{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:34:47Z","timestamp":1790667287143,"version":"4.1.0"},"reference-count":105,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T00:00:00Z","timestamp":1534464000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1038\/s41380-018-0221-3","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T08:32:42Z","timestamp":1534494762000},"page":"857-868","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Endosomal sorting and trafficking, the retromer complex and neurodegeneration"],"prefix":"10.1038","volume":"24","author":[{"given":"Alana N.","family":"Vagnozzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Pratic\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,17]]},"reference":[{"key":"221_CR1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ceb.2004.06.005","volume":"16","author":"M Miaczynska","year":"2004","unstructured":"Miaczynska M, Pelkmans L, Zerial M. Not just a sink: endosomes in control of signal transduction. Curr Opin Cell Biol. 2004;16:400\u20136.","journal-title":"Curr Opin Cell Biol"},{"key":"221_CR2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.tins.2013.11.006","volume":"37","author":"J Neefjes","year":"2014","unstructured":"Neefjes J, van der Kant R. Stuck in traffic: an emerging theme in diseases of the nervous system. Trends Neurosci. 2014;37:66\u201376.","journal-title":"Trends Neurosci"},{"key":"221_CR3","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.tins.2017.08.003","volume":"40","author":"SA Small","year":"2017","unstructured":"Small SA, Simoes-Spassov S, Mayeux R, Petsko GA. Endosomal traffic jams represent a pathogenic hub and therapeutic target in Alzheimer\u2019s disease. Trends Neurosci. 2017;40:592\u2013602.","journal-title":"Trends Neurosci"},{"key":"221_CR4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/bies.201200130","volume":"35","author":"CA Lamb","year":"2013","unstructured":"Lamb CA, Dooley HC, Tooze SA. Endocytosis and autophagy: shared machinery for degradation. Bioessays. 2013;35:34\u201345.","journal-title":"Bioessays"},{"key":"221_CR5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2014.03.034","volume":"31","author":"CC Scott","year":"2014","unstructured":"Scott CC, Vacca F, Gruenberg J. Endosome maturation, transport and functions. Semin Cell Dev Biol. 2014;31:2\u201310.","journal-title":"Semin Cell Dev Biol"},{"key":"221_CR6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1146\/annurev.biophys.35.040405.102126","volume":"35","author":"JH Hurley","year":"2006","unstructured":"Hurley JH, Emr SD. The ESCRT complexes: structure and mechanism of a membrane-trafficking network. Annu Rev Biophys Biomol Struct. 2006;35:277\u201398.","journal-title":"Annu Rev Biophys Biomol Struct"},{"key":"221_CR7","first-page":"30249","volume":"17","author":"N Kimura","year":"2017","unstructured":"Kimura N, Yanagisawa K. Traffic jam hypothesis: relationship between endocytic dysfunction and Alzheimer\u2019s disease. Neurochem Int. 2017;17:30249\u2013508.","journal-title":"Neurochem Int"},{"key":"221_CR8","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1038\/emboj.2011.286","volume":"30","author":"J Huotari","year":"2011","unstructured":"Huotari J, Helenius A. Endosome maturation. EMBO J. 2011;30:3481\u2013500.","journal-title":"EMBO J"},{"key":"221_CR9","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1007\/s00018-015-1935-x","volume":"72","author":"RJ Chi","year":"2015","unstructured":"Chi RJ, Harrison MS, Burd CG. Biogenesis of endosome-derived transport carriers. Cell Mol Life Sci. 2015;72:3441\u201355.","journal-title":"Cell Mol Life Sci"},{"key":"221_CR10","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ceb.2008.03.009","volume":"20","author":"JS Bonifacino","year":"2008","unstructured":"Bonifacino JS, Hurley JH. Retromer. Curr Opin Cell Biol. 2008;20:427\u201336.","journal-title":"Curr Opin Cell Biol"},{"key":"221_CR11","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/j.1600-0854.2011.01201.x","volume":"12","author":"IJ McGough","year":"2011","unstructured":"McGough IJ, Cullen PJ. Recent advances in retromer biology. Traffic. 2011;12:963\u201371.","journal-title":"Traffic"},{"key":"221_CR12","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1242\/jcs.103440","volume":"125","author":"MN Seaman","year":"2012","unstructured":"Seaman MN. The retromer complex - endosomal protein recycling and beyond. J Cell Sci. 2012;125:4693\u2013702.","journal-title":"J Cell Sci"},{"key":"221_CR13","doi-asserted-by":"crossref","first-page":"R687","DOI":"10.1016\/j.cub.2017.05.072","volume":"27","author":"M Lucas","year":"2017","unstructured":"Lucas M, Hierro A. Retromer. Curr Biol. 2017;27:R687\u20139.","journal-title":"Curr Biol"},{"key":"221_CR14","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1083\/jcb.142.3.665","volume":"142","author":"MN Seaman","year":"1998","unstructured":"Seaman MN, McCaffery JM, Emr SD. A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast. J Cell Biol. 1998;142:665\u201381.","journal-title":"J Cell Biol"},{"key":"221_CR15","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1091\/mbc.11.12.4105","volume":"11","author":"CR Haft","year":"2000","unstructured":"Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Mol Biol Cell. 2000;11:4105\u201316.","journal-title":"Mol Biol Cell"},{"key":"221_CR16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1083\/jcb.200312034","volume":"165","author":"MN Seaman","year":"2004","unstructured":"Seaman MN. Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J Cell Biol. 2004;165:111\u201322.","journal-title":"J Cell Biol"},{"key":"221_CR17","doi-asserted-by":"crossref","first-page":"a016774","DOI":"10.1101\/cshperspect.a016774","volume":"6","author":"C Burd","year":"2014","unstructured":"Burd C, Cullen PJ. Retromer: a master conductor of endosome sorting. Cold Spring Harb Perspect Biol. 2014;6:a016774.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"221_CR18","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.devcel.2009.04.016","volume":"17","author":"T Wassmer","year":"2009","unstructured":"Wassmer T, Attar N, Harterink M, van Weering JR, Traer CJ, Oakley J, Goud B, et al. The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell. 2009;17:110\u201322.","journal-title":"Dev Cell"},{"key":"221_CR19","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1242\/jcs.071472","volume":"123","author":"ME Harbour","year":"2010","unstructured":"Harbour ME, Breusegem SY, Antrobus R, Freeman C, Reid E, Seaman MN. The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics. J Cell Sci. 2010;123:3703\u201317.","journal-title":"J Cell Sci"},{"key":"221_CR20","first-page":"2392","volume":"142","author":"S Wang","year":"2015","unstructured":"Wang S, Bellen HJ. The retromer complex in development and disease. Dev Camb Engl. 2015;142:2392\u20136.","journal-title":"Dev Camb Engl"},{"key":"221_CR21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10072-015-2399-3","volume":"37","author":"S Sadigh-Eteghad","year":"2016","unstructured":"Sadigh-Eteghad S, Askari-Nejad MS, Mahmoudi J, Majdi A. Cargo trafficking in Alzheimer\u2019s disease: the possible role of retromer. Neurol Sci. 2016;37:17\u201322.","journal-title":"Neurol Sci"},{"key":"221_CR22","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/ncb2281","volume":"13","author":"M Harterink","year":"2011","unstructured":"Harterink M, Port F, Lorenowicz MJ, McGough IJ, Silhankova M, Betist MC, et al. A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nat Cell Biol. 2011;13:914\u201323.","journal-title":"Nat Cell Biol"},{"key":"221_CR23","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/nature06216","volume":"449","author":"A Hierro","year":"2007","unstructured":"Hierro A, Rojas AL, Rojas R, Murthy N, Effantin G, Kajava AV, et al. Functional architecture of the retromer cargo-recognition complex. Nature. 2007;449:1063\u20137.","journal-title":"Nature"},{"key":"221_CR24","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3390\/membranes5030288","volume":"5","author":"SC Klinger","year":"2015","unstructured":"Klinger SC, Siupka P, Nielsen MS. Retromer-mediated trafficking of transmembrane receptors and transporters. Membranes. 2015;5:288\u2013306.","journal-title":"Membranes"},{"key":"221_CR25","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/ncb2252","volume":"13","author":"P Temkin","year":"2011","unstructured":"Temkin P, Lauffer B, J\u00e4ger S, Cimermancic P, Krogan NJ, von Zastrow M. SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Nat Cell Biol. 2011;13:715\u201321.","journal-title":"Nat Cell Biol"},{"key":"221_CR26","doi-asserted-by":"crossref","first-page":"4940","DOI":"10.1242\/jcs.156299","volume":"127","author":"IJ McGough","year":"2014","unstructured":"McGough IJ, Steinberg F, Gallon M, Yatsu A, Ohbayashi N, Heesom KJ, et al. Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma membrane recycling. J Cell Sci. 2014;127:4940\u201353.","journal-title":"J Cell Sci"},{"key":"221_CR27","first-page":"42","volume":"8","author":"C Li","year":"2016","unstructured":"Li C, Shah SZ, Zhao D, Yang L. Role of the retromer complex in neurodegenerative diseases. Front Aging Neurosci. 2016;8:42.","journal-title":"Front Aging Neurosci"},{"key":"221_CR28","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1042\/BJ20111761","volume":"442","author":"ME Harbour","year":"2012","unstructured":"Harbour ME, Breusegem SY, Seaman MN. Recruitment of the endosomal WASH complex is mediated by the extended \u201ctail\u201d of Fam21 binding to the retromer protein Vps35. Biochem J. 2012;442:209\u201320.","journal-title":"Biochem J"},{"key":"221_CR29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1083\/jcb.200312055","volume":"165","author":"CN Arighi","year":"2004","unstructured":"Arighi CN, Hartnell LM, Aguilar RC, Haft CR, Bonifacino JS. Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J Cell Biol. 2004;165:123\u201333.","journal-title":"J Cell Biol"},{"key":"221_CR30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbrc.2010.10.121","volume":"403","author":"E Kim","year":"2010","unstructured":"Kim E, Lee Y, Lee HJ, Kim JS, Song BS, Huh JW, et al. Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking. Biochem Biophys Res Commun. 2010;403:167\u201371.","journal-title":"Biochem Biophys Res Commun"},{"key":"221_CR31","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.neuron.2013.06.046","volume":"79","author":"KM Lucin","year":"2013","unstructured":"Lucin KM, O\u2019Brien CE, Bieri G, Czirr E, Mosher KI, Abbey RJ, et al. Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer\u2019s disease. Neuron. 2013;79:873\u201386.","journal-title":"Neuron"},{"key":"221_CR32","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nrn3896","volume":"16","author":"SA Small","year":"2015","unstructured":"Small SA, Petsko GA. Retromer in Alzheimer disease, Parkinson disease and other neurological disorders. Nat Rev Neurosci. 2015;16:126\u201332.","journal-title":"Nat Rev Neurosci"},{"key":"221_CR33","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.3390\/ijms18081601","volume":"18","author":"YS Abubakar","year":"2017","unstructured":"Abubakar YS, Zheng W, Olsson S, Zhou J. Updated insight into the physiological and pathological roles of the retromer complex. Int J Mol Sci. 2017;18:1601.","journal-title":"Int J Mol Sci"},{"key":"221_CR34","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","volume":"276","author":"MH Polymeropoulos","year":"1997","unstructured":"Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson\u2019s disease. Science. 1997;276:2045\u20137.","journal-title":"Science"},{"key":"221_CR35","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3233\/JPD-161020","volume":"7","author":"ET Williams","year":"2017","unstructured":"Williams ET, Chen X, Moore DJ. VPS35, the retromer complex and Parkinson\u2019s disease. J Parkinson\u2019s Dis. 2017;7:219\u201333.","journal-title":"J Parkinson\u2019s Dis"},{"key":"221_CR36","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ajhg.2011.06.001","volume":"89","author":"C Vilarino-Guell","year":"2011","unstructured":"Vilarino-Guell C, Wider C, Ross O, Dachsel J, Kachergus J, Lincoln S, et al. VPS35 mutations in Parkinson disease. Am J Hum Genet. 2011;89:162\u20137.","journal-title":"Am J Hum Genet"},{"key":"221_CR37","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.neuron.2012.11.033","volume":"77","author":"DA MacLeod","year":"2013","unstructured":"MacLeod DA, Rhinn H, Kuwahara T, Zolin A, Di Paolo G, McCabe BD, et al. RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson\u2019s disease risk. Neuron. 2013;77:425\u201339.","journal-title":"Neuron"},{"issue":"2","key":"221_CR38","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/brain\/awx344","volume":"141","author":"Ye Zhao","year":"2017","unstructured":"Zhao Y, Perera G, Takahashi-Fujigasaki J, Mash DC, Vonsattel J-P G, Uchino A,\u00a0 et al. Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers. Brain. 2018; 141:486-495","journal-title":"Brain"},{"key":"221_CR39","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1083\/jcb.201105109","volume":"195","author":"L Wen","year":"2011","unstructured":"Wen L, Tang FL, Hong Y, Luo SW, Wang CL, He W, et al. VPS35 haploinsufficiency increases Alzheimer\u2019s disease neuropathology. J Cell Biol. 2011;195:765\u201379.","journal-title":"J Cell Biol"},{"key":"221_CR40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2014.07.014","volume":"71","author":"E Miura","year":"2014","unstructured":"Miura E, Hasegawa T, Konno M, Suzuki M, Sugeno N, Fujikake N, et al. VPS35 dysfunction impairs lysosomal degradation of alpha-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson\u2019s disease. Neurobiol Dis. 2014;71:1\u201313.","journal-title":"Neurobiol Dis"},{"key":"221_CR41","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1093\/hmg\/ddu582","volume":"24","author":"LN Munsie","year":"2015","unstructured":"Munsie LN, Milnerwood AJ, Seibler P, Beccano-Kelly DA, Tatarnikov I, Khinda J, et al. Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson\u2019s Disease VPS35 mutation p. D620N. Hum Mol Genet. 2015;24:1691\u2013703.","journal-title":"Hum Mol Genet"},{"key":"221_CR42","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/tra.12136","volume":"15","author":"J Follett","year":"2014","unstructured":"Follett J, Norwood SJ, Hamilton NA, Mohan M, Kovtun O, Tay S, et al. The Vps35 D620N mutation linked to Parkinson\u2019s disease disrupts the cargo sorting function of retromer. Traffic. 2014;15:230\u201344.","journal-title":"Traffic"},{"key":"221_CR43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1750-1326-9-23","volume":"9","author":"R Linhart","year":"2014","unstructured":"Linhart R, Wong SA, Cao J, Tran M, Huynh A, Ardrey C, et al. Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson\u2019s disease mutant of leucine-rich repeat kinase 2 (LRRK2). Mol Neurodegener. 2014;9:23.","journal-title":"Mol Neurodegener"},{"key":"221_CR44","doi-asserted-by":"crossref","first-page":"10613","DOI":"10.1523\/JNEUROSCI.0042-15.2015","volume":"35","author":"FL Tang","year":"2015","unstructured":"Tang FL, Erion JR, Tian Y, Liu W, Yin DM, Ye J, et al. VPS35 in dopamine neurons is required for endosome-to-Golgi retrieval of Lamp2a, a receptor of chaperone-mediated autophagy that is critical for alpha-synuclein degradation and prevention of pathogenesis of Parkinson\u2019s disease. J Neurosci. 2015;35:10613\u201328.","journal-title":"J Neurosci"},{"key":"221_CR45","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.celrep.2015.08.001","volume":"12","author":"FL Tang","year":"2015","unstructured":"Tang FL, Liu W, Hu JX, Erion JR, Ye J, Mei L, Xiong WC. VPS35 deficiency or mutation causes dopaminergic neuronal loss by impairing mitochondrial fusion and function. Cell Rep. 2015;12:1631\u201343.","journal-title":"Cell Rep"},{"key":"221_CR46","first-page":"4507","volume":"25","author":"N Ishizu","year":"2016","unstructured":"Ishizu N, Yui D, Hebisawa A, Aizawa H, Cui W, Fujita Y, et al. Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice. Hum Mol Genet. 2016;25:4507\u201317.","journal-title":"Hum Mol Genet"},{"key":"221_CR47","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1093\/hmg\/ddu178","volume":"23","author":"E Tsika","year":"2014","unstructured":"Tsika E, Glauser L, Moser R, Fiser A, Daniel G, Sheerin UM, et al. Parkinson\u2019s disease-linked mutations in VPS35 induce dopaminergic neurodegeneration. Hum Mol Genet. 2014;23:4621\u201338.","journal-title":"Hum Mol Genet"},{"key":"221_CR48","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1083\/jcb.201709072","volume":"217","author":"CL Klaips","year":"2018","unstructured":"Klaips CL, Jayaraj GG, Hartl FU. Pathways of cellular proteostasis in aging and disease. J Cell Biol. 2018;217:51\u201363.","journal-title":"J Cell Biol"},{"issue":"1","key":"221_CR49","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ajhg.2011.06.008","volume":"89","author":"Alexander Zimprich","year":"2011","unstructured":"Zimprich A, Benet-Pag\u00e8s A, Struhal W, Graf E, Eck SH, Offman MN, et al. A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease. The American Journal of Human Genetics. 2011; 89:168-175","journal-title":"The American Journal of Human Genetics"},{"issue":"4","key":"221_CR50","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/mds.26104","volume":"30","author":"Emil K. Gustavsson","year":"2014","unstructured":"Gustavsson EK, Guella I, Trinh J, Szu-Tu C, Rajput A, Rajput AH, et al. Genetic variability of the retromer cargo recognition complex in parkinsonism. Movement Disorders. 2011; 30:580-584","journal-title":"Movement Disorders"},{"key":"221_CR51","doi-asserted-by":"crossref","unstructured":"Shannon B, Soto-Ortolaza A, Rayaprolu S, Cannon HD, Labb\u00e9 C, Benitez BA, et al. Genetic variation of the retromer subunits VPS26A\/B-VPS29 in Parkinson's disease. Neurobiology of Aging. 2014; 35:1958.e1-1958.e2","DOI":"10.1016\/j.neurobiolaging.2014.03.004"},{"key":"221_CR52","doi-asserted-by":"crossref","unstructured":"Gambardella S, Biagioni F, Ferese R, Busceti CL, Frati A, Novelli G, et al. Vacuolar Protein Sorting Genes in Parkinson's Disease: A Re-appraisal of Mutations Detection Rate and Neurobiology of Disease. Frontiers in Neuroscience. 2016; 10","DOI":"10.3389\/fnins.2016.00532"},{"issue":"35","key":"221_CR53","doi-asserted-by":"crossref","first-page":"18283","DOI":"10.1074\/jbc.M115.703157","volume":"291","author":"Jordan Follett","year":"2016","unstructured":"Follett J, Bugarcic A, Yang Z, Ariotti N,\u00a0 Norwood SJ,\u00a0 Collins BM, et al. Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces \u00ce\u00b1-Synuclein Aggregation. Journal of Biological Chemistry. 2016; 291:18283-18298","journal-title":"Journal of Biological Chemistry"},{"issue":"15","key":"221_CR54","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1093\/hmg\/ddx179","volume":"26","author":"Tsuyoshi Inoshita","year":"2017","unstructured":"Inoshita T, Arano T, Hosaka Y, Meng H, Umezaki Y, Kosugi S, et al. Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila. Human Molecular Genetics. 2017; 26: 2933-2948","journal-title":"Human Molecular Genetics"},{"issue":"2","key":"221_CR55","first-page":"242-250.e4","volume":"4","author":"Chee Yeun Chung","year":"2017","unstructured":"Chung CY, Khurana V, Yi S, Sahni N, Loh KH, Auluck PK, et al. In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons. Cell Systems. 2017;4: 242\u2013250.e4","journal-title":"Cell Systems"},{"key":"221_CR56","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-00579-4","volume":"8","author":"RF Sowade","year":"2017","unstructured":"Sowade RF, Jahn TR. Seed-induced acceleration of amyloid-\u03b2 mediated neurotoxicity in vivo. Nat Commun. 2017;8:512.","journal-title":"Nat Commun"},{"key":"221_CR57","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0002-9440(10)64538-5","volume":"157","author":"AM Cataldo","year":"2000","unstructured":"Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer\u2019s disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol. 2000;157:277\u201386.","journal-title":"Am J Pathol"},{"key":"221_CR58","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/ana.20667","volume":"58","author":"SA Small","year":"2005","unstructured":"Small SA, Kent K, Pierce A, Leung C, Kang MS, Okada H, et al. Model-guided microarray implicates the retromer complex in Alzheimer\u2019s disease. Ann Neurol. 2005;58:909\u201319.","journal-title":"Ann Neurol"},{"key":"221_CR59","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.neurobiolaging.2012.04.020","volume":"33","author":"BN Vardarajan","year":"2012","unstructured":"Vardarajan BN, Bruesegem SY, Harbour ME, Inzelberg R, Friedland R, St George-Hyslop P, et al. Identification of Alzheimer disease-associated variants in genes that regulate retromer function. Neurobiol Aging. 2012;33:2231.","journal-title":"Neurobiol Aging"},{"key":"221_CR60","doi-asserted-by":"crossref","first-page":"13461","DOI":"10.1073\/pnas.0503689102","volume":"102","author":"OM Andersen","year":"2005","unstructured":"Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, et al. Neuronal sorting protein-related receptor sorLA\/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci USA. 2005;102:13461\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"key":"221_CR61","doi-asserted-by":"crossref","first-page":"32956","DOI":"10.1074\/jbc.M705073200","volume":"282","author":"V Schmidt","year":"2007","unstructured":"Schmidt V, Sporbert A, Rohe M, Reimer T, Rehm A, Andersen OM, Willnow TE. SorLA\/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1. J Biol Chem. 2007;282:32956\u201364.","journal-title":"J Biol Chem"},{"key":"221_CR62","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1074\/jbc.M114.619940","volume":"290","author":"A Mehmedbasic","year":"2015","unstructured":"Mehmedbasic A, Christensen SK, Nilsson J, R\u00fcetschi U, Gustafsen C, Poulsen AS, et al. SorLA complement-type repeat domains protect the amyloid precursor protein against processing. J Biol Chem. 2015;290:3359\u201376.","journal-title":"J Biol Chem"},{"key":"221_CR63","volume":"6","author":"A Lao","year":"2012","unstructured":"Lao A, Schmidt V, Schmitz Y, Willnow TE, Wolkenhauer O. Multi-compartmental modeling of SORLA\u2019s influence on amyloidogenic processing in Alzheimer\u2019s disease. BMC Syst Biol. 2012;6:74.","journal-title":"BMC Syst Biol"},{"key":"221_CR64","doi-asserted-by":"crossref","first-page":"223ra20","DOI":"10.1126\/scitranslmed.3007747","volume":"6","author":"S Caglayan","year":"2014","unstructured":"Caglayan S, Takagi-Niidome S, Liao F, Carlo AS, Schmidt V, Burgert T, et al. Lysosomal sorting of amyloid-\u03b2 by the SORLA receptor is impaired by a familial Alzheimer\u2019s disease mutation. Sci Transl Med. 2014;6:223ra20.","journal-title":"Sci Transl Med"},{"key":"221_CR65","doi-asserted-by":"crossref","first-page":"e40527","DOI":"10.1371\/journal.pone.0040527","volume":"7","author":"KL Sager","year":"2012","unstructured":"Sager KL, Wuu J, Herskowitz JH, Mufson EJ, Levey AI, Lah JJ. Neuronal LR11 expression does not differentiate between clinically-defined Alzheimer\u2019s disease and control brains. PLoS ONE. 2012;7:e40527.","journal-title":"PLoS ONE"},{"key":"221_CR66","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/humu.20953","volume":"30","author":"X Liang","year":"2009","unstructured":"Liang X, Slifer M, Martin ER, Schnetz-Boutaud N, Barlett J, Anderson B, et al. Genomic convergence to identify candidate genes for Alzheimer\u2019s disease on chromosome 10. Hum Mutat. 2009;30:463\u201371.","journal-title":"Hum Mutat"},{"key":"221_CR67","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.2337\/db06-1677","volume":"56","author":"MO Goodarzi","year":"2007","unstructured":"Goodarzi MO, Lehaman DM, Taylor KD, Guo X, Cui J, Quinones MJ, et al. SORCS1: a novel human type 2-diabetes susceptibility gene suggested by the mouse. Diabetes. 2007;56:1922\u20139.","journal-title":"Diabetes"},{"key":"221_CR68","doi-asserted-by":"crossref","first-page":"13110","DOI":"10.1523\/JNEUROSCI.3872-10.2010","volume":"30","author":"RF Lane","year":"2010","unstructured":"Lane RF, Raines SM, Steele JW, Ehrlich ME, Lah JA, Small SA, et al. Diabetes-associated SorCS1 regulates Alzheimer\u2019s amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. J Neurosci. 2010;30:13110\u20135.","journal-title":"J Neurosci"},{"key":"221_CR69","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40478-016-0282-y","volume":"4","author":"EM Knight","year":"2016","unstructured":"Knight EM, Ruiz HH, Kim SH, Harte JC, Hsieh W, Glabe C, Klein WL, Attie AD, Buettner C, Ehrlich ME, Gandy S. Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer\u2019s APP\/PSEN1 mice by gene targeting of diabetes-Alzheimer\u2019s-related Sorcs1. Acta Neuropath Commun. 2016;4:16.","journal-title":"Acta Neuropath Commun"},{"key":"221_CR70","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neurobiolaging.2016.12.025","volume":"52","author":"J Chu","year":"2017","unstructured":"Chu J, Pratic\u00f2 D. The retromer complex system in a transgenic mouse model of AD: influence of age. Neurobiol Aging. 2017;52:32\u20138.","journal-title":"Neurobiol Aging"},{"key":"221_CR71","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nrn.2015.1","volume":"17","author":"Y Wang","year":"2016","unstructured":"Wang Y, Mandelkow E. Tau in physiology and pathology. Nat Rev Neurosci. 2016;17:5\u201321.","journal-title":"Nat Rev Neurosci"},{"key":"221_CR72","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1074\/jbc.M112.394528","volume":"288","author":"JW Wu","year":"2013","unstructured":"Wu JW, Herman M, Liu L, Simoes S, Acker CM, Figueroa H, et al. Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons. J Biol Chem. 2013;288:1856\u201370.","journal-title":"J Biol Chem"},{"key":"221_CR73","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1074\/jbc.M113.515445","volume":"289","author":"CH Michel","year":"2014","unstructured":"Michel CH, Kumar S, Pinotsi D, Tunnacliffe A, St George-Hyslop P, Mandelkow E, et al. Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology. J Biol Chem. 2014;289:956\u201367.","journal-title":"J Biol Chem"},{"key":"221_CR74","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1093\/brain\/awl107","volume":"129","author":"E Siintola","year":"2006","unstructured":"Siintola E, Partanen S, Str\u00f6mme P, Haapanen A, Haltia M, Maehlen J, et al. Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis. Brain. 2006;129:1438\u201345.","journal-title":"Brain"},{"key":"221_CR75","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1086\/504159","volume":"78","author":"R Steinfeld","year":"2006","unstructured":"Steinfeld R, Reinhardt K, Schreiber K, Hillebrand M, Kraetzner R, Bruck W, et al. Cathepsin D deficiency is associated with a human neurodegenerative disorder. Am J Hum Genet. 2006;78:988\u201398.","journal-title":"Am J Hum Genet"},{"key":"221_CR76","doi-asserted-by":"crossref","first-page":"e1001026","DOI":"10.1371\/journal.pgen.1001026","volume":"6","author":"V Khurana","year":"2010","unstructured":"Khurana V, Elson-Schwab I, Fulga TA, Sharp KA, Loewen CA, Mulkearns E, et al. Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. PLoS Genet. 2010;6:e1001026.","journal-title":"PLoS Genet"},{"key":"221_CR77","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/jnc.13994","volume":"141","author":"L Rodriguez","year":"2017","unstructured":"Rodriguez L, Mohamed NV, Desjardins A, Lipp\u00e9 R, Fon EA, Leclerc N. Rab7A regulates tau secretion. J Neurochem. 2017;141:592\u2013605.","journal-title":"J Neurochem"},{"key":"221_CR78","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1091\/mbc.11.2.467","volume":"11","author":"C Bucci","year":"2000","unstructured":"Bucci C, Thomsen P, Nicoziani P, McCarthy J, van Deurs B. Rab7: a key to lysosome biogenesis. Mol Biol Cell. 2000;11:467\u201380.","journal-title":"Mol Biol Cell"},{"key":"221_CR79","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1083\/jcb.200804048","volume":"183","author":"R Rojas","year":"2008","unstructured":"Rojas R, van Vlijmen T, Mardones GA, Prabhu Y, Rojas AL, Mohammed S, et al. Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7. J Cell Biol. 2008;183:513\u201326.","journal-title":"J Cell Biol"},{"key":"221_CR80","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neuron.2014.02.018","volume":"82","author":"RWY Choy","year":"2014","unstructured":"Choy RW-Y, Park M, Temkin P, Herring BE, Marley A, Nicoll RA, von Zastrow M. Retromer mediates a discrete route of local membrane delivery to dendrites. Neuron. 2014;82:55\u201362.","journal-title":"Neuron"},{"key":"221_CR81","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neuron.2017.03.020","volume":"94","author":"P Temkin","year":"2017","unstructured":"Temkin P, Morishita W, Goswami D, Arendt K, Chen L, Malenka R. The retromer supports AMPA receptor trafficking during LTP. Neuron. 2017;94:74\u201382.","journal-title":"Neuron"},{"key":"221_CR82","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","volume":"119","author":"MV Sofroniew","year":"2010","unstructured":"Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. Acta Neuropathol. 2010;119:7\u201335.","journal-title":"Acta Neuropathol"},{"key":"221_CR83","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature09612","volume":"468","author":"C Eroglu","year":"2010","unstructured":"Eroglu C, Barres BA. Regulation of synaptic connectivity by glia. Nature. 2010;468:223\u201331.","journal-title":"Nature"},{"key":"221_CR84","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neulet.2013.12.071","volume":"565","author":"M Pekny","year":"2014","unstructured":"Pekny M, Wilhelmsson U, Pekna M. The dual role of astrocyte activation and reactive gliosis. Neurosci Lett. 2014;565:30\u20138.","journal-title":"Neurosci Lett"},{"key":"221_CR85","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13024-016-0098-z","volume":"11","author":"S S\u00f6llvander","year":"2016","unstructured":"S\u00f6llvander S, Nikitidou E, Brolin R, S\u00f6derberg L, Sehlin D, Lannfelt L, Erlandsson A. Accumulation of amyloid-\u03b2 by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons. Mol Neurodegener. 2016;11:38.","journal-title":"Mol Neurodegener"},{"key":"221_CR86","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13024-017-0197-5","volume":"12","author":"TR Jay","year":"2017","unstructured":"Jay TR, von Saucken VE, Landreth GE. TREM2 in neurodegenerative diseases. Mol Neurodegener. 2017;12:56.","journal-title":"Mol Neurodegener"},{"key":"221_CR87","doi-asserted-by":"crossref","first-page":"243ra86","DOI":"10.1126\/scitranslmed.3009093","volume":"6","author":"G Kleinberger","year":"2014","unstructured":"Kleinberger G, Yamanishi Y, Su\u00e1rez-Calvet M, Czirr E, Lohmann E, Cuyvers E, et al. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med. 2014;6:243ra86.","journal-title":"Sci Transl Med"},{"key":"221_CR88","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1111\/tra.12451","volume":"17","author":"J Yin","year":"2016","unstructured":"Yin J, Liu X, He Q, Zhou L, Yuan Z, Zhao S. Vps35-dependent recycling of Trem2 regulates microglial function. Traffic. 2016;17:1286\u201396.","journal-title":"Traffic"},{"key":"221_CR89","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuron.2016.09.016","volume":"92","author":"P Yuan","year":"2016","unstructured":"Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, et al. TREM2 haplo-deficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy. Neuron. 2016;92:252\u201364.","journal-title":"Neuron"},{"key":"221_CR90","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13024-017-0216-6","volume":"12","author":"SM Bemiller","year":"2017","unstructured":"Bemiller SM, McCray TJ, Allan K, Formica SV, Xu G, Wilson G, et al. TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy. Mol Neurodegener. 2017;12:74.","journal-title":"Mol Neurodegener"},{"key":"221_CR91","doi-asserted-by":"crossref","first-page":"11524","DOI":"10.1073\/pnas.1710311114","volume":"114","author":"CEG Leyns","year":"2017","unstructured":"Leyns CEG, Ulrich JD, Finn MB, Stewart FR, Koscal LJ, Remolina Serrano J, et al. TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy. Proc Natl Acad Sci USA. 2017;114:11524\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"key":"221_CR92","volume":"9","author":"D Ringe","year":"2009","unstructured":"Ringe D, Petsko GA. What are pharmacological chaperones and why are they interesting? J Biol. 2009;9:80.","journal-title":"J Biol"},{"key":"221_CR93","doi-asserted-by":"crossref","first-page":"11007","DOI":"10.1073\/pnas.1320556111","volume":"111","author":"M Oh","year":"2014","unstructured":"Oh M, Lee JH, Wang W, et al. Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated \u03b1-synuclein. Proc Natl Acad Sci USA. 2014;111:11007\u201312.","journal-title":"Proc Natl Acad Sci USA"},{"key":"221_CR94","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nchembio.1508","volume":"10","author":"VJ Mecozzi","year":"2014","unstructured":"Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, et al. Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol. 2014;10:443\u20139.","journal-title":"Nat Chem Biol"},{"key":"221_CR95","unstructured":"Zavodszky E,\u00a0Seaman MN,\u00a0Moreau K,\u00a0Jimenez-Sanchez M,\u00a0Breusegem SY,\u00a0Harbour ME,\u00a0Rubinsztein DC. Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy. Nat. Commun. 2014; 5: 3828"},{"issue":"9","key":"221_CR96","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/mp.2015.100","volume":"20","author":"A Rovelet-Lecrux","year":"2015","unstructured":"Rovelet-Lecrux A, Charbonnier C, Wallon D, Nicolas G, Seaman MNJ, Pottier C, et al. De novo deleterious genetic variations target a biological network centered on A\u00ce\u00b2 peptide in early-onset Alzheimer disease. Molecular Psychiatry. 2015; 20 :1046-1056","journal-title":"Molecular Psychiatry"},{"issue":"6","key":"221_CR97","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/mp.2015.121","volume":"21","author":"G Nicolas","year":"2015","unstructured":"Nicolas G, Charbonnier C, Wallon D, Quenez O, Bellenguez C, Grenier-Boley B, et al.\u00a0SORL1 rare variants: a major risk factor for familial early-onset Alzheimer's disease.\u00a0Mol Psychiatry.\u00a02016;\u00a021:831-6.","journal-title":"Molecular Psychiatry"},{"key":"221_CR98","doi-asserted-by":"crossref","unstructured":"Vardarajan BN, Zhang Y, Lee JH, Cheng R, Bohm C, Ghani M, et al. Coding mutations in SORL1 and Alzheimer disease.\u00a0Ann Neurol. 2015; 77:215-27.","DOI":"10.1002\/ana.24305"},{"issue":"22","key":"221_CR99","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.1093\/hmg\/ddx321","volume":"26","author":"Prasad Tammineni","year":"2017","unstructured":"Tammineni P, Jeong YY, Feng T, Aikal D, Cai Q. Impaired\u00a0axonal\u00a0retrograde\u00a0trafficking\u00a0of the\u00a0retromer\u00a0complex augments lysosomal deficits in Alzheimer's disease neurons.\u00a0Hum Mol Genet. 2017; 26:4352-4366","journal-title":"Human Molecular Genetics"},{"issue":"1","key":"221_CR100","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.nbd.2012.03.030","volume":"47","author":"Akhil Bhalla","year":"2012","unstructured":"Bhalla A, Vetanovetz CP, Morel E, Chamoun Z, Di Paolo G, Small SA.\u00a0The\u00a0location\u00a0and\u00a0trafficking\u00a0routes\u00a0of the\u00a0neuronal\u00a0retromer\u00a0and its role in amyloid precursor protein transport.\u00a0Neurobiol Dis.\u00a02012; 47:126-34","journal-title":"Neurobiology of Disease"},{"issue":"20","key":"221_CR101","doi-asserted-by":"crossref","first-page":"7327","DOI":"10.1073\/pnas.0802545105","volume":"105","author":"A. Muhammad","year":"2008","unstructured":"Muhammad A, Flores I, Zhang H, Yu R, Staniszewski A, Planel E, et al.\u00a0Retromer\u00a0deficiency\u00a0observed\u00a0in\u00a0Alzheimer's\u00a0disease\u00a0causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation.\u00a0Proc Natl Acad Sci U S A. 2008; 105:7327-32","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"6","key":"221_CR102","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1007\/s12035-015-9306-z","volume":"53","author":"Tuancheng Feng","year":"2015","unstructured":"Feng T, Niu M, Ji C, Gao Y, Wen J, Bu G, et al.\u00a0SNX15\u00a0Regulates\u00a0Cell\u00a0Surface\u00a0Recycling of\u00a0APP\u00a0and A\u03b2 Generation.\u00a0Mol Neurobiol.\u00a02016; 53:3690-3701","journal-title":"Molecular Neurobiology"},{"issue":"30","key":"221_CR103","doi-asserted-by":"crossref","first-page":"7996","DOI":"10.1523\/JNEUROSCI.0206-16.2016","volume":"36","author":"Timothy Y. Huang","year":"2016","unstructured":"Huang TY, Zhao Y, Li X, Wang X, Tseng IC, Thompson R, et al.\u00a0SNX27\u00a0and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein.\u00a0J Neurosci.\u00a02016; 36:7996-8011","journal-title":"The Journal of Neuroscience"},{"key":"221_CR104","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.nbd.2013.12.017","volume":"65","author":"Michael V. Morabito","year":"2014","unstructured":"Morabito MV, Berman DE, Schneider RT, Zhang Y, Leibel RL, Small SA.\u00a0Hyperleucinemia\u00a0causes\u00a0hippocampal\u00a0retromer deficiency linking diabetes to Alzheimer's disease.\u00a0Neurobiol Dis.\u00a02014; 65:188-92.","journal-title":"Neurobiology of Disease"},{"issue":"2","key":"221_CR105","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.nbd.2011.04.002","volume":"43","author":"Christopher P. Sullivan","year":"2011","unstructured":"Sullivan CP, Jay AG, Stack EC, Pakaluk M, Wadlinger E, Fine RE, et al.\u00a0Retromer\u00a0disruption\u00a0promotes\u00a0amyloidogenic APP processing.\u00a0Neurobiol Dis.\u00a02011; 43:338-45","journal-title":"Neurobiology of Disease"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41380-018-0221-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41380-018-0221-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41380-018-0221-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T09:19:56Z","timestamp":1720516796000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-018-0221-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,17]]},"references-count":105,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["221"],"URL":"https:\/\/doi.org\/10.1038\/s41380-018-0221-3","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,17]]},"assertion":[{"value":"17 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}