{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:14:26Z","timestamp":1792034066445,"version":"4.4.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T00:00:00Z","timestamp":1588550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T00:00:00Z","timestamp":1588550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000065","name":"U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS093652"],"award-info":[{"award-number":["NS093652"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS093652"],"award-info":[{"award-number":["NS093652"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["AG020670"],"award-info":[{"award-number":["AG020670"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["AG054111"],"award-info":[{"award-number":["AG054111"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["AG057509"],"award-info":[{"award-number":["AG057509"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging"},{"name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging"},{"name":"U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1038\/s41380-020-0738-0","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T14:04:07Z","timestamp":1588601047000},"page":"5925-5939","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading"],"prefix":"10.1038","volume":"26","author":[{"given":"Yin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob A.","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanta","family":"Horie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1381-4604","authenticated-orcid":false,"given":"Andrea","family":"Ballabio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6854-5547","authenticated-orcid":false,"given":"Celeste M.","family":"Karch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Holtzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"key":"738_CR1","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1146\/annurev.neuro.24.1.1121","volume":"24","author":"VM Lee","year":"2001","unstructured":"Lee VM, Goedert M, Trojanowski JQ. Neurodegenerative tauopathies. Annu Rev Neurosci. 2001;24:1121\u201359.","journal-title":"Annu Rev Neurosci"},{"key":"738_CR2","doi-asserted-by":"crossref","first-page":"a006247","DOI":"10.1101\/cshperspect.a006247","volume":"2","author":"EM Mandelkow","year":"2012","unstructured":"Mandelkow EM, Mandelkow E. Biochemistry and cell biology of tau protein in neurofibrillary degeneration. Cold Spring Harb Perspect Med. 2012;2:a006247.","journal-title":"Cold Spring Harb Perspect Med"},{"key":"738_CR3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1750-1326-4-13","volume":"4","author":"TF Gendron","year":"2009","unstructured":"Gendron TF, Petrucelli L. The role of tau in neurodegeneration. Mol Neurodegener. 2009;4:13.","journal-title":"Mol Neurodegener"},{"key":"738_CR4","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.neuron.2014.12.064","volume":"85","author":"T Wisniewski","year":"2015","unstructured":"Wisniewski T, Goni F. Immunotherapeutic approaches for Alzheimer\u2019s disease. Neuron. 2015;85:1162\u201376.","journal-title":"Neuron"},{"key":"738_CR5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41582-018-0116-6","volume":"15","author":"F Panza","year":"2019","unstructured":"Panza F, Lozupone M, Logroscino G, Imbimbo BP. A critical appraisal of amyloid-beta-targeting therapies for Alzheimer disease. Nat Rev Neurol. 2019;15:73\u201388.","journal-title":"Nat Rev Neurol"},{"issue":"(Suppl 2)","key":"738_CR6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/jnc.13632","volume":"139","author":"E Karran","year":"2016","unstructured":"Karran E, De Strooper B. The amyloid cascade hypothesis: are we poised for success or failure? J Neurochem. 2016;139 (Suppl 2):237\u201352.","journal-title":"J Neurochem"},{"key":"738_CR7","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1212\/01.WNL.0000063311.58879.01","volume":"60","author":"P Giannakopoulos","year":"2003","unstructured":"Giannakopoulos P, Herrmann FR, Bussiere T, Bouras C, Kovari E, Perl DP, et al. Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer\u2019s disease. Neurology. 2003;60:1495\u2013500.","journal-title":"Neurology"},{"key":"738_CR8","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1001\/jamaneurol.2019.1424","volume":"76","author":"BJ Hanseeuw","year":"2019","unstructured":"Hanseeuw BJ, Betensky RA, Jacobs HIL, Schultz AP, Sepulcre J, Becker JA, et al. Association of amyloid and Tau with cognition in preclinical alzheimer disease: a longitudinal study. JAMA Neurol. 2019;76:915\u201324.","journal-title":"JAMA Neurol"},{"key":"738_CR9","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.jalz.2016.06.006","volume":"12","author":"MR Khanna","year":"2016","unstructured":"Khanna MR, Kovalevich J, Lee VM, Trojanowski JQ, Brunden KR. Therapeutic strategies for the treatment of tauopathies: hopes and challenges. Alzheimers Dement. 2016;12:1051\u201365.","journal-title":"Alzheimers Dement"},{"key":"738_CR10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991;82:239\u201359.","journal-title":"Acta Neuropathol"},{"key":"738_CR11","doi-asserted-by":"crossref","first-page":"12845","DOI":"10.1074\/jbc.M808759200","volume":"284","author":"B Frost","year":"2009","unstructured":"Frost B, Jacks RL, Diamond MI. Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem. 2009;284:12845\u201352.","journal-title":"J Biol Chem"},{"key":"738_CR12","doi-asserted-by":"crossref","first-page":"15317","DOI":"10.1074\/jbc.M110.209296","volume":"286","author":"JL Guo","year":"2011","unstructured":"Guo JL, Lee VM. Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles. J Biol Chem. 2011;286:15317\u201331.","journal-title":"J Biol Chem"},{"key":"738_CR13","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/ncb1901","volume":"11","author":"F Clavaguera","year":"2009","unstructured":"Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, et al. Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol. 2009;11:909\u201313.","journal-title":"Nat Cell Biol"},{"key":"738_CR14","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.neuron.2011.11.033","volume":"73","author":"A de Calignon","year":"2012","unstructured":"de Calignon A, Polydoro M, Suarez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, et al. Propagation of tau pathology in a model of early Alzheimer\u2019s disease. Neuron. 2012;73:685\u201397.","journal-title":"Neuron"},{"key":"738_CR15","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1523\/JNEUROSCI.2642-12.2013","volume":"33","author":"M Iba","year":"2013","unstructured":"Iba M, Guo JL, McBride JD, Zhang B, Trojanowski JQ, Lee VM. Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer\u2019s-like tauopathy. J Neurosci. 2013;33:1024\u201337.","journal-title":"J Neurosci"},{"key":"738_CR16","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.neuron.2014.04.047","volume":"82","author":"DW Sanders","year":"2014","unstructured":"Sanders DW, Kaufman SK, DeVos SL, Sharma AM, Mirbaha H, Li A, et al. Distinct tau prion strains propagate in cells and mice and define different tauopathies. Neuron. 2014;82:1271\u201388.","journal-title":"Neuron"},{"key":"738_CR17","doi-asserted-by":"crossref","first-page":"13110","DOI":"10.1523\/JNEUROSCI.2569-11.2011","volume":"31","author":"K Yamada","year":"2011","unstructured":"Yamada K, Cirrito JR, Stewart FR, Jiang H, Finn MB, Holmes BB, et al. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci. 2011;31:13110\u20137.","journal-title":"J Neurosci"},{"key":"738_CR18","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/nn.4328","volume":"19","author":"JW Wu","year":"2016","unstructured":"Wu JW, Hussaini SA, Bastille IM, Rodriguez GA, Mrejeru A, Rilett K, et al. Neuronal activity enhances tau propagation and tau pathology in vivo. Nat Neurosci. 2016;19:1085\u201392.","journal-title":"Nat Neurosci"},{"key":"738_CR19","doi-asserted-by":"crossref","first-page":"34457","DOI":"10.1074\/jbc.M111.229633","volume":"286","author":"X Chai","year":"2011","unstructured":"Chai X, Wu S, Murray TK, Kinley R, Cella CV, Sims H, et al. Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression. J Biol Chem. 2011;286:34457\u201367.","journal-title":"J Biol Chem"},{"key":"738_CR20","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/acn3.176","volume":"2","author":"K Yanamandra","year":"2015","unstructured":"Yanamandra K, Jiang H, Mahan TE, Maloney SE, Wozniak DF, Diamond MI, et al. Anti-tau antibody reduces insoluble tau and decreases brain atrophy. Ann Clin Transl Neurol. 2015;2:278\u201388.","journal-title":"Ann Clin Transl Neurol"},{"key":"738_CR21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.neuron.2013.07.046","volume":"80","author":"K Yanamandra","year":"2013","unstructured":"Yanamandra K, Kfoury N, Jiang H, Mahan TE, Ma S, Maloney SE, et al. Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo. Neuron. 2013;80:402\u201314.","journal-title":"Neuron"},{"key":"738_CR22","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00401-013-1151-4","volume":"126","author":"JB Toledo","year":"2013","unstructured":"Toledo JB, Xie SX, Trojanowski JQ, Shaw LM. Longitudinal change in CSF Tau and Abeta biomarkers for up to 48 months in ADNI. Acta Neuropathol. 2013;126:659\u201370.","journal-title":"Acta Neuropathol"},{"key":"738_CR23","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1074\/jbc.M111.277061","volume":"287","author":"S Saman","year":"2012","unstructured":"Saman S, Kim W, Raya M, Visnick Y, Miro S, Saman S, et al. Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. J Biol Chem. 2012;287:3842\u20139.","journal-title":"J Biol Chem"},{"key":"738_CR24","doi-asserted-by":"crossref","first-page":"42751","DOI":"10.1074\/jbc.M112.380642","volume":"287","author":"CM Karch","year":"2012","unstructured":"Karch CM, Jeng AT, Goate AM. Extracellular Tau levels are influenced by variability in Tau that is associated with tauopathies. J Biol Chem. 2012;287:42751\u201362.","journal-title":"J Biol Chem"},{"key":"738_CR25","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.nbd.2012.05.021","volume":"48","author":"X Chai","year":"2012","unstructured":"Chai X, Dage JL, Citron M. Constitutive secretion of tau protein by an unconventional mechanism. Neurobiol Dis. 2012;48:356\u201366.","journal-title":"Neurobiol Dis"},{"key":"738_CR26","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/nn.4067","volume":"18","author":"M Morris","year":"2015","unstructured":"Morris M, Knudsen GM, Maeda S, Trinidad JC, Ioanoviciu A, Burlingame AL, et al. Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice. Nat Neurosci. 2015;18:1183\u20139.","journal-title":"Nat Neurosci"},{"key":"738_CR27","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13024-015-0011-1","volume":"10","author":"L Song","year":"2015","unstructured":"Song L, Lu SX, Ouyang X, Melchor J, Lee J, Terracina G, et al. Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology. Mol Neurodegener. 2015;10:14.","journal-title":"Mol Neurodegener"},{"key":"738_CR28","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1093\/hmg\/ddp367","volume":"18","author":"Y Wang","year":"2009","unstructured":"Wang Y, Martinez-Vicente M, Kruger U, Kaushik S, Wong E, Mandelkow EM, et al. Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. Hum Mol Genet. 2009;18:4153\u201370.","journal-title":"Hum Mol Genet"},{"key":"738_CR29","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1074\/jbc.M113.515445","volume":"289","author":"CH Michel","year":"2014","unstructured":"Michel CH, Kumar S, Pinotsi D, Tunnacliffe A, St George-Hyslop P, Mandelkow E, et al. Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology. J Biol Chem. 2014;289:956\u201367.","journal-title":"J Biol Chem"},{"key":"738_CR30","doi-asserted-by":"crossref","first-page":"e36584","DOI":"10.7554\/eLife.36584","volume":"7","author":"H Mirbaha","year":"2018","unstructured":"Mirbaha H, Chen D, Morazova OA, Ruff KM, Sharma AM, Liu X, et al. Inert and seed-competent tau monomers suggest structural origins of aggregation. Elife. 2018;7:e36584.","journal-title":"Elife"},{"key":"738_CR31","doi-asserted-by":"crossref","first-page":"e76523","DOI":"10.1371\/journal.pone.0076523","volume":"8","author":"JE Meredith Jr","year":"2013","unstructured":"Meredith JE Jr, Sankaranarayanan S, Guss V, Lanzetti AJ, Berisha F, Neely RJ, et al. Characterization of novel CSF Tau and ptau biomarkers for Alzheimer\u2019s disease. PLoS ONE. 2013;8:e76523.","journal-title":"PLoS ONE"},{"key":"738_CR32","doi-asserted-by":"crossref","first-page":"10851","DOI":"10.1523\/JNEUROSCI.0387-15.2015","volume":"35","author":"D Kanmert","year":"2015","unstructured":"Kanmert D, Cantlon A, Muratore CR, Jin M, O\u2019Malley TT, Lee G, et al. C-terminally truncated forms of Tau, but not full-length Tau or Its C-terminal fragments, are released from neurons independently of cell death. J Neurosci. 2015;35:10851\u201365.","journal-title":"J Neurosci"},{"key":"738_CR33","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.neuron.2018.02.015","volume":"97","author":"C Sato","year":"2018","unstructured":"Sato C, Barthelemy NR, Mawuenyega KG, Patterson BW, Gordon BA, Jockel-Balsarotti J, et al. Tau kinetics in neurons and the human central nervous system. Neuron. 2018;97:1284\u201398. e1287","journal-title":"Neuron"},{"key":"738_CR34","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1174447","volume":"325","author":"M Sardiello","year":"2009","unstructured":"Sardiello M, Palmieri M, di Ronza A, Medina DL, Valenza M, Gennarino VA, et al. A gene network regulating lysosomal biogenesis and function. Science. 2009;325:473\u20137.","journal-title":"Science"},{"key":"738_CR35","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.15252\/emmm.201303671","volume":"6","author":"VA Polito","year":"2014","unstructured":"Polito VA, Li H, Martini-Stoica H, Wang B, Yang L, Xu Y, et al. Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB. EMBO Mol Med. 2014;6:1142\u201360.","journal-title":"EMBO Mol Med"},{"key":"738_CR36","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/ncb2718","volume":"15","author":"C Settembre","year":"2013","unstructured":"Settembre C, De Cegli R, Mansueto G, Saha PK, Vetrini F, Visvikis O, et al. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol. 2013;15:647\u201358.","journal-title":"Nat Cell Biol"},{"key":"738_CR37","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1080\/15548627.2018.1532258","volume":"15","author":"Y Xu","year":"2019","unstructured":"Xu Y, Zhang S, Zheng H. The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau). Autophagy. 2019;15:583\u201398.","journal-title":"Autophagy"},{"key":"738_CR38","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13024-016-0100-9","volume":"11","author":"Y Xu","year":"2016","unstructured":"Xu Y, Martini-Stoica H, Zheng H. A seeding based cellular assay of tauopathy. Mol Neurodegener. 2016;11:32.","journal-title":"Mol Neurodegener"},{"key":"738_CR39","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1083\/jcb.201501002","volume":"210","author":"CL Nezich","year":"2015","unstructured":"Nezich CL, Wang C, Fogel AI, Youle RJ. MiT\/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5. J Cell Biol. 2015;210:435\u201350.","journal-title":"J Cell Biol"},{"key":"738_CR40","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.stemcr.2019.09.006","volume":"13","author":"CM Karch","year":"2019","unstructured":"Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, et al. A comprehensive resource for induced pluripotent stem cells from patients with primary tauopathies. Stem Cell Rep. 2019;13:939\u201355.","journal-title":"Stem Cell Rep"},{"key":"738_CR41","volume":"8","author":"S Jiang","year":"2018","unstructured":"Jiang S, Wen N, Li Z, Dube U, Del Aguila J, Budde J, et al. Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP. Transl Psychiatry. 2018;8:265.","journal-title":"Transl Psychiatry"},{"key":"738_CR42","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1126\/science.aan6298","volume":"358","author":"M Abu-Remaileh","year":"2017","unstructured":"Abu-Remaileh M, Wyant GA, Kim C, Laqtom NN, Abbasi M, Chan SH, et al. Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes. Science. 2017;358:807\u201313.","journal-title":"Science"},{"key":"738_CR43","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1084\/jem.20131685","volume":"211","author":"K Yamada","year":"2014","unstructured":"Yamada K, Holth JK, Liao F, Stewart FR, Mahan TE, Jiang H, et al. Neuronal activity regulates extracellular tau in vivo. J Exp Med. 2014;211:387\u201393.","journal-title":"J Exp Med"},{"key":"738_CR44","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.97","volume":"8","author":"CL Croft","year":"2017","unstructured":"Croft CL, Wade MA, Kurbatskaya K, Mastrandreas P, Hughes MM, Phillips EC, et al. Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures. Cell Death Dis. 2017;8:e2671.","journal-title":"Cell Death Dis"},{"key":"738_CR45","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.devcel.2011.07.016","volume":"21","author":"DL Medina","year":"2011","unstructured":"Medina DL, Fraldi A, Bouche V, Annunziata F, Mansueto G, Spampanato C, et al. Transcriptional activation of lysosomal exocytosis promotes cellular clearance. Dev Cell. 2011;21:421\u201330.","journal-title":"Dev Cell"},{"key":"738_CR46","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ymgme.2006.05.016","volume":"89","author":"JM LaPlante","year":"2006","unstructured":"LaPlante JM, Sun M, Falardeau J, Dai D, Brown EM, Slaugenhaupt SA, et al. Lysosomal exocytosis is impaired in mucolipidosis type IV. Mol Genet Metab. 2006;89:339\u201348.","journal-title":"Mol Genet Metab"},{"key":"738_CR47","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1084\/jem.20172158","volume":"215","author":"H Martini-Stoica","year":"2018","unstructured":"Martini-Stoica H, Cole AL, Swartzlander DB, Chen F, Wan YW, Bajaj L, et al. TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading. J Exp Med. 2018;215:2355\u201377.","journal-title":"J Exp Med"},{"key":"738_CR48","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.tins.2016.02.002","volume":"39","author":"H Martini-Stoica","year":"2016","unstructured":"Martini-Stoica H, Xu Y, Ballabio A, Zheng H. The autophagy-lysosomal pathway in neurodegeneration: a TFEB perspective. Trends Neurosci. 2016;39:221\u201334.","journal-title":"Trends Neurosci"},{"key":"738_CR49","doi-asserted-by":"crossref","first-page":"5760","DOI":"10.1523\/JNEUROSCI.3085-18.2019","volume":"39","author":"T Tsunemi","year":"2019","unstructured":"Tsunemi T, Perez-Rosello T, Ishiguro Y, Yoroisaka A, Jeon S, Hamada K, et al. Increased lysosomal exocytosis induced by lysosomal Ca(2+) channel agonists protects human dopaminergic neurons from alpha-synuclein toxicity. J Neurosci. 2019;39:5760\u201372.","journal-title":"J Neurosci"},{"key":"738_CR50","volume":"5","author":"W Luo","year":"2015","unstructured":"Luo W, Liu W, Hu X, Hanna M, Caravaca A, Paul SM. Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody. Sci Rep. 2015;5:11161.","journal-title":"Sci Rep"},{"key":"738_CR51","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/s41380-018-0258-3","volume":"24","author":"M Audrain","year":"2019","unstructured":"Audrain M, Haure-Mirande JV, Wang M, Kim SH, Fanutza T, Chakrabarty P, et al. Integrative approach to sporadic Alzheimer\u2019s disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau. Mol Psychiatry. 2019;24:1383\u201397.","journal-title":"Mol Psychiatry"},{"key":"738_CR52","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nn.4132","volume":"18","author":"H Asai","year":"2015","unstructured":"Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, et al. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015;18:1584\u201393.","journal-title":"Nat Neurosci"},{"key":"738_CR53","volume":"15","author":"SC Hopp","year":"2018","unstructured":"Hopp SC, Lin Y, Oakley D, Roe AD, DeVos SL, Hanlon D, et al. The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer\u2019s disease. J Neuroinflammation. 2018;15:269.","journal-title":"J Neuroinflammation"},{"key":"738_CR54","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13024-016-0143-y","volume":"12","author":"Y Wang","year":"2017","unstructured":"Wang Y, Balaji V, Kaniyappan S, Kruger L, Irsen S, Tepper K, et al. The release and trans-synaptic transmission of Tau via exosomes. Mol Neurodegener. 2017;12:5.","journal-title":"Mol Neurodegener"},{"key":"738_CR55","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1126\/science.aav2546","volume":"363","author":"JK Holth","year":"2019","unstructured":"Holth JK, Fritschi SK, Wang C, Pedersen NP, Cirrito JR, Mahan TE, et al. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. Science. 2019;363:880\u20134.","journal-title":"Science"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41380-020-0738-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-020-0738-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-020-0738-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T19:10:45Z","timestamp":1642101045000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-020-0738-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,4]]},"references-count":55,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["738"],"URL":"https:\/\/doi.org\/10.1038\/s41380-020-0738-0","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,4]]},"assertion":[{"value":"19 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}