{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:35:51Z","timestamp":1790516151910,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":1836,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1038\/s41379-018-0093-8","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T10:40:54Z","timestamp":1530182454000},"page":"1717-1732","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Clinicopathologic and molecular features in hairy cell leukemia-variant: single institutional experience"],"prefix":"10.1016","volume":"31","author":[{"given":"Evgeniya A.","family":"Angelova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Muzzafar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2621-3584","authenticated-orcid":false,"given":"Joseph D.","family":"Khoury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Ravandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyur P.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Kanagal-Shamanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41379-018-0093-8_bib1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0145-2126(80)90066-1","article-title":"A chronic lymphoproliferative disorder with distinctive features: a distinct variant of hairy-cell leukaemia","volume":"4","author":"Cawley","year":"1980","journal-title":"Leuk Res"},{"key":"10.1038\/s41379-018-0093-8_bib2","unstructured":"Foucar K, Catovsky D. Hairy cell leukaemia. In: Jaffe E, Harris N, Stein H, (eds.) WHO Classification Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press, 2001. p. 138-41."},{"key":"10.1038\/s41379-018-0093-8_bib3","unstructured":"Piris M, Foucar K, Mollejo M. et al. In: Swerdlow S, Campo E, Harris N, (eds.) Splenic B-cell lymphoma\/leukemia, unclassifiable. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Revised 4th Edition Lyon, France: IARC; 2017. p. 229\u201331. ."},{"key":"10.1038\/s41379-018-0093-8_bib4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1309\/8QYTYQ1CLQMHQ9CL","article-title":"Hairy cell leukemia-variant: fact or fiction","volume":"123","author":"Cessna","year":"2005","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/s41379-018-0093-8_bib5","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1365-2141.2012.09163.x","article-title":"The prognostic impact of clinical and molecular features in hairy cell leukaemia variant and splenic marginal zone lymphoma","volume":"158","author":"Hockley","year":"2012","journal-title":"Br J Haematol"},{"key":"10.1038\/s41379-018-0093-8_bib6","first-page":"9","article-title":"Refractory hairy cell leukemia-variant","volume":"92","author":"Hu","year":"2016","journal-title":"Am J Hematol"},{"key":"10.1038\/s41379-018-0093-8_bib7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1080\/10428194.2016.1185786","article-title":"Detection of activating MAP2K1 mutations in atypical hairy cell leukemia and hairy cell leukemia variant","volume":"58","author":"Mason","year":"2017","journal-title":"Leuk Lymphoma"},{"key":"10.1038\/s41379-018-0093-8_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.leukres.2012.11.021","article-title":"Distinguishing hairy cell leukemia variant from hairy cell leukemia: development and validation of diagnostic criteria","volume":"37","author":"Shao","year":"2013","journal-title":"Leuk Res"},{"key":"10.1038\/s41379-018-0093-8_bib9","first-page":"7","article-title":"Hairy cell leukemia variant: a morphologic, immunologic and clinical study of 7 cases","volume":"75","author":"Zinzani","year":"1990","journal-title":"Haematologica"},{"key":"10.1038\/s41379-018-0093-8_bib10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/1078-0432.CCR-17-1597","article-title":"Validation of immunohistochemical assays for integral biomarkers in the NCI-MATCH EAY131 clinical trial","volume":"24","author":"Khoury","year":"2018","journal-title":"Clin Cancer Res"},{"key":"10.1038\/s41379-018-0093-8_bib11","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/modpathol.2017.135","article-title":"CD200 expression in mantle cell lymphoma identifies a unique subgroup of patients with frequent IGHV mutations, absence of SOX11 expression, and an indolent clinical course","volume":"31","author":"Hu","year":"2018","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-018-0093-8_bib12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.leukres.2018.01.013","article-title":"8q24\/MYC rearrangement is a recurrent cytogenetic abnormality in blastic plasmacytoid dendritic cell neoplasms","volume":"66","author":"Boddu","year":"2018","journal-title":"Leuk Res"},{"key":"10.1038\/s41379-018-0093-8_bib13","unstructured":"ISCN 2016: An International System for Human Cytogenomic Nomenclature. In: McGowan-Jordan JAS Schmid M, (eds.) 1st ed. Switzerland: Karger Publishers; 2016;149:1-140."},{"key":"10.1038\/s41379-018-0093-8_bib14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/bjh.15018","article-title":"The absolute percent deviation of IGHV mutation rather than a 98% cut-off predicts survival of chronic lymphocytic leukaemia patients treated with fludarabine, cyclophosphamide and rituximab","volume":"180","author":"Jain","year":"2018","journal-title":"Br J Haematol"},{"key":"10.1038\/s41379-018-0093-8_bib15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.humpath.2015.12.029","article-title":"BRAF and MAP2K1 mutations in Langerhans cell histiocytosis: a study of 50 cases","volume":"52","author":"Alayed","year":"2016","journal-title":"Hum Pathol"},{"key":"10.1038\/s41379-018-0093-8_bib16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.beha.2015.09.002","article-title":"Hairy cell leukaemia-variant: disease features and treatment","volume":"28","author":"Matutes","year":"2015","journal-title":"Best Pract Res Clin Haematol"},{"key":"10.1038\/s41379-018-0093-8_bib17","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1182\/blood.V76.1.157.157","article-title":"A variant form of hairy cell leukemia resistant to alpha-interferon: clinical and phenotypic characteristics of 17 patients","volume":"76","author":"Sainati","year":"1990","journal-title":"Blood"},{"key":"10.1038\/s41379-018-0093-8_bib18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/10428194.2017.1365853","article-title":"Trametinib for the treatment of IGHV4-34, MAP2K1-mutant variant hairy cell leukemia","volume":"59","author":"Andritsos","year":"2018","journal-title":"Leuk Lymphoma"},{"key":"10.1038\/s41379-018-0093-8_bib19","doi-asserted-by":"crossref","first-page":"162","DOI":"10.21037\/atm.2017.03.85","article-title":"Hairy cell leukaemia variant with periarticular joint infiltration and excellent radiotherapy response","volume":"5","author":"McKay","year":"2017","journal-title":"Ann Transl Med"},{"key":"10.1038\/s41379-018-0093-8_bib20","doi-asserted-by":"crossref","first-page":"e186","DOI":"10.1200\/JCO.2012.44.8787","article-title":"Rare case of hairy cell leukemia with brain parenchymal involvement: a diagnostic dilemma","volume":"31","author":"Chandana","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1038\/s41379-018-0093-8_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.beha.2015.10.020","article-title":"Hairy cell leukemia: Uncommon clinical features, unusual sites of involvement and some rare associations","volume":"28","author":"Tadmor","year":"2015","journal-title":"Best Pract Res Clin Haematol"},{"key":"10.1038\/s41379-018-0093-8_bib22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5858\/2005-129-395-HCLVWF","article-title":"Hairy cell leukemia variant with features of intrasinusoidal bone marrow involvement","volume":"129","author":"Ya-In","year":"2005","journal-title":"Arch Pathol Lab Med"},{"key":"10.1038\/s41379-018-0093-8_bib23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/sj.leu.2401999","article-title":"The natural history and clinico-pathological features of the variant form of hairy cell leukemia","volume":"15","author":"Matutes","year":"2001","journal-title":"Leukemia"},{"key":"10.1038\/s41379-018-0093-8_bib24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/PAS.0b013e318271243d","article-title":"Bone marrow histopathology in the diagnostic evaluation of splenic marginal-zone and splenic diffuse red pulp small B-cell lymphoma: a reliable substitute for spleen histopathology?","volume":"36","author":"Ponzoni","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/s41379-018-0093-8_bib25","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1182\/blood-2009-01-201731","article-title":"VH4-34 + hairy cell leukemia, a new variant with poor prognosis despite standard therapy","volume":"114","author":"Arons","year":"2009","journal-title":"Blood"},{"key":"10.1038\/s41379-018-0093-8_bib26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.hoc.2006.06.012","article-title":"Immunophenotyping and differential diagnosis of hairy cell leukemia","volume":"20","author":"Matutes","year":"2006","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1038\/s41379-018-0093-8_bib27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1309\/AJCPL13YDUHFKPJU","article-title":"Immunophenotypic analysis of CD103 + B-lymphoproliferative disorders: hairy cell leukemia and its mimics","volume":"131","author":"Dong","year":"2009","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/s41379-018-0093-8_bib28","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0140-6736(04)16356-3","article-title":"Simple diagnostic assay for hairy cell leukaemia by immunocytochemical detection of annexin A1 (ANXA1)","volume":"363","author":"Falini","year":"2004","journal-title":"Lancet"},{"key":"10.1038\/s41379-018-0093-8_bib29","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/leu.2011.47","article-title":"High-resolution genomic profiling in hairy cell leukemia-variant compared with typical hairy cell leukemia","volume":"25","author":"Hockley","year":"2011","journal-title":"Leukemia"},{"key":"10.1038\/s41379-018-0093-8_bib30","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/path.2665","article-title":"Splenic marginal zone lymphoma: characterization of 7q deletion and its value in diagnosis","volume":"220","author":"Watkins","year":"2010","journal-title":"J Pathol"},{"key":"10.1038\/s41379-018-0093-8_bib31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0145-2126(99)00127-7","article-title":"p53 gene deletion and trisomy 12 in hairy cell leukemia and its variant","volume":"23","author":"Vallianatou","year":"1999","journal-title":"Leuk Res"},{"key":"10.1038\/s41379-018-0093-8_bib32","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/ng.2828","article-title":"High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias","volume":"46","author":"Waterfall","year":"2014","journal-title":"Nat Genet"},{"key":"10.1038\/s41379-018-0093-8_bib33","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1182\/blood-2017-01-765107","article-title":"Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations","volume":"130","author":"Durham","year":"2017","journal-title":"Blood"},{"key":"10.1038\/s41379-018-0093-8_bib34","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/bjh.14129","article-title":"Long-term durable remission by cladribine followed by rituximab in patients with hairy cell leukaemia: update of a phase II trial","volume":"174","author":"Chihara","year":"2016","journal-title":"Br J Haematol"},{"key":"10.1038\/s41379-018-0093-8_bib35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/bjh.14207","article-title":"Treatment outcomes and secondary cancer incidence in young patients with hairy cell leukaemia","volume":"175","author":"Getta","year":"2016","journal-title":"Br J Haematol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41379-018-0093-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41379-018-0093-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222600103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222600103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41379-018-0093-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:57:23Z","timestamp":1760230643000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222600103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0893395222600103"],"URL":"https:\/\/doi.org\/10.1038\/s41379-018-0093-8","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinicopathologic and molecular features in hairy cell leukemia-variant: single institutional experience","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41379-018-0093-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}