{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T05:51:05Z","timestamp":1774763465681,"version":"3.50.1"},"reference-count":66,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":832,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1038\/s41379-020-0564-6","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T12:06:45Z","timestamp":1589371605000},"page":"2035-2045","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Chronic myeloid leukemia with insertion-derived BCR\u2013ABL1 fusion: redefining complex chromosomal abnormalities by correlation of FISH and karyotype predicts prognosis"],"prefix":"10.1016","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8079-9945","authenticated-orcid":false,"given":"Zhenya","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokce A.","family":"Toruner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Cameron Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7110-3814","authenticated-orcid":false,"given":"Shimin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beenu","family":"Thakral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sa A.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8467-5464","authenticated-orcid":false,"given":"Roberto N.","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2621-3584","authenticated-orcid":false,"given":"Joseph D.","family":"Khoury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/s41379-020-0564-6_bib1","unstructured":"Vardiman JW, Melo JV, Radich JP, Kvasnicka HM. Chronic myeloid leukemia, BCR-ABL1-positive. Revised 4th ed. Lyon, France: International Agency for Research on Cancer; 2017. p. 30\u20136."},{"key":"10.1038\/s41379-020-0564-6_bib2","unstructured":"Borowitz MJ, Chan JKC, Downing JR, Le Beau MM, Arber DA. B-lymphoblastic leukemia\/lymphoma with recurrent genetic abnormalities. Revised 4th ed. Lyon, France: International Agency for Research on Cancer; 2017. p. 203\u20139."},{"key":"10.1038\/s41379-020-0564-6_bib3","unstructured":"Arber DA, Brunning RD, Le Beau MM, Falini B, Vardiman JW, Porwit A, et al. Acute myeloid leukemia with recurrent genetic abnormalities. Revised 4th ed. Lyon, France: International Agency for Research on Cancer; 2017. p. 130\u201352."},{"key":"10.1038\/s41379-020-0564-6_bib4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0165-4608(99)00187-9","article-title":"FISH study of variant Philadelphia rearrangements","volume":"118","author":"Reddy","year":"2000","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-020-0564-6_bib5","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1046\/j.1365-2141.2003.04291.x","article-title":"Survival implications of molecular heterogeneity in variant Philadelphia-positive chronic myeloid leukaemia","volume":"121","author":"Reid","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1038\/s41379-020-0564-6_bib6","doi-asserted-by":"crossref","unstructured":"Albano F, Anelli L, Zagaria A, Coccaro N, Casieri P, Rossi AR, et al. Non random distribution of genomic features in breakpoint regions involved in chronic myeloid leukemia cases with variant t(9;22) or additional chromosomal rearrangements. Mol Cancer. 2010;9. https:\/\/doi.org\/10.1186\/1476-4598-9-120.","DOI":"10.1186\/1476-4598-9-120"},{"key":"10.1038\/s41379-020-0564-6_bib7","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1158\/1078-0432.CCR-05-0250","article-title":"Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein and chronic myelogenous leukemia","volume":"11","author":"Li","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1038\/s41379-020-0564-6_bib8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cancergencyto.2006.10.006","article-title":"On the genesis and prognosis of variant translocations in chronic myeloid leukemia","volume":"173","author":"Gorusu","year":"2007","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-020-0564-6_bib9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cancergencyto.2009.05.010","article-title":"Molecular cytogenetic characterization of variant Philadelphia translocations in chronic myeloid leukemia: genesis and deletion of derivative chromosome 9","volume":"194","author":"Bennour","year":"2009","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-020-0564-6_bib10","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1182\/blood.V98.10.3074","article-title":"Chronic myeloid leukemia and interferon-alpha: a study of complete cytogenetic responders","volume":"98","author":"Bonifazi","year":"2001","journal-title":"Blood"},{"key":"10.1038\/s41379-020-0564-6_bib11","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1182\/blood.V95.3.738.003k21_738_743","article-title":"Large deletions at the t(9;22) breakpoint are common and may identify a poor-prognosis subgroup of patients with chronic myeloid leukemia","volume":"95","author":"Sinclair","year":"2000","journal-title":"Blood"},{"key":"10.1038\/s41379-020-0564-6_bib12","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1182\/blood.V98.6.1732","article-title":"Deletions of the derivative chromosome 9 occur at the time of the Philadelphia translocation and provide a powerful and independent prognostic indicator in chronic myeloid leukemia","volume":"98","author":"Huntly","year":"2001","journal-title":"Blood"},{"key":"10.1038\/s41379-020-0564-6_bib13","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1182\/blood-2003-01-0123","article-title":"Double jeopardy from a single translocation: deletions of the derivative chromosome 9 in chronic myeloid leukemia","volume":"102","author":"Huntly","year":"2003","journal-title":"Blood"},{"key":"10.1038\/s41379-020-0564-6_bib14","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1182\/blood-2002-09-2763","article-title":"Imatinib improves but may not fully reverse the poor prognosis of patients with CML with derivative chromosome 9 deletions","volume":"102","author":"Huntly","year":"2003","journal-title":"Blood"},{"key":"10.1038\/s41379-020-0564-6_bib15","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1182\/blood-2004-06-2208","article-title":"Imatinib mesylate therapy may overcome the poor prognostic significance of deletions of derivative chromosome 9 in patients with chronic myelogenous leukemia","volume":"105","author":"Quintas-Cardama","year":"2005","journal-title":"Blood"},{"key":"10.1038\/s41379-020-0564-6_bib16","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/cncr.23607","article-title":"No significance of derivative chromosome 9 deletion on the clearance kinetics of BCR\/ABL fusion transcripts, cytogenetic or molecular response, loss of response, or treatment failure to imatinib mesylate therapy for chronic myeloid leukemia","volume":"113","author":"Kim","year":"2008","journal-title":"Cancer"},{"key":"10.1038\/s41379-020-0564-6_bib17","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1200\/JCO.2009.26.7963","article-title":"Deletions of the derivative chromosome 9 do not influence the response and the outcome of chronic myeloid leukemia in early chronic phase treated with imatinib mesylate: GIMEMA CML Working Party analysis","volume":"28","author":"Castagnetti","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1038\/s41379-020-0564-6_bib18","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1002\/cncr.26147","article-title":"Prognostic impact of deletions of derivative chromosome 9 in patients with chronic myelogenous leukemia treated with nilotinib or dasatinib","volume":"117","author":"Quintas-Cardama","year":"2011","journal-title":"Cancer"},{"key":"10.1038\/s41379-020-0564-6_bib19","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cancergencyto.2004.02.026","article-title":"Fluorescence in situ hybridization characterization of different cryptic BCR-ABL rearrangements in chronic myeloid leukemia","volume":"155","author":"Haigh","year":"2004","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-020-0564-6_bib20","first-page":"454","article-title":"Lack of reciprocal translocation in BCR-ABL positive Ph-negative chronic myeloid leukaemia","volume":"8","author":"Lazaridou","year":"1994","journal-title":"Leukemia"},{"key":"10.1038\/s41379-020-0564-6_bib21","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1182\/blood.V88.6.2236.bloodjournal8862236","article-title":"A novel BCR-ABL fusion gene (e6a2) in a patient with Philadelphia chromosome-negative chronic myelogenous leukemia","volume":"88","author":"Hochhaus","year":"1996","journal-title":"Blood"},{"key":"10.1038\/s41379-020-0564-6_bib22","doi-asserted-by":"crossref","unstructured":"Ratajczak B, Gniot M, Przybylowicz-Chalecka A, Czerwinska-Rybak J, Komarnicki M, Lewandowski K, et al. Characterization and significance of the Philadelphia negative\/BCR-ABL1 positive rearrangement or masked Philadelphia translocation in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a single-center study. Leuk Lymphoma. 2020:189\u201393.","DOI":"10.1080\/10428194.2019.1648807"},{"key":"10.1038\/s41379-020-0564-6_bib23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0165-4608(81)90017-0","article-title":"Unusual translocation and chronic myelocytic leukemia: \u201cmasked\u201d Philadelphia chromosome (Ph 1)","volume":"4","author":"Lessard","year":"1981","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-020-0564-6_bib24","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/BF00193575","article-title":"Complex translocations, simple variant translocations and Ph-negative cases in chronic myelogenous leukaemia","volume":"85","author":"Huret","year":"1990","journal-title":"Hum Genet"},{"key":"10.1038\/s41379-020-0564-6_bib25","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1182\/blood.V76.9.1812.1812","article-title":"Ph-negative chronic myeloid leukemia: molecular analysis of ABL insertion into M-BCR on chromosome 22","volume":"76","author":"Morris","year":"1990","journal-title":"Blood"},{"key":"10.1038\/s41379-020-0564-6_bib26","first-page":"273","article-title":"Interstitial insertion of varying amounts of ABL-containing genetic material into chromosome 22 in Ph-negative CML","volume":"4","author":"Rassool","year":"1990","journal-title":"Leukemia"},{"key":"10.1038\/s41379-020-0564-6_bib27","first-page":"385","article-title":"Absence in Ph-negative, M-BCR rearrangement-positive chronic myelogenous leukemia of linkage between 5' ABL and 3' M-BCR sequences in Philadelphia translocation","volume":"6","author":"Nishigaki","year":"1992","journal-title":"Leukemia"},{"key":"10.1038\/s41379-020-0564-6_bib28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/gcc.2870080210","article-title":"Direct visualization of the transposed ABL gene in a duplicated masked Ph chromosome","volume":"8","author":"Macera","year":"1993","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/s41379-020-0564-6_bib29","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1365-2141.1994.tb04933.x","article-title":"Philadelphia-negative chronic myeloid leukaemia: detection by FISH of BCR-ABL fusion gene localized either to chromosome 9 or chromosome 22","volume":"87","author":"Nacheva","year":"1994","journal-title":"Br J Haematol"},{"key":"10.1038\/s41379-020-0564-6_bib30","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0165-4608(94)00118-U","article-title":"Detection of M-bcr\/abl fusion by fluorescence in situ hybridization (FISH) in a case of Ph negative CML","volume":"80","author":"Mohamed","year":"1995","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-020-0564-6_bib31","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/(SICI)1098-2264(199710)20:2<148::AID-GCC5>3.0.CO;2-3","article-title":"Location of the BCR-ABL fusion gene on the 9q34 band in two cases of Ph-positive chronic myeloid leukemia","volume":"20","author":"Aurich","year":"1997","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/s41379-020-0564-6_bib32","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0165-4608(96)00298-1","article-title":"A Ph-negative chronic myeloid leukemia patient with a non-classical BCR-ABL rearrangement characterized by fluorescence in situ hybridization","volume":"96","author":"Estop","year":"1997","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-020-0564-6_bib33","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0165-4608(98)00020-X","article-title":"Identification of BCR-ABL fusion on chromosome 9 by fluorescence in situ hybridization in two chronic myeloid leukemia cases","volume":"105","author":"Abruzzese","year":"1998","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-020-0564-6_bib34","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1023\/A:1008349405763","article-title":"Analysis of Philadelphia chromosome-negative BCR-ABL-positive chronic myelogenous leukemia by hypermetaphase fluorescence in situ hybridization","volume":"10","author":"Seong","year":"1999","journal-title":"Ann Oncol"},{"key":"10.1038\/s41379-020-0564-6_bib35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0165-4608(99)00036-9","article-title":"Insertion of the 5' part of BCR within the ABL gene at 9q34 in a Philadelphia-negative chronic myeloid leukemia","volume":"114","author":"Vieira","year":"1999","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-020-0564-6_bib36","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0165-4608(00)00370-8","article-title":"Insertion (22;9)(q11;q34q21) in a patient with chronic myeloid leukemia characterized by fluorescence in situ hybridization","volume":"125","author":"Martin-Subero","year":"2001","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-020-0564-6_bib37","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0165-4608(00)00371-X","article-title":"Problems with interphase fluorescence in situ hybridization in detecting BCR\/ABL-positive cells in some patients using a novel technique with extra signals","volume":"127","author":"Mohr","year":"2001","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-020-0564-6_bib38","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/gcc.10056","article-title":"Heterogenic molecular basis for loss of ABL1-BCR transcription: deletions in der(9)t(9;22) and variants of standard t(9;22) in BCR-ABL1-positive chronic myeloid leukemia","volume":"34","author":"Loncarevic","year":"2002","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/s41379-020-0564-6_bib39","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0165-4608(03)00204-8","article-title":"Contribution of fluorescence in situ hybridization analyses to the characterization of masked and complex Philadelphia chromosome translocations in chronic myelocytic leukemia","volume":"147","author":"Morel","year":"2003","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-020-0564-6_bib40","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.cancergencyto.2004.02.012","article-title":"Interphase fluorescence in situ hybridization studies for the detection of 9q34 deletions in chronic myelogenous leukemia: a practical approach to clinical diagnosis","volume":"154","author":"Aoun","year":"2004","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-020-0564-6_bib41","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1532\/IJH97.04007","article-title":"Fluorescent in situ hybridization analysis of Philadelphia chromosome-negative chronic myeloid leukemia with the bcr\/abl fusion gene","volume":"80","author":"Monma","year":"2004","journal-title":"Int J Hematol"},{"key":"10.1038\/s41379-020-0564-6_bib42","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/sj.leu.2403197","article-title":"Atypical fluorescence in situ hybridisation pattern in chronic myeloid leukaemia due to cryptic insertion of BCR at 9q34","volume":"18","author":"Wan","year":"2004","journal-title":"Leukemia"},{"key":"10.1038\/s41379-020-0564-6_bib43","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.cancergencyto.2005.04.021","article-title":"BCR\/ABL rearrangement in two cases of Philadelphia chromosome negative chronic myeloid leukemia: deletion on the derivative chromosome 9 may or not be present","volume":"163","author":"Batista","year":"2005","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-020-0564-6_bib44","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.cancergencyto.2005.05.010","article-title":"Masked Philadelphia chromosome due to atypical BCR\/ABL localization on the 9q34 band and duplication of the der(9) in a case of chronic myelogenous leukemia","volume":"163","author":"Fugazza","year":"2005","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-020-0564-6_bib45","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/hon.775","article-title":"Generation of the BCR\/ABL fusion gene in a Philadelphia chromosome-negative chronic myeloid leukaemia: insertion of 5.6 Mb of 9q34 into the BCR region of chromosome 22","volume":"24","author":"Valle","year":"2006","journal-title":"Hematol Oncol"},{"key":"10.1038\/s41379-020-0564-6_bib46","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cancergencyto.2007.08.004","article-title":"Confirmation of a novel recurrent association: BCR-ABL t(9;22) and t(19;21)","volume":"179","author":"Struski","year":"2007","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-020-0564-6_bib47","doi-asserted-by":"crossref","unstructured":"Virgili A, Brazma D, Reid AG, Howard-Reeves J, Valganon M, Chanalaris A, et al. FISH mapping of Philadelphia negative BCR\/ABL1 positive CML. Mol Cytogenet. 2008;1. https:\/\/doi.org\/10.1186\/1755-8166-1-14.","DOI":"10.1186\/1755-8166-1-14"},{"key":"10.1038\/s41379-020-0564-6_bib48","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3892\/ol.2010.180","article-title":"Insertion of the 3' ABL region into the long arm of chromosome 1 in a Philadelphia chromosome-negative chronic myeloid leukemia case","volume":"1","author":"Al-Achkar","year":"2010","journal-title":"Oncol Lett"},{"key":"10.1038\/s41379-020-0564-6_bib49","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cancergencyto.2010.05.014","article-title":"Cytogenetic and molecular characterization of double inversion 3 associated with a cryptic BCR-ABL1 rearrangement and additional genetic changes","volume":"201","author":"Toydemir","year":"2010","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/s41379-020-0564-6_bib50","first-page":"21","article-title":"A chronic myelogenous leukemia (CML) case with a cryptic insertion of the ABL1 gene of chromosome 9 into 22 resulting in a fusion signal on the derivative 22: 46,XY.ish ins(22;9)(q11.2;q34q34)BCR+,ABL1","volume":"39","author":"Boles","year":"2013","journal-title":"J Assoc Genet Technol"},{"key":"10.1038\/s41379-020-0564-6_bib51","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s12288-013-0316-6","article-title":"Location of the BCR\/ABL fusion genes on both chromosomes 9 in Ph negative young cml patients: an indian experience","volume":"30","author":"Brahmbhatt","year":"2014","journal-title":"Indian J Hematol Blood Transfus"},{"key":"10.1038\/s41379-020-0564-6_bib52","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000442039","article-title":"Comprehensive molecular analyses in a case of masked philadelphia chronic myeloid leukemia","volume":"147","author":"Cattaneo","year":"2015","journal-title":"Cytogenet Genome Res"},{"key":"10.1038\/s41379-020-0564-6_bib53","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.cancergen.2015.04.006","article-title":"Cytogenetic, fluorescence in situ hybridization, and genomic array characterization of chronic myeloid leukemia with cryptic BCR-ABL1 fusions","volume":"208-209","author":"Shao","year":"2015","journal-title":"Cancer Genet"},{"key":"10.1038\/s41379-020-0564-6_bib54","first-page":"13707","article-title":"Chronic myeloid leukemia with variation of translocation at (Ph) [ins (22;9) (q11;q21q34)]: a case report","volume":"8","author":"Wang","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1038\/s41379-020-0564-6_bib55","doi-asserted-by":"crossref","first-page":"29906","DOI":"10.18632\/oncotarget.15369","article-title":"Cryptic BCR-ABL fusion gene as variant rearrangement in chronic myeloid leukemia: molecular cytogenetic characterization and influence on TKIs therapy","volume":"8","author":"Luatti","year":"2017","journal-title":"Oncotarget"},{"key":"10.1038\/s41379-020-0564-6_bib56","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.leukres.2018.09.006","article-title":"Genomic aberrations involving 12p\/ETV6 are highly prevalent in blastic plasmacytoid dendritic cell neoplasms and might represent early clonal events","volume":"73","author":"Tang","year":"2018","journal-title":"Leuk Res"},{"key":"10.1038\/s41379-020-0564-6_bib57","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cancergen.2019.03.002","article-title":"Deciphering the complexities of MECOM rearrangement-driven chromosomal aberrations","volume":"233-234","author":"Tang","year":"2019","journal-title":"Cancer Genet"},{"key":"10.1038\/s41379-020-0564-6_bib58","series-title":"ISCN (2016): an International System for Human Cytogenetic Nomenclature","author":"Jean McGowan-Jordan","year":"2016"},{"key":"10.1038\/s41379-020-0564-6_bib59","doi-asserted-by":"crossref","first-page":"38","DOI":"10.21926\/obm.genet.1804038","article-title":"Quality assurance\/quality control of fluorescence in situ hybridization tests in hematologic malignancies","volume":"2","author":"Tang","year":"2018","journal-title":"OBM Genet"},{"key":"10.1038\/s41379-020-0564-6_bib60","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/modpathol.3800026","article-title":"TaqMan RT-PCR assay coupled with capillary electrophoresis for quantification and identification of bcr-abl transcript type","volume":"17","author":"Luthra","year":"2004","journal-title":"Mod Pathol"},{"key":"10.1038\/s41379-020-0564-6_bib61","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/ajh.23652","article-title":"BRAF kinase domain mutations are present in a subset of chronic myelomonocytic leukemia with wild-type RAS","volume":"89","author":"Zhang","year":"2014","journal-title":"Am J Hematol"},{"key":"10.1038\/s41379-020-0564-6_bib62","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.6004\/jnccn.2018.0071","article-title":"Chronic myeloid leukemia, version 1.2019, NCCN Clinical Practice Guidelines in Oncology","volume":"16","author":"Radich","year":"2018","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1038\/s41379-020-0564-6_bib63","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/sj.leu.2402963","article-title":"Patterns of BCR\/ABL gene rearrangements by interphase fluorescence in situ hybridization (FISH) in BCR\/ABL+ leukemias: incidence and underlying genetic abnormalities","volume":"17","author":"Primo","year":"2003","journal-title":"Leukemia"},{"key":"10.1038\/s41379-020-0564-6_bib64","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1755-8166-3-15","article-title":"Genomic amplification of BCR\/ABL1 and a region downstream of ABL1 in chronic myeloid leukaemia: a FISH mapping study of CML patients and cell lines","volume":"3","author":"Virgili","year":"2010","journal-title":"Mol Cytogenet"},{"key":"10.1038\/s41379-020-0564-6_bib65","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/gcc.20303","article-title":"Genomewide screening of DNA copy number changes in chronic myelogenous leukemia with the use of high-resolution array-based comparative genomic hybridization","volume":"45","author":"Hosoya","year":"2006","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/s41379-020-0564-6_bib66","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1046\/j.1365-2141.2002.03508.x","article-title":"Dual transcription of b2a2 and b3a2 BCR-ABL transcripts in chronic myeloid leukaemia is confined to patients with a linked polymorphism within the BCR gene","volume":"117","author":"Branford","year":"2002","journal-title":"Br J Haematol"}],"updated-by":[{"DOI":"10.1038\/s41379-020-0632-y","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000}}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41379-020-0564-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41379-020-0564-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222004732?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222004732?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41379-020-0564-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T19:46:07Z","timestamp":1675539967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222004732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":66,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0893395222004732"],"URL":"https:\/\/doi.org\/10.1038\/s41379-020-0564-6","relation":{"erratum":[{"id-type":"doi","id":"10.1038\/s41379-020-0632-y","asserted-by":"object"}]},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic myeloid leukemia with insertion-derived BCR\u2013ABL1 fusion: redefining complex chromosomal abnormalities by correlation of FISH and karyotype predicts prognosis","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41379-020-0564-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1038\/s41379-020-0632-y","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}