{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:21:44Z","timestamp":1784031704818,"version":"3.55.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":1351,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1038\/s41379-018-0188-2","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T03:34:54Z","timestamp":1544758494000},"page":"621-626","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Human papillomavirus in laryngeal and hypopharyngeal lymphoepithelial carcinoma"],"prefix":"10.1016","volume":"32","author":[{"given":"Gabriela","family":"Acu\u00f1a","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Gom\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9516-1680","authenticated-orcid":false,"given":"Jordi","family":"Temprana-Salvador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Garcia-Bragado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Llucia","family":"Al\u00f3s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Ordi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cardesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5366-093X","authenticated-orcid":false,"given":"Alfons","family":"Nadal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41379-018-0188-2_bib1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1080\/00016480260000148","article-title":"Lymphoepithelial carcinoma of the larynx","volume":"122","author":"Marioni","year":"2002","journal-title":"Acta Otolaryngol"},{"issue":"Suppl 1","key":"10.1038\/s41379-018-0188-2_bib2","first-page":"E1294","article-title":"Non-nasopharyngeal head and neck lymphoepithelioma-like carcinoma in the United States: a population-based study","volume":"38","author":"Chan","year":"2016","journal-title":"Head Neck"},{"key":"10.1038\/s41379-018-0188-2_bib3","unstructured":"Gaulard P, Bishop J, Gillison M. Lymphoepithelial carcinoma. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. Who classification of head and neck tumours, 4th edn. Lyon: International Agency for Research in Cancer; 2017, p. 90."},{"key":"10.1038\/s41379-018-0188-2_bib4","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1097\/PAS.0b013e3181d9ba21","article-title":"Lymphoepithelial-like carcinoma of the oropharynx: a morphologic variant of HPV-related head and neck carcinoma","volume":"34","author":"Singhi","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/s41379-018-0188-2_bib5","unstructured":"Servei Catal\u00e0 de la Salut, Generalitat de Catalunya. Depend\u00e8ncia\u2014influencia territorial Regi\u00f3 Sanit\u00e0ria Barcelona. \u00c0rees b\u00e0siques de salut Hospitals [Internet]. http:\/\/catsalut.gencat.cat\/web\/.content\/minisite\/catsalut\/catsalut_territori\/barcelona\/documents\/arxiu\/dependencia_influencia_territorial_rsb_abs-hospitals_2005.pdf"},{"key":"10.1038\/s41379-018-0188-2_bib6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-2273.1979.tb01751.x","article-title":"Lymphoepitheliomas of the larynx (undifferentiated carcinoma of nasopharyngeal type)","volume":"4","author":"Micheau","year":"1979","journal-title":"Clin Otolaryngol"},{"key":"10.1038\/s41379-018-0188-2_bib7","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/S0046-8177(96)90311-1","article-title":"Lymphoepithelial carcinoma of the larynx and hypopharynx: study of eight cases with relationship to Epstein-Barr virus and p53 gene alterations, and review of the literature","volume":"27","author":"MacMillan","year":"1996","journal-title":"Hum Pathol"},{"key":"10.1038\/s41379-018-0188-2_bib8","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1177\/000348949510400410","article-title":"Nonnasopharyngeal lymphoepitheliomas (undifferentiated carcinomas) of the upper aerodigestive tract","volume":"104","author":"Frank","year":"1995","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1038\/s41379-018-0188-2_bib9","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/ajcp\/96.2.156","article-title":"Lymphoepithelioma-like carcinoma and its relationship to the Epstein-Barr virus","volume":"96","author":"Weiss","year":"1991","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/s41379-018-0188-2_bib10","first-page":"1461","article-title":"Abundant expression of EBER1 small nuclear RNA in nasopharyngeal carcinoma. A morphologically distinctive target for detection of Epstein-Barr virus in formalin-fixed paraffin-embedded carcinoma specimens","volume":"138","author":"Wu","year":"1991","journal-title":"Am J Pathol"},{"key":"10.1038\/s41379-018-0188-2_bib11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0196-0709(96)90046-0","article-title":"Lymphoepithelioma of the larynx","volume":"17","author":"Andryk","year":"1996","journal-title":"Am J Otolaryngol"},{"key":"10.1038\/s41379-018-0188-2_bib12","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0194-59989770053-6","article-title":"Undifferentiated carcinoma of nasopharyngeal type of the laryngopharyngeal region","volume":"117","author":"Zbaren","year":"1997","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1038\/s41379-018-0188-2_bib13","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1046\/j.1365-2559.1997.d01-582.x","article-title":"Absence of EBV genome in lymphoepithelioma-like carcinomas of the larynx","volume":"30","author":"Tardio","year":"1997","journal-title":"Histopathology"},{"key":"10.1038\/s41379-018-0188-2_bib14","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0194-5998(98)70185-8","article-title":"Lymphoepithelioma-like carcinoma of the larynx associated with an Epstein-Barr viral infection","volume":"119","author":"Sone","year":"1998","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1038\/s41379-018-0188-2_bib15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0196-0709(98)90129-6","article-title":"Lymphoepitheliomas of the laryngohypopharynx","volume":"19","author":"Dray","year":"1998","journal-title":"Am J Otolaryngol"},{"key":"10.1038\/s41379-018-0188-2_bib16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.anorl.2015.05.004","article-title":"Epstein\u2013Barr virus-associated lymphoepithelial carcinoma of the larynx","volume":"132","author":"Kermani","year":"2015","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"10.1038\/s41379-018-0188-2_bib17","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/modpathol.2011.87","article-title":"Undifferentiated carcinoma of the oropharynx: a human papillomavirus-associated tumor with a favorable prognosis","volume":"24","author":"Carpenter","year":"2011","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-018-0188-2_bib18","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.ijrobp.2013.11.246","article-title":"Nonendemic HPV-positive nasopharyngeal carcinoma: association with poor prognosis","volume":"88","author":"Stenmark","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1038\/s41379-018-0188-2_bib19","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/hed.23362","article-title":"Human papillomavirus 16 detected in nasopharyngeal carcinoma in white americans but not in endemic southern Chinese patients","volume":"35","author":"Lin","year":"2014","journal-title":"Head Neck"},{"key":"10.1038\/s41379-018-0188-2_bib20","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/modpathol.2013.155","article-title":"High-risk papillomavirus is transcriptionally active in a subset of sinonasal squamous call carcinomas","volume":"27","author":"Larque","year":"2014","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-018-0188-2_bib21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/modpathol.2012.159","article-title":"Detection and significance of human papillomavirus, CDKN2A (p16) and CDKN1A (p21) expression in squamous cell carcinoma of the larynx","volume":"26","author":"Chernock","year":"2013","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-018-0188-2_bib22","doi-asserted-by":"crossref","first-page":"djv403","DOI":"10.1093\/jnci\/djv403","article-title":"HPV involvement in head and neck cancers: comprehensive assessment of biomarkers in 3680 patients","volume":"108","author":"Castellsagu\u00e9","year":"2016","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/s41379-018-0188-2_bib23","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1002\/ijc.31006","article-title":"Histological characteristics of HPV-associated and -independent squamous cell carcinomas of the vulva: a study of 1,594 cases","volume":"141","author":"Rakislova","year":"2017","journal-title":"Int J Cancer"},{"key":"10.1038\/s41379-018-0188-2_bib24","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/(SICI)1097-0215(19990531)81:5<705::AID-IJC6>3.0.CO;2-W","article-title":"Disregulation of p16MTS1\/CDK4I protein and mRNA expression is associated with gene alterations in squamous-cell carcinoma of the larynx","volume":"81","author":"Jares","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1038\/s41379-018-0188-2_bib25","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00428-015-1725-8","article-title":"p16INK4a overexpression is associated with CDKN2A mutation and worse prognosis in HPV-negative laryngeal squamous cell carcinomas","volume":"466","author":"Larque","year":"2015","journal-title":"Virchows Arch"},{"key":"10.1038\/s41379-018-0188-2_bib26","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/01.pgp.0000130108.03231.89","article-title":"Immunohistochemical staining for p16 and p53 in premalignant and malignant epithelial lesions of the vulva","volume":"23","author":"Santos","year":"2004","journal-title":"Int J Gynecol Pathol"},{"key":"10.1038\/s41379-018-0188-2_bib27","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/sj.onc.1201309","article-title":"p16MTS1\/CDK4I mutations and concomitant loss of heterozygosity at 9p21-23 are frequent events in squamous cell carcinoma of the larynx","volume":"15","author":"Jares","year":"1997","journal-title":"Oncogene"},{"key":"10.1038\/s41379-018-0188-2_bib28","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1126\/science.1208130","article-title":"The mutational landscape of head and neck squamous cell carcinoma","volume":"333","author":"Stransky","year":"2011","journal-title":"Science"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41379-018-0188-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41379-018-0188-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222010729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222010729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41379-018-0188-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:44:50Z","timestamp":1760229890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222010729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0893395222010729"],"URL":"https:\/\/doi.org\/10.1038\/s41379-018-0188-2","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human papillomavirus in laryngeal and hypopharyngeal lymphoepithelial carcinoma","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41379-018-0188-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}