{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:14:27Z","timestamp":1777914867713,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["110-2320-B-002-021"],"award-info":[{"award-number":["110-2320-B-002-021"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1038\/s41379-021-00970-z","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T07:04:08Z","timestamp":1640243048000},"page":"680-687","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Molecular features of primary hepatic undifferentiated carcinoma"],"prefix":"10.1016","volume":"35","author":[{"given":"Jia-Huei","family":"Tsai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Ming","family":"Jeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Hsiang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1336-3850","authenticated-orcid":false,"given":"Jau-Yu","family":"Liau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/s41379-021-00970-z_bib1","unstructured":"WHO Classification of Tumours Editorial Board. Digestive system tumours. Lyon (France): International Agency for Research on Cancer; p262, 2019. (WHO classification of tumours series, 5th ed. vol. 1)."},{"key":"10.1038\/s41379-021-00970-z_bib2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40792-017-0288-0","article-title":"Undifferentiated carcinoma of the liver: a case report with immunohistochemical analysis","volume":"3","author":"Maeda","year":"2017","journal-title":"Surg. Case Rep."},{"key":"10.1038\/s41379-021-00970-z_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijscr.2020.11.153","article-title":"Undifferentiated carcinoma of the liver in a 3-year-old girl treated by neoadjuvant chemotherapy and complete resection","volume":"78","author":"Ochi","year":"2021","journal-title":"Int. J. Surg. Case Rep."},{"key":"10.1038\/s41379-021-00970-z_bib4","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s12328-020-01180-x","article-title":"Undifferentiated carcinoma of the liver demonstrated by contrast-enhanced ultrasonography","volume":"13","author":"Ogasawara","year":"2020","journal-title":"Clin. J. Gastroenterol."},{"key":"10.1038\/s41379-021-00970-z_bib5","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/modpathol.2015.155","article-title":"Loss of switch\/sucrose non-fermenting complex protein expression is associated with dedifferentiation in endometrial carcinomas","volume":"29","author":"Karnezis","year":"2016","journal-title":"Mod. Pathol."},{"key":"10.1038\/s41379-021-00970-z_bib6","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1097\/PAS.0000000000001599","article-title":"SMARCA4\/SMARCA2-deficient carcinoma of the esophagus and gastroesophageal junction","volume":"45","author":"Horton","year":"2021","journal-title":"Am. J. Surg. Pathol"},{"key":"10.1038\/s41379-021-00970-z_bib7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jtho.2019.10.023","article-title":"SMARCA4-deficient thoracic sarcomatoid tumors represent primarily smoking-related undifferentiated carcinomas rather than primary thoracic sarcomas","volume":"15","author":"Rekhtman","year":"2020","journal-title":"J. Thorac. Oncol."},{"key":"10.1038\/s41379-021-00970-z_bib8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/hep.510240201","article-title":"An algorithm for grading activity in chronic hepatitis C","volume":"24","author":"Bedossa","year":"1996","journal-title":"Hepatology"},{"key":"10.1038\/s41379-021-00970-z_bib9","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1097\/PAS.0000000000001716","article-title":"Lymphoepithelioma-like intrahepatic cholangiocarcinoma is a distinct entity with frequent pTERT\/TP53 mutations and comprises 2 subgroups based on Epstein-Barr virus Infection","volume":"45","author":"Tsai","year":"2021","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1038\/s41379-021-00970-z_bib10","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJMra1713263","article-title":"Hepatocellular Carcinoma","volume":"380","author":"Villanueva","year":"2019","journal-title":"N. Engl J. Med."},{"key":"10.1038\/s41379-021-00970-z_bib11","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.jhep.2016.05.035","article-title":"Genetic profiling of hepatocellular carcinoma using next-generation sequencing","volume":"65","author":"Schulze","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1038\/s41379-021-00970-z_bib12","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.cell.2017.05.046","article-title":"Comprehensive and integrative genomic characterization of hepatocellular carcinoma","volume":"169","author":"Cancer Genome Atlas Research Network.","year":"2017","journal-title":"Cell"},{"key":"10.1038\/s41379-021-00970-z_bib13","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/ng.3126","article-title":"Trans-ancestry mutational landscape of hepatocellular carcinoma genomes","volume":"46","author":"Totoki","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1038\/s41379-021-00970-z_bib14","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/ng.2813","article-title":"Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas","volume":"45","author":"Jiao","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1038\/s41379-021-00970-z_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms7087","article-title":"Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma","volume":"6","author":"Sia","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1038\/s41379-021-00970-z_bib16","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1016\/j.celrep.2017.02.033","article-title":"Integrative genomic analysis of cholangiocarcinoma identifies distinct IDH-mutant molecular profiles","volume":"18","author":"Farshidfar","year":"2017","journal-title":"Cell Rep."},{"key":"10.1038\/s41379-021-00970-z_bib17","doi-asserted-by":"crossref","first-page":"e12791","DOI":"10.1111\/cpr.12791","article-title":"The roles of mutated SWI\/SNF complexes in the initiation and development of hepatocellular carcinoma and its regulatory effect on the immune system: a review","volume":"53","author":"Hu","year":"2020","journal-title":"Cell Prolif"},{"key":"10.1038\/s41379-021-00970-z_bib18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev-pathol-012414-040445","article-title":"SWI\/SNF chromatin remodeling and human malignancies","volume":"10","author":"Masliah-Planchon","year":"2015","journal-title":"Annu. Rev. Pathol."},{"key":"10.1038\/s41379-021-00970-z_bib19","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.jhep.2019.06.001","article-title":"Molecular and histological correlations in liver cancer","volume":"71","author":"Calderaro","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1038\/s41379-021-00970-z_bib20","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.jhep.2017.05.014","article-title":"Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification","volume":"67","author":"Calderaro","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1038\/s41379-021-00970-z_bib21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1136\/gutjnl-2018-318021","article-title":"Polyploidy spectrum: a new marker in HCC classification","volume":"69","author":"Bou-Nader","year":"2020","journal-title":"Gut"},{"key":"10.1038\/s41379-021-00970-z_bib22","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41571-020-0357-3","article-title":"The SWI\/SNF complex in cancer - biology, biomarkers and therapy","volume":"17","author":"Mittal","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1038\/s41379-021-00970-z_bib23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrc3068","article-title":"SWI\/SNF nucleosome remodellers and cancer","volume":"11","author":"Wilson","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1038\/s41379-021-00970-z_bib24","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1038\/onc.2009.4","article-title":"The SWI\/SNF complex and cancer","volume":"28","author":"Reisman","year":"2009","journal-title":"Oncogene"},{"key":"10.1038\/s41379-021-00970-z_bib25","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/ng.2323","article-title":"BAP1 loss defines a new class of renal cell carcinoma","volume":"44","author":"Pe\u00f1a-Llopis","year":"2012","journal-title":"Nat. Genet"},{"key":"10.1038\/s41379-021-00970-z_bib26","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/modpathol.2015.68","article-title":"Intratumoral morphologic and molecular heterogeneity of rhabdoid renal cell carcinoma: challenges for personalized therapy","volume":"28","author":"Singh","year":"2015","journal-title":"Mod. Pathol."},{"key":"10.1038\/s41379-021-00970-z_bib27","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13000-021-01112-4","article-title":"SWI\/SNF-deficient undifferentiated\/rhabdoid carcinoma of the gallbladder carrying a POLE mutation in a 30-year-old woman: a case report","volume":"16","author":"Gerber","year":"2021","journal-title":"Diagn. Pathol"},{"key":"10.1038\/s41379-021-00970-z_bib28","doi-asserted-by":"crossref","first-page":"e0153718","DOI":"10.1371\/journal.pone.0153718","article-title":"PBRM1 regulates the expression of genes involved in metabolism and cell adhesion in renal clear cell carcinoma","volume":"11","author":"Chowdhury","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1038\/s41379-021-00970-z_bib29","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.isci.2019.04.027","article-title":"PBRM1 regulates stress response in epithelial cells","volume":"15","author":"Porter","year":"2019","journal-title":"iScience"},{"key":"10.1038\/s41379-021-00970-z_bib30","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1001\/jamaoncol.2017.0013","article-title":"A prospective, multi-institutional, pathologist-based assessment of 4 immunohistochemistry assays for PD-L1 expression in non-small cell lung cancer","volume":"3","author":"Rimm","year":"2017","journal-title":"JAMA Oncol."},{"key":"10.1038\/s41379-021-00970-z_bib31","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.canlet.2017.11.014","article-title":"Progress and challenges of predictive biomarkers of anti PD-1\/PD-L1 immunotherapy: A systematic review","volume":"414","author":"Teng","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1038\/s41379-021-00970-z_bib32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH720>3.0.CO;2-3","article-title":"Expression of mutant nuclear beta-catenin correlates with non-invasive hepatocellular carcinoma, absence of portal vein spread, and good prognosis","volume":"193","author":"Mao","year":"2001","journal-title":"J. Pathol"},{"key":"10.1038\/s41379-021-00970-z_bib33","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/hep.29762","article-title":"Macrotrabecular-massive hepatocellular carcinoma: a distinctive histological subtype with clinical relevance","volume":"68","author":"Ziol","year":"2018","journal-title":"Hepatology"},{"key":"10.1038\/s41379-021-00970-z_bib34","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1158\/1078-0432.CCR-19-0859","article-title":"ESM1 as a marker of macrotrabecular-massive hepatocellular carcinoma","volume":"25","author":"Calderaro","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1038\/s41379-021-00970-z_bib35","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.1249484","article-title":"Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma","volume":"343","author":"Honeyman","year":"2014","journal-title":"Science"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41379-021-00970-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41379-021-00970-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089339522200120X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089339522200120X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41379-021-00970-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:28:34Z","timestamp":1760228914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089339522200120X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S089339522200120X"],"URL":"https:\/\/doi.org\/10.1038\/s41379-021-00970-z","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular features of primary hepatic undifferentiated carcinoma","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41379-021-00970-z","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}