{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T13:41:53Z","timestamp":1794490913153,"version":"4.9.1"},"reference-count":96,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":1015,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1038\/s41379-019-0406-6","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T07:07:02Z","timestamp":1572937622000},"page":"576-590","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["Infantile inflammatory myofibroblastic tumors: clinicopathological and molecular characterization of 12 cases"],"prefix":"10.1016","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3649-3885","authenticated-orcid":false,"given":"Oscar","family":"Lopez-Nunez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryane N.","family":"Panasiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarangarajan","family":"Ranganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Gr\u00e9laud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Buccoliero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Alaggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6944-2232","authenticated-orcid":false,"given":"Lea F.","family":"Surrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41379-019-0406-6_bib1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/00000478-199508000-00001","article-title":"Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases","volume":"19","author":"Coffin","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/PAS.0b013e318200cfd5","article-title":"Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK","volume":"35","author":"Marino-Enriquez","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib3","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2350\/10-12-0944-PB.1","article-title":"Fibroblastic and myofibroblastic tumors in children and adolescents","volume":"15","author":"Coffin","year":"2012","journal-title":"Pediatr Dev Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib4","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1097\/PAS.0000000000000404","article-title":"Molecular characterization of inflammatory myofibroblastic tumors with frequent ALK and ROS1 gene fusions and rare novel RET rearrangement","volume":"39","author":"Antonescu","year":"2015","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib5","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1158\/2159-8290.CD-14-0377","article-title":"Inflammatory myofibroblastic tumors harbor multiple potentially actionable kinase fusions","volume":"4","author":"Lovly","year":"2014","journal-title":"Cancer Discov"},{"key":"10.1038\/s41379-019-0406-6_bib6","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/dc.23950","article-title":"Cytodiagnosis of inflammatory myofibroblastic tumor: A report of three cases in infants","volume":"46","author":"Ghosh","year":"2018","journal-title":"Diagn Cytopathol"},{"key":"10.1038\/s41379-019-0406-6_bib7","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1097\/00000478-200111000-00003","article-title":"Anaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor: a comparative immunohistochemical study","volume":"25","author":"Cook","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib8","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.prp.2014.03.011","article-title":"Inflammatory myofibroblastic tumor: clinical, morphological, immunohistochemical and molecular features of a pediatric case","volume":"210","author":"Buccoliero","year":"2014","journal-title":"Pathol Res Pract"},{"key":"10.1038\/s41379-019-0406-6_bib9","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/modpathol.2010.226","article-title":"IgG4 plasma cells in inflammatory myofibroblastic tumor: inflammatory marker or pathogenic link?","volume":"24","author":"Saab","year":"2011","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib10","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s00428-015-1842-4","article-title":"Omental mesenteric myxoid hamartoma, a subtype of inflammatory myofibroblastic tumor? Considerations based on the histopathological evaluation of four cases","volume":"467","author":"Ludwig","year":"2015","journal-title":"Virchows Arch"},{"key":"10.1038\/s41379-019-0406-6_bib11","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/00000478-198309000-00007","article-title":"Omental-mesenteric myxoid hamartomas. Infantile lesions simulating malignant tumors","volume":"7","author":"Gonzalez-Crussi","year":"1983","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib12","unstructured":"Fletcher CDM, World Health Organization., International Agency for Research on Cancer. WHO classification of tumours of soft tissue and bone. In: World Health Organization classification of tumours. 4th edn, Lyon:IARC Press;2013, p. 468."},{"key":"10.1038\/s41379-019-0406-6_bib13","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0002-9440(10)61711-7","article-title":"Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor","volume":"159","author":"Bridge","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib14","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/PAS.0000000000000677","article-title":"ETV6-NTRK3 is expressed in a subset of ALK-negative inflammatory myofibroblastic tumors","volume":"40","author":"Alassiri","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib15","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/cncr.24684","article-title":"Inflammatory myofibroblastic tumors in childhood: a report from the Italian Cooperative Group studies","volume":"116","author":"Alaggio","year":"2010","journal-title":"Cancer"},{"key":"10.1038\/s41379-019-0406-6_bib16","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jpedsurg.2015.11.015","article-title":"Inflammatory myofibroblastic tumors in children","volume":"51","author":"Dalton","year":"2016","journal-title":"J Pediatr Surg"},{"key":"10.1038\/s41379-019-0406-6_bib17","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.jpedsurg.2011.07.009","article-title":"Abdominal inflammatory myofibroblastic tumor a clinicopathologic study with reappraisal of biologic behavior","volume":"46","author":"Fragoso","year":"2011","journal-title":"J Pediatr Surg"},{"key":"10.1038\/s41379-019-0406-6_bib18","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/his.12910","article-title":"ALK, ROS1 and NTRK3 gene rearrangements in inflammatory myofibroblastic tumours","volume":"69","author":"Yamamoto","year":"2016","journal-title":"Histopathology"},{"key":"10.1038\/s41379-019-0406-6_bib19","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/modpathol.2014.165","article-title":"Expression of ROS1 predicts ROS1 gene rearrangement in inflammatory myofibroblastic tumors","volume":"28","author":"Hornick","year":"2015","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.humpath.2017.06.013","article-title":"Inflammatory myofibroblastic tumors of the lung carrying a chimeric A2M-ALK gene: report of 2 infantile cases and review of the differential diagnosis of infantile pulmonary lesions","volume":"66","author":"Tanaka","year":"2017","journal-title":"Hum Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/15513815.2017.1385667","article-title":"Inflammatory Myofibroblastic Tumor of the Tongue. Report of a Pediatric Case and Review of the Literature","volume":"37","author":"Caporalini","year":"2018","journal-title":"Fetal Pediatr Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib22","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/j.athoracsur.2006.02.070","article-title":"Multiple cardiac inflammatory myofibroblastic tumors in the right ventricle in an infant","volume":"82","author":"Tian","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1038\/s41379-019-0406-6_bib23","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.jtcvs.2005.02.018","article-title":"Myofibroblastic tumor of the heart: a rare intracardiac tumor","volume":"130","author":"Gandy","year":"2005","journal-title":"J Thorac Cardiovascular Surg"},{"key":"10.1038\/s41379-019-0406-6_bib24","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1053\/adpa.2002.32380","article-title":"Inflammatory pseudotumor (myofibroblastic tumor) of the heart","volume":"6","author":"Li","year":"2002","journal-title":"Ann Diagn Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib25","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.humpath.2007.07.012","article-title":"Inflammatory myofibroblastic tumor of the central nervous system and its relationship to inflammatory pseudotumor","volume":"39","author":"Swain","year":"2008","journal-title":"Hum Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.carpath.2008.03.002","article-title":"Asymptomatic inflammatory myofibroblastic tumor of the heart: immunohistochemical profile, differential diagnosis, and review of the literature","volume":"18","author":"Pucci","year":"2009","journal-title":"Cardiovasc Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib27","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s10024-001-0198-8","article-title":"Intravascular inflammatory myofibroblastic tumors in infancy","volume":"5","author":"Sebire","year":"2002","journal-title":"Pediatr Dev Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib28","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.ijcard.2016.08.029","article-title":"Inflammatory myofibroblastic tumor of the left atrium in infant","volume":"222","author":"Bao","year":"2016","journal-title":"Int J Cardiol"},{"key":"10.1038\/s41379-019-0406-6_bib29","first-page":"49","article-title":"Omental myxoid hamartomas\u2013a case report with review of literature","volume":"30","author":"Shukla","year":"2009","journal-title":"Trop Gastroenterol"},{"key":"10.1038\/s41379-019-0406-6_bib30","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.ijporl.2013.02.020","article-title":"Inflammatory myofibroblastic tumor of parotid in infancy\u2013a new entity","volume":"77","author":"Dhua","year":"2013","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"10.1038\/s41379-019-0406-6_bib31","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3109\/15513818909026914","article-title":"Mesocolic myxoid hamartoma showing neural differentiation: an ultrastructural and immunohistochemical study","volume":"9","author":"Henriquez","year":"1989","journal-title":"Pediatr Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib32","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1097\/00000478-199705000-00016","article-title":"Congenital pulmonary myofibroblastic tumor: a case report with cytogenetic analysis and review of the literature","volume":"21","author":"Alobeid","year":"1997","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib33","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1046\/j.1442-2042.2000.00223.x","article-title":"Inflammatory pseudotumor of the bladder in neonates","volume":"7","author":"Asanuma","year":"2000","journal-title":"Int J Urol"},{"key":"10.1038\/s41379-019-0406-6_bib34","doi-asserted-by":"crossref","unstructured":"Houben CH, Kn\u00fcchel-Clarke R. Neonatal umbilical inflammatory myofibroblastic tumor. Ann Pediatr Surg. 2017;13:160\u20132.","DOI":"10.1097\/01.XPS.0000462545.01690.7a"},{"key":"10.1038\/s41379-019-0406-6_bib35","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1067\/mhn.2003.45","article-title":"Inflammatory myofibroblastic tumor in the neonate: a case report","volume":"128","author":"Klein","year":"2003","journal-title":"Otolaryngol\u2013Head Neck Surg"},{"key":"10.1038\/s41379-019-0406-6_bib36","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cancergen.2013.10.002","article-title":"A novel ALK rearrangement in an inflammatory myofibroblastic tumor in a neonate","volume":"206","author":"Owusu-Brackett","year":"2013","journal-title":"Cancer Genet"},{"key":"10.1038\/s41379-019-0406-6_bib37","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00381-008-0718-1","article-title":"Is radical surgery necessary to head and neck inflammatory myofibroblastic tumor (IMT) in children?","volume":"25","author":"Ma","year":"2009","journal-title":"Childs Nerv Syst"},{"key":"10.1038\/s41379-019-0406-6_bib38","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.anpedi.2009.06.010","article-title":"Tumor miofibrobl\u00e1stico en la edad pedi\u00e1trica. A prop\u00f3sito de 3 casos","volume":"71","author":"Oscoz Lizarbe","year":"2009","journal-title":"An de Pediatr\u00eda"},{"key":"10.1038\/s41379-019-0406-6_bib39","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/S0025-6196(12)64918-0","article-title":"Inoperable plasma cell granuloma of the heart: spontaneous decrease in size during an 11-month period","volume":"63","author":"Pearson","year":"1988","journal-title":"Mayo Clin Proc"},{"key":"10.1038\/s41379-019-0406-6_bib40","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1097\/IOP.0b013e3182696922","article-title":"Infantile inflammatory myofibroblastic tumor of the orbit with apical bone involvement","volume":"29","author":"Tawfik","year":"2013","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"10.1038\/s41379-019-0406-6_bib41","doi-asserted-by":"crossref","first-page":"e20143544","DOI":"10.1542\/peds.2014-3544","article-title":"Febrile Illness in an infant with an intracardiac inflammatory myofibroblastic tumor","volume":"137","author":"Pang","year":"2016","journal-title":"Pediatrics"},{"key":"10.1038\/s41379-019-0406-6_bib42","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/MPG.0b013e31829e0b3b","article-title":"Inflammatory myofibroblastic tumor of the liver in children","volume":"57","author":"Nagarajan","year":"2013","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1038\/s41379-019-0406-6_bib43","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/gcc.10177","article-title":"Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor","volume":"37","author":"Ma","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/s41379-019-0406-6_bib44","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1016\/j.jpedsurg.2005.03.033","article-title":"Myofibroblastic tumor causing severe neonatal distress. Successful surgical resection after embolization","volume":"40","author":"Castanon","year":"2005","journal-title":"J Pediatr Surg"},{"key":"10.1038\/s41379-019-0406-6_bib45","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/01.pas.0000213393.57322.c7","article-title":"Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases","volume":"31","author":"Coffin","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib46","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/gcc.1121","article-title":"ALK probe rearrangement in a t(2;11;2)(p23;p15;q31) translocation found in a prenatal myofibroblastic fibrous lesion: toward a molecular definition of an inflammatory myofibroblastic tumor family?","volume":"31","author":"Sirvent","year":"2001","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/s41379-019-0406-6_bib47","doi-asserted-by":"crossref","first-page":"E17","DOI":"10.1016\/S0022-3468(03)00523-2","article-title":"Congenital multifocal inflammatory pseudotumor: a case report","volume":"38","author":"Thompson","year":"2003","journal-title":"J Pediatr Surg"},{"key":"10.1038\/s41379-019-0406-6_bib48","doi-asserted-by":"crossref","first-page":"e27012","DOI":"10.1002\/pbc.27012","article-title":"Inflammatory myofibroblastic tumors-A retrospective analysis of the Cooperative Weichteilsarkom Studiengruppe","volume":"65","author":"Kube","year":"2018","journal-title":"Pediatr Blood Cancer"},{"key":"10.1038\/s41379-019-0406-6_bib49","doi-asserted-by":"crossref","unstructured":"Shukla SK, Parashar S. Intra-abdominal inflammatory myofibroblastic tumour (IMT) mimicking gonadal mass in a male infant with undescended testes. BMJ Case Rep. 2017;2017:pii:\u00a0bcr-2017-219745.","DOI":"10.1136\/bcr-2017-219745"},{"key":"10.1038\/s41379-019-0406-6_bib50","doi-asserted-by":"crossref","unstructured":"Di Maria M, N Campbell D, B Mitchell M, et al. Successful orthotopic heart transplant in an infant with an inflammatory myofibroblastic tumor of the left ventricle. J Heart Lung Transplant. 2008;27:792\u20136.","DOI":"10.1016\/j.healun.2008.03.005"},{"key":"10.1038\/s41379-019-0406-6_bib51","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/modpathol.3880390","article-title":"Calcifying fibrous pseudotumor versus inflammatory myofibroblastic tumor: a histological and immunohistochemical comparison","volume":"14","author":"Hill","year":"2001","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib52","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1053\/adpa.2001.29340","article-title":"Fibroma and inflammatory myofibroblastic tumor of the heart","volume":"5","author":"de Montpreville","year":"2001","journal-title":"Ann Diagn Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib53","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/0218492317739474","article-title":"Inflammatory myofibroblastic tumor of heart in a 4-month-old infant","volume":"26","author":"Syed","year":"2018","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"10.1038\/s41379-019-0406-6_bib54","doi-asserted-by":"crossref","unstructured":"Jenkins PC, Dickison AE. Flanagan MFJPC. Cardiac Inflammatory Pseudotumor: rapid appearance in an infant with congenital heart disease. Pediatr Cardiol. 1996;17:399\u2013401.","DOI":"10.1007\/s002469900088"},{"key":"10.1038\/s41379-019-0406-6_bib55","doi-asserted-by":"crossref","first-page":"E174","DOI":"10.1111\/chd.12026","article-title":"An unexpected cause of respiratory distress and cyanosis: cardiac inflammatory myofibroblastic tumor","volume":"8","author":"Elkiran","year":"2013","journal-title":"Congenit Heart Dis"},{"key":"10.1038\/s41379-019-0406-6_bib56","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1055\/s-0029-1238320","article-title":"An inflammatory myofibroblastic tumor of the stomach as a rare cause of gastric outlet obstruction in an 8-month-old infant","volume":"222","author":"Hirschburger","year":"2010","journal-title":"Klin Padiatr"},{"key":"10.1038\/s41379-019-0406-6_bib57","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.humpath.2007.10.010","article-title":"Inflammatory myofibroblastic tumor and low-grade myofibroblastic sarcoma: a comparative study of clinicopathologic features and further observations on the immunohistochemical profile of myofibroblasts","volume":"39","author":"Qiu","year":"2008","journal-title":"Hum Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib58","doi-asserted-by":"crossref","first-page":"e298","DOI":"10.1097\/MPH.0000000000000558","article-title":"Inflammatory Myofibroblastic Tumor of the Heart in the Infant: Review of the Literature","volume":"38","author":"Mizia-Malarz","year":"2016","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1038\/s41379-019-0406-6_bib59","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/pbc.20294","article-title":"Pediatric inflammatory myofibroblastic tumor: anaplastic lymphoma kinase (ALK) expression and prognosis","volume":"45","author":"Chun","year":"2005","journal-title":"Pediatr Blood Cancer"},{"key":"10.1038\/s41379-019-0406-6_bib60","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.jpedsurg.2005.06.021","article-title":"Inflammatory myofibroblastic tumor in children: clinical review with anaplastic lymphoma kinase, Epstein-Barr virus, and human herpesvirus 8 detection analysis","volume":"40","author":"Mergan","year":"2005","journal-title":"J Pediatr Surg"},{"key":"10.1038\/s41379-019-0406-6_bib61","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1055\/s-0036-1593380","article-title":"Surgical treatment of childhood inflammatory myofibroblastic tumors","volume":"27","author":"Soyer","year":"2017","journal-title":"Eur J Pediatr Surg"},{"key":"10.1038\/s41379-019-0406-6_bib62","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/modpathol.3800938","article-title":"Absence of human herpesvirus-8 in pulmonary inflammatory myofibroblastic tumor: immunohistochemical and molecular analysis of 20 cases","volume":"20","author":"Tavora","year":"2007","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib63","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0002-9440(10)64550-6","article-title":"TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors","volume":"157","author":"Lawrence","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib64","doi-asserted-by":"crossref","DOI":"10.1186\/s13073-019-0644-8","article-title":"Clinical utility of custom-designed NGS panel testing in pediatric tumors","volume":"11","author":"Surrey","year":"2019","journal-title":"Genome Med"},{"key":"10.1038\/s41379-019-0406-6_bib65","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/01.pas.0000190784.18198.d8","article-title":"Primitive myxoid mesenchymal tumor of infancy: a clinicopathologic report of 6 cases","volume":"30","author":"Alaggio","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib66","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/1746-1596-8-147","article-title":"Inflammatory myofibroblastic tumor with RANBP2 and ALK gene rearrangement: a report of two cases and literature review","volume":"8","author":"Li","year":"2013","journal-title":"Diagn Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib67","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cancergencyto.2007.04.004","article-title":"RANBP2 and CLTC are involved in ALK rearrangements in inflammatory myofibroblastic tumors","volume":"176","author":"Patel","year":"2007","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-019-0406-6_bib68","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1056\/NEJMoa1007056","article-title":"Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor","volume":"363","author":"Butrynski","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1038\/s41379-019-0406-6_bib69","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.3892\/ol.2016.4082","article-title":"Inflammatory myofibroblastic tumor with RANBP2 and ALK gene rearrangement with bland cytological features mimicking desmoid-type fibromatosis: a case report and review of the literature","volume":"11","author":"Huang","year":"2016","journal-title":"Oncol Lett"},{"key":"10.1038\/s41379-019-0406-6_bib70","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/path.4836","article-title":"ALK oncoproteins in atypical inflammatory myofibroblastic tumours: novel RRBP1-ALK fusions in epithelioid inflammatory myofibroblastic sarcoma","volume":"241","author":"Lee","year":"2017","journal-title":"J Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib71","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s11748-013-0204-x","article-title":"Epithelioid inflammatory myofibroblastic sarcoma arising in the pleural cavity","volume":"62","author":"Kozu","year":"2014","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"10.1038\/s41379-019-0406-6_bib72","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/j.humpath.2008.04.016","article-title":"An inflammatory myofibroblastic tumor in liver with ALK and RANBP2 gene rearrangement: combination of distinct morphologic, immunohistochemical, and genetic features","volume":"39","author":"Chen","year":"2008","journal-title":"Hum Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib73","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/PGP.0000000000000431","article-title":"Epithelioid inflammatory myofibroblastic sarcoma of the ovary with RANB2-ALK fusion: report of a case","volume":"37","author":"Fang","year":"2018","journal-title":"Int J Gynecol Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib74","first-page":"9317","article-title":"Clinicopathological analysis of epithelioid inflammatory myofibroblastic sarcoma","volume":"15","author":"Du","year":"2018","journal-title":"Oncol Lett"},{"key":"10.1038\/s41379-019-0406-6_bib75","first-page":"15328","article-title":"Epithelioid inflammatory myofibroblastic sarcoma treated with ALK inhibitor: a case report and review of literature","volume":"8","author":"Liu","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib76","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1093\/jjco\/hyu069","article-title":"A case report of epithelioid inflammatory myofibroblastic sarcoma with RANBP2-ALK fusion gene treated with the ALK inhibitor, crizotinib","volume":"44","author":"Kimbara","year":"2014","journal-title":"Jpn J Clin Oncol"},{"key":"10.1038\/s41379-019-0406-6_bib77","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.2169\/internalmedicine.53.2546","article-title":"Epithelioid inflammatory myofibroblastic sarcoma responsive to surgery and an ALK inhibitor in a patient with panhypopituitarism","volume":"53","author":"Kurihara-Hosokawa","year":"2014","journal-title":"Intern Med"},{"key":"10.1038\/s41379-019-0406-6_bib78","first-page":"4213","article-title":"Epithelioid inflammatory myofibroblastic sarcoma in abdominal cavity: a case report and review of literature","volume":"8","author":"Wu","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib79","doi-asserted-by":"crossref","first-page":"e31323","DOI":"10.1371\/journal.pone.0031323","article-title":"KLC1-ALK: a novel fusion in lung cancer identified using a formalin-fixed paraffin-embedded tissue only","volume":"7","author":"Togashi","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1038\/s41379-019-0406-6_bib80","doi-asserted-by":"crossref","first-page":"183","DOI":"10.20892\/j.issn.2095-3941.2017.0017","article-title":"Rapid response of brain metastasis to crizotinib in a patient with KLC1-ALK fusion and MET gene amplification positive non-small cell lung cancer: a case report","volume":"14","author":"Wang","year":"2017","journal-title":"Cancer Biol Med"},{"key":"10.1038\/s41379-019-0406-6_bib81","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.lungcan.2017.12.004","article-title":"ALK fusion variants detection by targeted RNA-next generation sequencing and clinical responses to crizotinib in ALK-positive non-small cell lung cancer","volume":"116","author":"McLeer-Florin","year":"2018","journal-title":"Lung Cancer"},{"key":"10.1038\/s41379-019-0406-6_bib82","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.2147\/OTT.S172124","article-title":"ALK-rearrangement neuroendocrine carcinoma of the lung: a comprehensive study of a rare case series and review of literature","volume":"11","author":"Zheng","year":"2018","journal-title":"Onco Targets Ther"},{"key":"10.1038\/s41379-019-0406-6_bib83","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.jtho.2018.12.003","article-title":"Expanding the molecular characterization of thoracic inflammatory myofibroblastic tumors beyond ALK gene rearrangements","volume":"14","author":"Chang","year":"2019","journal-title":"J Thorac Oncol"},{"key":"10.1038\/s41379-019-0406-6_bib84","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/PAS.0000000000000801","article-title":"Uterine inflammatory myofibroblastic tumors frequently harbor ALK fusions with IGFBP5 and THBS1","volume":"41","author":"Haimes","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib85","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/pbc.25424","article-title":"FN1: a novel fusion partner of ALK in an inflammatory myofibroblastic tumor","volume":"62","author":"Ouchi","year":"2015","journal-title":"Pediatr Blood Cancer"},{"key":"10.1038\/s41379-019-0406-6_bib86","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1158\/1541-7786.MCR-18-0171","article-title":"ALK fusion partners impact response to ALK inhibition: differential effects on sensitivity, cellular phenotypes, and biochemical properties","volume":"16","author":"Childress","year":"2018","journal-title":"Mol Cancer Res"},{"key":"10.1038\/s41379-019-0406-6_bib87","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1593\/neo.11222","article-title":"Identification of oncogenic point mutations and hyperphosphorylation of anaplastic lymphoma kinase in lung cancer","volume":"13","author":"Wang","year":"2011","journal-title":"Neoplasia"},{"key":"10.1038\/s41379-019-0406-6_bib88","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1002\/cncr.28311","article-title":"Native and rearranged ALK copy number and rearranged cell count in non-small cell lung cancer: implications for ALK inhibitor therapy","volume":"119","author":"Camidge","year":"2013","journal-title":"Cancer"},{"key":"10.1038\/s41379-019-0406-6_bib89","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.jtho.2017.01.004","article-title":"ROS1 fusions rarely overlap with other oncogenic drivers in non-small cell lung cancer","volume":"12","author":"Lin","year":"2017","journal-title":"J Thorac Oncol"},{"key":"10.1038\/s41379-019-0406-6_bib90","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/neup.12513","article-title":"Expanding the spectrum of pediatric NTRK-rearranged fibroblastic tumors to the central nervous system: a case report with RBPMS-NTRK3 fusion","volume":"38","author":"Torre","year":"2018","journal-title":"Neuropathology"},{"key":"10.1038\/s41379-019-0406-6_bib91","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1177\/0300060518780873","article-title":"Anaplastic lymphoma kinase-negative uterine inflammatory myofibroblastic tumor containing the ETV6-NTRK3 fusion gene: a case report","volume":"46","author":"Takahashi","year":"2018","journal-title":"J Int Med Res"},{"key":"10.1038\/s41379-019-0406-6_bib92","doi-asserted-by":"crossref","unstructured":"Pavlick D, Schrock AB, Malicki D, et al. Identification of NTRK fusions in pediatric mesenchymal tumors. Pediatr Blood Cancer 2017;64:e26433.","DOI":"10.1002\/pbc.26433"},{"key":"10.1038\/s41379-019-0406-6_bib93","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/bpa.12504","article-title":"Intracranial myxoid mesenchymal tumors with EWSR1-CREB family gene fusions: myxoid variant of angiomatoid fibrous histiocytoma or novel entity?","volume":"28","author":"Bale","year":"2018","journal-title":"Brain Pathol"},{"key":"10.1038\/s41379-019-0406-6_bib94","doi-asserted-by":"crossref","unstructured":"Tsakiri K, Kotoula V, Lakis S, et al. Crizotinib failure in a TPM4-ALK\u2013rearranged inflammatory myofibroblastic tumor with an emerging ALK kinase domain mutation. 2017;1:1\u20137.","DOI":"10.1200\/PO.17.00015"},{"key":"10.1038\/s41379-019-0406-6_bib95","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S1470-2045(13)70095-0","article-title":"Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study","volume":"14","author":"Mosse","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1038\/s41379-019-0406-6_bib96","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1111\/bcp.12741","article-title":"Pharmacokinetics in neonatal prescribing: evidence base, paradigms and the future","volume":"80","author":"O'Hara","year":"2015","journal-title":"Br J Clin Pharm"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41379-019-0406-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41379-019-0406-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222008845?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222008845?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41379-019-0406-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:41:06Z","timestamp":1760229666000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222008845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":96,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0893395222008845"],"URL":"https:\/\/doi.org\/10.1038\/s41379-019-0406-6","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Infantile inflammatory myofibroblastic tumors: clinicopathological and molecular characterization of 12 cases","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41379-019-0406-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}