{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:31:57Z","timestamp":1790544717954,"version":"4.1.0"},"reference-count":184,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1038\/s41380-020-00965-3","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T09:03:51Z","timestamp":1608109431000},"page":"1044-1059","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":137,"title":["Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology"],"prefix":"10.1038","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3850-4867","authenticated-orcid":false,"given":"Deidiane Elisa","family":"Ribeiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8666-9471","authenticated-orcid":false,"given":"\u00c1gatha","family":"Oliveira-Giacomelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talita","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa F.","family":"Arnaud-Sampaio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Andrejew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz","family":"Dieckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Baranova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiana","family":"Lameu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz Z.","family":"Ratajczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2114-3815","authenticated-orcid":false,"given":"Henning","family":"Ulrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,16]]},"reference":[{"key":"965_CR1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.cell.2020.02.058","volume":"181","author":"AC Walls","year":"2020","unstructured":"Walls AC, Park Y-J, Tortorici MA, Wall A, McGuire AT, Veesler D. Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell. 2020;181:281\u201392.","journal-title":"Cell"},{"key":"965_CR2","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/s41564-020-0688-y","volume":"5","author":"M Letko","year":"2020","unstructured":"Letko M, Marzi A, Munster V. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nat Microbiol. 2020;5:562\u20139.","journal-title":"Nat Microbiol"},{"key":"965_CR3","doi-asserted-by":"publisher","unstructured":"Wang K, Chen W, Zhou Y-S, Lian J-Q, Zhang Z, Du P, et al. SARS-CoV-2 invades host cells via a novel route: CD147-spike protein. 2020. https:\/\/doi.org\/10.1101\/2020.03.14.988345.","DOI":"10.1101\/2020.03.14.988345"},{"key":"965_CR4","first-page":"1","volume":"2020","author":"H Ulrich","year":"2020","unstructured":"Ulrich H, Pillat MM. CD147 as a target for COVID-19 treatment: suggested effects of azithromycin and stem cell engagement. Stem Cell Rev Rep. 2020;2020:1\u20137.","journal-title":"Stem Cell Rev Rep"},{"key":"965_CR5","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","volume":"181","author":"M Hoffmann","year":"2020","unstructured":"Hoffmann M, Kleine-Weber H, Schroeder S, Kr\u00fcger N, Herrler T, Erichsen S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181:271\u201380.e8.","journal-title":"Cell"},{"key":"965_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15562-9","volume":"11","author":"X Ou","year":"2020","unstructured":"Ou X, Liu Y, Lei X, Li P, Mi D, Ren L, et al. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nat Commun. 2020;11:1620.","journal-title":"Nat Commun"},{"key":"965_CR7","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1038\/sj.leu.2404296","volume":"20","author":"J Ratajczak","year":"2006","unstructured":"Ratajczak J, Wysoczynski M, Hayek F, Janowska-Wieczorek A, Ratajczak MZ. Membrane-derived microvesicles: Important and underappreciated mediators of cell-to-cell communication. Leukemia. 2006;20:1487\u201395.","journal-title":"Leukemia"},{"key":"965_CR8","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1097\/00002030-200301030-00006","volume":"17","author":"T Rozmyslowicz","year":"2003","unstructured":"Rozmyslowicz T, Majka M, Kijowski J, Murphy SL, Conover DO, Poncz M, et al. Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV. AIDS. 2003;17:33\u201342.","journal-title":"AIDS"},{"key":"965_CR9","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.cytogfr.2020.04.002","volume":"53","author":"X Sun","year":"2020","unstructured":"Sun X, Wang T, Cai D, Hu Z, Chen J, Liao H, et al. Cytokine storm intervention in the early stages of COVID-19 pneumonia. Cytokine Growth Factor Rev. 2020;53:38\u201342.","journal-title":"Cytokine Growth Factor Rev"},{"key":"965_CR10","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1001\/jamaneurol.2020.2065","volume":"77","author":"AS Zubair","year":"2020","unstructured":"Zubair AS, McAlpine LS, Gardin T, Farhadian S, Kuruvilla DE, Spudich H. Neuropathogenesis and neurologic manifestations of the coronaviruses in the age of coronavirus disease 2019: a review. JAMA Neurol. 2020;77:1018\u201327.","journal-title":"JAMA Neurol"},{"key":"965_CR11","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1084\/jem.20050828","volume":"202","author":"J Gu","year":"2005","unstructured":"Gu J, Gong E, Zhang B, Zheng J, Gao Z, Zhong Y, et al. Multiple organ infection and the pathogenesis of SARS. J Exp Med. 2005;202:415\u201324.","journal-title":"J Exp Med"},{"key":"965_CR12","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1001\/jamaneurol.2020.2125","volume":"77","author":"LS Politi","year":"2020","unstructured":"Politi LS, Salsano E, Grimaldi M. Magnetic resonance imaging alteration of the brain in a patient with coronavirus disease 2019 (COVID-19) and anosmia. JAMA Neurol. 2020;77:1028\u20139.","journal-title":"JAMA Neurol"},{"key":"965_CR13","doi-asserted-by":"publisher","first-page":"E119","DOI":"10.1148\/radiol.2020201187","volume":"296","author":"N Poyiadji","year":"2020","unstructured":"Poyiadji N, Shahin G, Noujaim D, Stone M, Patel S, Griffith B. COVID-19-associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features. Radiology. 2020;296:E119\u201320.","journal-title":"Radiology"},{"key":"965_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00401-020-02166-2","volume":"140","author":"R Reichard","year":"2020","unstructured":"Reichard R, Kashani K, Boire N, Constantopoulos E, Guo Y, Lucchinetti C. Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM)-like pathology. Acta Neuropathol. 2020;140:1\u20136.","journal-title":"Acta Neuropathol"},{"key":"965_CR15","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nrneurol.2016.46","volume":"12","author":"JM Ferro","year":"2016","unstructured":"Ferro JM, Caeiro L, Figueira ML. Neuropsychiatric sequelae of stroke. Nat Rev Neurol. 2016;12:269\u201380.","journal-title":"Nat Rev Neurol"},{"key":"965_CR16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.immuni.2017.06.020","volume":"47","author":"F Di Virgilio","year":"2017","unstructured":"Di Virgilio F, Dal Ben D, Sarti AC, Giuliani AL, Falzoni S. The P2X7 receptor in infection and inflammation. Immunity. 2017;47:15\u201331.","journal-title":"Immunity"},{"key":"965_CR17","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s12015-019-09888-1","volume":"15","author":"MZ Ratajczak","year":"2019","unstructured":"Ratajczak MZ, Mack A, Bujko K, Domingues A, Pedziwiatr D, Kucia M, et al. ATP-Nlrp3 inflammasome-complement cascade axis in sterile brain inflammation in psychiatric patients and its impact on stem cell trafficking. Stem Cell Rev Rep. 2019;15:497\u2013505.","journal-title":"Stem Cell Rev Rep"},{"key":"965_CR18","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1038\/s41375-020-0827-8","volume":"34","author":"MZ Ratajczak","year":"2020","unstructured":"Ratajczak MZ, Bujko K, Cymer M, Thapa A, Adamiak M, Ratajczak J, et al. The Nlrp3 inflammasome as a \u201crising star\u201d in studies of normal and malignant hematopoiesis. Leukemia. 2020;34:1512\u201323.","journal-title":"Leukemia"},{"key":"965_CR19","doi-asserted-by":"crossref","unstructured":"Sluyter R. The P2X7 receptor. In: Atassi M, editor. Protein reviews. Advances in experimental medicine and biology. Singapore: Springer; 2017. p. 17\u201353.","DOI":"10.1007\/5584_2017_59"},{"key":"965_CR20","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.bcp.2017.12.021","volume":"151","author":"E Adinolfi","year":"2018","unstructured":"Adinolfi E, Giuliani AL, De Marchi E, Pegoraro A, Orioli E, Di Virgilio F. The P2X7 receptor: a main player in inflammation. Biochem Pharmacol. 2018;151:234\u201344.","journal-title":"Biochem Pharmacol."},{"key":"965_CR21","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.tips.2014.08.002","volume":"35","author":"B Sperl\u00e1gh","year":"2014","unstructured":"Sperl\u00e1gh B, Illes P. P2X7 receptor: An emerging target in central nervous system diseases. Trends Pharm Sci. 2014;35:537\u201347.","journal-title":"Trends Pharm Sci"},{"key":"965_CR22","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/s41582-020-0398-3","volume":"16","author":"A Pezzini","year":"2020","unstructured":"Pezzini A, Padovani A. Lifting the mask on neurological manifestations of COVID-19. Nat Rev Neurol. 2020;16:636\u201344.","journal-title":"Nat Rev Neurol."},{"key":"965_CR23","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.thromres.2020.04.013","volume":"191","author":"FA Klok","year":"2020","unstructured":"Klok FA, Kruip MJHA, van der Meer NJM, Arbous MS, Gommers DAMPJ, Kant KM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020;191:145\u20137.","journal-title":"Thromb Res"},{"key":"965_CR24","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1021\/acschemneuro.0c00172","volume":"11","author":"R Butowt","year":"2020","unstructured":"Butowt R, Bilinska K. SARS-CoV-2: olfaction, brain infection, and the urgent need for clinical samples allowing earlier virus detection. ACS Chem Neurosci. 2020;11:1200\u20133.","journal-title":"ACS Chem Neurosci"},{"key":"965_CR25","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1056\/NEJMc2011400","volume":"383","author":"VG Puelles","year":"2020","unstructured":"Puelles VG, L\u00fctgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L, et al. Multiorgan and renal tropism of SARS-CoV-2 [letter]. N Engl J Med. 2020;383:590\u201392.","journal-title":"N Engl J Med."},{"key":"965_CR26","doi-asserted-by":"publisher","unstructured":"Song E, Zhang C, Israelow B, Lu-Culligan A, Prado AV, Skriabine S, et al. Neuroinvasion of SARS-CoV-2 in human and mouse brain. 2020. https:\/\/doi.org\/10.1101\/2020.06.25.169946.","DOI":"10.1101\/2020.06.25.169946"},{"key":"965_CR27","doi-asserted-by":"publisher","unstructured":"Gomes IC, Karmirian K, Oliveira J, Pedrosa C, Rosman FC, Chimelli L, et al. SARS-CoV-2 infection in the central nervous system of a 1-year-old infant submitted to complete autopsy. 2020:2020090297. https:\/\/doi.org\/10.20944\/preprints202009.0297.v1.","DOI":"10.20944\/preprints202009.0297.v1"},{"key":"965_CR28","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1002\/jmv.25915","volume":"92","author":"A Paniz-Mondolfi","year":"2020","unstructured":"Paniz-Mondolfi A, Bryce C, Grimes Z, Gordon RE, Reidy J, Lednicky J, et al. Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). J Med Virol. 2020;92:699\u2013702.","journal-title":"J Med Virol"},{"key":"965_CR29","first-page":"18","volume":"6","author":"A Yarlagadda","year":"2009","unstructured":"Yarlagadda A, Alfson E, Clayton AH. The blood\u2013brain barrier and the role of cytokines in neuropsychiatry. Psychiatry. 2009;6:18\u201322.","journal-title":"Psychiatry"},{"key":"965_CR30","doi-asserted-by":"publisher","first-page":"3729","DOI":"10.2174\/138161211798220918","volume":"17","author":"W Pan","year":"2011","unstructured":"Pan W, Stone KP, Hsuchou H, Manda VK, Zhang Y, Kastin AJ. Cytokine signaling modulates blood\u2013brain barrier function. Curr Pharm Des. 2011;17:3729\u201340.","journal-title":"Curr Pharm Des"},{"key":"965_CR31","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.tim.2012.03.009","volume":"20","author":"KR Spindler","year":"2012","unstructured":"Spindler KR, Hsu TH. Viral disruption of the blood\u2013brain barrier. Trends Microbiol. 2012;20:282\u201390.","journal-title":"Trends Microbiol"},{"key":"965_CR32","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1002\/jmv.25728","volume":"92","author":"YC Li","year":"2020","unstructured":"Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol. 2020;92:552\u20135.","journal-title":"J Med Virol"},{"key":"965_CR33","doi-asserted-by":"publisher","unstructured":"Fodoulian L, Tuberosa J, Rossier D, Landis B, Carleton A, Rodriguez I. SARS-CoV-2 receptor and entry genes are expressed by sustentacular cells in the human olfactory neuroepithelium. 2020. https:\/\/doi.org\/10.1101\/2020.03.31.013268.","DOI":"10.1101\/2020.03.31.013268"},{"key":"965_CR34","doi-asserted-by":"publisher","first-page":"eabc5801","DOI":"10.1126\/sciadv.abc5801","volume":"6","author":"DH Brann","year":"2020","unstructured":"Brann DH, Tsukahara T, Weinreb C, Lipovsek M, Van den Berge K, Gong B, et al. Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. Sci Adv. 2020;6:eabc5801.","journal-title":"Sci Adv"},{"key":"965_CR35","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1128\/JVI.02012-06","volume":"81","author":"PB McCray","year":"2007","unstructured":"McCray PB, Pewe L, Wohlford-Lenane C, Hickey M, Manzel L, Shi L, et al. Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol. 2007;81:813\u201321.","journal-title":"J Virol"},{"key":"965_CR36","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/S0042-6822(03)00323-4","volume":"315","author":"H Jacomy","year":"2003","unstructured":"Jacomy H, Talbot PJ. Vacuolating encephalitis in mice infected by human coronavirus OC43. Virology. 2003;315:20\u201333.","journal-title":"Virology"},{"key":"965_CR37","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1093\/infdis\/jiv499","volume":"213","author":"K Li","year":"2016","unstructured":"Li K, Wohlford-Lenane C, Perlman S, Zhao J, Jewell AK, Reznikov LR, et al. Middle east respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4. J Infect Dis. 2016;213:712\u201322.","journal-title":"J Infect Dis"},{"key":"965_CR38","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/S2213-2600(20)30076-X","volume":"8","author":"Z Xu","year":"2020","unstructured":"Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8:420\u20132.","journal-title":"Lancet Respir Med"},{"key":"965_CR39","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1165\/rcmb.2011-0392TR","volume":"46","author":"M Bhatia","year":"2012","unstructured":"Bhatia M, Zemans RL, Jeyaseelan S. Role of chemokines in the pathogenesis of acute lung injury. Am J Respir Cell Mol Biol. 2012;46:566\u201372.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"965_CR40","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/cr.2009.139","volume":"20","author":"JR Dunkelberger","year":"2010","unstructured":"Dunkelberger JR, Song WC. Complement and its role in innate and adaptive immune responses. Cell Res. 2010;20:34\u201350.","journal-title":"Cell Res"},{"key":"965_CR41","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","volume":"19","author":"KV Swanson","year":"2019","unstructured":"Swanson KV, Deng M, Ting JP. The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol. 2019;19:477\u201389.","journal-title":"Nat Rev Immunol"},{"key":"965_CR42","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/cmi.2016.34","volume":"14","author":"D Bertheloot","year":"2017","unstructured":"Bertheloot D, Latz E. HMGB1, IL-1alpha, IL-33 and S100 proteins: dual-function alarmins. Cell Mol Immunol. 2017;14:43\u201364.","journal-title":"Cell Mol Immunol"},{"key":"965_CR43","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/s41440-020-0455-8","volume":"43","author":"H Kai","year":"2020","unstructured":"Kai H, Kai M. Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors\u2014lessons from available evidence and insights into COVID-19. Hypertens Res. 2020;43:648\u201354.","journal-title":"Hypertens Res"},{"key":"965_CR44","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3389\/fncel.2017.00227","volume":"11","author":"F Albalawi","year":"2017","unstructured":"Albalawi F, Lu W, Beckel JM, Lim JC, McCaughey SA, Mitchell CH. The P2X7 receptor primes IL-1beta and the NLRP3 inflammasome in astrocytes exposed to mechanical strain. Front Cell Neurosci. 2017;11:227.","journal-title":"Front Cell Neurosci"},{"key":"965_CR45","doi-asserted-by":"publisher","first-page":"829","DOI":"10.36660\/abc.20200308","volume":"114","author":"JHP Nascimento","year":"2020","unstructured":"Nascimento JHP, Gomes BF, de O, Do Carmo J\u00fanior PR, Petriz JLF, Rizk SI, et al. Covid-19 and hypercoagulable state: a new therapeutic perspective. Arq Bras Cardiol. 2020;114:829\u201333.","journal-title":"Arq Bras Cardiol"},{"key":"965_CR46","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3389\/fpsyt.2018.00060","volume":"9","author":"MZ Ratajczak","year":"2018","unstructured":"Ratajczak MZ, Pedziwiatr D, Cymer M, Kucia M, Kucharska-Mazur J, Samochowiec J. Sterile inflammation of brain, due to activation of innate immunity, as a culprit in psychiatric disorders. Front Psychiatry. 2018;9:60.","journal-title":"Front Psychiatry"},{"key":"965_CR47","doi-asserted-by":"crossref","unstructured":"Burnstock G, Kennedy C. P2X receptors in health and disease. In: Advances in pharmacology, vol. 61. Academic Press Inc; 2011. p. 333\u201372.","DOI":"10.1016\/B978-0-12-385526-8.00011-4"},{"key":"965_CR48","doi-asserted-by":"publisher","first-page":"883","DOI":"10.4049\/jimmunol.1801101","volume":"202","author":"L Janks","year":"2019","unstructured":"Janks L, Sprague RS, Egan TM. ATP-gated P2X7 receptors require chloride channels to promote inflammation in human macrophages. J Immunol. 2019;202:883\u201398.","journal-title":"J Immunol"},{"key":"965_CR49","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.bbrc.2004.05.048","volume":"319","author":"Z Chen","year":"2004","unstructured":"Chen Z, Jin N, Narasaraju T, Chen J, McFarland LR, Scott M, et al. Identification of two novel markers for alveolar epithelial type I and II cells. Biochem Biophys Res Commun. 2004;319:774\u201380.","journal-title":"Biochem Biophys Res Commun"},{"key":"965_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7554\/eLife.36217","volume":"7","author":"K Kaczmarek-Hajek","year":"2018","unstructured":"Kaczmarek-Hajek K, Zhang J, Kopp R, Grosche A, Rissiek B, Saul A, et al. Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody. Elife. 2018;7:1\u201329.","journal-title":"Elife"},{"key":"965_CR51","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s11302-016-9546-z","volume":"13","author":"MW Metzger","year":"2017","unstructured":"Metzger MW, Walser SM, Aprile-Garcia F, Dedic N, Chen A, Holsboer F, et al. Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice. Purinergic Signal. 2017;13:153\u201370.","journal-title":"Purinergic Signal"},{"key":"965_CR52","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0904-8","volume":"14","author":"Y He","year":"2017","unstructured":"He Y, Taylor N, Fourgeaud L, Bhattacharya A. The role of microglial P2X7: modulation of cell death and cytokine release. J Neuroinflammation. 2017;14:135.","journal-title":"J Neuroinflammation"},{"key":"965_CR53","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1046\/j.1471-4159.2002.00920.x","volume":"81","author":"B Sperl\u00e1gh","year":"2002","unstructured":"Sperl\u00e1gh B, K\u00f6falvi A, Deuchars J, Atkinson L, Milligan CJ, Buckley NJ, et al. Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus. J Neurochem. 2002;81:1196\u2013211.","journal-title":"J Neurochem"},{"key":"965_CR54","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1111\/j.1471-4159.2005.03465.x","volume":"95","author":"K Wirkner","year":"2005","unstructured":"Wirkner K, K\u00f6falvi A, Fischer W, G\u00fcnther A, Franke H, Gr\u00f6ger-Arndt H, et al. Supersensitivity of P2X7 receptors in cerebrocortical cell cultures after in vitro ischemia. J Neurochem. 2005;95:1421\u201337.","journal-title":"J Neurochem"},{"key":"965_CR55","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.brainres.2007.11.064","volume":"1194","author":"Y Yu","year":"2008","unstructured":"Yu Y, Ugawa S, Ueda T, Ishida Y, Inoue K, Kyaw Nyunt A, et al. Cellular localization of P2X7 receptor mRNA in the rat brain. Brain Res. 2008;1194:45\u201355.","journal-title":"Brain Res"},{"key":"965_CR56","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.tins.2006.03.003","volume":"29","author":"CM Anderson","year":"2006","unstructured":"Anderson CM, Nedergaard M. Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons. Trends Neurosci. 2006;29:257\u201362.","journal-title":"Trends Neurosci"},{"key":"965_CR57","doi-asserted-by":"publisher","first-page":"7049","DOI":"10.1523\/JNEUROSCI.3103-16.2017","volume":"37","author":"P Illes","year":"2017","unstructured":"Illes P, Khan TM, Rubini P. Neuronal P2X7 receptors revisited: do they really exist? J Neurosci. 2017;37:7049\u201362.","journal-title":"J Neurosci"},{"key":"965_CR58","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.brainresbull.2018.07.016","volume":"151","author":"MT Khan","year":"2018","unstructured":"Khan MT, Deussing J, Tang Y, Illes P. Astrocytic rather than neuronal P2X7 receptors modulate the function of the tri-synaptic network in the rodent hippocampus. Brain Res Bull. 2018;151:164\u201373.","journal-title":"Brain Res Bull"},{"key":"965_CR59","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.neuroscience.2009.02.026","volume":"160","author":"W Fischer","year":"2009","unstructured":"Fischer W, Appelt K, Grohmann M, Franke H, N\u00f6renberg W, Illes P. Increase of intracellular Ca2+ by P2X and P2Y receptor-subtypes in cultured cortical astroglia of the rat. Neuroscience. 2009;160:767\u201383.","journal-title":"Neuroscience"},{"key":"965_CR60","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1007\/s00210-014-1005-1","volume":"387","author":"P Rubini","year":"2014","unstructured":"Rubini P, Pagel G, Mehri S, Marquardt P, Riedel T, Illes P. Functional P2X7 receptors at cultured hippocampal astrocytes but not neurons. Naunyn Schmiedebergs Arch Pharm. 2014;387:943\u201354.","journal-title":"Naunyn Schmiedebergs Arch Pharm"},{"key":"965_CR61","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1038\/s41375-020-0887-9","volume":"34","author":"MZ Ratajczak","year":"2020","unstructured":"Ratajczak MZ, Kucia M. SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine \u201cstorm\u201d and risk factor for damage of hematopoietic stem cells. Leukemia. 2020;34:1726\u20139.","journal-title":"Leukemia"},{"key":"965_CR62","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1038\/sj.bjp.0701278","volume":"121","author":"IP Chessell","year":"1997","unstructured":"Chessell IP, Michel AD, Humphrey PPA. Properties of the pore-forming P2X7 purinoceptor in mouse NTW8 microglial cells. Br J Pharm. 1997;121:1429\u201337.","journal-title":"Br J Pharm"},{"key":"965_CR63","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1038\/sj.bjp.0701958","volume":"124","author":"IP Chessell","year":"1998","unstructured":"Chessell IP, Michel AD, Humphrey PPA. Effects of antagonists at the human recombinant P2X7 receptor. Br J Pharm. 1998;124:1314\u201320.","journal-title":"Br J Pharm"},{"key":"965_CR64","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.tcb.2018.01.005","volume":"28","author":"F Di Virgilio","year":"2018","unstructured":"Di Virgilio F, Schmalzing G, Markwardt F. The elusive P2X7 macropore. Trends Cell Biol. 2018;28:392\u2013404.","journal-title":"Trends Cell Biol"},{"key":"965_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnmol.2019.00183","volume":"12","author":"R Kopp","year":"2019","unstructured":"Kopp R, Krautloher A, Ram\u00edrez-Fern\u00e1ndez A, Nicke A. P2X7 interactions and signaling\u2014making head or tail of it. Front Mol Neurosci. 2019;12:1\u201325.","journal-title":"Front Mol Neurosci"},{"key":"965_CR66","doi-asserted-by":"publisher","first-page":"41","DOI":"10.2174\/187221511794839219","volume":"5","author":"R Sluyter","year":"2011","unstructured":"Sluyter R, Stokes L. Significance of p2x7 receptor variants to human health and disease. Recent Pat DNA Gene Seq. 2011;5:41\u201354.","journal-title":"Recent Pat DNA Gene Seq"},{"key":"965_CR67","doi-asserted-by":"publisher","first-page":"20120101","DOI":"10.1098\/rsfs.2012.0101","volume":"3","author":"S Falzoni","year":"2013","unstructured":"Falzoni S, Donvito G, Di Virgilio F. Detecting adenosine triphosphate in the pericellular space. Interface Focus. 2013;3:20120101.","journal-title":"Interface Focus"},{"key":"965_CR68","doi-asserted-by":"publisher","first-page":"e2599","DOI":"10.1371\/journal.pone.0002599","volume":"3","author":"P Pellegatti","year":"2008","unstructured":"Pellegatti P, Raffaghello L, Bianchi G, Piccardi F, Pistoia V, Di Virgilio F. Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferase. PLoS ONE. 2008;3:e2599.","journal-title":"PLoS ONE"},{"key":"965_CR69","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1038\/nm.2242","volume":"16","author":"K Wilhelm","year":"2010","unstructured":"Wilhelm K, Ganesan J, Grimm M, Beilhack A, Krempl CD, Sorichter S, et al. Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R. Nat Med. 2010;16:1434\u20139.","journal-title":"Nat Med"},{"key":"965_CR70","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.1096\/fj.12-205765","volume":"26","author":"M Barber\u00e0\u2010Cremades","year":"2012","unstructured":"Barber\u00e0\u2010Cremades M, Baroja-Mazo A, Gomez AI, Machado F, Di Virgilio F, Pelegr\u00edn P. P2X7 receptor\u2010stimulation causes fever via PGE2 and IL\u20101\u03b2 release. FASEB J. 2012;26:2951\u201362.","journal-title":"FASEB J"},{"key":"965_CR71","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/cmi.2015.95","volume":"13","author":"EK Jo","year":"2016","unstructured":"Jo EK, Kim JK, Shin DM, Sasakawa C. Molecular mechanisms regulating NLRP3 inflammasome activation. Cell Mol Immunol. 2016;13:148\u201359.","journal-title":"Cell Mol Immunol"},{"key":"965_CR72","first-page":"1","volume":"10","author":"A Gustin","year":"2015","unstructured":"Gustin A, Kirchmeyer M, Koncina E, Felten P, Losciuto S, Heurtaux T, et al. NLRP3 inflammasome is expressed and functional in mouse brain microglia but not in astrocytes. PLoS ONE. 2015;10:1\u201319.","journal-title":"PLoS ONE"},{"key":"965_CR73","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.psyneuen.2018.08.015","volume":"98","author":"A Bhattacharya","year":"2018","unstructured":"Bhattacharya A, Jones DNC. Emerging role of the P2X7-NLRP3-IL1\u03b2 pathway in mood disorders. Psychoneuroendocrinology. 2018;98:95\u2013100.","journal-title":"Psychoneuroendocrinology"},{"key":"965_CR74","doi-asserted-by":"publisher","first-page":"C1538","DOI":"10.1152\/ajpcell.1998.275.6.C1538","volume":"275","author":"DG Perregaux","year":"1998","unstructured":"Perregaux DG, Gabel CA. Human monocyte stimulus-coupled IL-1\u03b2 posttranslational processing: modulation via monovalent cations. Am J Physiol - Cell Physiol. 1998;275:C1538\u201347.","journal-title":"Am J Physiol - Cell Physiol"},{"key":"965_CR75","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.4049\/jimmunol.179.3.1913","volume":"179","author":"Y Qu","year":"2007","unstructured":"Qu Y, Franchi L, Nunez G, Dubyak GR. Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages. J Immunol. 2007;179:1913\u201325.","journal-title":"J Immunol"},{"key":"965_CR76","doi-asserted-by":"publisher","first-page":"7268","DOI":"10.4049\/jimmunol.174.11.7268","volume":"174","author":"F Bianco","year":"2005","unstructured":"Bianco F, Pravettoni E, Colombo A, Schenk U, M\u00f6ller T, Matteoli M, et al. Astrocyte-derived ATP induces vesicle shedding and IL-1\u03b2 release from microglia. J Immunol. 2005;174:7268\u201377.","journal-title":"J Immunol"},{"key":"965_CR77","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/j.1471-4159.2008.05744.x","volume":"108","author":"A Kataoka","year":"2009","unstructured":"Kataoka A, Tozaki-Saitoh H, Koga Y, Tsuda M, Inoue K. Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT. J Neurochem. 2009;108:115\u201325.","journal-title":"J Neurochem"},{"key":"965_CR78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1523\/JNEUROSCI.3792-03.2004","volume":"24","author":"T Suzuki","year":"2004","unstructured":"Suzuki T, Hide I, Ido K, Kohsaka S, Inoue K, Nakata Y. Production and release of neuroprotective tumor necrosis factor by P2X 7 receptor-activated microglia. J Neurosci. 2004;24:1\u20137.","journal-title":"J Neurosci"},{"key":"965_CR79","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1002\/glia.22628","volume":"62","author":"CH Shieh","year":"2014","unstructured":"Shieh CH, Heinrich A, Serchov T, van Calker D, Biber K. P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-\u03b1 in cultured mouse microglia. Glia. 2014;62:592\u2013607.","journal-title":"Glia"},{"key":"965_CR80","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1111\/j.1471-4159.2010.06809.x","volume":"114","author":"M Shiratori","year":"2010","unstructured":"Shiratori M, Tozaki-Saitoh H, Yoshitake M, Tsuda M, Inoue K. P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC\/MAPK pathways. J Neurochem. 2010;114:810\u20139.","journal-title":"J Neurochem"},{"key":"965_CR81","doi-asserted-by":"publisher","first-page":"169","DOI":"10.4103\/2319-4170.127803","volume":"37","author":"A Morandini","year":"2014","unstructured":"Morandini A, Savio L, Coutinho-Silva R. The role of p2x7 receptor in infectious inflammatory diseases and the influence of ectonucleotidases. Biomed J. 2014;37:169\u201377.","journal-title":"Biomed J"},{"key":"965_CR82","doi-asserted-by":"crossref","unstructured":"Savio LEB, Mello P de A, da Silva CG, Coutinho-Silva R. The P2X7 receptor in inflammatory diseases: angel or demon? Front Pharmacol. 2018;9:1\u201331.","DOI":"10.3389\/fphar.2018.00052"},{"key":"965_CR83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-019-10626-x","volume":"10","author":"J Mart\u00ednez-Garc\u00eda","year":"2019","unstructured":"Mart\u00ednez-Garc\u00eda J, Mart\u00ednez-Banaclocha H, Angosto-Bazarra D, De Torre-Minguela C, Baroja-Mazo A, Alarc\u00f3n-Vila C, et al. P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis. Nat Commun. 2019;10:1\u201314.","journal-title":"Nat Commun"},{"key":"965_CR84","doi-asserted-by":"publisher","first-page":"6459","DOI":"10.1007\/s12035-016-0168-9","volume":"54","author":"LEB Savio","year":"2017","unstructured":"Savio LEB, Juste Andrade MG, de Andrade Mello P, Teixeira Santana P, Cristina Abreu Moreira-Souza A, Kolling J, et al. P2X7 receptor signaling contributes to sepsis-associated brain dysfunction. Mol Neurobiol. 2017;54:6459\u201370.","journal-title":"Mol Neurobiol"},{"key":"965_CR85","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.pain.2005.01.002","volume":"114","author":"IP Chessell","year":"2005","unstructured":"Chessell IP, Hatcher JP, Bountra C, Michel AD, Hughes JP, Green P, et al. Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain. 2005;114:386\u201396.","journal-title":"Pain"},{"key":"965_CR86","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1096\/fj.08-126458","volume":"23","author":"L Yip","year":"2009","unstructured":"Yip L, Woehrle T, Corriden R, Hirsh M, Chen Y, Inoue Y, et al. Autocrine regulation of T\u2010cell activation by ATP release and P2X7 receptors. FASEB J. 2009;23:1685\u201393.","journal-title":"FASEB J"},{"key":"965_CR87","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1152\/ajplung.00417.2015","volume":"310","author":"L Galam","year":"2016","unstructured":"Galam L, Rajan A, Failla A, Soundararajan R, Lockey RF, Kolliputi N. Deletion of P2X7 attenuates hyperoxia-induced acute lung injury via inflammasome suppression. Am J Physiol - Lung Cell Mol Physiol. 2016;310:572\u201381.","journal-title":"Am J Physiol - Lung Cell Mol Physiol"},{"key":"965_CR88","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.molimm.2018.07.027","volume":"101","author":"L Duan","year":"2018","unstructured":"Duan L, Hu Ghuang, Li Yjin, Zhang Cliang, Jiang M. P2X7 receptor is involved in lung injuries induced by ischemia-reperfusion in pulmonary arterial hypertension rats. Mol Immunol. 2018;101:409\u201318.","journal-title":"Mol Immunol"},{"key":"965_CR89","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1164\/rccm.201003-0359OC","volume":"182","author":"N Riteau","year":"2010","unstructured":"Riteau N, Gasse P, Fauconnier L, Gombault A, Couegnat M, Fick L, et al. Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am J Respir Crit Care Med. 2010;182:774\u201383.","journal-title":"Am J Respir Crit Care Med"},{"key":"965_CR90","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.intimp.2015.04.035","volume":"27","author":"S Wang","year":"2015","unstructured":"Wang S, Zhao J, Wang H, Liang Y, Yang N, Huang Y. Blockage of P2X7 attenuates acute lung injury in mice by inhibiting NLRP3 inflammasome. Int Immunopharmacol. 2015;27:38\u201345.","journal-title":"Int Immunopharmacol"},{"key":"965_CR91","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yexcr.2018.03.002","volume":"366","author":"R Li","year":"2018","unstructured":"Li R, Wang J, Li R, Zhu F, Xu W, Zha G, et al. ATP\/P2X7-NLRP3 axis of dendritic cells participates in the regulation of airway inflammation and hyper-responsiveness in asthma by mediating HMGB1 expression and secretion. Exp Cell Res. 2018;366:1\u201315.","journal-title":"Exp Cell Res"},{"key":"965_CR92","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/mp.2017.188","volume":"23","author":"A Cheffer","year":"2018","unstructured":"Cheffer A, Castillo AR, Corr\u00eaa-Velloso JC, Gon\u00e7alves MCB, Naaldijk Y, Nascimento IC, et al. Purinergic system in psychiatric diseases. Mol Psychiatry. 2018;23:94\u2013106.","journal-title":"Mol Psychiatry"},{"key":"965_CR93","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1002\/glia.23001","volume":"64","author":"A Bhattacharya","year":"2016","unstructured":"Bhattacharya A, Biber K. The microglial ATP-gated ion channel P2X7 as a CNS drug target. Glia. 2016;64:1772\u201387.","journal-title":"Glia"},{"key":"965_CR94","doi-asserted-by":"publisher","first-page":"257","DOI":"10.2174\/1871527315666160922104848","volume":"16","author":"G Burnstock","year":"2017","unstructured":"Burnstock G. Purinergic signalling and neurological diseases: an update. CNS Neurol Disord - Drug Targets. 2017;16:257\u201365.","journal-title":"CNS Neurol Disord - Drug Targets"},{"key":"965_CR95","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3389\/fnmol.2020.00124","volume":"13","author":"R Andrejew","year":"2020","unstructured":"Andrejew R, Oliveira-Giacomelli \u00c1, Ribeiro DE, Glaser T, Arnaud-Sampaio VF, Lameu C, et al. The P2X7 receptor: central hub of brain diseases. Front Mol Neurosci. 2020;13:124.","journal-title":"Front Mol Neurosci"},{"key":"965_CR96","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1128\/MMBR.05015-11","volume":"76","author":"JR Tisoncik","year":"2012","unstructured":"Tisoncik JR, Korth MJ, Simmons CP, Farrar J, Martin TR, Katze MG. Into the eye of the cytokine storm. Microbiol Mol Biol Rev. 2012;76:16\u201332.","journal-title":"Microbiol Mol Biol Rev"},{"key":"965_CR97","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.jinf.2020.03.037","volume":"80","author":"Q Ye","year":"2020","unstructured":"Ye Q, Wang B, Mao J. The pathogenesis and treatment of the \u2018Cytokine Storm\u201d in COVID-19. J Infect. 2020;80:607\u201313.","journal-title":"J Infect"},{"key":"965_CR98","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","volume":"395","author":"C Huang","year":"2020","unstructured":"Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497\u2013506.","journal-title":"Lancet"},{"key":"965_CR99","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jaci.2020.04.027","volume":"146","author":"Y Yang","year":"2020","unstructured":"Yang Y, Shen C, Li J, Yuan J, Wei J, Huang F, et al. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. J Allergy Clin Immunol. 2020;146:119\u201327.","journal-title":"J Allergy Clin Immunol"},{"key":"965_CR100","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.1172\/JCI137647","volume":"130","author":"SF Pedersen","year":"2020","unstructured":"Pedersen SF, Ho YC. SARS-CoV-2: a storm is raging. J Clin Invest. 2020;130:2202\u20135.","journal-title":"J Clin Invest"},{"key":"965_CR101","doi-asserted-by":"publisher","first-page":"2620","DOI":"10.1172\/JCI137244","volume":"130","author":"G Chen","year":"2020","unstructured":"Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 2020;130:2620\u20139.","journal-title":"J Clin Invest"},{"key":"965_CR102","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1093\/cid\/ciaa248","volume":"71","author":"C Qin","year":"2020","unstructured":"Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of immune response in patients With COVID-19 in Wuhan, China. Clin Infect Dis. 2020;71:762\u20138.","journal-title":"Clin Infect Dis"},{"key":"965_CR103","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1002\/jmv.25770","volume":"92","author":"Y Gao","year":"2020","unstructured":"Gao Y, Li T, Han M, Li X, Wu D, Xu Y, et al. Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19. J Med Virol. 2020;92:791\u20136.","journal-title":"J Med Virol"},{"key":"965_CR104","doi-asserted-by":"publisher","first-page":"e12421","DOI":"10.15252\/emmm.202012421","volume":"12","author":"T Liu","year":"2020","unstructured":"Liu T, Zhang J, Yang Y, Ma H, Li Z, Zhang J, et al. The role of interleukin-6 in monitoring severe case of coronavirus disease 2019. EMBO Mol Med. 2020;12:e12421.","journal-title":"EMBO Mol Med"},{"key":"965_CR105","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1093\/cid\/ciaa272","volume":"71","author":"Z Wang","year":"2020","unstructured":"Wang Z, Yang B, Li Q, Wen L, Zhang R. Clinical features of 69 cases with coronavirus disease 2019 in Wuhan, China. Clin Infect Dis. 2020;71:769\u201377.","journal-title":"Clin Infect Dis"},{"key":"965_CR106","doi-asserted-by":"crossref","unstructured":"Di Virgilio F, Tang Y, Sarti AC, Rossato M. A rationale for targeting the P2X7 receptor in Coronavirus disease 19 (Covid-19). Br J Pharmacol. 2020;177:4990\u201394.","DOI":"10.1111\/bph.15138"},{"key":"965_CR107","doi-asserted-by":"publisher","first-page":"e110185","DOI":"10.1371\/journal.pone.0110185","volume":"9","author":"LC Mon\u00e7\u00e3o-Ribeiro","year":"2014","unstructured":"Mon\u00e7\u00e3o-Ribeiro LC, Faffe DS, Santana PT, Vieira FS, da Gra\u00e7a CLAL, Marques-da-Silva C, et al. P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica. PLoS ONE. 2014;9:e110185.","journal-title":"PLoS ONE"},{"key":"965_CR108","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.4049\/jimmunol.1700187","volume":"199","author":"C Zhang","year":"2017","unstructured":"Zhang C, He H, Wang L, Zhang N, Huang H, Xiong Q, et al. Virus-triggered ATP release limits viral replication through facilitating IFN-\u03b2 production in a P2X7-dependent manner. J Immunol. 2017;199:1372\u201381.","journal-title":"J Immunol"},{"key":"965_CR109","doi-asserted-by":"publisher","first-page":"E3265","DOI":"10.1073\/pnas.1500656112","volume":"112","author":"F Graziano","year":"2015","unstructured":"Graziano F, Desdouits M, Garzetti L, Podini P, Alfano M, Rubartelli A, et al. Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages. Proc Natl Acad Sci U S A. 2015;112:E3265\u201373.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"965_CR110","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/mBio.00229-17","volume":"8","author":"VH Leyva-Grado","year":"2017","unstructured":"Leyva-Grado VH, Ermler ME, Schotsaert M, Gonzalez MG, Gillespie V, Lim JK, et al. Contribution of the purinergic receptor P2X7 to development of lung immunopathology during influenza virus infection. MBio. 2017;8:1\u201315.","journal-title":"MBio"},{"key":"965_CR111","doi-asserted-by":"publisher","first-page":"e35812","DOI":"10.1371\/journal.pone.0035812","volume":"7","author":"BH Lee","year":"2012","unstructured":"Lee BH, Hwang DM, Palaniyar N, Grinstein S, Philpott DJ, Hu J. Activation of P2X(7) receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection. PLoS ONE. 2012;7:e35812.","journal-title":"PLoS ONE"},{"key":"965_CR112","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1007\/s00134-020-05985-9","volume":"46","author":"H Zhang","year":"2020","unstructured":"Zhang H, Penninger JM, Li Y, Zhong N, Slutsky AS. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Med. 2020;46:586\u201390.","journal-title":"Intensive Care Med"},{"key":"965_CR113","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1002\/cyto.a.24190","volume":"97","author":"MM Pillat","year":"2020","unstructured":"Pillat MM, Kr\u00fcger A, Guimar\u00e3es LMF, Lameu C, de Souza EE, Wrenger C, et al. Insights in chloroquine action: perspectives and implications in Malaria and COVID-19. Cytom Part A. 2020;97:872\u201381.","journal-title":"Cytom Part A"},{"key":"965_CR114","doi-asserted-by":"publisher","DOI":"10.1038\/srep15561","volume":"5","author":"J Wang","year":"2015","unstructured":"Wang J, Chen L, Chen B, Meliton A, Liu SQ, Shi Y, et al. Chronic activation of the renin-angiotensin system induces lung fibrosis. Sci Rep. 2015;5:15561.","journal-title":"Sci Rep"},{"key":"965_CR115","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1042\/CS20180189","volume":"132","author":"MM Gironacci","year":"2018","unstructured":"Gironacci MM, Vicario A, Cerezo G, Silva MG. The depressor axis of the renin-angiotensin system and brain disorders: A translational approach. Clin Sci. 2018;132:1021\u201338.","journal-title":"Clin Sci"},{"key":"965_CR116","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1161\/CIRCRESAHA.120.317015","volume":"126","author":"M Gheblawi","year":"2020","unstructured":"Gheblawi M, Wang K, Viveiros A, Nguyen Q, Zhong JC, Turner AJ, et al. Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2. Circ Res. 2020;126:1456\u201374.","journal-title":"Circ Res"},{"key":"965_CR117","doi-asserted-by":"publisher","first-page":"876","DOI":"10.3390\/ijms19030876","volume":"19","author":"L Jackson","year":"2018","unstructured":"Jackson L, Eldahshan W, Fagan SC, Ergul A. Within the brain: the renin angiotensin system. Int J Mol Sci. 2018;19:876.","journal-title":"Int J Mol Sci"},{"key":"965_CR118","doi-asserted-by":"publisher","first-page":"2778","DOI":"10.3390\/ijms20112778","volume":"20","author":"DE Ribeiro","year":"2019","unstructured":"Ribeiro DE, Roncalho AL, Glaser T, Ulrich H, Wegener G, Joca S. P2X7 receptor signaling in stress and depression. Int J Mol Sci. 2019;20:2778.","journal-title":"Int J Mol Sci"},{"key":"965_CR119","doi-asserted-by":"publisher","first-page":"E4041","DOI":"10.3390\/ijms21114041","volume":"21","author":"R Bautista-P\u00e9rez","year":"2020","unstructured":"Bautista-P\u00e9rez R, P\u00e9rez-M\u00e9ndez O, Cano-Mart\u00ednez A, Pacheco U, Santamar\u00eda J, Rodr\u00edguez-Iturbe FRB, et al. The role of P2X7 purinergic receptors in the renal inflammation associated with angiotensin II-induced hypertension. Int J Mol Sci. 2020;21:E4041.","journal-title":"Int J Mol Sci"},{"key":"965_CR120","doi-asserted-by":"publisher","first-page":"117640","DOI":"10.1016\/j.lfs.2020.117640","volume":"251","author":"M Nascimento","year":"2020","unstructured":"Nascimento M, Punaro GR, Serralha RS, Lima DY, Mouro MG, Oliveira LCG, et al. Inhibition of the P2X7 receptor improves renal function via renin-angiotensin system and nitric oxide on diabetic nephropathy in rats. Life Sci. 2020;251:117640.","journal-title":"Life Sci"},{"key":"965_CR121","doi-asserted-by":"publisher","first-page":"a020412","DOI":"10.1101\/cshperspect.a020412","volume":"7","author":"R Daneman","year":"2015","unstructured":"Daneman R, Prat A. The blood\u2013brain barrier. Cold Spring Harb Perspect Biol. 2015;7:a020412.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"965_CR122","first-page":"8928530","volume":"2016","author":"F Yang","year":"2016","unstructured":"Yang F, Zhao K, Zhang X, Zhang J, Xu B. ATP induces disruption of tight junction proteins via IL-1 beta-dependent MMP-9 activation of human blood\u2013brain barrier in vitro. Neural Plast. 2016;2016:8928530.","journal-title":"Neural Plast"},{"key":"965_CR123","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3389\/fphar.2017.00123","volume":"8","author":"AL Giuliani","year":"2017","unstructured":"Giuliani AL, Sarti AC, Falzoni S, Di Virgilio F. The P2X7 receptor-interleukin-1 liaison. Front Pharm. 2017;8:123.","journal-title":"Front Pharm"},{"key":"965_CR124","doi-asserted-by":"publisher","DOI":"10.1038\/srep23286","volume":"6","author":"H Zhao","year":"2016","unstructured":"Zhao H, Zhang X, Dai Z, Feng Y, Li Q, Zhang JH, et al. P2X7 receptor suppression preserves blood\u2013brain barrier through inhibiting RhoA activation after experimental intracerebral hemorrhage in rats. Sci Rep. 2016;6:23286.","journal-title":"Sci Rep"},{"key":"965_CR125","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.arcmed.2014.11.013","volume":"45","author":"GG Ortiz","year":"2014","unstructured":"Ortiz GG, Pacheco-Moises FP, Macias-Islas MA, Flores-Alvarado LJ, Mireles-Ramirez MA, Gonzalez-Renovato ED, et al. Role of the blood\u2013brain barrier in multiple sclerosis. Arch Med Res. 2014;45:687\u201397.","journal-title":"Arch Med Res"},{"key":"965_CR126","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1038\/jcbfm.2013.135","volume":"33","author":"MA Erickson","year":"2013","unstructured":"Erickson MA, Banks WA. Blood\u2013brain barrier dysfunction as a cause and consequence of Alzheimer\u2019s disease. J Cereb Blood Flow Metab. 2013;33:1500\u201313.","journal-title":"J Cereb Blood Flow Metab"},{"key":"965_CR127","doi-asserted-by":"publisher","first-page":"3326","DOI":"10.1073\/pnas.1914655117","volume":"117","author":"KA Dudek","year":"2020","unstructured":"Dudek KA, Dion-Albert L, Lebel M, LeClair K, Labrecque S, Tuck E, et al. Molecular adaptations of the blood\u2013brain barrier promote stress resilience vs. Depression Proc Natl Acad Sci U S A. 2020;117:3326\u201336.","journal-title":"Depression Proc Natl Acad Sci U S A"},{"key":"965_CR128","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.bbi.2020.04.077","volume":"87","author":"A Avula","year":"2020","unstructured":"Avula A, Nalleballe K, Narula N, Sapozhnikov S, Dandu V, Toom S, et al. COVID-19 presenting as stroke. Brain Behav Immun. 2020;87:115\u20139.","journal-title":"Brain Behav Immun"},{"key":"965_CR129","doi-asserted-by":"publisher","first-page":"e006938","DOI":"10.1161\/CIRCOUTCOMES.120.006938","volume":"13","author":"UN Khot","year":"2020","unstructured":"Khot UN, Reimer AP, Brown A, Hustey FM, Hussain MS, Kapadia SR, et al. Impact of COVID-19 pandemic on critical care transfers for ST-elevation myocardial infarction, stroke, and aortic emergencies. Circ Cardiovasc Qual Outcomes. 2020;13:e006938.","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"965_CR130","doi-asserted-by":"publisher","first-page":"10022","DOI":"10.18632\/aging.103335","volume":"12","author":"H Wang","year":"2020","unstructured":"Wang H, Tang X, Fan H, Luo Y, Song Y, Xu Y, et al. Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients. Aging. 2020;12:10022\u201334.","journal-title":"Aging"},{"key":"965_CR131","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2045-8118-11-18","volume":"11","author":"RF Keep","year":"2014","unstructured":"Keep RF, Zhou N, Xiang J, Andjelkovic AV, Hua Y, Xi G. Vascular disruption and blood\u2013brain barrier dysfunction in intracerebral hemorrhage. Fluids Barriers CNS. 2014;11:1\u201313.","journal-title":"Fluids Barriers CNS"},{"key":"965_CR132","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s12035-014-9070-5","volume":"53","author":"Y Tang","year":"2016","unstructured":"Tang Y, Le W. Differential Roles of M1 and M2 microglia in neurodegenerative diseases. Mol Neurobiol. 2016;53:1181\u201394.","journal-title":"Mol Neurobiol"},{"key":"965_CR133","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1021\/acschemneuro.8b00072","volume":"9","author":"C Lois","year":"2018","unstructured":"Lois C, Gonz\u00e1lez I, Izquierdo-Garc\u00eda D, Z\u00fcrcher NR, Wilkens P, Loggia ML, et al. Neuroinflammation in Huntington\u2019s disease: new Insights with 11C-PBR28 PET\/MRI. ACS Chem Neurosci. 2018;9:2563\u201371.","journal-title":"ACS Chem Neurosci"},{"key":"965_CR134","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/s00702-010-0438-z","volume":"117","author":"MT Heneka","year":"2010","unstructured":"Heneka MT, O\u2019Banion MK, Terwel D, Kummer MP. Neuroinflammatory processes in Alzheimer\u2019s disease. J Neural Transm. 2010;117:919\u201347.","journal-title":"J Neural Transm"},{"key":"965_CR135","doi-asserted-by":"publisher","first-page":"860","DOI":"10.3389\/fneur.2018.00860","volume":"9","author":"P Troncoso-Escudero","year":"2018","unstructured":"Troncoso-Escudero P, Parra A, Nassif M, Vidal RL. Outside in: unraveling the role of neuroinflammation in the progression of Parkinson\u2019s disease. Front Neurol. 2018;9:860.","journal-title":"Front Neurol"},{"key":"965_CR136","doi-asserted-by":"publisher","first-page":"5071786","DOI":"10.1155\/2017\/5071786","volume":"2017","author":"FA Radtke","year":"2017","unstructured":"Radtke FA, Chapman G, Hall J, Syed YA. Modulating neuroinflammation to treat neuropsychiatric disorders. Biomed Res Int. 2017;2017:5071786.","journal-title":"Biomed Res Int"},{"key":"965_CR137","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3389\/fncel.2015.00028","volume":"9","author":"R Sankowski","year":"2015","unstructured":"Sankowski R, Mader S, Vald\u00e9s-Ferrer SI. Systemic inflammation and the brain: novel roles of genetic, molecular, and environmental cues as drivers of neurodegeneration. Front Cell Neurosci. 2015;9:98.","journal-title":"Front Cell Neurosci"},{"key":"965_CR138","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3389\/fphar.2018.00325","volume":"9","author":"\u00c1 Oliveira-Giacomelli","year":"2018","unstructured":"Oliveira-Giacomelli \u00c1, Naaldijk Y, Sard\u00e1-Arroyo L, Gon\u00e7alves MCB, Corr\u00eaa-Velloso J, Pillat MM, et al. Purinergic receptors in neurological diseases with motor symptoms: targets for therapy. Front Pharm. 2018;9:325.","journal-title":"Front Pharm"},{"key":"965_CR139","doi-asserted-by":"publisher","first-page":"476","DOI":"10.3389\/fncel.2019.00476","volume":"13","author":"\u00c1 Oliveira-Giacomelli","year":"2019","unstructured":"Oliveira-Giacomelli \u00c1, Albino CM, de Souza HDN, Corr\u00eaa-Velloso J, de Jesus Santos AP, Baranova J, et al. P2Y6 and P2X7 receptor antagonism exerts neuroprotective\/ neuroregenerative effects in an animal model of Parkinson\u2019s disease. Front Cell Neurosci. 2019;13:476.","journal-title":"Front Cell Neurosci"},{"key":"965_CR140","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1743-422X-10-1","volume":"10","author":"L Zhou","year":"2013","unstructured":"Zhou L, Miranda-Saksena M, Saksena NK. Viruses and neurodegeneration. Virol J. 2013;10:1\u201317.","journal-title":"Virol J"},{"key":"965_CR141","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-37186-2","volume":"9","author":"S Lee","year":"2019","unstructured":"Lee S, Nedumaran B, Hypolite J, Caldwell B, Rudolph MC, Malykhina AP. Differential neurodegenerative phenotypes are associated with heterogeneous voiding dysfunction in a coronavirus-induced model of multiple sclerosis. Sci Rep. 2019;9:1\u201311.","journal-title":"Sci Rep"},{"key":"965_CR142","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.nbd.2016.12.013","volume":"109","author":"NL Rey","year":"2018","unstructured":"Rey NL, Wesson DW, Brundin P. The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases. Neurobiol Dis. 2018;109:226\u201348.","journal-title":"Neurobiol Dis"},{"key":"965_CR143","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s11302-017-9567-2","volume":"13","author":"A Wilkaniec","year":"2017","unstructured":"Wilkaniec A, G\u0105ssowska M, Czapski GA, Cie\u015blik M, Sulkowski G, Adamczyk A. P2X7 receptor-pannexin 1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells. Purinergic Signal. 2017;13:347\u201361.","journal-title":"Purinergic Signal"},{"key":"965_CR144","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1016\/j.neurobiolaging.2015.03.015","volume":"36","author":"T Jiang","year":"2015","unstructured":"Jiang T, Hoekstra J, Heng X, Kang W, Ding J, Liu J, et al. P2X7 receptor is critical in \u03b1-synuclein-mediated microglial NADPH oxidase activation. Neurobiol Aging. 2015;36:2304\u201318.","journal-title":"Neurobiol Aging"},{"key":"965_CR145","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.molmed.2018.07.005","volume":"24","author":"JM Deussing","year":"2018","unstructured":"Deussing JM, Arzt E. P2X7 receptor: a potential therapeutic target for depression? Trends Mol Med. 2018;24:736\u201347.","journal-title":"Trends Mol Med"},{"key":"965_CR146","doi-asserted-by":"publisher","first-page":"e7834","DOI":"10.7717\/peerj.7834","volume":"7","author":"DE Ribeiro","year":"2019","unstructured":"Ribeiro DE, Casarotto PC, Staquini L, Pinto E, Silva MA, Biojone C, et al. Reduced P2X receptor levels are associated with antidepressant effect in the learned helplessness model. PeerJ. 2019;7:e7834.","journal-title":"PeerJ"},{"key":"965_CR147","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.biopsych.2015.11.026","volume":"80","author":"M Iwata","year":"2016","unstructured":"Iwata M, Ota KT, Li X-Y, Sakaue F, Li N, Dutheil S, et al. Psychological stress activates the inflammasome via release of adenosine triphosphate and stimulation of the purinergic type 2X7 receptor. Biol Psychiatry. 2016;80:12\u201322.","journal-title":"Biol Psychiatry"},{"key":"965_CR148","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1177\/0269881119872173","volume":"33","author":"DE Ribeiro","year":"2019","unstructured":"Ribeiro DE, M\u00fcller HK, Elfving B, Eskelund A, Joca SRL, Wegener G. Antidepressant-like effect induced by P2X7 receptor blockade in FSL rats is associated with BDNF signalling activation. J Psychopharmacol. 2019;33:1436\u201346.","journal-title":"J Psychopharmacol"},{"key":"965_CR149","doi-asserted-by":"crossref","unstructured":"Bo HX, Li W, Yang Y, Wang Y, Zhang Q, Cheung T, et al. Posttraumatic stress symptoms and attitude toward crisis mental health services among clinically stable patients with COVID-19 in China. Psychological Medicine. 2020;1-9.","DOI":"10.1017\/S0033291720000999"},{"key":"965_CR150","doi-asserted-by":"publisher","unstructured":"Kong X, Zheng K, Tang M, Kong F, Zhou J, Diao L, et al. Prevalence and Factors Associated with Depression and Anxiety of Hospitalized Patients with COVID-19. 2020. https:\/\/doi.org\/10.1101\/2020.03.24.20043075.","DOI":"10.1101\/2020.03.24.20043075"},{"key":"965_CR151","doi-asserted-by":"publisher","first-page":"355","DOI":"10.30773\/pi.2017.10.25.1","volume":"15","author":"HC Kim","year":"2018","unstructured":"Kim HC, Yoo SY, Lee BH, Lee SH, Shin HS. Psychiatric findings in suspected and confirmed middle east respiratory syndrome patients quarantined in hospital: a retrospective chart analysis. Psychiatry Investig. 2018;15:355\u201360.","journal-title":"Psychiatry Investig"},{"key":"965_CR152","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1192\/bjp.184.4.359","volume":"184","author":"SKW Cheng","year":"2004","unstructured":"Cheng SKW, Tsang JSK, Ku KH, Wong CW, Ng YK. Psychiatric complications in patients with severe acute respiratory syndrome (SARS) during the acute treatment phase: a series of 10 cases. Br J Psychiatry. 2004;184:359\u201360.","journal-title":"Br J Psychiatry"},{"key":"965_CR153","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1177\/070674370404900607","volume":"49","author":"SE Chua","year":"2004","unstructured":"Chua SE, Cheung V, McAlonan GM, Cheung C, Wong JWS, Cheung EPT, et al. Stress and psychological impact on SARS patients during the outbreak. Can J Psychiatry. 2004;49:385\u201390.","journal-title":"Can J Psychiatry"},{"key":"965_CR154","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1177\/070674370705200405","volume":"52","author":"AM Lee","year":"2007","unstructured":"Lee AM, Wong JGWS, McAlonan GM, Cheung V, Cheung C, Sham PC, et al. Stress and psychological distress among SARS survivors 1 year after the outbreak. Can J Psychiatry. 2007;52:233\u201340.","journal-title":"Can J Psychiatry"},{"key":"965_CR155","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.eurpsy.2004.06.023","volume":"20","author":"B Sheng","year":"2005","unstructured":"Sheng B, Cheng SKW, Kwok KL, Ho LL, Chan ELY. The effects of disease severity, use of corticosteroids and social factors on neuropsychiatric complaints in severe acute respiratory syndrome (SARS) patients at acute and convalescent phases. Eur Psychiatry. 2005;20:236\u201342.","journal-title":"Eur Psychiatry"},{"key":"965_CR156","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1017\/S0033291704002272","volume":"34","author":"SKW Cheng","year":"2004","unstructured":"Cheng SKW, Wong CW, Tsang J, Wong KC. Psychological distress and negative appraisals in survivors of severe acute respiratory syndrome (SARS). Psychol Med. 2004;34:1187\u201395.","journal-title":"Psychol Med"},{"key":"965_CR157","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.genhosppsych.2009.03.001","volume":"31","author":"IWC Mak","year":"2009","unstructured":"Mak IWC, Chu CM, Pan PC, Yiu MGC, Chan VL. Long-term psychiatric morbidities among SARS survivors. Gen Hosp Psychiatry. 2009;31:318\u201326.","journal-title":"Gen Hosp Psychiatry"},{"key":"965_CR158","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.genhosppsych.2009.06.008","volume":"31","author":"X Hong","year":"2009","unstructured":"Hong X, Currier GW, Zhao X, Jiang Y, Zhou W, Wei J. Posttraumatic stress disorder in convalescent severe acute respiratory syndrome patients: a 4-year follow-up study. Gen Hosp Psychiatry. 2009;31:546\u201354.","journal-title":"Gen Hosp Psychiatry"},{"key":"965_CR159","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1001\/archinternmed.2009.384","volume":"169","author":"MHB Lam","year":"2009","unstructured":"Lam MHB, Wing YK, Yu MWM, Leung CM, Ma RCW, Kong APS, et al. Mental morbidities and chronic fatigue in severe acute respiratory syndrome survivors long-term follow-up. Arch Intern Med. 2009;169:2142\u20137.","journal-title":"Arch Intern Med"},{"key":"965_CR160","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.jad.2010.09.029","volume":"130","author":"O Okusaga","year":"2011","unstructured":"Okusaga O, Yolken RH, Langenberg P, Lapidus M, Arling TA, Dickerson FB, et al. Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts. J Affect Disord. 2011;130:220\u20135.","journal-title":"J Affect Disord"},{"key":"965_CR161","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/sj.mp.4000908","volume":"6","author":"N Hiroi","year":"2001","unstructured":"Hiroi N, Wong ML, Licinio J, Park C, Young M, Gold PW, et al. Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls. Mol Psychiatry. 2001;6:540\u20136.","journal-title":"Mol Psychiatry"},{"key":"965_CR162","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.bbi.2020.05.048","volume":"89","author":"N Vindegaard","year":"2020","unstructured":"Vindegaard N, Eriksen Benros M. COVID-19 pandemic and mental health consequences: systematic review of the current evidence. Brain Behav Immun. 2020;89:531\u201342.","journal-title":"Brain Behav Immun"},{"key":"965_CR163","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.psyneuen.2018.07.016","volume":"97","author":"RK Farooq","year":"2018","unstructured":"Farooq RK, Tanti A, Ainouche S, Roger S, Belzung C, Camus V. A P2X7 receptor antagonist reverses behavioural alterations, microglial activation and neuroendocrine dysregulation in an unpredictable chronic mild stress (UCMS) model of depression in mice. Psychoneuroendocrinology. 2018;97:120\u201330.","journal-title":"Psychoneuroendocrinology"},{"key":"965_CR164","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1017\/S1461145711001933","volume":"16","author":"C Cs\u00f6lle","year":"2013","unstructured":"Cs\u00f6lle C, And\u00f3 RD, Kittel A, G\u00f6l\u00f6ncs\u00e9r F, Baranyi M, Soproni K, et al. The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice. Int J Neuropsychopharmacol. 2013;16:213\u201333.","journal-title":"Int J Neuropsychopharmacol"},{"key":"965_CR165","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.3389\/fimmu.2020.01170","volume":"11","author":"\u00cd Raony","year":"2020","unstructured":"Raony \u00cd, de Figueiredo CS, Pandolfo P, Giestal-de-Araujo E, Oliveira-Silva Bomfim P, Savino W. Psycho-Neuroendocrine-Immune Interactions in COVID-19: potential impacts on mental health. Front Immunol. 2020;11:1170.","journal-title":"Front Immunol"},{"key":"965_CR166","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/npp.2016.125","volume":"42","author":"M Fleshner","year":"2017","unstructured":"Fleshner M, Frank M, Maier SF. Danger signals and inflammasomes: stress-evoked sterile inflammation in mood disorders. Neuropsychopharmacology. 2017;42:36\u201345.","journal-title":"Neuropsychopharmacology"},{"key":"965_CR167","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1021\/acschemneuro.0c00294","volume":"11","author":"XX Yin","year":"2020","unstructured":"Yin XX, Zheng XR, Peng W, Wu ML, Mao XY. Vascular endothelial growth factor (VEGF) as a vital target for brain inflammation during the COVID-19 outbreak. ACS Chem Neurosci. 2020;11:1704\u20135.","journal-title":"ACS Chem Neurosci"},{"key":"965_CR168","doi-asserted-by":"publisher","first-page":"401","DOI":"10.3389\/fncel.2019.00401","volume":"13","author":"JM Kanellopoulos","year":"2019","unstructured":"Kanellopoulos JM, Delarasse C. Pleiotropic roles of P2X7 in the central nervous system. Front Cell Neurosci. 2019;13:401.","journal-title":"Front Cell Neurosci"},{"key":"965_CR169","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jpsychires.2014.08.005","volume":"59","author":"A Clark-Raymond","year":"2014","unstructured":"Clark-Raymond A, Meresh E, Hoppensteadt D, Fareed J, Sinacore J, Halaris A. Vascular endothelial growth factor: a potential diagnostic biomarker for major depression. J Psychiatr Res. 2014;59:22\u20137.","journal-title":"J Psychiatr Res"},{"key":"965_CR170","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.npep.2011.05.005","volume":"46","author":"MM Nowacka","year":"2012","unstructured":"Nowacka MM, Obuchowicz E. Vascular endothelial growth factor (VEGF) and its role in the central nervous system: a new element in the neurotrophic hypothesis of antidepressant drug action. Neuropeptides. 2012;46:1\u201310.","journal-title":"Neuropeptides"},{"key":"965_CR171","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/j.cell.2020.04.035","volume":"181","author":"CGK Ziegler","year":"2020","unstructured":"Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, et al. SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell. 2020;181:1016\u201335.","journal-title":"Cell"},{"key":"965_CR172","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1113\/jphysiol.2005.103465","volume":"572","author":"J Chen","year":"2006","unstructured":"Chen J, Chen Z, Chintagari NR, Bhaskaran M, Jin N, Narasaraju T, et al. Alveolar type I cells protect rat lung epithelium from oxidative injury. J Physiol. 2006;572:625\u201338.","journal-title":"J Physiol"},{"key":"965_CR173","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1042\/CS20130324","volume":"126","author":"RW Regenhardt","year":"2014","unstructured":"Regenhardt RW, Bennion DM, Sumners C. Cerebroprotective action of angiotensin peptides in stroke. Clin Sci. 2014;126:195\u2013205.","journal-title":"Clin Sci"},{"key":"965_CR174","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3389\/fncel.2019.00112","volume":"13","author":"N Rotermund","year":"2019","unstructured":"Rotermund N, Schulz K, Hirnet D, Lohr C. Purinergic signaling in the vertebrate olfactory system. Front Cell Neurosci. 2019;13:112.","journal-title":"Front Cell Neurosci"},{"key":"965_CR175","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/1097-0215(20001001)88:1<21::AID-IJC4>3.0.CO;2-S","volume":"88","author":"T Sameshima","year":"2000","unstructured":"Sameshima T, Nabeshima K, Toole BP, Yokogami K, Okada Y, Goya T, et al. Expression of emmprin (CD147), a cell surface inducer of matrix metalloproteinases, in normal human brain and gliomas. Int J Cancer. 2000;88:21\u20137.","journal-title":"Int J Cancer"},{"key":"965_CR176","doi-asserted-by":"crossref","unstructured":"Radzikowska U, Ding M, Tan G, Zhakparov D, Peng Y, Wawrzyniak P, et al. Distribution of ACE2, CD147, CD26 and other SARS\u2010CoV\u20102 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID\u201019 risk factors. Allergy. 2020;75:2829\u201345.","DOI":"10.1111\/all.14429"},{"key":"965_CR177","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3233\/JAD-131442","volume":"39","author":"LJ Kanyenda","year":"2014","unstructured":"Kanyenda LJ, Verdile G, Martins R, Meloni BP, Chieng J, Mastaglia F, et al. Is cholesterol and amyloid-\u03b2 stress induced CD147 expression a protective response? Evidence that extracellular cyclophilin a mediated neuroprotection is reliant on CD147. J Alzheimer\u2019s Dis. 2014;39:545\u201356.","journal-title":"J Alzheimer\u2019s Dis"},{"key":"965_CR178","doi-asserted-by":"publisher","first-page":"113382","DOI":"10.1016\/j.psychres.2020.113382","volume":"293","author":"Y Krishnamoorthy","year":"2020","unstructured":"Krishnamoorthy Y, Nagarajan R, Saya GK, Menon V. Prevalence of psychological morbidities among general population, healthcare workers and COVID-19 patients amidst the COVID-19 pandemic: a systematic review and meta-analysis. Psychiatry Res. 2020;293:113382.","journal-title":"Psychiatry Res"},{"key":"965_CR179","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jad.2020.08.001","volume":"277","author":"J Xiong","year":"2020","unstructured":"Xiong J, Lipsitz O, Nasri F, Lui LMW, Gill H, Phan L, et al. Impact of COVID-19 pandemic on mental health in the general population: a systematic review. J Affect Disord. 2020;277:55\u201364.","journal-title":"J Affect Disord"},{"key":"965_CR180","doi-asserted-by":"publisher","first-page":"110062","DOI":"10.1016\/j.pnpbp.2020.110062","volume":"104","author":"FCT da Silva","year":"2021","unstructured":"da Silva FCT, Neto MLR. Psychological effects caused by the COVID-19 pandemic in health professionals: a systematic review with meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2021;104:110062.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"965_CR181","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12992-020-00589-w","volume":"16","author":"N Salari","year":"2020","unstructured":"Salari N, Hosseinian-Far A, Jalali R, Vaisi-Raygani A, Rasoulpoor S, Mohammadi M, et al. Prevalence of stress, anxiety, depression among the general population during the COVID-19 pandemic: a systematic review and meta-analysis. Glob Health. 2020;16:57.","journal-title":"Glob Health"},{"key":"965_CR182","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.jad.2020.06.022","volume":"275","author":"GS de Pablo","year":"2020","unstructured":"de Pablo GS, Vaquerizo-Serrano J, Catalan A, Arango C, Moreno C, Ferre F, et al. Impact of coronavirus syndromes on physical and mental health of health care workers: systematic review and meta-analysis. J Affect Disord. 2020;275:48\u201357.","journal-title":"J Affect Disord"},{"key":"965_CR183","doi-asserted-by":"publisher","first-page":"113190","DOI":"10.1016\/j.psychres.2020.113190","volume":"291","author":"M Luo","year":"2020","unstructured":"Luo M, Guo L, Yu M, Wang H. The psychological and mental impact of coronavirus disease 2019 (COVID-19) on medical staff and general public\u2014a systematic review and meta-analysis. Psychiatry Res. 2020;291:113190.","journal-title":"Psychiatry Res"},{"key":"965_CR184","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.bbi.2020.05.026","volume":"88","author":"S Pappa","year":"2020","unstructured":"Pappa S, Ntella V, Giannakas T, Giannakoulis VG, Papoutsi E, Katsaounouc P, et al. Prevalence of depression, anxiety, and insomnia among healthcare workers during the COVID-19 pandemic: a systematic review and meta-analysis. Brain Behav Immun. 2020;88:901\u20137.","journal-title":"Brain Behav Immun"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41380-020-00965-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-020-00965-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-020-00965-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T07:53:55Z","timestamp":1670226835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-020-00965-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,16]]},"references-count":184,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["965"],"URL":"https:\/\/doi.org\/10.1038\/s41380-020-00965-3","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,16]]},"assertion":[{"value":"22 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}