{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:41:41Z","timestamp":1787002901342,"version":"build-2736575974"},"reference-count":25,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000953"],"award-info":[{"award-number":["82000953"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2018RU003"],"award-info":[{"award-number":["2018RU003"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012543","name":"Shanghai Science and Technology Development Foundation","doi-asserted-by":"publisher","award":["19411950600"],"award-info":[{"award-number":["19411950600"]}],"id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Clinical Research Plan of SHDC"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1038\/s41379-021-00959-8","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T06:06:05Z","timestamp":1638770765000},"page":"594-600","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of clinicopathologic features and expression of NR4A3 in sinonasal acinic cell carcinoma"],"prefix":"10.1016","volume":"35","author":[{"given":"Huan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changwen","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huankang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xicai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmeng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41379-021-00959-8_bib1","unstructured":"El-Naggar, A. K., C. J., Grandis, J. R., Takata, T. & Slootweg, P. J. WHO Classification of Head and Neck Tumours. (IARC, 2017)."},{"key":"10.1038\/s41379-021-00959-8_bib2","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1007\/s00405-015-3855-7","article-title":"Salivary acinic cell carcinoma: reappraisal and update","volume":"273","author":"Vander Poorten","year":"2016","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1038\/s41379-021-00959-8_bib3","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/alr.21301","article-title":"Case-control analysis of survival outcomes in sinonasal acinic cell carcinoma","volume":"4","author":"Biron","year":"2014","journal-title":"Int. Forum Allergy Rhinol."},{"key":"10.1038\/s41379-021-00959-8_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-08069-x","article-title":"Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands","volume":"10","author":"Haller","year":"2019","journal-title":"Nat. Commun"},{"key":"10.1038\/s41379-021-00959-8_bib5","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/his.12673","article-title":"Are acinic cell carcinomas of the breast and salivary glands distinct diseases?","volume":"67","author":"Piscuoglio","year":"2015","journal-title":"Histopathology"},{"key":"10.1038\/s41379-021-00959-8_bib6","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/his.13962","article-title":"Whole-exome sequencing and RNA sequencing analyses of acinic cell carcinomas of the breast","volume":"75","author":"Beca","year":"2019","journal-title":"Histopathology"},{"key":"10.1038\/s41379-021-00959-8_bib7","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1097\/PAS.0000000000001279","article-title":"Nuclear NR4A3 immunostaining is a specific and sensitive novel marker for acinic cell carcinoma of the salivary glands","volume":"43","author":"Haller","year":"2019","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1038\/s41379-021-00959-8_bib8","first-page":"55","article-title":"ETV6-rearranged low-grade sinonasal non-intestinal-type adenocarcinoma: a clinicopathological analysis.","volume":"50","author":"Zhai","year":"2021","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"10.1038\/s41379-021-00959-8_bib9","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s12105-020-01213-4","article-title":"NR4A3 immunohistochemistry reliably discriminates acinic cell carcinoma from mimics","volume":"15","author":"Wong","year":"2021","journal-title":"Head Neck Pathol"},{"key":"10.1038\/s41379-021-00959-8_bib10","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/his.14347","article-title":"Clinicopathological analysis of low-grade papillary Schneiderian carcinoma: report of five new cases and review of the literature","volume":"79","author":"Zhai","year":"2021","journal-title":"Histopathology"},{"key":"10.1038\/s41379-021-00959-8_bib11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.semcancer.2019.09.016","article-title":"Translational genomics of sinonasal cancers","volume":"61","author":"Hermsen","year":"2020","journal-title":"Semin. Cancer Biol"},{"key":"10.1038\/s41379-021-00959-8_bib12","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/hed.20186","article-title":"Sinonasal acinic cell carcinoma: a clinicopathologic study of four cases","volume":"27","author":"Neto","year":"2005","journal-title":"Head Neck"},{"key":"10.1038\/s41379-021-00959-8_bib13","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/PAS.0b013e318242a5b0","article-title":"The profile of acinic cell carcinoma after recognition of mammary analog secretory carcinoma","volume":"36","author":"Chiosea","year":"2012","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1038\/s41379-021-00959-8_bib14","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1097\/PAS.0b013e3182841554","article-title":"Most nonparotid \u201cacinic cell carcinomas\u201d represent mammary analog secretory carcinomas","volume":"37","author":"Bishop","year":"2013","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1038\/s41379-021-00959-8_bib15","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/PAS.0b013e3181d9efcc","article-title":"Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity","volume":"34","author":"Skalova","year":"2010","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1038\/s41379-021-00959-8_bib16","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1007\/s00405-019-05604-4","article-title":"Clinical characteristics of acinic cell carcinoma and secretory carcinoma of the parotid gland","volume":"276","author":"Terada","year":"2019","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1038\/s41379-021-00959-8_bib17","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41379-020-00693-7","article-title":"Problematic breast tumors reassessed in light of novel molecular data","volume":"34","author":"Pareja","year":"2021","journal-title":"Mod. Pathol."},{"key":"10.1038\/s41379-021-00959-8_bib18","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s12105-018-0917-3","article-title":"Characterisation of DOG-1 expression in salivary gland tumours and comparison with myoepithelial markers","volume":"13","author":"Khurram","year":"2019","journal-title":"Head Neck Pathol."},{"key":"10.1038\/s41379-021-00959-8_bib19","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1097\/PAS.0000000000000912","article-title":"ETV6 gene rearrangements characterize a morphologically distinct subset of sinonasal low-grade non-intestinal-type adenocarcinoma: a novel translocation-associated carcinoma restricted to the sinonasal tract","volume":"41","author":"Andreasen","year":"2017","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1038\/s41379-021-00959-8_bib20","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1097\/PAS.0000000000001494","article-title":"Nuclear NR4A2 (Nurr1) immunostaining is a novel marker for acinic cell carcinoma of the salivary glands lacking the classic NR4A3 (NOR-1) upregulation","volume":"44","author":"Haller","year":"2020","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1038\/s41379-021-00959-8_bib21","doi-asserted-by":"crossref","unstructured":"Lee, D. Y. et al. Oncogenic orphan nuclear receptor NR4A3 interacts and cooperates with MYB in acinic cell carcinoma. Cancers12 (2020).","DOI":"10.3390\/cancers12092433"},{"key":"10.1038\/s41379-021-00959-8_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.humpath.2020.05.001","article-title":"NOR-1 distinguishes acinic cell carcinoma from its mimics on fine-needle aspiration biopsy specimens","volume":"102","author":"Nguyen","year":"2020","journal-title":"Hum. Pathol."},{"key":"10.1038\/s41379-021-00959-8_bib23","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/cncy.22338","article-title":"Evaluation of NR4A3 immunohistochemistry (IHC) and fluorescence in situ hybridization and comparison with DOG1 IHC for FNA diagnosis of acinic cell carcinoma","volume":"129","author":"Skaugen","year":"2021","journal-title":"Cancer Cytopathol."},{"key":"10.1038\/s41379-021-00959-8_bib24","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.5037\/jomr.2021.12104","article-title":"NR4A3 (NOR-1) immunostaining shows better performance than DOG1 immunostaining in acinic cell carcinoma of salivary gland: a preliminary study","volume":"12","author":"Owosho","year":"2021","journal-title":"J. Oral Maxillofac. Res."},{"key":"10.1038\/s41379-021-00959-8_bib25","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1097\/PAS.0000000000001346","article-title":"NR4A3 immunohistochemistry lacks sensitivity for the diagnosis of extraskeletal myxoid chondrosarcoma","volume":"43","author":"Vargas","year":"2019","journal-title":"Am. J. Surg. Pathol."}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41379-021-00959-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41379-021-00959-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222001107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222001107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41379-021-00959-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:28:52Z","timestamp":1760228932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222001107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S0893395222001107"],"URL":"https:\/\/doi.org\/10.1038\/s41379-021-00959-8","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of clinicopathologic features and expression of NR4A3 in sinonasal acinic cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41379-021-00959-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}