Rees, D. C. Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel. Science 298, 1582\u20131587 (2002).","journal-title":"Science"},{"key":"1320_CR93","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03502-7","volume":"9","author":"M Moroni","year":"2018","unstructured":"Moroni, M., Servin-Vences, M. R., Fleischer, R., S\u00e1nchez-Carranza, O. & Lewin, G. R. Voltage gating of mechanosensitive PIEZO channels. Nat. Commun. 9, 1096 (2018).","journal-title":"Nat. Commun."},{"key":"1320_CR94","doi-asserted-by":"crossref","unstructured":"Gnanasambandam, R., Gottlieb, P. A. & Sachs, F. The kinetics and the permeation properties of Piezo channels. Curr. Top. Membr. 79, 275-307 (2017).","DOI":"10.1016\/bs.ctm.2016.11.004"},{"key":"1320_CR95","doi-asserted-by":"crossref","unstructured":"Kaestner, L. & Egee, S. Commentary: Voltage gating of mechanosensitive PIEZO channels. Front. Physiol. 9, 1565 (2018).","DOI":"10.3389\/fphys.2018.01565"},{"key":"1320_CR96","doi-asserted-by":"publisher","first-page":"11066","DOI":"10.1021\/acsnano.1c03087","volume":"15","author":"A Cafarelli","year":"2021","unstructured":"Cafarelli, A. et al. Piezoelectric nanomaterials activated by ultrasound: the pathway from discovery to future clinical adoption. ACS Nano 15, 11066\u201311086 (2021).","journal-title":"ACS Nano"},{"key":"1320_CR97","doi-asserted-by":"publisher","first-page":"7678","DOI":"10.1021\/acsnano.5b03162","volume":"9","author":"A Marino","year":"2015","unstructured":"Marino, A. et al. Piezoelectric nanoparticle-assisted wireless neuronal stimulation. ACS Nano 9, 7678\u20137689 (2015).","journal-title":"ACS Nano"},{"key":"1320_CR98","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201802084","volume":"31","author":"MT Chorsi","year":"2019","unstructured":"Chorsi, M. T. et al. Piezoelectric biomaterials for sensors and actuators. Adv. Mater. 31, 1802084 (2019).","journal-title":"Adv. Mater."},{"key":"1320_CR99","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/s41551-022-00965-4","volume":"7","author":"T Kim","year":"2023","unstructured":"Kim, T. et al. Deep brain stimulation by blood\u2013brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound. Nat. Biomed. Eng. 7, 149\u2013163 (2023).","journal-title":"Nat. Biomed. Eng."},{"key":"1320_CR100","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202001976","volume":"32","author":"P Zhu","year":"2020","unstructured":"Zhu, P., Chen, Y. & Shi, J. Piezocatalytic tumor therapy by ultrasound-triggered and BaTiO3-mediated piezoelectricity. Adv. Mater. 32, 2001976 (2020).","journal-title":"Adv. Mater."},{"key":"1320_CR101","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44065-6","volume":"14","author":"T Li","year":"2023","unstructured":"Li, T. et al. Soft ferroelectret ultrasound receiver for targeted peripheral neuromodulation. Nat. Commun. 14, 8386 (2023).","journal-title":"Nat. Commun."},{"key":"1320_CR102","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.114763","volume":"195","author":"Q Huang","year":"2023","unstructured":"Huang, Q. et al. Nanoparticles-mediated ion channels manipulation: from their membrane interactions to bioapplications. Adv. Drug Deliv. Rev. 195, 114763 (2023).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"1320_CR103","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.biomaterials.2017.10.003","volume":"150","author":"G Thrivikraman","year":"2018","unstructured":"Thrivikraman, G., Boda, S. K. & Basu, B. Unraveling the mechanistic effects of electric field stimulation towards directing stem cell fate and function: a tissue engineering perspective. Biomaterials 150, 60\u201386 (2018).","journal-title":"Biomaterials"},{"key":"1320_CR104","doi-asserted-by":"crossref","unstructured":"Abasi, S., Jain, A., Cooke, J. P. & Guiseppi-Elie, A. Electrically stimulated gene expression under exogenously applied electric fields. Front. Mol. Biosci. 10, 1161191 (2023).","DOI":"10.3389\/fmolb.2023.1161191"},{"key":"1320_CR105","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/lsa.2017.39","volume":"6","author":"DL Gao","year":"2017","unstructured":"Gao, D. L. et al. Optical manipulation from the microscale to the nanoscale: fundamentals, advances and prospects. Light Sci. Appl. 6, 15 (2017).","journal-title":"Light Sci. Appl."},{"key":"1320_CR106","first-page":"11","volume":"12","author":"F Falleroni","year":"2018","unstructured":"Falleroni, F., Torre, V. & Cojoc, D. Cell mechanotransduction with piconewton forces applied by optical tweezers. Front. Cell Neurosci. 12, 11 (2018).","journal-title":"Front. Cell Neurosci."},{"key":"1320_CR107","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.isci.2022.103807","volume":"25","author":"F Falleroni","year":"2022","unstructured":"Falleroni, F. et al. Mechanotransduction in hippocampal neurons operates under localized low picoNewton forces. iScience 25, 19 (2022).","journal-title":"iScience"},{"key":"1320_CR108","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/nmeth.f.324","volume":"8","author":"K Deisseroth","year":"2011","unstructured":"Deisseroth, K. Optogenetics. Nat. Methods 8, 26\u201329 (2011).","journal-title":"Nat. Methods"},{"key":"1320_CR109","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1021\/acs.accounts.6b00559","volume":"50","author":"TH Shin","year":"2017","unstructured":"Shin, T. H. & Cheon, J. Synergism of nanomaterials with physical stimuli for biology and medicine. Acc. Chem. Res. 50, 567\u2013572 (2017).","journal-title":"Acc. Chem. Res."},{"key":"1320_CR110","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.neuron.2011.06.004","volume":"71","author":"O Yizhar","year":"2011","unstructured":"Yizhar, O., Fenno, L. E., Davidson, T. J., Mogri, M. & Deisseroth, K. Optogenetics in neural systems. Neuron 71, 9\u201334 (2011).","journal-title":"Neuron"},{"key":"1320_CR111","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1126\/science.aau6324","volume":"362","author":"WZ Zeng","year":"2018","unstructured":"Zeng, W. Z. et al. PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex. Science 362, 464\u2013467 (2018).","journal-title":"Science"},{"key":"1320_CR112","doi-asserted-by":"publisher","first-page":"20813","DOI":"10.1073\/pnas.1318715110","volume":"110","author":"D Lemoine","year":"2013","unstructured":"Lemoine, D. et al. Optical control of an ion channel gate. Proc. Natl. Acad. Sci. USA. 110, 20813\u201320818 (2013).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"1320_CR113","doi-asserted-by":"publisher","first-page":"E3786","DOI":"10.1073\/pnas.1701379114","volume":"114","author":"M Harkat","year":"2017","unstructured":"Harkat, M. et al. On the permeation of large organic cations through the pore of ATP-gated P2X receptors. Proc. Natl. Acad. Sci. USA. 114, E3786\u2013E3795 (2017).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"1320_CR114","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35711-6","volume":"14","author":"FA Peralta","year":"2023","unstructured":"Peralta, F. A. et al. Optical control of PIEZO1 channels. Nat. Commun. 14, 13 (2023).","journal-title":"Nat. Commun."},{"key":"1320_CR115","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1021\/ar200085c","volume":"44","author":"D Yoo","year":"2011","unstructured":"Yoo, D., Lee, J. H., Shin, T. H. & Cheon, J. Theranostic magnetic nanoparticles. Acc. Chem. Res. 44, 863\u2013874 (2011).","journal-title":"Acc. Chem. Res."},{"key":"1320_CR116","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/nnano.2008.39","volume":"3","author":"J Dobson","year":"2008","unstructured":"Dobson, J. Remote control of cellular behaviour with magnetic nanoparticles. Nat. Nanotechnol. 3, 139\u2013143 (2008).","journal-title":"Nat. Nanotechnol."},{"key":"1320_CR117","doi-asserted-by":"publisher","first-page":"R167","DOI":"10.1088\/0022-3727\/36\/13\/201","volume":"36","author":"QA Pankhurst","year":"2003","unstructured":"Pankhurst, Q. A., Connolly, J., Jones, S. K. & Dobson, J. Applications of magnetic nanoparticles in biomedicine. J. Phys. D Appl. Phys. 36, R167\u2013R181 (2003).","journal-title":"J. Phys. D Appl. Phys."},{"key":"1320_CR118","doi-asserted-by":"publisher","first-page":"8036","DOI":"10.1021\/acsnano.0c00562","volume":"14","author":"D Gregurec","year":"2020","unstructured":"Gregurec, D. et al. Magnetic vortex nanodiscs enable remote magnetomechanical neural stimulation. ACS Nano 14, 8036\u20138045 (2020).","journal-title":"ACS Nano"},{"key":"1320_CR119","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s12195-023-00786-8","volume":"16","author":"A Gomez","year":"2023","unstructured":"Gomez, A. et al. Elucidating mechanotransduction processes during magnetomechanical neuromodulation mediated by magnetic nanodiscs. Cell Mol. Bioeng. 16, 283\u2013298 (2023).","journal-title":"Cell Mol. Bioeng."},{"key":"1320_CR120","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.isci.2022.105401","volume":"25","author":"L Signorelli","year":"2022","unstructured":"Signorelli, L., Hescham, S. A., Pralle, A. & Gregurec, D. Magnetic nanomaterials for wireless thermal and mechanical neuromodulation. iScience 25, 13 (2022).","journal-title":"iScience"},{"key":"1320_CR121","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1098\/rsif.2007.1274","volume":"5","author":"S Hughes","year":"2008","unstructured":"Hughes, S., McBain, S., Dobson, J. & El Haj, A. J. Selective activation of mechanosensitive ion channels using magnetic particles. J. R. Soc. Interface 5, 855\u2013863 (2008).","journal-title":"J. R. Soc. Interface"},{"key":"1320_CR122","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1038\/s41563-020-00896-y","volume":"20","author":"JU Lee","year":"2021","unstructured":"Lee, J. U et al. Non-contact long-range magnetic stimulation of mechanosensitive ion channels in freely moving animals. Nat. Mater. 20, 1029\u20131036 (2021).","journal-title":"Nat. Mater."},{"key":"1320_CR123","doi-asserted-by":"publisher","first-page":"2968","DOI":"10.1063\/1.1802383","volume":"85","author":"BD Matthews","year":"2004","unstructured":"Matthews, B. D., LaVan, D. A., Overby, D. R., Karavitis, J. & Ingber, D. E. Electromagnetic needles with submicron pole tip radii for nanomanipulation of biomolecules and living cells. Appl. Phys. Lett. 85, 2968\u20132970 (2004).","journal-title":"Appl. Phys. Lett."},{"key":"1320_CR124","doi-asserted-by":"publisher","first-page":"6590","DOI":"10.1021\/nn5020616","volume":"8","author":"JH Lee","year":"2014","unstructured":"Lee, J. H. et al. Magnetic nanoparticles for ultrafast mechanical control of inner ear hair cells. ACS Nano 8, 6590\u20136598 (2014).","journal-title":"ACS Nano"},{"key":"1320_CR125","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/nnano.2013.23","volume":"8","author":"F Etoc","year":"2013","unstructured":"Etoc, F. et al. Subcellular control Rac-GTPase signalling by magnetogenetic manipulation inside living cells. Nat. Nanotechnol. 8, 193\u2013198 (2013).","journal-title":"Nat. Nanotechnol."},{"key":"1320_CR126","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/nnano.2007.418","volume":"3","author":"RJ Mannix","year":"2008","unstructured":"Mannix, R. J. et al. Nanomagnetic actuation of receptor-mediated signal transduction. Nat. Nanotechnol. 3, 36\u201340 (2008).","journal-title":"Nat. Nanotechnol."},{"key":"1320_CR127","doi-asserted-by":"publisher","first-page":"3393","DOI":"10.7150\/ijms.111082","volume":"22","author":"G Yuan","year":"2025","unstructured":"Yuan, G. et al. Exploring the multifactorial regulation of PIEZO1 in chondrocytes: mechanisms and implications. Int. J. Med. Sci. 22, 3393\u20133411 (2025).","journal-title":"Int. J. Med. Sci."},{"key":"1320_CR128","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.889663","volume":"16","author":"J Ahn","year":"2022","unstructured":"Ahn, J. et al. Correlated activity in the degenerate retina inhibits focal response to electrical stimulation. Front. Cell Neurosci. 16, 889663 (2022).","journal-title":"Front. Cell Neurosci."},{"key":"1320_CR129","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s43586-022-00136-4","volume":"2","author":"V Emiliani","year":"2022","unstructured":"Emiliani, V. et al. Optogenetics for light control of biological systems. Nat. Rev. Methods Prim. 2, 55 (2022).","journal-title":"Nat. Rev. Methods Prim."},{"key":"1320_CR130","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.811493","volume":"16","author":"D Zhu","year":"2022","unstructured":"Zhu, D., Johnson, H. J., Chen, J. & Schaffer, D. V. Optogenetic application to investigating cell behavior and neurological disease. Front. Cell Neurosci. 16, 811493 (2022).","journal-title":"Front. Cell Neurosci."},{"key":"1320_CR131","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2025.1489940","volume":"19","author":"M Alipour","year":"2025","unstructured":"Alipour, M. et al. Advances in magnetic field approaches for non-invasive targeting neuromodulation. Front. Hum. Neurosci. 19, 1489940 (2025).","journal-title":"Front. Hum. Neurosci."},{"key":"1320_CR132","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-018-0052-7","volume":"4","author":"DW Wong","year":"2018","unstructured":"Wong, D. W., Gan, W. L., Teo, Y. K. & Lew, W. S. Interplay of cell death signaling pathways mediated by alternating magnetic field gradient. Cell Death Discov. 4, 49 (2018).","journal-title":"Cell Death Discov."},{"key":"1320_CR133","doi-asserted-by":"crossref","unstructured":"Ranade, S. S. et al. Piezo2 is the major transducer of mechanical forces for touch sensation in mice. Nature 516, 121\u2013125 (2014).","DOI":"10.1038\/nature13980"},{"key":"1320_CR134","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/nature13250","volume":"509","author":"S Maksimovic","year":"2014","unstructured":"Maksimovic, S. et al. Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors. Nature 509, 617\u2013621 (2014).","journal-title":"Nature"},{"key":"1320_CR135","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1126\/scitranslmed.aat9892","volume":"10","author":"M Szczot","year":"2018","unstructured":"Szczot, M. et al. PIEZO2 mediates injury-induced tactile pain in mice and humans. Sci. Transl. Med. 10, 9 (2018).","journal-title":"Sci. Transl. Med."},{"key":"1320_CR136","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1126\/scitranslmed.aat9897","volume":"10","author":"SE Murthy","year":"2018","unstructured":"Murthy, S. E. et al. The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice. Sci. Transl. Med. 10, 11 (2018).","journal-title":"Sci. Transl. Med."},{"key":"1320_CR137","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1038\/nn.4162","volume":"18","author":"SH Woo","year":"2015","unstructured":"Woo, S. H. et al. Piezo2 is the principal mechanotransduction channel for proprioception. Nat. Neurosci. 18, 1756\u20131762 (2015).","journal-title":"Nat. Neurosci."},{"key":"1320_CR138","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13831-w","volume":"11","author":"E Assaraf","year":"2020","unstructured":"Assaraf, E. et al. Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity. Nat. Commun. 11, 15 (2020).","journal-title":"Nat. Commun."},{"key":"1320_CR139","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/nature20793","volume":"541","author":"K Nonomura","year":"2017","unstructured":"Nonomura, K. et al. Piezo2 senses airway stretch and mediates lung inflation-induced apnoea. Nature 541, 176 (2017).","journal-title":"Nature"},{"key":"1320_CR140","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/d41586-020-03217-0","volume":"588","author":"KL Marshall","year":"2020","unstructured":"Marshall, K. L. et al. PIEZO2 in sensory neurons and urothelial cells coordinates urination. Nature 588, 15 (2020).","journal-title":"Nature"},{"key":"1320_CR141","doi-asserted-by":"publisher","first-page":"2750","DOI":"10.1097\/j.pain.0000000000002356","volume":"162","author":"SM Shin","year":"2021","unstructured":"Shin, S. M. et al. Piezo2 mechanosensitive ion channel is located to sensory neurons and nonneuronal cells in rat peripheral sensory pathway: implications in pain. Pain 162, 2750\u20132768 (2021).","journal-title":"Pain"},{"key":"1320_CR142","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.coi.2020.01.003","volume":"62","author":"P Ayata","year":"2020","unstructured":"Ayata, P. & Schaefer, A. Innate sensing of mechanical properties of brain tissue by microglia. Curr. Opin. Immunol. 62, 123\u2013130 (2020).","journal-title":"Curr. Opin. Immunol."},{"key":"1320_CR143","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.isci.2023.105993","volume":"26","author":"T Zhu","year":"2023","unstructured":"Zhu, T. et al. The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia. iScience 26, 22 (2023).","journal-title":"iScience"},{"key":"1320_CR144","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23482-5","volume":"12","author":"H Atcha","year":"2021","unstructured":"Atcha, H. et al. Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing. Nat. Commun. 12, 3256 (2021).","journal-title":"Nat. Commun."},{"key":"1320_CR145","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1002\/glia.24311","volume":"71","author":"P Malko","year":"2023","unstructured":"Malko, P., Jia, X., Wood, I. & Jiang, L. H. Piezo1 channel-mediated Ca2+ signaling inhibits lipopolysaccharide-induced activation of the NF-\u03baB inflammatory signaling pathway and generation of TNF-\u03b1 and IL-6 in microglial cells. Glia 71, 848\u2013865 (2023).","journal-title":"Glia"},{"key":"1320_CR146","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.immuni.2020.09.018","volume":"53","author":"A Shemer","year":"2020","unstructured":"Shemer, A. et al. Interleukin-10 prevents pathological microglia hyperactivation following peripheral endotoxin challenge. Immunity 53, 1033\u20131049.e1037 (2020).","journal-title":"Immunity"},{"key":"1320_CR147","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1002\/glia.23760","volume":"68","author":"YL Hu","year":"2020","unstructured":"Hu, Y. L. et al. mTOR-mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP. Glia 68, 1031\u20131045 (2020).","journal-title":"Glia"},{"key":"1320_CR148","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/glia.20173","volume":"50","author":"V Waetzig","year":"2005","unstructured":"Waetzig, V. et al. c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia. Glia 50, 235\u2013246 (2005).","journal-title":"Glia"},{"key":"1320_CR149","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/s41586-020-03060-3","volume":"590","author":"JH Lee","year":"2021","unstructured":"Lee, J. H. et al. Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis. Nature 590, 612\u2013617 (2021).","journal-title":"Nature"},{"key":"1320_CR150","doi-asserted-by":"publisher","DOI":"10.1126\/science.abh2858","volume":"374","author":"J Lezmy","year":"2021","unstructured":"Lezmy, J. et al. Astrocyte Ca2+-evoked ATP release regulates myelinated axon excitability and conduction speed. Science 374, eabh2858 (2021).","journal-title":"Science"},{"key":"1320_CR151","doi-asserted-by":"crossref","unstructured":"Mishra, A. et al. Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles. Nat. Neurosci. 19, 1619\u20131627 (2020).","DOI":"10.1038\/nn.4428"},{"key":"1320_CR152","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.tins.2009.05.001","volume":"32","author":"G Perea","year":"2009","unstructured":"Perea, G., Navarrete, M. & Araque, A. Tripartite synapses: astrocytes process and control synaptic information. Trends Neurosci. 32, 421\u2013431 (2009).","journal-title":"Trends Neurosci."},{"key":"1320_CR153","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1002\/stem.1408","volume":"31","author":"X Cao","year":"2013","unstructured":"Cao, X. et al. Astrocytic adenosine 5\u2032-triphosphate release regulates the proliferation of neural stem cells in the adult hippocampus. Stem Cells 31, 1633\u20131643 (2013).","journal-title":"Stem Cells"},{"key":"1320_CR154","doi-asserted-by":"publisher","first-page":"2984","DOI":"10.1016\/j.neuron.2022.07.010","volume":"110","author":"SP Chi","year":"2022","unstructured":"Chi, S. P. et al. Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions. Neuron 110, 2984 (2022).","journal-title":"Neuron"},{"key":"1320_CR155","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/glia.23709","volume":"68","author":"M Velasco-Estevez","year":"2020","unstructured":"Velasco-Estevez, M., Rolle, S. O., Mampay, M., Dev, K. K. & Sheridan, G. K. Piezo1 regulates calcium oscillations and cytokine release from astrocytes. Glia 68, 145\u2013160 (2020).","journal-title":"Glia"},{"key":"1320_CR156","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3389\/fncel.2023.1200946","volume":"17","author":"D Yu","year":"2023","unstructured":"Yu, D. et al. Inflammation condition sensitizes Piezo1 mechanosensitive channel in mouse cerebellum astrocyte. Front. Cell Neurosci. 17, 9 (2023).","journal-title":"Front. Cell Neurosci."},{"key":"1320_CR157","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1152\/physrev.00031.2018","volume":"99","author":"C Stadelmann","year":"2019","unstructured":"Stadelmann, C., Timmler, S., Barrantes-Freer, A. & Simons, M. Myelin in the central nervous system: structure, function, and pathology. Physiol. Rev. 99, 1381\u20131431 (2019).","journal-title":"Physiol. Rev."},{"key":"1320_CR158","doi-asserted-by":"publisher","first-page":"4178","DOI":"10.1093\/brain\/awac307","volume":"145","author":"V Tepavcevi","year":"2022","unstructured":"Tepavcevi, V. & Lubetzki, C. Oligodendrocyte progenitor cell recruitment and remyelination in multiple sclerosis: the more, the merrier? Brain 145, 4178\u20134192 (2022).","journal-title":"Brain"},{"key":"1320_CR159","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/s41586-019-1484-9","volume":"573","author":"M Segel","year":"2019","unstructured":"Segel, M. et al. Niche stiffness underlies the ageing of central nervous system progenitor cells. Nature 573, 130 (2019).","journal-title":"Nature"},{"key":"1320_CR160","doi-asserted-by":"crossref","unstructured":"Velasco-Estevez, M., Koch, N., Klejbor, I., Caratis, F. & Rutkowska, A. Mechanoreceptor Piezo1 is downregulated in multiple sclerosis brain and is involved in the maturation and migration of oligodendrocytes in vitro. Front. Cell Neurosci. 16, 9 (2022).","DOI":"10.3389\/fncel.2022.914985"},{"key":"1320_CR161","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.arr.2023.102026","volume":"90","author":"BY Zong","year":"2023","unstructured":"Zong, B. Y. et al. Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central nervous system. Ageing Res. Rev. 90, 25 (2023).","journal-title":"Ageing Res. Rev."},{"key":"1320_CR162","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/nrn3383","volume":"13","author":"WJ Tyler","year":"2012","unstructured":"Tyler, W. J. The mechanobiology of brain function. Nat. Rev. Neurosci. 13, 867\u2013878 (2012).","journal-title":"Nat. Rev. Neurosci."},{"key":"1320_CR163","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1161\/CIRCRESAHA.122.320827","volume":"130","author":"OF Harraz","year":"2022","unstructured":"Harraz, O. F., Klug, N. R., Senatore, A. J., Hill-Eubanks, D. C. & Nelson, M. T. Piezo1 is a mechanosensor channel in central nervous system capillaries. Circ. Res. 130, 1531\u20131546 (2022).","journal-title":"Circ. Res."},{"key":"1320_CR164","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20208-x","volume":"12","author":"F Li","year":"2021","unstructured":"Li, F. et al. The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation. Nat. Commun. 12, 20 (2021).","journal-title":"Nat. Commun."},{"key":"1320_CR165","first-page":"14","volume":"28","author":"YX Wang","year":"2023","unstructured":"Wang, Y. X. et al. Immunoregulatory role of the mechanosensitive ion channel Piezo1 in inflammation and cancer. Molecules 28, 14 (2023).","journal-title":"Molecules"},{"key":"1320_CR166","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/s10557-020-07071-0","volume":"34","author":"A Hanna","year":"2020","unstructured":"Hanna, A. & Frangogiannis, N. G. Inflammatory cytokines and chemokines as therapeutic targets in heart failure. Cardiovasc. Drugs Ther. 34, 849\u2013863 (2020).","journal-title":"Cardiovasc. Drugs Ther."},{"key":"1320_CR167","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.actbio.2019.02.048","volume":"89","author":"R Sridharan","year":"2019","unstructured":"Sridharan, R., Cavanagh, B., Cameron, A. R., Kelly, D. J. & O\u2019Brien, F. J. Material stiffness influences the polarization state, function and migration mode of macrophages. Acta Biomater. 89, 47\u201359 (2019).","journal-title":"Acta Biomater."},{"key":"1320_CR168","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1111\/imm.12910","volume":"154","author":"SC Funes","year":"2018","unstructured":"Funes, S. C., Rios, M., Escobar-Vera, J. & Kalergis, A. M. Implications of macrophage polarization in autoimmunity. Immunology 154, 186\u2013195 (2018).","journal-title":"Immunology"},{"key":"1320_CR169","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41586-019-1485-8","volume":"573","author":"AG Solis","year":"2019","unstructured":"Solis, A. G. et al. Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity. Nature 573, 69\u201374 (2019).","journal-title":"Nature"},{"key":"1320_CR170","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s00395-021-00897-1","volume":"116","author":"M Rao","year":"2021","unstructured":"Rao, M. et al. Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level. Basic Res. Cardiol. 116, 19 (2021).","journal-title":"Basic Res. Cardiol."},{"key":"1320_CR171","doi-asserted-by":"publisher","first-page":"5830","DOI":"10.3390\/cimb45070369","volume":"45","author":"WH Yuan","year":"2023","unstructured":"Yuan, W. H., Zhang, X. C. & Fan, X. M. The role of the Piezo1 mechanosensitive channel in heart failure. Curr. Issues Mol. Biol. 45, 5830\u20135848 (2023).","journal-title":"Curr. Issues Mol. Biol."},{"key":"1320_CR172","doi-asserted-by":"publisher","first-page":"17395","DOI":"10.1074\/jbc.RA119.009167","volume":"294","author":"NM Blythe","year":"2019","unstructured":"Blythe, N. M. et al. Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion. J. Biol. Chem. 294, 17395\u201317408 (2019).","journal-title":"J. Biol. Chem."},{"key":"1320_CR173","doi-asserted-by":"crossref","unstructured":"Guo, Y. et al. In vitro cell stretching technology (IsoStretcher) as an approach to unravel Piezo1-mediated cardiac mechanotransduction. Prog. Biophys. Mol. Biol. 159, 22\u201333 (2021).","DOI":"10.1016\/j.pbiomolbio.2020.07.003"},{"key":"1320_CR174","doi-asserted-by":"publisher","first-page":"H1694","DOI":"10.1152\/ajpheart.00908.2008","volume":"296","author":"I Banerjee","year":"2009","unstructured":"Banerjee, I., Fuseler, J. W., Intwala, A. R. & Baudino, T. A. IL-6 loss causes ventricular dysfunction, fibrosis, reduced capillary density, and dramatically alters the cell populations of the developing and adult heart. Am. J. Physiol. Heart Circ. Physiol. 296, H1694\u2013H1704 (2009).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"1320_CR175","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1002\/mc.22831","volume":"57","author":"JL Zhang","year":"2018","unstructured":"Zhang, J. L. et al. PIEZO1 functions as a potential oncogene by promoting cell proliferation and migration in gastric carcinogenesis. Mol. Carcinog. 57, 1144\u20131155 (2018).","journal-title":"Mol. Carcinog."},{"key":"1320_CR176","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1007\/s00432-020-03179-w","volume":"146","author":"YH Sun","year":"2020","unstructured":"Sun, Y. H. et al. The function of Piezo1 in colon cancer metastasis and its potential regulatory mechanism. J. Cancer Res. Clin. Oncol. 146, 1139\u20131152 (2020).","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"1320_CR177","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ceca.2021.102367","volume":"95","author":"SL Liu","year":"2021","unstructured":"Liu, S. L. et al. Piezo1 impairs hepatocellular tumor growth via deregulation of the MAPK-mediated YAP signaling pathway. Cell Calcium 95, 12 (2021).","journal-title":"Cell Calcium"},{"key":"1320_CR178","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1371\/journal.pone.0040346","volume":"7","author":"BJ McHugh","year":"2012","unstructured":"McHugh, B. J., Murdoch, A., Haslett, C. & Sethi, T. Loss of the integrin-activating transmembrane protein Fam38A (Piezo1) promotes a switch to a reduced integrin-dependent mode of cell migration. PLoS ONE 7, 7 (2012).","journal-title":"PLoS ONE"},{"key":"1320_CR179","first-page":"16","volume":"135","author":"P O\u2019Callaghan","year":"2022","unstructured":"O\u2019Callaghan, P. et al. Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells. J. Cell Sci. 135, 16 (2022).","journal-title":"J. Cell Sci."},{"key":"1320_CR180","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1002\/path.5553","volume":"253","author":"K Hasegawa","year":"2021","unstructured":"Hasegawa, K. et al. YAP signaling induces PIEZO1 to promote oral squamous cell carcinoma cell proliferation. J. Pathol. 253, 80\u201393 (2021).","journal-title":"J. Pathol."},{"key":"1320_CR181","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1126\/sciimmunol.abb5168","volume":"5","author":"B Aykut","year":"2020","unstructured":"Aykut, B. et al. Targeting Piezo1 unleashes innate immunity against cancer and infectious disease. Sci. Immunol. 5, 12 (2020).","journal-title":"Sci. Immunol."},{"key":"1320_CR182","first-page":"20","volume":"13","author":"HL Liu","year":"2022","unstructured":"Liu, H. L. et al. Piezo1 channels as force sensors in mechanical force-related chronic inflammation. Front. Immunol. 13, 20 (2022).","journal-title":"Front. Immunol."},{"key":"1320_CR183","doi-asserted-by":"publisher","first-page":"25","DOI":"10.7554\/eLife.47454","volume":"8","author":"WJ Sun","year":"2019","unstructured":"Sun, W. J. et al. The mechanosensitive Piezo1 channel is required for bone formation. eLife 8, 25 (2019).","journal-title":"eLife"},{"key":"1320_CR184","doi-asserted-by":"publisher","first-page":"22","DOI":"10.7554\/eLife.49631","volume":"8","author":"XH Li","year":"2019","unstructured":"Li, X. H. et al. Stimulation of Piezo1 by mechanical signals promotes bone anabolism. eLife 8, 22 (2019).","journal-title":"eLife"},{"key":"1320_CR185","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41413-022-00190-4","volume":"10","author":"LJ Wang","year":"2022","unstructured":"Wang, L. J., You, X. L., Zhang, L. L., Zhang, C. Q. & Zou, W. G. Mechanical regulation of bone remodeling. Bone Res. 10, 15 (2022).","journal-title":"Bone Res."},{"key":"1320_CR186","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/jor.20809","volume":"27","author":"AK Amin","year":"2009","unstructured":"Amin, A. K., Huntley, J. S., Bush, P. G., Simpson, H. R. W. & Hall, A. C. Chondrocyte death in mechanically injured articular cartilage\u2014the influence of extracellular calcium. J. Orthop. Res. 27, 778\u2013784 (2009).","journal-title":"J. Orthop. Res."},{"key":"1320_CR187","doi-asserted-by":"publisher","first-page":"E5114","DOI":"10.1073\/pnas.1414298111","volume":"111","author":"W Lee","year":"2014","unstructured":"Lee, W. et al. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Proc. Natl. Acad. Sci. USA. 111, E5114\u2013E5122 (2014).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"1320_CR188","doi-asserted-by":"publisher","first-page":"E203","DOI":"10.1097\/BRS.0000000000004203","volume":"47","author":"ZG Sun","year":"2022","unstructured":"Sun, Z. G. et al. Single impact injury of vertebral endplates without structural disruption, initiates disc degeneration through Piezo1 mediated inflammation and metabolism dysfunction. Spine 47, E203\u2013E213 (2022).","journal-title":"Spine"},{"key":"1320_CR189","doi-asserted-by":"publisher","first-page":"26035","DOI":"10.3390\/ijms161125943","volume":"16","author":"HS Hwang","year":"2015","unstructured":"Hwang, H. S. & Kim, H. A. Chondrocyte apoptosis in the pathogenesis of osteoarthritis. Int. J. Mol. Sci. 16, 26035\u201326054 (2015).","journal-title":"Int. J. Mol. Sci."},{"key":"1320_CR190","doi-asserted-by":"publisher","first-page":"112","DOI":"10.2174\/1874306401509010112","volume":"9","author":"R Carrasco Loza","year":"2015","unstructured":"Carrasco Loza, R., Villamizar Rodriguez, G. & Medel Fernandez, N. Ventilator-induced lung injury (VILI) in acute respiratory distress syndrome (ARDS): volutrauma and molecular effects. Open Respir. Med. J. 9, 112\u2013119 (2015).","journal-title":"Open Respir. Med. J."},{"key":"1320_CR191","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1164\/rccm.201708-1563ED","volume":"196","author":"A Vieillard-Baron","year":"2017","unstructured":"Vieillard-Baron, A. & Dreyfuss, D. Ventilator-induced lung injury: follow the right direction! Another piece of the puzzle in the ventilator-induced lung injury epic. Am. J. Respir. Crit. Care Med. 196, 1366\u20131368 (2017).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"1320_CR192","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/ng.2916","volume":"46","author":"HY Yoo","year":"2014","unstructured":"Yoo, H. Y. et al. A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma. Nat. Genet. 46, 371\u2013375 (2014).","journal-title":"Nat. Genet."},{"key":"1320_CR193","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12931-021-01844-3","volume":"22","author":"Y Zhang","year":"2021","unstructured":"Zhang, Y. et al. Mechanosensitive cation channel Piezo1 contributes to ventilator-induced lung injury by activating RhoA\/ROCK1 in rats. Respir. Res. 22, 14 (2021).","journal-title":"Respir. Res."},{"key":"1320_CR194","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.intimp.2019.03.059","volume":"72","author":"HJ Dai","year":"2019","unstructured":"Dai, H. J. et al. RhoA inhibitor suppresses the production of microvesicles and rescues high ventilation induced lung injury. Int. Immunopharmacol. 72, 74\u201381 (2019).","journal-title":"Int. Immunopharmacol."},{"key":"1320_CR195","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.yexcr.2019.111596","volume":"384","author":"CK Zhang","year":"2019","unstructured":"Zhang, C. K. et al. Exosome-delivered syndecan-1 rescues acute lung injury via a FAK\/p190RhoGAP\/RhoA\/ROCK\/NF-\u03baB signaling axis and glycocalyx enhancement. Exp. Cell Res. 384, 17 (2019).","journal-title":"Exp. Cell Res."},{"key":"1320_CR196","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/nrn.2016.70","volume":"17","author":"B Yao","year":"2016","unstructured":"Yao, B. et al. Epigenetic mechanisms in neurogenesis. Nat. Rev. Neurosci. 17, 537\u2013549 (2016).","journal-title":"Nat. Rev. Neurosci."},{"key":"1320_CR197","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk0639","volume":"10","author":"Y Song","year":"2024","unstructured":"Song, Y. et al. Biphasic regulation of epigenetic state by matrix stiffness during cell reprogramming. Sci. Adv. 10, eadk0639 (2024).","journal-title":"Sci. Adv."},{"key":"1320_CR198","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-59190-7","volume":"16","author":"Y Wu","year":"2025","unstructured":"Wu, Y. et al. Viscoelastic extracellular matrix enhances epigenetic remodeling and cellular plasticity. Nat. Commun. 16, 4054 (2025).","journal-title":"Nat. Commun."},{"key":"1320_CR199","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202317112","volume":"63","author":"J Hahmann","year":"2024","unstructured":"Hahmann, J., Ishaqat, A., Lammers, T. & Herrmann, A. Sonogenetics for monitoring and modulating biomolecular function by ultrasound. Angew. Chem. Int. Ed. 63, e202317112 (2024).","journal-title":"Angew. Chem. Int. Ed."}],"container-title":["Microsystems &amp; Nanoengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41378-026-01320-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41378-026-01320-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41378-026-01320-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:03:15Z","timestamp":1786611795000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41378-026-01320-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":199,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1320"],"URL":"https:\/\/doi.org\/10.1038\/s41378-026-01320-2","relation":{},"ISSN":["2055-7434"],"issn-type":[{"value":"2055-7434","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"assertion":[{"value":"6 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"289"}}