{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:40:42Z","timestamp":1789522842184,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST110-2320-B-075-003-MY3"],"award-info":[{"award-number":["MOST110-2320-B-075-003-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1038\/s41379-022-01117-4","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T06:21:26Z","timestamp":1655187686000},"page":"1587-1595","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Nuclear expression of AFF2 C-terminus is a sensitive and specific ancillary marker for DEK::AFF2 carcinoma of the sinonasal tract"],"prefix":"10.1016","volume":"35","author":[{"given":"Ying-Ju","family":"Kuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"James S.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tra","family":"Truong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chen","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6253-0478","authenticated-orcid":false,"given":"Rebecca D.","family":"Chernock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changwen","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-An","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Hongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Kuan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuying","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaylou M.","family":"Velez Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana B.","family":"Geromes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8289-7418","authenticated-orcid":false,"given":"Ying-Hsia","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0594-3732","authenticated-orcid":false,"given":"Min-Shu","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9148-6445","authenticated-orcid":false,"given":"Hidetaka","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Weinreb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-2784","authenticated-orcid":false,"given":"Jen-Fan","family":"Hang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41379-022-01117-4_bib1","doi-asserted-by":"crossref","unstructured":"Yang, W., Lee, K.W., Srivastava, R.M., Kuo, F., Krishna, C., Chowell, D. et al. Immunogenic neoantigens derived from gene fusions stimulate T cell responses. Nat. Med.25, 767\u2013775 (2019).","DOI":"10.1038\/s41591-019-0434-2"},{"key":"10.1038\/s41379-022-01117-4_bib2","doi-asserted-by":"crossref","unstructured":"Todorovic, E., Truong, T., Eskander, A., Lin, V., Swanson, D., Dickson, B.C. et al. Middle ear and temporal bone nonkeratinizing squamous cell carcinomas with DEK-AFF2 fusion: an emerging entity. Am. J. Surg. Pathol.44, 1244\u20131250 (2020).","DOI":"10.1097\/PAS.0000000000001498"},{"key":"10.1038\/s41379-022-01117-4_bib3","doi-asserted-by":"crossref","unstructured":"Bishop, J.A., Gagan, J., Paterson, C., McLellan, D., Sandison, A. Nonkeratinizing Squamous Cell Carcinoma of the Sinonasal Tract With DEK-AFF2: Further Solidifying an Emerging Entity. Am. J. Surg. Pathol.45, 718\u2013720 (2021).","DOI":"10.1097\/PAS.0000000000001596"},{"key":"10.1038\/s41379-022-01117-4_bib4","doi-asserted-by":"crossref","unstructured":"Kuo, Y.J., Lewis, J.S., Jr, Zhai C., Chen, Y.A., Chernock, R.D., Hsieh, M.S. et al. DEK-AFF2 fusion-associated papillary squamous cell carcinoma of the sinonasal tract: clinicopathologic characterization of seven cases with deceptively bland morphology. Mod. Pathol.34, 1820\u20131830 (2021).","DOI":"10.1038\/s41379-021-00846-2"},{"key":"10.1038\/s41379-022-01117-4_bib5","doi-asserted-by":"crossref","unstructured":"Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, et al. DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: Detailed Clinicopathologic Characterization of a Distinctive Entity. Am. J. Surg. Pathol.45, 1682\u20131693 (2021).","DOI":"10.1097\/PAS.0000000000001741"},{"key":"10.1038\/s41379-022-01117-4_bib6","doi-asserted-by":"crossref","unstructured":"Waldmann, T., Scholten, I., Kappes, F., Hu, H.G., Knippers, R. The DEK protein-an abundant and ubiquitous constituent of mammalian chromatin. Gene343, 1\u20139 (2004).","DOI":"10.1016\/j.gene.2004.08.029"},{"key":"10.1038\/s41379-022-01117-4_bib7","doi-asserted-by":"crossref","unstructured":"Riveiro-Falkenbach, E., Soengas, M.S. Control of tumorigenesis and chemoresistance by the DEK oncogene. Clin. Cancer Res.16, 2932\u20132938 (2010).","DOI":"10.1158\/1078-0432.CCR-09-2330"},{"key":"10.1038\/s41379-022-01117-4_bib8","doi-asserted-by":"crossref","unstructured":"Teng, Y., Lang, L., Jauregui, C.E. The Complexity of DEK Signaling in Cancer Progression. Curr. Cancer Drug Targets18, 256\u2013265 (2018).","DOI":"10.2174\/1568009617666170522094730"},{"key":"10.1038\/s41379-022-01117-4_bib9","doi-asserted-by":"crossref","unstructured":"Ishida, K., Nakashima, T., Shibata, T., Hara, A., Tomita, H. Role of the DEK oncogene in the development of squamous cell carcinoma. Int. J. Clin. Oncol.25, 1563\u20131569 (2020).","DOI":"10.1007\/s10147-020-01735-5"},{"key":"10.1038\/s41379-022-01117-4_bib10","doi-asserted-by":"crossref","unstructured":"Wise-Draper, T.M., Draper, D.J., Gutkind, J.S., Molinolo, A.A., Wikenheiser-Brokamp, K.A., Wells, S.I. Future directions and treatment strategies for head and neck squamous cell carcinomas. Transl. Res.160, 167\u2013177 (2012).","DOI":"10.1016\/j.trsl.2012.02.002"},{"key":"10.1038\/s41379-022-01117-4_bib11","doi-asserted-by":"crossref","unstructured":"Adams, A.K., Hallenbeck, G.E., Casper, K.A., Patil, Y.J., Wilson, K.M., Kimple, R.J., et al. DEK promotes HPV-positive and -negative head and neck cancer cell proliferation. Oncogene34, 868\u2013877 (2015).","DOI":"10.1038\/onc.2014.15"},{"key":"10.1038\/s41379-022-01117-4_bib12","doi-asserted-by":"crossref","unstructured":"Nakashima, T., Tomita, H., Hirata, A., Ishida, K., Hisamatsu, K., Hatano, Y. et al. Promotion of cell proliferation by the proto-oncogene DEK enhances oral squamous cell carcinogenesis through field cancerization. Cancer Med.6, 2424\u20132439 (2017).","DOI":"10.1002\/cam4.1157"},{"key":"10.1038\/s41379-022-01117-4_bib13","doi-asserted-by":"crossref","unstructured":"Bensaid, M., Melko, M., Bechara, E.G., Davidovic, L., Berretta, A., Catania, M.V. et al. FRAXE-associated mental retardation protein (FMR2) is an RNA-binding protein with high affinity for G-quartet RNA forming structure. Nucleic Acids Res.37, 1269\u20131279 (2009).","DOI":"10.1093\/nar\/gkn1058"},{"key":"10.1038\/s41379-022-01117-4_bib14","doi-asserted-by":"crossref","unstructured":"Ge, H., Liu, K., Juan, T., Fang, F., Newman, M., Hoeck, W. FusionMap: detecting fusion genes from next-generation sequencing data at base-pair resolution. Bioinformatics27, 1922\u20131928 (2011).","DOI":"10.1093\/bioinformatics\/btr310"},{"key":"10.1038\/s41379-022-01117-4_bib15","doi-asserted-by":"crossref","unstructured":"Robinson, J.T., Thorvaldsdottir, H., Wenger, A.M., Zehir, A., Mesirov, J.P. Variant Review with the Integrative Genomics Viewer. Cancer Res.77, e31\u2013e34 (2017).","DOI":"10.1158\/0008-5472.CAN-17-0337"},{"key":"10.1038\/s41379-022-01117-4_bib16","doi-asserted-by":"crossref","unstructured":"Dobin, A., Davis, C.A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics29, 15\u201321 (2013).","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"10.1038\/s41379-022-01117-4_bib17","doi-asserted-by":"crossref","unstructured":"Anders, S., Pyl, P.T., Huber, W. HTSeq-a Python framework to work with high-throughput sequencing data. Bioinformatics31, 166\u2013169 (2015).","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"10.1038\/s41379-022-01117-4_bib18","doi-asserted-by":"crossref","unstructured":"Bell, D., Bell, A.H., Kupferman, M.E., Prieto, V.G., Weber, R.S., Hanna, E.Y. Comparative transcriptome analysis of sinonasal inverted papilloma and associated squamous cell carcinoma: Out-HOXing developmental genes. Head Neck41, 3090\u20133104 (2019).","DOI":"10.1002\/hed.25795"},{"key":"10.1038\/s41379-022-01117-4_bib19","doi-asserted-by":"crossref","unstructured":"Saab-Chalhoub, M.W., Guo, X., Shi, Q., Chernock, R.D., Lewis, J.S., Jr Low Grade Papillary Sinonasal (Schneiderian) Carcinoma: A Series of Five Cases of a Unique Malignant Neoplasm with Comparison to Inverted Papilloma and Conventional Nonkeratinizing Squamous Cell Carcinoma. Head Neck Pathol.15, 1221\u20131234 (2021).","DOI":"10.1007\/s12105-021-01335-3"},{"key":"10.1038\/s41379-022-01117-4_bib20","doi-asserted-by":"crossref","unstructured":"Lewis, J.S., Jr., Chernock, R.D., Haynes, W., El-Mofty, S.K. Low-grade papillary schneiderian carcinoma, a unique and deceptively bland malignant neoplasm: report of a case. Am. J. Surg. Pathol.39, 714\u2013721 (2015).","DOI":"10.1097\/PAS.0000000000000390"},{"key":"10.1038\/s41379-022-01117-4_bib21","doi-asserted-by":"crossref","unstructured":"Zhai, C., Wang, H., Li, S., Wang, D. Clinicopathological analysis of low-grade papillary Schneiderian carcinoma: report of five new cases and review of the literature. Histopathology79, 370\u2013380 (2021).","DOI":"10.1111\/his.14347"},{"key":"10.1038\/s41379-022-01117-4_bib22","unstructured":"Bishop, J.A., Brandwein-Gensler, M., Nicolai, P., Steens, S., Syjanen, S., Westra, W.H. Non-keratinizing squamous cell carcinoma, (eds El-Naggar, A.K., Chan, J.K.C., Grandis, J.R., Takata, T., Slootweg, P.J.). WHO Classification of Head and Neck Tumours. 4th edn. 15\u201317 (IARC: Lyon, 2017)."},{"key":"10.1038\/s41379-022-01117-4_bib23","doi-asserted-by":"crossref","unstructured":"Bishop, J.A., Guo, T.W., Smith, D.F., Wang, H., Ogawa, T., Pai, S.I. et al. Human papillomavirus-related carcinomas of the sinonasal tract. Am. J. Surg. Pathol.37, 185\u2013192 (2013).","DOI":"10.1097\/PAS.0b013e3182698673"},{"key":"10.1038\/s41379-022-01117-4_bib24","doi-asserted-by":"crossref","unstructured":"El-Mofty, S.K., Lu, D.W. Prevalence of high-risk human papillomavirus DNA in nonkeratinizing (cylindrical cell) carcinoma of the sinonasal tract: a distinct clinicopathologic and molecular disease entity. Am. J. Surg. Pathol.29, 1367\u20131372 (2005).","DOI":"10.1097\/01.pas.0000173240.63073.fe"},{"key":"10.1038\/s41379-022-01117-4_bib25","doi-asserted-by":"crossref","unstructured":"Larque, A.B., Hakim, S., Ordi, J., Nadal, A., Diaz, A., del Pino, M., et al. High-risk human papillomavirus is transcriptionally active in a subset of sinonasal squamous cell carcinomas. Mod. Pathol.27, 343\u2013351 (2014).","DOI":"10.1038\/modpathol.2013.155"},{"key":"10.1038\/s41379-022-01117-4_bib26","doi-asserted-by":"crossref","unstructured":"Nudell, J., Chiosea, S., Thompson, L.D. Carcinoma ex-Schneiderian papilloma (malignant transformation): a clinicopathologic and immunophenotypic study of 20 cases combined with a comprehensive review of the literature. Head Neck Pathol.8, 269\u2013286 (2014).","DOI":"10.1007\/s12105-014-0527-7"},{"key":"10.1038\/s41379-022-01117-4_bib27","doi-asserted-by":"crossref","unstructured":"Bubola, J., MacMillan, C.M., Weinreb, I., Witterick, I., Swanson, D., Zhang, L., et al. A Poorly Differentiated Non-keratinizing Sinonasal Squamous Cell Carcinoma with a Novel ETV6-TNFRSF8 Fusion Gene. Head Neck Pathol.15, 1284\u20131288 (2021).","DOI":"10.1007\/s12105-020-01249-6"},{"key":"10.1038\/s41379-022-01117-4_bib28","doi-asserted-by":"crossref","unstructured":"Agaimy, A., Hartmann, A., Antonescu, C.R., Chiosea, S.I., El-Mofty, S.K., Geddert, H. et al. SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity. Am. J. Surg. Pathol.41, 458\u2013471 (2017).","DOI":"10.1097\/PAS.0000000000000797"},{"key":"10.1038\/s41379-022-01117-4_bib29","doi-asserted-by":"crossref","unstructured":"French, C.A. NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatment. Pathol. Int.68, 583\u2013595 (2018).","DOI":"10.1111\/pin.12727"},{"key":"10.1038\/s41379-022-01117-4_bib30","doi-asserted-by":"crossref","unstructured":"Bishop, J.A., Alaggio, R., Zhang, L., Seethala, R.R., Antonescu, C.R. Adamantinoma-like Ewing family tumors of the head and neck: a pitfall in the differential diagnosis of basaloid and myoepithelial carcinomas. Am. J. Surg. Pathol.39, 1267\u20131274 (2015).","DOI":"10.1097\/PAS.0000000000000460"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41379-022-01117-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41379-022-01117-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222002253?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222002253?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41379-022-01117-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:34:45Z","timestamp":1760229285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222002253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S0893395222002253"],"URL":"https:\/\/doi.org\/10.1038\/s41379-022-01117-4","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nuclear expression of AFF2 C-terminus is a sensitive and specific ancillary marker for DEK::AFF2 carcinoma of the sinonasal tract","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41379-022-01117-4","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}