{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T19:19:10Z","timestamp":1781896750422,"version":"3.54.5"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["ZIA-MH00284311\/NCT00001174"],"award-info":[{"award-number":["ZIA-MH00284311\/NCT00001174"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["ZIA-MH00284311\/NCT00001174"],"award-info":[{"award-number":["ZIA-MH00284311\/NCT00001174"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["ZIA-MH00284311\/NCT00001174"],"award-info":[{"award-number":["ZIA-MH00284311\/NCT00001174"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["ZIA-MH00284311\/NCT00001174"],"award-info":[{"award-number":["ZIA-MH00284311\/NCT00001174"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["ZIA-MH00284311\/NCT00001174"],"award-info":[{"award-number":["ZIA-MH00284311\/NCT00001174"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["ZIA-MH00284311\/NCT00001174"],"award-info":[{"award-number":["ZIA-MH00284311\/NCT00001174"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["ZIA-MH00284311\/NCT00001174"],"award-info":[{"award-number":["ZIA-MH00284311\/NCT00001174"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["ZIA-MH00284311\/NCT00001174"],"award-info":[{"award-number":["ZIA-MH00284311\/NCT00001174"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["ZIA-MH00284311\/NCT00001174"],"award-info":[{"award-number":["ZIA-MH00284311\/NCT00001174"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1038\/s41380-018-0207-1","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T07:46:05Z","timestamp":1534923965000},"page":"613-624","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Sodium valproate rescues expression of TRANK1 in iPSC-derived neural cells that carry a genetic variant associated with serious mental illness"],"prefix":"10.1038","volume":"24","author":[{"given":"Xueying","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevilla D.","family":"Detera-Wadleigh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmala","family":"Akula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara S.","family":"Mallon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiaojiang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Felsenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9469-305X","authenticated-orcid":false,"given":"Francis J.","family":"McMahon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,22]]},"reference":[{"key":"207_CR1","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/mp.2011.11","volume":"17","author":"AL Richards","year":"2012","unstructured":"Richards AL, Jones L, Moskvina V, Kirov G, Gejman PV, Levinson DF, et al. Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain. Mol Psychiatry. 2012;17:193\u2013201.","journal-title":"Mol Psychiatry"},{"key":"207_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-014-0493-5","volume":"16","author":"G Shinozaki","year":"2014","unstructured":"Shinozaki G, Potash JB. New developments in the genetics of bipolar disorder. Curr Psychiatry Rep. 2014;16:493.","journal-title":"Curr Psychiatry Rep"},{"key":"207_CR3","doi-asserted-by":"publisher","first-page":"4746","DOI":"10.1093\/hmg\/ddv194","volume":"24","author":"H Kirsten","year":"2015","unstructured":"Kirsten H, Al-Hasani H, Holdt L, Gross A, Beutner F, Krohn K, et al. Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding loci. Hum Mol Genet. 2015;24:4746\u201363.","journal-title":"Hum Mol Genet"},{"key":"207_CR4","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/ng.2653","volume":"45","author":"GTEx Consortium.","year":"2013","unstructured":"GTEx Consortium. The genotype-tissue expression (GTEx) project. Nat Genet. 2013;45:580\u20135.","journal-title":"Nat Genet"},{"key":"207_CR5","doi-asserted-by":"publisher","first-page":"3308","DOI":"10.1074\/jbc.M113.515817","volume":"289","author":"F Liu","year":"2014","unstructured":"Liu F, Wang X, Hu G, Wang Y, Zhou J. The transcription factor TEAD1 represses smooth muscle-specific gene expression by abolishing myocardin function. J Biol Chem. 2014;289:3308\u201316.","journal-title":"J Biol Chem"},{"key":"207_CR6","doi-asserted-by":"publisher","first-page":"4503","DOI":"10.1182\/blood-2007-06-097964","volume":"110","author":"M De Gobbi","year":"2007","unstructured":"De Gobbi M, Anguita E, Hughes J, Sloane-Stanley JA, Sharpe JA, Koch CM, et al. Tissue-specific histone modification and transcription factor binding in alpha globin gene expression. Blood. 2007;110:4503\u201310.","journal-title":"Blood"},{"key":"207_CR7","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1126\/science.aaa0355","volume":"348","author":"M Mele","year":"2015","unstructured":"Mele M, Ferreira PG, Reverter F, DeLuca DS, Monlong J, Sammeth M, et al. Human genomics. The human transcriptome across tissues and individuals. Science. 2015;348:660\u20135.","journal-title":"Science"},{"key":"207_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-015-0134-4","volume":"13","author":"MH Gay","year":"2015","unstructured":"Gay MH, Valenta T, Herr P, Paratore-Hari L, Basler K, Sommer L. Distinct adhesion-independent functions of beta-catenin control stage-specific sensory neurogenesis and proliferation. BMC Biol. 2015;13:24.","journal-title":"BMC Biol"},{"key":"207_CR9","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1046\/j.1432-0436.1996.5950269.x","volume":"59","author":"KE Latham","year":"1995","unstructured":"Latham KE. Stage-specific and cell type-specific aspects of genomic imprinting effects in mammals. Differentiation. 1995;59:269\u201382.","journal-title":"Differentiation"},{"key":"207_CR10","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1038\/mp.2012.104","volume":"18","author":"EH Rueckert","year":"2013","unstructured":"Rueckert EH, Barker D, Ruderfer D, Bergen SE, O\u2019Dushlaine C, Luce CJ, et al. Cis-acting regulation of brain-specific ANK3 gene expression by a genetic variant associated with bipolar disorder. Mol Psychiatry. 2013;18:922\u20139.","journal-title":"Mol Psychiatry"},{"key":"207_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.mcn.2015.12.004","volume":"73","author":"JA Korecka","year":"2016","unstructured":"Korecka JA, Levy S, Isacson O. In vivo modeling of neuronal function, axonal impairment and connectivity in neurodegenerative and neuropsychiatric disorders using induced pluripotent stem cells. Mol Cell Neurosci. 2016;73:3\u201312.","journal-title":"Mol Cell Neurosci"},{"key":"207_CR12","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/s41588-017-0005-8","volume":"50","author":"J Schwartzentruber","year":"2018","unstructured":"Schwartzentruber J, Foskolou S, Kilpinen H, Rodrigues J, Alasoo K, Knights AJ, et al. Molecular and functional variation in iPSC-derived sensory neurons. Nat Genet. 2018;50:54\u201361.","journal-title":"Nat Genet"},{"key":"207_CR13","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1126\/science.1243472","volume":"342","author":"MJ McConnell","year":"2013","unstructured":"McConnell MJ, Lindberg MR, Brennand KJ, Piper JC, Voet T, Cowing-Zitron C, et al. Mosaic copy number variation in human neurons. Science. 2013;342:632\u20137.","journal-title":"Science"},{"key":"207_CR14","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1007\/s12015-010-9138-1","volume":"6","author":"DS Kim","year":"2010","unstructured":"Kim DS, Lee JS, Leem JW, Huh YJ, Kim JY, Kim HS, et al. Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity. Stem Cell Rev. 2010;6:270\u201381.","journal-title":"Stem Cell Rev"},{"key":"207_CR15","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/nature13716","volume":"515","author":"Z Wen","year":"2014","unstructured":"Wen Z, Nguyen HN, Guo Z, Lalli MA, Wang X, Su Y, et al. Synaptic dysregulation in a human iPS cell model of mental disorders. Nature. 2014;515:414\u20138.","journal-title":"Nature"},{"key":"207_CR16","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/mp.2014.22","volume":"20","author":"K Brennand","year":"2015","unstructured":"Brennand K, Savas JN, Kim Y, Tran N, Simone A, Hashimoto-Torii K, et al. Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. Mol Psychiatry. 2015;20:361\u20138.","journal-title":"Mol Psychiatry"},{"key":"207_CR17","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/nature15526","volume":"527","author":"J Mertens","year":"2015","unstructured":"Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, et al. Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. 2015;527:95\u201399.","journal-title":"Nature"},{"key":"207_CR18","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1126\/science.aad5487","volume":"351","author":"M Bidinosti","year":"2016","unstructured":"Bidinosti M, Botta P, Kruttner S, Proenca CC, Stoehr N, Bernhard M, et al. CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency. Science. 2016;351:1199\u2013203.","journal-title":"Science"},{"key":"207_CR19","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.stem.2017.07.008","volume":"21","author":"MP Forrest","year":"2017","unstructured":"Forrest MP, Zhang H, Moy W, McGowan H, Leites C, Dionisio LE, et al. Open chromatin profiling in hIPSC-derived neurons prioritizes functional noncoding psychiatric risk variants and highlights neurodevelopmental loci. Cell Stem Cell. 2017;21:305\u201318 e308.","journal-title":"Cell Stem Cell"},{"key":"207_CR20","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/mp.2011.157","volume":"18","author":"DT Chen","year":"2013","unstructured":"Chen DT, Jiang X, Akula N, Shugart YY, Wendland JR, Steele CJ, et al. Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. Mol Psychiatry. 2013;18:195\u2013205.","journal-title":"Mol Psychiatry"},{"issue":"9","key":"207_CR21","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/mp.2013.138","volume":"19","author":"D M Ruderfer","year":"2013","unstructured":"Ruderfer DM, Fanous AH, Ripke S, McQuillin A, Amdur RL, Gejman PV, et al. Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. Mol Psychiatry. 2013;19:1017\u201324.","journal-title":"Molecular Psychiatry"},{"key":"207_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.106","volume":"2","author":"FS Goes","year":"2012","unstructured":"Goes FS, Hamshere ML, Seifuddin F, Pirooznia M, Belmonte-Mahon P, Breuer R, et al. Genome-wide association of mood-incongruent psychotic bipolar disorder. Transl Psychiatry. 2012;2:e180.","journal-title":"Transl Psychiatry"},{"key":"207_CR23","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/S0140-6736(12)62129-1","volume":"381","author":"Cross-Disorder Group of the Psychiatric Genomics Consortium.","year":"2013","unstructured":"Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet. 2013;381:1371\u20139.","journal-title":"Lancet"},{"key":"207_CR24","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nature13595","volume":"511","author":"Schizophrenia Working Group of the Psychiatric Genomics Consortium.","year":"2014","unstructured":"Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014;511:421\u20137.","journal-title":"Nature"},{"key":"207_CR25","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1126\/science.1151526","volume":"318","author":"J Yu","year":"2007","unstructured":"Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science. 2007;318:1917\u201320.","journal-title":"Science"},{"key":"207_CR26","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/mp.2012.73","volume":"17","author":"SE Bergen","year":"2012","unstructured":"Bergen SE, O\u2019Dushlaine CT, Ripke S, Lee PH, Ruderfer DM, Akterin S, et al. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. Mol Psychiatry. 2012;17:880\u20136.","journal-title":"Mol Psychiatry"},{"issue":"11","key":"207_CR27","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1038\/mp.2013.170","volume":"19","author":"N Akula","year":"2014","unstructured":"Akula N, Barb J, Jiang X, Wendland JR, Choi KH, Sen SK, et al. RNA-sequencing of the brain transcriptome implicates dysregulation of neuroplasticity, circadian rhythms and GTPase binding in bipolar disorder. Mol Psychiatry. 2014;19:1179\u201385.","journal-title":"Molecular Psychiatry"},{"key":"207_CR28","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jneumeth.2017.01.019","volume":"280","author":"J Kreutzer","year":"2017","unstructured":"Kreutzer J, Yla-Outinen L, Maki AJ, Ristola M, Narkilahti S, Kallio P. Cell culture chamber with gas supply for prolonged recording of human neuronal cells on microelectrode array. J Neurosci Methods. 2017;280:27\u201335.","journal-title":"J Neurosci Methods"},{"key":"207_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4339","volume":"5","author":"TW Muhleisen","year":"2014","unstructured":"Muhleisen TW, Leber M, Schulze TG, Strohmaier J, Degenhardt F, Treutlein J, et al. Genome-wide association study reveals two new risk loci for bipolar disorder. Nat Commun. 2014;5:3339.","journal-title":"Nat Commun"},{"key":"207_CR30","doi-asserted-by":"publisher","first-page":"D877","DOI":"10.1093\/nar\/gkv1340","volume":"44","author":"LD Ward","year":"2016","unstructured":"Ward LD, Kellis M. HaploRegv4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease. Nucleic Acids Res. 2016;44:D877\u2013881.","journal-title":"Nucleic Acids Res"},{"key":"207_CR31","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1101\/gad.277863.116","volume":"30","author":"R Ghirlando","year":"2016","unstructured":"Ghirlando R, Felsenfeld G. CTCF: making the right connections. Genes Dev. 2016;30:881\u201391.","journal-title":"Genes Dev"},{"key":"207_CR32","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1007\/s11064-013-1098-9","volume":"38","author":"MR Hasan","year":"2013","unstructured":"Hasan MR, Kim JH, Kim YJ, Kwon KJ, Shin CY, Kim HY, et al. Effect of HDAC inhibitors on neuroprotection and neurite outgrowth in primary rat cortical neurons following ischemic insult. Neurochem Res. 2013;38:1921\u201334.","journal-title":"Neurochem Res"},{"key":"207_CR33","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s10059-011-0019-5","volume":"31","author":"BW Kim","year":"2011","unstructured":"Kim BW, Yang S, Lee CH, Son H. A critical time window for the survival of neural progenitor cells by HDAC inhibitors in the hippocampus. Mol Cells. 2011;31:159\u201364.","journal-title":"Mol Cells"},{"key":"207_CR34","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.neuropharm.2008.09.019","volume":"56","author":"IT Yu","year":"2009","unstructured":"Yu IT, Park JY, Kim SH, Lee JS, Kim YS, Son H. Valproic acid promotes neuronal differentiation by induction of proneural factors in association with H4 acetylation. Neuropharmacology. 2009;56:473\u201380.","journal-title":"Neuropharmacology"},{"key":"207_CR35","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1038\/nn.4142","volume":"18","author":"WS Chung","year":"2015","unstructured":"Chung WS, Welsh CA, Barres BA, Stevens B. Do glia drive synaptic and cognitive impairment in disease? Nat Neurosci. 2015;18:1539\u201345.","journal-title":"Nat Neurosci"},{"key":"207_CR36","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1586\/14737175.2016.1171144","volume":"16","author":"L Peng","year":"2016","unstructured":"Peng L, Li B, Verkhratsky A. Targeting astrocytes in bipolar disorder. Expert Rev Neurother. 2016;16:649\u201357.","journal-title":"Expert Rev Neurother"},{"key":"207_CR37","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1126\/science.aaf2849","volume":"351","author":"B Stevens","year":"2016","unstructured":"Stevens B, Muthukumar AK. Cellular neuroscience. Differences among astrocytes. Science. 2016;351:813.","journal-title":"Science"},{"key":"207_CR38","doi-asserted-by":"publisher","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","volume":"20","author":"M Gottlicher","year":"2001","unstructured":"Gottlicher M, Minucci S, Zhu P, Kramer OH, Schimpf A, Giavara S, et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J. 2001;20:6969\u201378.","journal-title":"EMBO J"},{"key":"207_CR39","doi-asserted-by":"publisher","first-page":"55","DOI":"10.2174\/1570159X13666151021111609","volume":"14","author":"SA Ganai","year":"2016","unstructured":"Ganai SA, Ramadoss M, Mahadevan V. Histone deacetylase (HDAC) inhibitors\u2014emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration. Curr Neuropharmacol. 2016;14:55\u201371.","journal-title":"Curr Neuropharmacol"},{"key":"207_CR40","first-page":"3153","volume":"9","author":"Y Guo","year":"2015","unstructured":"Guo Y, Fu X, Jin Y, Sun J, Liu Y, Huo B, et al. Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation. Drug Des Devel Ther. 2015;9:3153\u201362.","journal-title":"Drug Des Devel Ther"},{"key":"207_CR41","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1093\/nar\/28.8.1707","volume":"28","author":"M Lutz","year":"2000","unstructured":"Lutz M, Burke LJ, Barreto G, Goeman F, Greb H, Arnold R, et al. Transcriptional repression by the insulator protein CTCF involves histone deacetylases. Nucleic Acids Res. 2000;28:1707\u201313.","journal-title":"Nucleic Acids Res"},{"key":"207_CR42","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-2516-6","volume":"17","author":"M Oti","year":"2016","unstructured":"Oti M, Falck J, Huynen MA, Zhou H. CTCF-mediated chromatin loops enclose inducible gene regulatory domains. BMC Genom. 2016;17:252.","journal-title":"BMC Genom"},{"key":"207_CR43","doi-asserted-by":"publisher","first-page":"4490","DOI":"10.1093\/hmg\/ddq380","volume":"19","author":"F Buonocore","year":"2010","unstructured":"Buonocore F, Hill MJ, Campbell CD, Oladimeji PB, Jeffries AR, Troakes C, et al. Effects of cis-regulatory variation differ across regions of the adult human brain. Human Mol Genet. 2010;19:4490\u20136.","journal-title":"Human Mol Genet"},{"key":"207_CR44","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.mcn.2013.07.007","volume":"56","author":"MF Burkhardt","year":"2013","unstructured":"Burkhardt MF, Martinez FJ, Wright S, Ramos C, Volfson D, Mason M, et al. A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells. Mol Cell Neurosci. 2013;56:355\u201364.","journal-title":"Mol Cell Neurosci"},{"key":"207_CR45","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nature19847","volume":"538","author":"H Won","year":"2016","unstructured":"Won H, de la Torre-Ubieta L, Stein JL, Parikshak NN, Huang J, Opland CK, et al. Chromosome conformation elucidates regulatory relationships in developing human brain. Nature. 2016;538:523\u20137.","journal-title":"Nature"},{"key":"207_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jviromet.2011.06.019","volume":"177","author":"AR Cooper","year":"2011","unstructured":"Cooper AR, Patel S, Senadheera S, Plath K, Kohn DB, Hollis RP. Highly efficient large-scale lentiviral vector concentration by tandem tangential flow filtration. J Virol Methods. 2011;177:1\u20139.","journal-title":"J Virol Methods"},{"key":"207_CR47","unstructured":"Muller FJ, Brandl B, Loring JF. Assessment of human pluripotent stem cells with PluriTest. Cambridge, MA: StemBook; 2008."},{"key":"207_CR48","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1523\/JNEUROSCI.2262-07.2008","volume":"28","author":"X Jiang","year":"2008","unstructured":"Jiang X, Tian F, Du Y, Copeland NG, Jenkins NA, Tessarollo L, et al. BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability. J Neurosci. 2008;28:1118\u201330.","journal-title":"J Neurosci"},{"key":"207_CR49","doi-asserted-by":"publisher","first-page":"2174","DOI":"10.1128\/MCB.05093-11","volume":"31","author":"T Xiao","year":"2011","unstructured":"Xiao T, Wallace J, Felsenfeld G. Specific sites in the C terminus of CTCF interact with the SA2 subunit of the cohesin complex and are required for cohesin-dependent insulation activity. Mol Cell Biol. 2011;31:2174\u201383.","journal-title":"Mol Cell Biol"},{"key":"207_CR50","doi-asserted-by":"publisher","first-page":"8620","DOI":"10.1073\/pnas.0402938101","volume":"101","author":"TM Yusufzai","year":"2004","unstructured":"Yusufzai TM, Felsenfeld G. The 5\u2019-HS4 chicken beta-globin insulator is a CTCF-dependent nuclear matrix-associated element. Proc Natl Acad Sci USA. 2004;101:8620\u20134.","journal-title":"Proc Natl Acad Sci USA"},{"key":"207_CR51","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"W Huang da","year":"2009","unstructured":"Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4:44\u201357.","journal-title":"Nat Protoc"},{"key":"207_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/nar\/gkn923","volume":"37","author":"W Huang da","year":"2009","unstructured":"Huang da W, Sherman BT, Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 2009;37:1\u201313.","journal-title":"Nucleic Acids Res"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41380-018-0207-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41380-018-0207-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41380-018-0207-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T16:58:51Z","timestamp":1684601931000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-018-0207-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,22]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["207"],"URL":"https:\/\/doi.org\/10.1038\/s41380-018-0207-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/192815","asserted-by":"object"}]},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,22]]},"assertion":[{"value":"18 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}