{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:19:10Z","timestamp":1791231550393,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":1351,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1192"],"award-info":[{"award-number":["SFB1192"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RI 2811 1\/1"],"award-info":[{"award-number":["RI 2811 1\/1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1192"],"award-info":[{"award-number":["SFB1192"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1192"],"award-info":[{"award-number":["SFB1192"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1192"],"award-info":[{"award-number":["SFB1192"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1192"],"award-info":[{"award-number":["SFB1192"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1192"],"award-info":[{"award-number":["SFB 1192"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004426","name":"Dr Werner J\u00e4ckst\u00e4dt Stiftung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004426","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1038\/s41379-018-0186-4","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T04:40:57Z","timestamp":1544762457000},"page":"684-700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Bevacizumab-associated glomerular microangiopathy"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7489-9667","authenticated-orcid":false,"given":"Fermin","family":"Person","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus M.","family":"Rinschen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke R.","family":"Brix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Wulf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de las Mercedes","family":"Noriega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Fehrle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Ivanyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver M.","family":"Steinmetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Reinhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elion","family":"Hoxha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6149-2411","authenticated-orcid":false,"given":"Peter F.","family":"Zipfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Hinrich","family":"Br\u00e4sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Wiech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41379-018-0186-4_bib1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrd1381","article-title":"Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer","volume":"3","author":"Ferrara","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"10.1038\/s41379-018-0186-4_bib2","doi-asserted-by":"crossref","unstructured":"Ronca R, Benkheil M, Mitola S, Struyf S, Liekens S Tumor angiogenesis revisited: Regulators and clinical implications. Med Res Rev 2017;1\u201344.","DOI":"10.1002\/med.21452"},{"key":"10.1038\/s41379-018-0186-4_bib3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40942-017-0066-y","article-title":"Aqueous vascular endothelial growth factor and clinical outcomes correlation after single intravitreal injection of bevacizumab in patients with neovascular age - related macular degeneration","volume":"3","author":"Cabral","year":"2017","journal-title":"Int J Retin Vitr"},{"key":"10.1038\/s41379-018-0186-4_bib4","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ejca.2009.11.001","article-title":"VEGF signalling inhibition-induced proteinuria: Mechanisms, significance and management","volume":"46","author":"Izzedine","year":"2010","journal-title":"Eur J Cancer"},{"key":"10.1038\/s41379-018-0186-4_bib5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000365156","article-title":"Incidence and relevance of proteinuria in bevacizumab-treated patients: Pooled analysis from randomized controlled trials","volume":"40","author":"Lafayette","year":"2014","journal-title":"Am J Nephrol"},{"key":"10.1038\/s41379-018-0186-4_bib6","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s11523-015-0368-7","article-title":"Renal toxicities of targeted therapies","volume":"10","author":"Abbas","year":"2015","journal-title":"Target Oncol"},{"key":"10.1038\/s41379-018-0186-4_bib7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1177\/1078155212466421","article-title":"Case report of interstitial nephritis induced by bevacizumab therapy for glioblastoma multiforme","volume":"19","author":"Lomax","year":"2013","journal-title":"J Oncol Pharm Pract"},{"key":"10.1038\/s41379-018-0186-4_bib8","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1345\/aph.1H635","article-title":"Interstitial nephritis secondary to bevacizumab treatment in metastatic leiomyosarcoma","volume":"41","author":"Barakat","year":"2007","journal-title":"Ann Pharmacother"},{"key":"10.1038\/s41379-018-0186-4_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/ckj\/sfv139","article-title":"Minimal change disease onset observed after bevacizumab administration","volume":"9","author":"Hanna","year":"2016","journal-title":"Clin Kidney J"},{"key":"10.1038\/s41379-018-0186-4_bib10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1470-2045(07)70037-2","article-title":"Renal thrombotic microangiopathy caused by anti-VEGF-antibody treatment for metastatic renal-cell carcinoma","volume":"8","author":"Frangi\u00e9","year":"2007","journal-title":"Lancet Oncol"},{"key":"10.1038\/s41379-018-0186-4_bib11","first-page":"36","article-title":"Progressive bevacizumab-associated renal thrombotic microangiopathy","volume":"2","author":"Uy","year":"2009","journal-title":"NDT Plus"},{"key":"10.1038\/s41379-018-0186-4_bib12","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1097\/TP.0000000000000750","article-title":"Intravitreal antivascular endothelial growth factor therapy may induce proteinuria and antibody mediated injury in renal allografts","volume":"99","author":"Cheungpasitporn","year":"2015","journal-title":"Transplantation"},{"key":"10.1038\/s41379-018-0186-4_bib13","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1056\/NEJMoa0707330","article-title":"VEGF Inhibition and Renal Thrombotic Microangiopathy","volume":"11","author":"Eremina","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1038\/s41379-018-0186-4_bib14","first-page":"973","article-title":"Microangiopathy. Experience from the Oklahoma Registry and The Bloodcenter of Wisconsin","volume":"3","author":"Gelaye","year":"2016","journal-title":"Am J Hematol"},{"key":"10.1038\/s41379-018-0186-4_bib15","doi-asserted-by":"crossref","first-page":"439","DOI":"10.21873\/invivo.11080","article-title":"Thrombotic microangiopathy following chemotherapy with s-1 and cisplatin in a patient with gastric cancer: a case report","volume":"31","author":"Muto","year":"2017","journal-title":"In Vivo (Brooklyn)"},{"key":"10.1038\/s41379-018-0186-4_bib16","doi-asserted-by":"crossref","first-page":"12605","DOI":"10.1074\/jbc.C300012200","article-title":"Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria","volume":"278","author":"Sugimoto","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1038\/s41379-018-0186-4_bib17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1172\/JCI86418","article-title":"VEGF regulates local inhibitory complement proteins in the eye and kidney","volume":"127","author":"Keir","year":"2017","journal-title":"J Clin Invest"},{"key":"10.1038\/s41379-018-0186-4_bib18","first-page":"8675","article-title":"Mechanism of kidney injury caused by bevacizumab in rats","volume":"7","author":"Zhao","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1038\/s41379-018-0186-4_bib19","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1073\/pnas.0611492104","article-title":"Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies","volume":"104","author":"Gerber","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1038\/s41379-018-0186-4_bib20","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1538-7836.2008.03212.x","article-title":"Bevacizumab immune complexes activate platelets and induce thrombosis in FCGR2A transgenic mice","volume":"7","author":"Meyer","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1038\/s41379-018-0186-4_bib21","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1136\/bjophthalmol-2012-302308","article-title":"In vitro induction of protein complexes between bevacizumab, VEGF-A and heparin: explanation for deposits observed on endothelial veins in monkey eyes","volume":"97","author":"Julien","year":"2013","journal-title":"Br J Ophthalmol"},{"key":"10.1038\/s41379-018-0186-4_bib22","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.kint.2017.02.003","article-title":"Oxford Classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group","volume":"91","author":"Trimarchi","year":"2017","journal-title":"Kidney Int"},{"key":"10.1038\/s41379-018-0186-4_bib23","unstructured":"Reagents PLA Duolink \u00ae PLA Brightfield Protocol. 2018.Available from: https:\/\/www.sigmaaldrich.com\/content\/dam\/sigma-aldrich\/docs\/promo_NOT_INDEXED\/General_Information\/1\/duolink-pla-brightfield-protocol-msig.pdf."},{"key":"10.1038\/s41379-018-0186-4_bib24","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1007\/s00467-010-1446-9","article-title":"DEAP-HUS: Deficiency of CFHR plasma proteins and autoantibody-positive form of hemolytic uremic syndrome","volume":"25","author":"Zipfel","year":"2010","journal-title":"Pediatr Nephrol"},{"key":"10.1038\/s41379-018-0186-4_bib25","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s00467-017-3612-9","article-title":"Successful discontinuation of eculizumab under immunosuppressive therapy in DEAP-HUS","volume":"32","author":"Hackl","year":"2017","journal-title":"Pediatr Nephrol"},{"key":"10.1038\/s41379-018-0186-4_bib26","doi-asserted-by":"crossref","unstructured":"H\u00f6hne M, Frese CK, Grahammer F, Dafinger C, Ciarimboli G, Butt L, et al. Single nephron proteomes connect morphology and function in proteinuric kidney disease. Kidney Int 2018;1308\u201319.","DOI":"10.1016\/j.kint.2017.12.012"},{"key":"10.1038\/s41379-018-0186-4_bib27","doi-asserted-by":"crossref","first-page":"757","DOI":"10.15252\/msb.20145625","article-title":"Ultrasensitive proteome analysis using paramagnetic bead technology","volume":"10","author":"Hughes","year":"2014","journal-title":"Mol Syst Biol"},{"key":"10.1038\/s41379-018-0186-4_bib28","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat Biotechnol"},{"key":"10.1038\/s41379-018-0186-4_bib29","unstructured":"www.drugbank.ca [Internet]. 2018.Available from: www.drugbank.ca."},{"key":"10.1038\/s41379-018-0186-4_bib30","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1074\/mcp.M113.031591","article-title":"Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ","volume":"13","author":"Cox","year":"2014","journal-title":"Mol Cell Proteomics"},{"key":"10.1038\/s41379-018-0186-4_bib31","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc Natl Acad Sci"},{"key":"10.1038\/s41379-018-0186-4_bib32","doi-asserted-by":"crossref","unstructured":"Han MH, Kim YJ Practical application of columbia classification for focal segmental glomerulosclerosis. Biomed Res Int 2016;2016. https:\/\/doi.org\/10.1155\/2016\/9375753.","DOI":"10.1155\/2016\/9375753"},{"key":"10.1038\/s41379-018-0186-4_bib33","doi-asserted-by":"crossref","unstructured":"NoBagchi S, Fredriksson R W-M\u00c5. In Situ Proximity Ligation Assay (PLA). In: Hnasko R (eds) ELISA. Methods in Molecular Biology, vol 1318. Humana Press, New York, NY, 1st ed. New York: Humana Press, 2015 https:\/\/doi.org\/10.1007\/978-1-4939-2742-5_15.","DOI":"10.1007\/978-1-4939-2742-5_15"},{"key":"10.1038\/s41379-018-0186-4_bib34","doi-asserted-by":"crossref","unstructured":"Andeen NK, Yang H-Y, Dai D-F, MacCoss MJ, Smith KD DnaJ Homolog Subfamily B Member 9 Is a Putative Autoantigen in Fibrillary GN. J Am Soc Nephrol 2017;ASN.2017050566.","DOI":"10.1681\/ASN.2017050566"},{"key":"10.1038\/s41379-018-0186-4_bib35","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.kint.2016.07.021","article-title":"Collapsing glomerulopathy is common in the\u00a0setting of thrombotic microangiopathy of\u00a0the\u00a0native kidney","volume":"90","author":"Buob","year":"2016","journal-title":"Kidney Int"},{"key":"10.1038\/s41379-018-0186-4_bib36","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/MNH.0b013e32833aff4a","article-title":"Thrombotic microangiopathies: new insights and new challenges","volume":"19","author":"Zipfel","year":"2010","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1038\/s41379-018-0186-4_bib37","doi-asserted-by":"crossref","unstructured":"Tanaka H, Takahashi K, Yamaguchi K, Kontani K, Motoki T, Asakura M, et al. Hypertension and Proteinuria as Predictive Factors of Effects of Bevacizumab on Advanced Breast Cancer in Japan. 2018;41:644\u20138.","DOI":"10.1248\/bpb.b17-00605"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41379-018-0186-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41379-018-0186-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222010791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222010791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41379-018-0186-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:44:30Z","timestamp":1760229870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222010791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0893395222010791"],"URL":"https:\/\/doi.org\/10.1038\/s41379-018-0186-4","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bevacizumab-associated glomerular microangiopathy","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41379-018-0186-4","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}