{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:19:01Z","timestamp":1790299141018,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["Brain\/MINDS"],"award-info":[{"award-number":["Brain\/MINDS"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["SRPBS"],"award-info":[{"award-number":["SRPBS"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["22110001"],"award-info":[{"award-number":["22110001"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["22110002"],"award-info":[{"award-number":["22110002"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1038\/s41380-018-0253-8","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T10:39:21Z","timestamp":1538563161000},"page":"2090-2110","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["The intellectual disability gene PQBP1 rescues Alzheimer\u2019s disease pathology"],"prefix":"10.1038","volume":"23","author":[{"given":"Hikari","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanoh","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xigui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Homma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Tagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0980-9896","authenticated-orcid":false,"given":"Aurelian","family":"Kerever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9659-9251","authenticated-orcid":false,"given":"Takashi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1970-6903","authenticated-orcid":false,"given":"Takaomi","family":"Saido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichi","family":"Muramatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyota","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Okazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"253_CR1","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1093\/hmg\/ddu475","volume":"24","author":"K Tagawa","year":"2015","unstructured":"Tagawa K, Homma H, Saito A, Fujita K, Chen X, Imoto S, et al. Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer\u2019s disease brain. Hum Mol Genet. 2015;24:540\u201358.","journal-title":"Hum Mol Genet"},{"key":"253_CR2","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1017\/S1355838200991982","volume":"6","author":"BJ Blencowe","year":"2000","unstructured":"Blencowe BJ, Bauren G, Eldridge AG, Issner R, Nickerson JA, et al. The SRm160\/300 splicing coactivator subunits. RNA. 2000;6:111\u201320.","journal-title":"RNA"},{"key":"253_CR3","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1038\/nrm2777","volume":"10","author":"M Chen","year":"2009","unstructured":"Chen M, Manley JL. Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat Rev Mol Cell Biol. 2009;10:741\u201354.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"253_CR4","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1006\/bbrc.1998.9725","volume":"253","author":"I Imafuku","year":"1998","unstructured":"Imafuku I, Waragai M, Takeuchi S, Kanazawa I, Kawabata M, Mouradian MM, et al. Polar amino acid-rich sequences bind to polyglutamine tracts. Biochem Biophys Res Commun. 1998;253:16\u201320.","journal-title":"Biochem Biophys Res Commun"},{"key":"253_CR5","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1093\/hmg\/8.6.977","volume":"8","author":"M Waragai","year":"1999","unstructured":"Waragai M, Lammers CH, Takeuchi S, Imafuku I, Udagawa Y, Kanazawa I, et al. PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival. Hum Mol Genet. 1999;8:977\u201387.","journal-title":"Hum Mol Genet"},{"key":"253_CR6","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/S0896-6273(02)00697-9","volume":"34","author":"H Okazawa","year":"2002","unstructured":"Okazawa H, Rich T, Chang A, Lin X, Waragai M, Kajikawa M, et al. Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death. Neuron. 2002;34:701\u201313.","journal-title":"Neuron"},{"key":"253_CR7","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/ng1264","volume":"35","author":"VM Kalscheuer","year":"2003","unstructured":"Kalscheuer VM, Freude K, Musante L, Jensen LR, Yntema HG, Gecz J, et al. Mutations in the polyglutamine binding protein 1 gene cause X-linked mental retardation. Nat Genet. 2003;35:313\u20135.","journal-title":"Nat Genet"},{"key":"253_CR8","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1086\/383205","volume":"74","author":"C Lenski","year":"2004","unstructured":"Lenski C, Abidi F, Meindl A, Gibson A, Platzer M, Frank Kooy R, et al. Novel truncating mutations in the polyglutamine tract binding protein 1 gene (PQBP1) cause Renpenning syndrome and X-linked mental retardation in another family with microcephaly. Am J Hum Genet. 2004;74:777\u201380.","journal-title":"Am J Hum Genet"},{"key":"253_CR9","doi-asserted-by":"publisher","first-page":"e30","DOI":"10.1136\/jmg.2005.037556","volume":"43","author":"H Lubs","year":"2006","unstructured":"Lubs H, Abidi FE, Echeverri R, Holloway L, Meindl A, Stevenson RE, et al. Golabi-Ito-Hall syndrome results from a missense mutation in the WW domain of the PQBP1 gene. J Med Genet. 2006;43:e30.","journal-title":"J Med Genet"},{"key":"253_CR10","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1002\/ajmg.a.30664","volume":"134","author":"RE Stevenson","year":"2005","unstructured":"Stevenson RE, Bennett CW, Abidi F, Kleefstra T, Porteous M, Simensen RJ, et al. Renpenning syndrome comes into focus. Am J Med Genet A. 2005;134:415\u201321.","journal-title":"Am J Med Genet A"},{"key":"253_CR11","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1126\/science.1077783","volume":"298","author":"EM Makarov","year":"2002","unstructured":"Makarov EM, Makarova OV, Urlaub H, Gentzel M, Will CL, Wilm M, et al. Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome. Science. 2002;298:2205\u20138.","journal-title":"Science"},{"key":"253_CR12","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1038\/sj.emboj.7600241","volume":"23","author":"OV Makarova","year":"2004","unstructured":"Makarova OV, Makarov EM, Urlaub H, Will CL, Gentzel M, Wilm M, et al. A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing. EMBO J. 2004;23:2381\u201391.","journal-title":"EMBO J"},{"key":"253_CR13","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1006\/bbrc.2000.2992","volume":"273","author":"M Waragai","year":"2000","unstructured":"Waragai M, Junn E, Kajikawa M, Takeuchi S, Kanazawa I, Shibata M, et al. PQBP-1\/Npw38, a nuclear protein binding to the polyglutamine tract, interacts with U5-15kD\/dim1p via the carboxyl-terminal domain. Biochem Biophys Res Commun. 2000;273:592\u20135.","journal-title":"Biochem Biophys Res Commun"},{"key":"253_CR14","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0378-1119(00)00372-3","volume":"257","author":"Y Zhang","year":"2000","unstructured":"Zhang Y, Lindblom T, Chang A, Sudol M, Sluder AE, Golemis EA. Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38\/PQBP-1. Gene. 2000;257:33\u201343.","journal-title":"Gene"},{"key":"253_CR15","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1101\/gad.212308.112","volume":"27","author":"Q Wang","year":"2013","unstructured":"Wang Q, Moore MJ, Adelmant G, Marto JA, Silver PA. PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth. Genes Dev. 2013;27:615\u201326.","journal-title":"Genes Dev"},{"key":"253_CR16","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/mp.2014.69","volume":"20","author":"H Ito","year":"2015","unstructured":"Ito H, Shiwaku H, Yoshida C, Homma H, Luo H, Chen X, et al. In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells. Mol Psychiatry. 2015;20:459\u201371.","journal-title":"Mol Psychiatry"},{"key":"253_CR17","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.celrep.2013.07.042","volume":"4","author":"Y Ikeuchi","year":"2013","unstructured":"Ikeuchi Y, de la Torre-Ubieta L, Matsuda T, Steen H, Okazawa H, Bonni A. The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons. Cell Rep. 2013;4:879\u201389.","journal-title":"Cell Rep"},{"key":"253_CR18","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/j.cell.2015.04.050","volume":"161","author":"SM Yoh","year":"2015","unstructured":"Yoh SM, Schneider M, Seifried J, Soonthornvacharin S, Akleh RE, Olivieri KC, et al. PQBP1 is a proximal sensor of the cGAS-dependent innate response to HIV-1. Cell. 2015;161:1293\u2013305.","journal-title":"Cell"},{"key":"253_CR19","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.molcel.2017.06.020","volume":"67","author":"M Morchikh","year":"2017","unstructured":"Morchikh M, Cribier A, Raffel R, Amraoui S, Cau J, Severac D, et al. HEXIM1 and NEAT1 long non-coding RNA form a multi-subunit complex that regulates DNA-mediated Innate immune response. Mol Cell. 2017;67:387\u201399 e385.","journal-title":"Mol Cell"},{"key":"253_CR20","doi-asserted-by":"publisher","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","volume":"26","author":"H Oakley","year":"2006","unstructured":"Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, et al. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: potential factors in amyloid plaque formation. J Neurosci. 2006;26:10129\u201340.","journal-title":"J Neurosci"},{"key":"253_CR21","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nn.3697","volume":"17","author":"T Saito","year":"2014","unstructured":"Saito T, Matsuba Y, Mihira N, Takano J, Nilsson P, Itohara S, et al. Single App knock-in mouse models of Alzheimer\u2019s disease. Nat Neurosci. 2014;17:661\u20133.","journal-title":"Nat Neurosci"},{"key":"253_CR22","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1538\/expanim.55.137","volume":"55","author":"H Kanki","year":"2006","unstructured":"Kanki H, Suzuki H, Itohara S. High-efficiency CAG-FLPe deleter mice in C57BL\/6J background. Exp Anim Tokyo. 2006;55:137\u201341.","journal-title":"Exp Anim Tokyo"},{"key":"253_CR23","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1038\/nprot.2007.207","volume":"2","author":"GJ Brewer","year":"2007","unstructured":"Brewer GJ, Torricelli JR. Isolation and culture of adult neurons and neurospheres. Nat Protoc. 2007;2:1490\u20138.","journal-title":"Nat Protoc"},{"key":"253_CR24","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1101\/gad.12.7.996","volume":"12","author":"BJ Blencowe","year":"1998","unstructured":"Blencowe BJ, Issner R, Nickerson JA, Sharp PA. A coactivator of pre-mRNA splicing. Genes Dev. 1998;12:996\u20131009.","journal-title":"Genes Dev"},{"key":"253_CR25","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nprot.2009.222","volume":"5","author":"G Yang","year":"2010","unstructured":"Yang G, Pan F, Parkhurst CN, Grutzendler J, Gan WB. Thinned-skull cranial window technique for long-term imaging of the cortex in live mice. Nat Protoc. 2010;5:201\u20138.","journal-title":"Nat Protoc"},{"key":"253_CR26","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.cell.2014.03.042","volume":"157","author":"EA Susaki","year":"2014","unstructured":"Susaki EA, Tainaka K, Perrin D, Kishino F, Tawara T, Watanabe TM, et al. Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis. Cell. 2014;157:726\u201339.","journal-title":"Cell"},{"key":"253_CR27","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1038\/nn.4107","volume":"18","author":"H Hama","year":"2015","unstructured":"Hama H, Hioki H, Namiki K, Hoshida T, Kurokawa H, Ishidate F, et al. ScaleS: an optical clearing palette for biological imaging. Nat Neurosci. 2015;18:1518\u201329.","journal-title":"Nat Neurosci"},{"key":"253_CR28","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1074\/mcp.T600050-MCP200","volume":"6","author":"IV Shilov","year":"2007","unstructured":"Shilov IV, Seymour SL, Patel AA, Loboda A, Tang WH, Keating SP, et al. The Paragon Algorithm, a next generation search engine that uses sequence temperature values and feature probabilities to identify peptides from tandem mass spectra. Mol Cell Proteom. 2007;6:1638\u201355.","journal-title":"Mol Cell Proteom"},{"key":"253_CR29","doi-asserted-by":"publisher","first-page":"5383","DOI":"10.1091\/mbc.e04-08-0715","volume":"15","author":"N Gilks","year":"2004","unstructured":"Gilks N, Kedersha N, Ayodele M, Shen L, Stoecklin G, Dember LM, et al. Stress granule assembly is mediated by prion-like aggregation of TIA-1. Mol Biol Cell. 2004;15:5383\u201398.","journal-title":"Mol Biol Cell"},{"key":"253_CR30","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1038\/ncb1333","volume":"7","author":"J Liu","year":"2005","unstructured":"Liu J, Rivas FV, Wohlschlegel J, Yates JR 3rd, Parker R, Hannon GJ. A role for the P-body component GW182 in microRNA function. Nat Cell Biol. 2005;7:1261\u20136.","journal-title":"Nat Cell Biol"},{"key":"253_CR31","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1242\/jcs.110.23.2925","volume":"110","author":"J Cotto","year":"1997","unstructured":"Cotto J, Fox S, Morimoto R. HSF1 granules: a novel stress-induced nuclear compartment of human cells. J Cell Sci. 1997;110:2925\u201334.","journal-title":"J Cell Sci"},{"key":"253_CR32","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.101","volume":"7","author":"Y Mao","year":"2016","unstructured":"Mao Y, Tamura T, Yuki Y, Abe D, Tamada Y, Imoto S, et al. The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing. Cell Death Dis. 2016;7:e2207.","journal-title":"Cell Death Dis"},{"key":"253_CR33","doi-asserted-by":"publisher","first-page":"3212","DOI":"10.1093\/hmg\/ddn217","volume":"17","author":"M Ikeda","year":"2008","unstructured":"Ikeda M, Hikita T, Taya S, Uraguchi-Asaki J, Toyo-oka K, Wynshaw-Boris A, et al. Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Human Mol Genet. 2008;17:3212\u201322.","journal-title":"Human Mol Genet"},{"key":"253_CR34","doi-asserted-by":"publisher","first-page":"4801","DOI":"10.1523\/JNEUROSCI.4393-13.2014","volume":"34","author":"HF Qiao","year":"2014","unstructured":"Qiao HF, Foote M, Graham K, Wu YY, Zhou Y. 14-3-3 proteins are required for hippocampal long-term potentiation and associative learning and memory. J Neurosci. 2014;34:4801\u20138.","journal-title":"J Neurosci"},{"key":"253_CR35","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1111\/cge.12773","volume":"90","author":"L Lange","year":"2016","unstructured":"Lange L, Pagnamenta AT, Lise S, Clasper S, Stewart H, Akha ES, et al. A de novo frameshift in HNRNPK causing a Kabuki-like syndrome with nodular heterotopia. Clin Genet. 2016;90:258\u201362.","journal-title":"Clin Genet"},{"key":"253_CR36","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1002\/humu.22837","volume":"36","author":"PYB Au","year":"2015","unstructured":"Au PYB, You J, Caluseriu O, Schwartzentruber J, Majewski J, Bernier FP, et al. GeneMatcher aids in the identification of a new malformation syndrome with intellectual disability, unique facial dysmorphisms, and skeletal and connective tissue abnormalities caused by de novo variants in HNRNPK. Hum Mutat. 2015;36:1009\u201314.","journal-title":"Hum Mutat"},{"key":"253_CR37","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1158\/1078-0432.CCR-14-2124","volume":"21","author":"ME Arcila","year":"2015","unstructured":"Arcila ME, Drilon A, Sylvester BE, Lovly CM, Borsu L, Reva B, et al. MAP2K1 (MEK1) mutations define a distinct subset of lung adenocarcinoma associated with smoking. Clin Cancer Res. 2015;21:1935\u201343.","journal-title":"Clin Cancer Res"},{"key":"253_CR38","doi-asserted-by":"publisher","first-page":"328","DOI":"10.15252\/emmm.201505846","volume":"8","author":"AJ Hinrich","year":"2016","unstructured":"Hinrich AJ, Jodelka FM, Chang JL, Brutman D, Bruno AM, Briggs CA, et al. Therapeutic correction of ApoER2 splicing in Alzheimer\u2019s disease mice using antisense oligonucleotides. EMBO Mol Med. 2016;8:328\u201345.","journal-title":"EMBO Mol Med"},{"key":"253_CR39","doi-asserted-by":"publisher","first-page":"16562","DOI":"10.1073\/pnas.1310249110","volume":"110","author":"B Bai","year":"2013","unstructured":"Bai B, Hales CM, Chen PC, Gozal Y, Dammer EB, Fritz JJ, et al. U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer\u2019s disease. Proc Natl Acad Sci USA. 2013;110:16562\u20137.","journal-title":"Proc Natl Acad Sci USA"},{"key":"253_CR40","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1038\/ncb1477","volume":"8","author":"S Tam","year":"2006","unstructured":"Tam S, Geller R, Spiess C, Frydman J. The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions. Nat Cell Biol. 2006;8:1155\u201362.","journal-title":"Nat Cell Biol"},{"key":"253_CR41","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13821","volume":"7","author":"M Pavel","year":"2016","unstructured":"Pavel M, Imarisio S, Menzies FM, Jimenez-Sanchez M, Siddiqi FH, Wu X, et al. CCT complex restricts neuropathogenic protein aggregation via autophagy. Nat Commun. 2016;7:13821.","journal-title":"Nat Commun"},{"key":"253_CR42","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/nm1298","volume":"11","author":"M Waza","year":"2005","unstructured":"Waza M, Adachi H, Katsuno M, Minamiyama M, Sang C, Tanaka F, et al. 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration. Nat Med. 2005;11:1088\u201395.","journal-title":"Nat Med"},{"key":"253_CR43","first-page":"2150","volume":"1843","author":"NJ Darling","year":"2014","unstructured":"Darling NJ, Cook SJ. The role of MAPK signalling pathways in the response to endoplasmic reticulum stress. Bba-Mol Cell Res. 2014;1843:2150\u201363.","journal-title":"Bba-Mol Cell Res"},{"key":"253_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/srep31895","volume":"6","author":"K Fujita","year":"2016","unstructured":"Fujita K, Motoki K, Tagawa K, Chen X, Hama H, Nakajima K, et al. HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer\u2019s disease. Sci Rep. 2016;6:31895.","journal-title":"Sci Rep"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41380-018-0253-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41380-018-0253-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41380-018-0253-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T20:59:12Z","timestamp":1684616352000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-018-0253-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["253"],"URL":"https:\/\/doi.org\/10.1038\/s41380-018-0253-8","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"9 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}