{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:57:07Z","timestamp":1791309427566,"version":"4.3.1"},"reference-count":87,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":954,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1038\/s41379-019-0424-4","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T13:02:51Z","timestamp":1576760571000},"page":"1092-1103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Next-generation sequencing implicates oncogenic roles for p53 and JAK\/STAT signaling in microcystic adnexal carcinomas"],"prefix":"10.1016","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0650-1266","authenticated-orcid":false,"given":"May P.","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komal R.","family":"Plouffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Jen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0633-9772","authenticated-orcid":false,"given":"Nallasivam","family":"Palanisamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Carskadon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4003-7193","authenticated-orcid":false,"given":"Rosalynn M.","family":"Nazarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison B.","family":"Durham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleodor A.","family":"Andea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1521-4947","authenticated-orcid":false,"given":"Rajiv M.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas R.","family":"Fullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Tomlins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8254-5404","authenticated-orcid":false,"given":"Aaron M.","family":"Udager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0802-2883","authenticated-orcid":false,"given":"Paul W.","family":"Harms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41379-019-0424-4_bib1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.jaad.2018.03.010","article-title":"Demographics and outcomes of microcystic adnexal carcinoma","volume":"79","author":"King","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/s41379-019-0424-4_bib2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1046\/j.1524-4725.2000.00005.x","article-title":"Metastatic microcystic adnexal carcinoma in an immunocompromised patient","volume":"26","author":"Carroll","year":"2000","journal-title":"Dermatol Surg"},{"key":"10.1038\/s41379-019-0424-4_bib3","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1159\/000074122","article-title":"Microcystic adnexal carcinoma with lymph node metastasis","volume":"207","author":"Ban","year":"2003","journal-title":"Dermatology"},{"key":"10.1038\/s41379-019-0424-4_bib4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/COC.0b013e31819791eb","article-title":"Surveillance, Epidemiology, and End Results (SEER) database analysis of microcystic adnexal carcinoma (sclerosing sweat duct carcinoma) of the skin","volume":"33","author":"Yu","year":"2010","journal-title":"Am J Clin Oncol"},{"key":"10.1038\/s41379-019-0424-4_bib5","first-page":"5109","article-title":"Metastatic microcystic adnexal carcinoma with DNA sequencing results and response to systemic antineoplastic chemotherapy","volume":"37","author":"Chen","year":"2017","journal-title":"Anticancer Res"},{"key":"10.1038\/s41379-019-0424-4_bib6","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1288\/00005537-199511000-00011","article-title":"Microcystic adnexal carcinoma: management options based on long-term follow-up","volume":"105","author":"Bier-Laning","year":"1995","journal-title":"Laryngoscope"},{"key":"10.1038\/s41379-019-0424-4_bib7","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1111\/jdv.13127","article-title":"Anatomoclinical study of 30 cases of sclerosing sweat duct carcinomas (microcystic adnexal carcinoma, syringomatous carcinoma and squamoid eccrine ductal carcinoma)","volume":"29","author":"Frouin","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1038\/s41379-019-0424-4_bib8","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3109\/09546634.2015.1089351","article-title":"Treatments for microcystic adnexal carcinoma-A review","volume":"27","author":"Chaudhari","year":"2016","journal-title":"J Dermatol Treat"},{"key":"10.1038\/s41379-019-0424-4_bib9","first-page":"275","article-title":"Microcystic adnexal carcinoma\u2014aggressive infiltrative tumor often with innocent clinical appearance","volume":"8","author":"Hamsch","year":"2010","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1038\/s41379-019-0424-4_bib10","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/1097-0142(19820801)50:3<566::AID-CNCR2820500330>3.0.CO;2-Q","article-title":"Microcystic adnexal carcinoma: a distinct clinicopathologic entity","volume":"50","author":"Goldstein","year":"1982","journal-title":"Cancer"},{"key":"10.1038\/s41379-019-0424-4_bib11","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/00000372-199510000-00006","article-title":"Solitary syringoma. Report of five cases and clinicopathologic comparison with microcystic adnexal carcinoma of the skin","volume":"17","author":"Henner","year":"1995","journal-title":"Am J Dermatopathol"},{"key":"10.1038\/s41379-019-0424-4_bib12","first-page":"810","article-title":"An important mimicker: plaque-type syringoma mistakenly diagnosed as microcystic adnexal carcinoma","volume":"40","author":"Wallace","year":"2014","journal-title":"Dermatol Surg"},{"key":"10.1038\/s41379-019-0424-4_bib13","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000057880","article-title":"Microcystic adnexal carcinoma: review of 51 Japanese patients","volume":"204","author":"Ohtsuka","year":"2002","journal-title":"Dermatology"},{"key":"10.1038\/s41379-019-0424-4_bib14","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1097\/DAD.0b013e3181ea1385","article-title":"Microcystic adnexal carcinoma with multiple areas of follicular differentiation toward germinative cells and specific follicular stroma (trichoblastomatous areas)","volume":"33","author":"Kazakov","year":"2011","journal-title":"Am J Dermatopathol"},{"key":"10.1038\/s41379-019-0424-4_bib15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/DAD.0b013e31825988df","article-title":"Microcystic adnexal carcinoma versus desmoplastic trichoepithelioma: a comparative study","volume":"35","author":"Tse","year":"2013","journal-title":"Am J Dermatopathol"},{"key":"10.1038\/s41379-019-0424-4_bib16","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/cup.12085","article-title":"The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers","volume":"40","author":"Sellheyer","year":"2013","journal-title":"J Cutan Pathol"},{"key":"10.1038\/s41379-019-0424-4_bib17","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/modpathol.3801000","article-title":"Microcystic adnexal carcinoma: an immunohistochemical reappraisal","volume":"21","author":"Hoang","year":"2008","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-019-0424-4_bib18","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0165-4608(96)00417-7","article-title":"Cytogenetic and fluorescence in situ hybridization analyses of a microcystic adnexal carcinoma with del(6)(q23q25)","volume":"98","author":"Wohlfahrt","year":"1997","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-019-0424-4_bib19","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/DAD.0b013e3181984f10","article-title":"Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2\/neu gene expression\/amplification, TP53 gene mutation analysis, and t(11;19) translocation","volume":"31","author":"Kazakov","year":"2009","journal-title":"Am J Dermatopathol"},{"key":"10.1038\/s41379-019-0424-4_bib20","doi-asserted-by":"crossref","first-page":"e47290","DOI":"10.1371\/journal.pone.0047290","article-title":"Apocrine-eccrine carcinomas: molecular and immunohistochemical analyses","volume":"7","author":"Le","year":"2012","journal-title":"PLoS One"},{"key":"10.1038\/s41379-019-0424-4_bib21","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1034\/j.1600-0560.2000.027001030.x","article-title":"Genetic changes in sweat gland carcinomas","volume":"27","author":"Takata","year":"2000","journal-title":"J Cutan Pathol"},{"key":"10.1038\/s41379-019-0424-4_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.humpath.2015.12.015","article-title":"Porocarcinomas harbor recurrent HRAS-activating mutations and tumor suppressor inactivating mutations","volume":"51","author":"Harms","year":"2016","journal-title":"Hum Pathol"},{"key":"10.1038\/s41379-019-0424-4_bib23","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.pathol.2017.10.011","article-title":"Targeted molecular profiling reveals genetic heterogeneity of poromas and porocarcinomas","volume":"50","author":"Bosic","year":"2018","journal-title":"Pathology"},{"key":"10.1038\/s41379-019-0424-4_bib24","doi-asserted-by":"crossref","unstructured":"Qin H, Moore RF, Ho CY, Eshleman J, Eberhart CG, Cuda J. Endocrine mucin-producing sweat gland carcinoma: a study of 11 cases with molecular analysis. J Cutan Pathol. 2018. https:\/\/doi.org\/10.1111\/cup.13308.","DOI":"10.1111\/cup.13308"},{"key":"10.1038\/s41379-019-0424-4_bib25","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.anndiagpath.2015.08.002","article-title":"Next-generation sequencing reveals rare genomic alterations in aggressive digital papillary adenocarcinoma","volume":"19","author":"Bell","year":"2015","journal-title":"Ann Diagn Pathol"},{"key":"10.1038\/s41379-019-0424-4_bib26","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/(SICI)1097-0215(19980504)76:3<317::AID-IJC5>3.0.CO;2-Y","article-title":"p53 mutations in sweat gland carcinomas","volume":"76","author":"Biernat","year":"1998","journal-title":"Int J Cancer"},{"key":"10.1038\/s41379-019-0424-4_bib27","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/modpathol.2011.48","article-title":"A potential role for targeted therapy in a subset of metastasizing adnexal carcinomas","volume":"24","author":"Dias-Santagata","year":"2011","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-019-0424-4_bib28","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.neo.2015.03.004","article-title":"Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors","volume":"17","author":"Hovelson","year":"2015","journal-title":"Neoplasia"},{"key":"10.1038\/s41379-019-0424-4_bib29","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1158\/1541-7786.MCR-14-0578","article-title":"Next-gen sequencing exposes frequent MED12 mutations and actionable therapeutic targets in phyllodes tumors","volume":"13","author":"Cani","year":"2015","journal-title":"Mol Cancer Res"},{"key":"10.1038\/s41379-019-0424-4_bib30","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00428-014-1699-y","article-title":"Tumor evolution and progression in multifocal and paired non-invasive\/invasive urothelial carcinoma","volume":"466","author":"Warrick","year":"2015","journal-title":"Virchows Arch"},{"key":"10.1038\/s41379-019-0424-4_bib31","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/modpathol.2016.79","article-title":"Comprehensive genomic profiling of orbital and ocular adnexal lymphomas identifies frequent alterations in MYD88 and chromatin modifiers: new routes to targeted therapies","volume":"29","author":"Cani","year":"2016","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-019-0424-4_bib32","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jmoldx.2014.09.008","article-title":"Assessing copy number alterations in targeted, amplicon-based next-generation sequencing data","volume":"17","author":"Grasso","year":"2015","journal-title":"J Mol Diagn"},{"key":"10.1038\/s41379-019-0424-4_bib33","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1073\/pnas.90.9.4216","article-title":"Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers","volume":"90","author":"Ziegler","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/s41379-019-0424-4_bib34","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/mc.2940090208","article-title":"P53 mutations in primary human lung tumors and their metastases","volume":"9","author":"Reichel","year":"1994","journal-title":"Mol Carcinog"},{"key":"10.1038\/s41379-019-0424-4_bib35","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/(SICI)1096-8652(199712)56:4<206::AID-AJH2>3.0.CO;2-0","article-title":"Detection of BCL-6 rearrangements and p53 mutations in Malt-lymphomas","volume":"56","author":"Gaidano","year":"1997","journal-title":"Am J Hematol"},{"key":"10.1038\/s41379-019-0424-4_bib36","first-page":"3119","article-title":"Unusual profile and high prevalence of p53 mutations in esophageal squamous cell carcinomas from northern Iran","volume":"61","author":"Biramijamal","year":"2001","journal-title":"Cancer Res"},{"key":"10.1038\/s41379-019-0424-4_bib37","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/modpathol.3880400","article-title":"Losses of chromosomal arms 1p and 19q in the diagnosis of oligodendroglioma. A study of paraffin-embedded sections","volume":"14","author":"Burger","year":"2001","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-019-0424-4_bib38","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1126\/science.1164368","article-title":"Core signaling pathways in human pancreatic cancers revealed by global genomic analyses","volume":"321","author":"Jones","year":"2008","journal-title":"Science"},{"key":"10.1038\/s41379-019-0424-4_bib39","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nature11017","article-title":"The landscape of cancer genes and mutational processes in breast cancer","volume":"486","author":"Stephens","year":"2012","journal-title":"Nature"},{"key":"10.1038\/s41379-019-0424-4_bib40","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1158\/0008-5472.CAN-15-0702","article-title":"The distinctive mutational spectra of polyomavirus-negative Merkel cell carcinoma","volume":"75","author":"Harms","year":"2015","journal-title":"Cancer Res"},{"key":"10.1038\/s41379-019-0424-4_bib41","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.cell.2015.03.053","article-title":"Prospective derivation of a living organoid biobank of colorectal cancer patients","volume":"161","author":"van de Wetering","year":"2015","journal-title":"Cell"},{"key":"10.1038\/s41379-019-0424-4_bib42","doi-asserted-by":"crossref","first-page":"26107","DOI":"10.18632\/oncotarget.8431","article-title":"Mutational analysis of single circulating tumor cells by next generation sequencing in metastatic breast cancer","volume":"7","author":"De Luca","year":"2016","journal-title":"Oncotarget"},{"key":"10.1038\/s41379-019-0424-4_bib43","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nm.4333","article-title":"Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients","volume":"23","author":"Zehir","year":"2017","journal-title":"Nat Med"},{"key":"10.1038\/s41379-019-0424-4_bib44","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nature10725","article-title":"The genetic basis of early T-cell precursor acute lymphoblastic leukaemia","volume":"481","author":"Zhang","year":"2012","journal-title":"Nature"},{"key":"10.1038\/s41379-019-0424-4_bib45","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/php.12377","article-title":"UV signature mutations","volume":"91","author":"Brash","year":"2015","journal-title":"Photochem Photobiol"},{"key":"10.1038\/s41379-019-0424-4_bib46","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/modpathol.2015.154","article-title":"Next generation sequencing of Cytokeratin 20-negative Merkel cell carcinoma reveals ultraviolet-signature mutations and recurrent TP53 and RB1 inactivation","volume":"29","author":"Harms","year":"2016","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-019-0424-4_bib47","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1001\/jamadermatol.2017.0507","article-title":"Molecular profiling of multiple primary Merkel cell carcinoma to distinguish genetically distinct tumors from clonally related metastases","volume":"153","author":"Harms","year":"2017","journal-title":"JAMA Dermatol"},{"key":"10.1038\/s41379-019-0424-4_bib48","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/978-0-387-77574-6_13","article-title":"UV damage and DNA repair in malignant melanoma and nonmelanoma skin cancer","volume":"624","author":"Rass","year":"2008","journal-title":"Adv Exp Med Biol"},{"key":"10.1038\/s41379-019-0424-4_bib49","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/jid.2013.276","article-title":"Mutational landscape of basal cell carcinomas by whole-exome sequencing","volume":"134","author":"Jayaraman","year":"2014","journal-title":"J Investig Dermatol"},{"key":"10.1038\/s41379-019-0424-4_bib50","doi-asserted-by":"crossref","first-page":"E82","DOI":"10.1002\/hed.25613","article-title":"Ultraviolet light-related DNA damage mutation signature distinguishes cutaneous from mucosal or other origin for head and neck squamous cell carcinoma of unknown primary site","volume":"41","author":"Chan","year":"2019","journal-title":"Head Neck"},{"key":"10.1038\/s41379-019-0424-4_bib51","doi-asserted-by":"crossref","first-page":"6582","DOI":"10.1158\/1078-0432.CCR-14-1768","article-title":"Mutational landscape of aggressive cutaneous squamous cell carcinoma","volume":"20","author":"Pickering","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1038\/s41379-019-0424-4_bib52","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/ng.3525","article-title":"Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma","volume":"48","author":"Bonilla","year":"2016","journal-title":"Nat Genet"},{"key":"10.1038\/s41379-019-0424-4_bib53","doi-asserted-by":"crossref","first-page":"560","DOI":"10.2174\/138161211795222603","article-title":"Pharmacologic activation of p53 by small-molecule MDM2 antagonists","volume":"17","author":"Shen","year":"2011","journal-title":"Curr Pharm Des"},{"key":"10.1038\/s41379-019-0424-4_bib54","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/sj.onc.1201459","article-title":"p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding","volume":"15","author":"Midgley","year":"1997","journal-title":"Oncogene"},{"key":"10.1038\/s41379-019-0424-4_bib55","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fonc.2015.00284","article-title":"Regulation of mutant p53 protein expression","volume":"5","author":"Vijayakumaran","year":"2015","journal-title":"Front Oncol"},{"key":"10.1038\/s41379-019-0424-4_bib56","first-page":"1699","article-title":"Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies","volume":"6","author":"Bartek","year":"1991","journal-title":"Oncogene"},{"key":"10.1038\/s41379-019-0424-4_bib57","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/00000372-199404000-00003","article-title":"p53 protein in benign and malignant sweat gland tumors","volume":"16","author":"Wienecke","year":"1994","journal-title":"Am J Dermatopathol"},{"key":"10.1038\/s41379-019-0424-4_bib58","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(05)71142-9","article-title":"Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders","volume":"365","author":"Baxter","year":"2005","journal-title":"Lancet"},{"key":"10.1038\/s41379-019-0424-4_bib59","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/nature03546","article-title":"A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera","volume":"434","author":"James","year":"2005","journal-title":"Nature"},{"key":"10.1038\/s41379-019-0424-4_bib60","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1056\/NEJMoa051113","article-title":"A gain-of-function mutation of JAK2 in myeloproliferative disorders","volume":"352","author":"Kralovics","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1038\/s41379-019-0424-4_bib61","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ccr.2005.03.023","article-title":"Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis","volume":"7","author":"Levine","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1038\/s41379-019-0424-4_bib62","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1084\/jem.20072182","article-title":"Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia","volume":"205","author":"Flex","year":"2008","journal-title":"J Exp Med"},{"key":"10.1038\/s41379-019-0424-4_bib63","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1038\/onc.2012.347","article-title":"JAK\/STAT signaling in hematological malignancies","volume":"32","author":"Vainchenker","year":"2013","journal-title":"Oncogene"},{"key":"10.1038\/s41379-019-0424-4_bib64","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(00)81277-5","article-title":"STATs: signal transducers and activators of transcription","volume":"84","author":"Ihle","year":"1996","journal-title":"Cell"},{"key":"10.1038\/s41379-019-0424-4_bib65","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/nm0996-968","article-title":"STATs and cytokine specificity","volume":"2","author":"Leonard","year":"1996","journal-title":"Nat Med"},{"key":"10.1038\/s41379-019-0424-4_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0161-5890(00)00018-3","article-title":"The Jak-STAT pathway","volume":"37","author":"Imada","year":"2000","journal-title":"Mol Immunol"},{"key":"10.1038\/s41379-019-0424-4_bib67","doi-asserted-by":"crossref","first-page":"82","DOI":"10.12688\/f1000research.13167.1","article-title":"JAK inhibitors for the treatment of myeloproliferative neoplasms and other disorders","volume":"7","author":"Vainchenker","year":"2018","journal-title":"F1000Res"},{"key":"10.1038\/s41379-019-0424-4_bib68","doi-asserted-by":"crossref","first-page":"26483","DOI":"10.18632\/oncotarget.4494","article-title":"Genomic amplification of 9p24.1 targeting JAK2, PD-L1, and PD-L2 is enriched in high-risk triple negative breast cancer","volume":"6","author":"Barrett","year":"2015","journal-title":"Oncotarget"},{"key":"10.1038\/s41379-019-0424-4_bib69","doi-asserted-by":"crossref","first-page":"334ra53","DOI":"10.1126\/scitranslmed.aad3001","article-title":"Triple-negative breast cancers with amplification of JAK2 at the 9p24 locus demonstrate JAK2-specific dependence","volume":"8","author":"Balko","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1038\/s41379-019-0424-4_bib70","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nature13480","article-title":"Comprehensive molecular characterization of gastric adenocarcinoma","volume":"513","author":"Cancer Genome Atlas Research Network.","year":"2014","journal-title":"Nature"},{"key":"10.1038\/s41379-019-0424-4_bib71","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/his.13339","article-title":"CD274 (PDL1) and JAK2 genomic amplifications in pulmonary squamous-cell and adenocarcinoma patients","volume":"72","author":"Clav\u00e9","year":"2018","journal-title":"Histopathology"},{"key":"10.1038\/s41379-019-0424-4_bib72","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/s41379-019-0269-x","article-title":"JAK2\/PD-L1\/PD-L2 (9p24.1) amplifications in renal cell carcinomas with sarcomatoid transformation: implications for clinical management","volume":"32","author":"Gupta","year":"2019","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-019-0424-4_bib73","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.humpath.2018.08.032","article-title":"JAK2, PD-L1, and PD-L2 (9p24.1) amplification in metastatic mucosal and cutaneous melanomas with durable response to immunotherapy","volume":"88","author":"Gupta","year":"2019","journal-title":"Hum Pathol"},{"key":"10.1038\/s41379-019-0424-4_bib74","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/gcc.22345","article-title":"Pienkowska-et al. Genomic alterations of the JAK2 and PDL loci occur in a broad spectrum of lymphoid malignancies","volume":"55","author":"Van Roosbroeck","year":"2016","journal-title":"Genes Chromosom Cancer"},{"key":"10.1038\/s41379-019-0424-4_bib75","doi-asserted-by":"crossref","first-page":"djv256","DOI":"10.1093\/jnci\/djv256","article-title":"Enhanced MAF oncogene expression and breast cancer bone metastasis","volume":"107","author":"Pavlovic","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/s41379-019-0424-4_bib76","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/S1470-2045(17)30603-4","article-title":"Effect of MAF amplification on treatment outcomes with adjuvant zoledronic acid in early breast cancer: a secondary analysis of the international, open-label, randomised, controlled, phase 3 AZURE (BIG 01\/04) trial","volume":"18","author":"Coleman","year":"2017","journal-title":"Lancet Oncol"},{"key":"10.1038\/s41379-019-0424-4_bib77","doi-asserted-by":"crossref","first-page":"83488","DOI":"10.18632\/oncotarget.13129","article-title":"SUMOylated MAFB promotes colorectal cancer tumorigenesis","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1038\/s41379-019-0424-4_bib78","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1349-7006.2006.00386.x","article-title":"Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32","volume":"98","author":"Taniguchi","year":"2007","journal-title":"Cancer Sci"},{"key":"10.1038\/s41379-019-0424-4_bib79","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ccr.2007.02.007","article-title":"JUN oncogene amplification and overexpression block adipocytic differentiation in highly aggressive sarcomas","volume":"11","author":"Mariani","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1038\/s41379-019-0424-4_bib80","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1038\/modpathol.2015.96","article-title":"Prognostic value of HMGA2, CDK4, and JUN amplification in well-differentiated and dedifferentiated liposarcomas","volume":"28","author":"Sa\u00e2da-Bouzid","year":"2015","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-019-0424-4_bib81","doi-asserted-by":"crossref","first-page":"e0141867","DOI":"10.1371\/journal.pone.0141867","article-title":"FGFR1 amplification is often homogeneous and strongly linked to the squamous cell carcinoma subtype in esophageal carcinoma","volume":"10","author":"von Loga","year":"2015","journal-title":"PLoS One"},{"key":"10.1038\/s41379-019-0424-4_bib82","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00428-016-1954-5","article-title":"Amplification of FGFR1 gene and expression of FGFR1 protein is found in different histological types of lung carcinoma","volume":"469","author":"Sousa","year":"2016","journal-title":"Virchows Arch"},{"key":"10.1038\/s41379-019-0424-4_bib83","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00432-017-2528-x","article-title":"Prevalence of fibroblast growth factor receptor 1 (FGFR1) amplification in squamous cell carcinomas of the head and neck","volume":"144","author":"Clauditz","year":"2018","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1038\/s41379-019-0424-4_bib84","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/PAS.0000000000000734","article-title":"Secretory carcinoma of the skin harboring ETV6 gene fusions: a cutaneous analogue to secretory carcinomas of the breast and salivary glands","volume":"41","author":"Bishop","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/s41379-019-0424-4_bib85","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1097\/PAS.0000000000001261","article-title":"Secretory carcinoma of the skin: Report of 6 cases, including a case with a novel NFIX-PKN1 translocation","volume":"43","author":"Kastnerova","year":"2019","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/s41379-019-0424-4_bib86","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.anndiagpath.2016.04.006","article-title":"Cutaneous hidradenoma: a study of 21 neoplasms revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions","volume":"23","author":"Kyrpychova","year":"2016","journal-title":"Ann Diagn Pathol"},{"key":"10.1038\/s41379-019-0424-4_bib87","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.humpath.2017.10.004","article-title":"A novel fusion gene CRTC3-MAML2 in hidradenoma: histopathological significance","volume":"70","author":"Kuma","year":"2017","journal-title":"Hum Pathol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41379-019-0424-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41379-019-0424-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222008389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222008389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41379-019-0424-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:40:46Z","timestamp":1760229646000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222008389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":87,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0893395222008389"],"URL":"https:\/\/doi.org\/10.1038\/s41379-019-0424-4","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Next-generation sequencing implicates oncogenic roles for p53 and JAK\/STAT signaling in microcystic adnexal carcinomas","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41379-019-0424-4","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}