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Here, we present a wearable, wireless stethoscope that enables high-fidelity acquisition of heart and respiratory sounds through a mechanically compliant, broadband sensing interface. The system is built on a piezoelectric micromachined ultrasonic transducer (PMUT) engineered to achieve ultrahigh sensitivity (\u2013167.5\u2009dB), a wide operating bandwidth (10\u2009Hz\u201310\u2009kHz), and a flat frequency response (\u00b10.5\u2009dB), enabling accurate reconstruction of subtle physiological signals across a broad spectral range. Integration with soft, skin-conformal packaging and a robust wireless readout minimizes motion-induced noise and supports stable, long-term monitoring during daily activities. Validation across multiple participants demonstrates strong agreement with clinical-grade systems, including consistent auscultation at standard cardiac sites and accurate heart-rate tracking during dynamic exercise. Furthermore, coupling the sensing platform with a residual neural network enables automated classification of five respiratory states (awake, asleep, apnea, rhonchi, and wheeze) with an accuracy of 98.7%. This work establishes a scalable, low-cost framework for continuous, high-fidelity cardiopulmonary monitoring in real-world environments.<\/jats:p>","DOI":"10.1038\/s41378-026-01460-5","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:00:46Z","timestamp":1790650846000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Broadband wearable acoustic sensing for continuous cardiopulmonary monitoring"],"prefix":"10.1038","volume":"12","author":[{"given":"Pengfan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0882-156X","authenticated-orcid":false,"given":"Hanjie","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengyu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2024-2595","authenticated-orcid":false,"given":"Xiaojing","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"1460_CR1","doi-asserted-by":"publisher","first-page":"2696","DOI":"10.1093\/eurheartj\/ehv428","volume":"36","author":"N Townsend","year":"2015","unstructured":"Townsend, N., Nichols, M., Scarborough, P. & Rayner, M. 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