{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T19:26:37Z","timestamp":1774466797222,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":893,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1038\/s41379-020-0513-4","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T08:03:16Z","timestamp":1583827396000},"page":"1492-1504","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Myositis ossificans-like soft tissue aneurysmal bone cyst: a clinical, radiological, and pathological study of seven cases with COL1A1-USP6 fusion and a novel ANGPTL2-USP6 fusion"],"prefix":"10.1016","volume":"33","author":[{"given":"Lingxin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinchun","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryma","family":"Benayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo Gord","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry A.","family":"Mullaney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly M.","family":"Rios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Purvil Y.","family":"Sukhadia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narasimhan","family":"Agaram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia A.","family":"Bridge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Healey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward A.","family":"Athanasian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meera","family":"Hameed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/s41379-020-0513-4_bib1","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1001\/archsurg.1942.01210240043003","article-title":"Solitary unicameral bone cyst: with emphysis on the roentgen picture, the pathologic appearance and the pathogenesis","volume":"44","author":"Jaffe","year":"1942","journal-title":"Arch Surg"},{"key":"10.1038\/s41379-020-0513-4_bib2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/(SICI)1098-2264(199911)26:3<265::AID-GCC12>3.0.CO;2-#","article-title":"Recurrent t(16;17)(q22;p13) in aneurysmal bone cysts","volume":"26","author":"Panoutsakopoulos","year":"1999","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/s41379-020-0513-4_bib3","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1158\/0008-5472.CAN-03-2827","article-title":"USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst","volume":"64","author":"Oliveira","year":"2004","journal-title":"Cancer Res"},{"key":"10.1038\/s41379-020-0513-4_bib4","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0002-9440(10)63432-3","article-title":"USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts","volume":"165","author":"Oliveira","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1038\/s41379-020-0513-4_bib5","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1038\/sj.onc.1208506","article-title":"Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150 and OMD genes","volume":"24","author":"Oliveira","year":"2005","journal-title":"Oncogene"},{"key":"10.1038\/s41379-020-0513-4_bib6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.cancergencyto.2007.09.017","article-title":"Fusion of the COL1A1 and USP6 genes in a benign bone tumor","volume":"180","author":"Panagopoulos","year":"2008","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-020-0513-4_bib7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/gcc.22432","article-title":"Anchored multiplex PCR for targeted next-generation sequencing reveals recurrent and novel USP6 fusions and upregulation of USP6 expression in aneurysmal bone cyst","volume":"56","author":"Guseva","year":"2017","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/s41379-020-0513-4_bib8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cancergen.2018.07.001","article-title":"Primary aneurysmal bone cyst with a novel SPARC-USP6 translocation identified by next-generation sequencing","volume":"228\u20139","author":"\u0160ekoranja","year":"2018","journal-title":"Cancer Genet"},{"key":"10.1038\/s41379-020-0513-4_bib9","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/gcc.22742","article-title":"RNA sequencing identifies a novel USP9X-USP6 promoter swap gene fusion in a primary aneurysmal bone cyst","volume":"58","author":"Blackburn","year":"2019","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/s41379-020-0513-4_bib10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00256-007-0442-z","article-title":"Frequency of USP6 rearrangements in myositis ossificans, brown tumor, and cherubism: molecular cytogenetic evidence that a subset of \u201cmyositis ossificans-like lesions\u201d are the early phases in the formation of soft-tissue aneurysmal bone cyst","volume":"37","author":"Sukov","year":"2008","journal-title":"Skelet Radiol"},{"key":"10.1038\/s41379-020-0513-4_bib11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.anndiagpath.2018.01.006","article-title":"Myositis ossificans\u2014another condition with USP6 rearrangement, providing evidence of a relationship with nodular fasciitis and aneurysmal bone cyst","volume":"34","author":"Bekers","year":"2018","journal-title":"Ann Diagn Pathol"},{"key":"10.1038\/s41379-020-0513-4_bib12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.humpath.2019.02.009","article-title":"Fibro-osseous pseudotumor of digits and myositis ossificans show consistent COL1A1-USP6 rearrangement: a clinicopathological and genetic study of 27 cases","volume":"88","author":"\u0160vajdler","year":"2019","journal-title":"Hum Pathol"},{"key":"10.1038\/s41379-020-0513-4_bib13","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s00256-018-3135-x","article-title":"Soft tissue aneurysmal bone cyst: six new cases with imaging details, molecular pathology, and review of the literature","volume":"48","author":"Song","year":"2019","journal-title":"Skelet Radiol"},{"key":"10.1038\/s41379-020-0513-4_bib14","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1038\/nm.3729","article-title":"Anchored multiplex PCR for targeted next-generation sequencing","volume":"20","author":"Zheng","year":"2014","journal-title":"Nat Med"},{"key":"10.1038\/s41379-020-0513-4_bib15","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41379-018-0175-7","article-title":"Diagnosis of known sarcoma fusions and novel fusion partners by targeted RNA sequencing with identification of a recurrent ACTB-FOSB fusion in pseudomyogenic hemangioendothelioma","volume":"32","author":"Zhu","year":"2019","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-020-0513-4_bib16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2106\/00004623-195840020-00004","article-title":"Extra-osseous localized non-neoplastic bone and cartilage formation (so-called myositis ossificans): clinical and pathological confusion with malignant neoplasms","volume":"40-A","author":"Ackerman","year":"1958","journal-title":"J Bone Jt Surg Am"},{"key":"10.1038\/s41379-020-0513-4_bib17","first-page":"e10172","article-title":"Heterotopic ossification: a comprehensive review","volume":"3","author":"Meyers","year":"2019","journal-title":"JBMR"},{"key":"10.1038\/s41379-020-0513-4_bib18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/00000658-190309000-00014","article-title":"XIII. Myositis ossificans traumatica","volume":"38","author":"Binnie","year":"1903","journal-title":"Ann Surg"},{"key":"10.1038\/s41379-020-0513-4_bib19","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1097\/00000658-192512010-00006","article-title":"Myositis ossificans circumscripta: a clinical and experimental study","volume":"82","author":"Gruca","year":"1925","journal-title":"Ann Surg"},{"key":"10.1038\/s41379-020-0513-4_bib20","first-page":"257","article-title":"Case report 729. Myositis ossificans and aneurysmal bone cyst","volume":"21","author":"Amir","year":"1992","journal-title":"Skelet Radiol"},{"key":"10.1038\/s41379-020-0513-4_bib21","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/00000478-199406000-00007","article-title":"Primary aneurysmal cyst of soft tissues (extraosseous aneurysmal cyst)","volume":"18","author":"Rodr\u00edguez-Peralto","year":"1994","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/s41379-020-0513-4_bib22","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF00193941","article-title":"Primary aneurysmal cyst of soft tissue: report of a case with ultrastructural and MRI studies","volume":"428","author":"Lopez-Barea","year":"1996","journal-title":"Virchows Arch"},{"key":"10.1038\/s41379-020-0513-4_bib23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0046-8177(97)90117-9","article-title":"Aneurysmal cyst of soft tissue: report of a case with serial magnetic resonance imaging and biopsy","volume":"28","author":"Shannon","year":"1997","journal-title":"Hum Pathol"},{"key":"10.1038\/s41379-020-0513-4_bib24","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/00000478-200201000-00007","article-title":"Soft tissue aneurysmal bone cyst","volume":"26","author":"Nielsen","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/s41379-020-0513-4_bib25","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00256-004-0748-z","article-title":"Soft tissue aneurysmal bone cyst","volume":"33","author":"Wang","year":"2004","journal-title":"Skelet Radiol"},{"key":"10.1038\/s41379-020-0513-4_bib26","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1007\/s00247-005-1560-1","article-title":"Extraosseous aneurysmal bone cyst in a 12-year-old girl","volume":"35","author":"Ajilogba","year":"2005","journal-title":"Pediatr Radiol"},{"key":"10.1038\/s41379-020-0513-4_bib27","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2350\/06-03-0070.1","article-title":"Soft-tissue aneurysmal bone cyst: report of a case with t(5;17)(q33;p13)","volume":"10","author":"Ellison","year":"2007","journal-title":"Pediatr Dev Pathol"},{"key":"10.1038\/s41379-020-0513-4_bib28","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.2106\/JBJS.J.00534","article-title":"Aneurysmal Bone cysts of soft tissue represent true neoplasms: a report of two cases","volume":"93","author":"Pietschmann","year":"2011","journal-title":"J Bone Jt Surg Am Vol"},{"key":"10.1038\/s41379-020-0513-4_bib29","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3892\/ol.2011.530","article-title":"Soft tissue aneurysmal bone cyst in a 10-year-old girl","volume":"3","author":"Hao","year":"2012","journal-title":"Oncol Lett"},{"key":"10.1038\/s41379-020-0513-4_bib30","doi-asserted-by":"crossref","unstructured":"Baker KS, Gould ES, Patel HB, Hwang SJ. Soft tissue aneurysmal bone cyst: a rare case in a middle aged patient. J Radiol Case Rep. 2015;9. https:\/\/doi.org\/10.3941\/jrcr.v9i1.2157.","DOI":"10.3941\/jrcr.v9i1.2157"},{"key":"10.1038\/s41379-020-0513-4_bib31","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1007\/s00256-015-2205-6","article-title":"Soft-tissue aneurysmal bone cyst with translocation t(17;17)(p13;q21) corresponding to COL1A1 and USP6 loci","volume":"44","author":"Jacquot","year":"2015","journal-title":"Skelet Radiol"},{"key":"10.1038\/s41379-020-0513-4_bib32","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1038\/labinvest.2011.118","article-title":"Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion","volume":"91","author":"Erickson-Johnson","year":"2011","journal-title":"Lab Investig"},{"key":"10.1038\/s41379-020-0513-4_bib33","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1038\/modpathol.2017.78","article-title":"USP6 activation in nodular fasciitis by promoter-swapping gene fusions","volume":"30","author":"Patel","year":"2017","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-020-0513-4_bib34","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/modpathol.2016.83","article-title":"USP6 genetic rearrangements in cellular fibroma of tendon sheath","volume":"29","author":"Carter","year":"2016","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-020-0513-4_bib35","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.humpath.2014.01.020","article-title":"USP6 gene rearrangements occur preferentially in giant cell reparative granulomas of the hands and feet but not in gnathic location","volume":"45","author":"Agaram","year":"2014","journal-title":"Hum Pathol"},{"key":"10.1038\/s41379-020-0513-4_bib36","doi-asserted-by":"crossref","first-page":"e222","DOI":"10.1016\/j.oooo.2017.06.081","article-title":"USP6 gene rearrangement in cranial fasciitis: a report of three cases","volume":"124","author":"Yancoskie","year":"2017","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1038\/s41379-020-0513-4_bib37","doi-asserted-by":"crossref","unstructured":"Paulson VA, Stojanov IA, Wasman JK, Restrepo T, Cano S, Plunkitt J, et al. Recurrent and novel USP6 fusions in cranial fasciitis identified by targeted RNA sequencing. Mod Pathol. 2019:1\u20136. https:\/\/doi.org\/10.1038\/s41379-019-0422-6. [Epub ahead of print].","DOI":"10.1038\/s41379-019-0422-6"},{"key":"10.1038\/s41379-020-0513-4_bib38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.anndiagpath.2018.05.003","article-title":"Fibro-osseous pseudotumor of digits\u2014expanding the spectrum of clonal transient neoplasms harboring USP6 rearrangement","volume":"35","author":"Flucke","year":"2018","journal-title":"Ann Diagn Pathol"},{"key":"10.1038\/s41379-020-0513-4_bib39","unstructured":"Online Mendelian Inheritance in Man, OMIM (TM). MIM #120150. 2018. http:\/\/www.ncbi.nlm.nih.gov\/omim."},{"key":"10.1038\/s41379-020-0513-4_bib40","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ng0197-95","article-title":"Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma","volume":"15","author":"Simon","year":"1997","journal-title":"Nat Genet"},{"key":"10.1038\/s41379-020-0513-4_bib41","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1017\/erm.2014.19","article-title":"Angiopoietin-like-2: a multifaceted protein with physiological and pathophysiological properties","volume":"16","author":"Thorin-Trescases","year":"2014","journal-title":"Expert Rev Mol Med"},{"key":"10.1038\/s41379-020-0513-4_bib42","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2741\/s271","article-title":"The TRE17\/USP6 oncogene: a riddle wrapped in a mystery inside an enigma","volume":"4","author":"Oliveira","year":"2012","journal-title":"Front Biosci"},{"key":"10.1038\/s41379-020-0513-4_bib43","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.1158\/0008-5472.CAN-15-2391","article-title":"Jak1\u2013STAT3 signals are essential effectors of the USP6\/TRE17 oncogene in tumorigenesis","volume":"76","author":"Quick","year":"2016","journal-title":"Cancer Res"},{"key":"10.1038\/s41379-020-0513-4_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.humpath.2013.03.005","article-title":"USP6-induced neoplasms: the biologic spectrum of aneurysmal bone cyst and nodular fasciitis","volume":"45","author":"Oliveira","year":"2014","journal-title":"Hum Pathol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41379-020-0513-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41379-020-0513-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089339522200792X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089339522200792X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41379-020-0513-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:40:03Z","timestamp":1760229603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089339522200792X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S089339522200792X"],"URL":"https:\/\/doi.org\/10.1038\/s41379-020-0513-4","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myositis ossificans-like soft tissue aneurysmal bone cyst: a clinical, radiological, and pathological study of seven cases with COL1A1-USP6 fusion and a novel ANGPTL2-USP6 fusion","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41379-020-0513-4","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}