{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T16:29:33Z","timestamp":1782491373939,"version":"3.54.5"},"reference-count":101,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["28941"],"award-info":[{"award-number":["28941"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-168865 and PJT-162164"],"award-info":[{"award-number":["PJT-168865 and PJT-162164"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000887","name":"Huntington\u2019s Disease Society of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000887","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1038\/s41380-021-01350-4","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T04:02:34Z","timestamp":1635393754000},"page":"269-280","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Prion-like properties of the mutant huntingtin protein in living organisms: the evidence and the relevance"],"prefix":"10.1038","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2782-5454","authenticated-orcid":false,"given":"Melanie","family":"Alpaugh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1978-5058","authenticated-orcid":false,"given":"H\u00e9l\u00e8na L.","family":"Denis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5490-1961","authenticated-orcid":false,"given":"Francesca","family":"Cicchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"1350_CR1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S1097-2765(04)00151-0","volume":"14","author":"P Venkatraman","year":"2004","unstructured":"Venkatraman P, Wetzel R, Tanaka M, Nukina N, Goldberg AL. Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins. Mol Cell. 2004;14:95\u2013104.","journal-title":"Mol Cell"},{"key":"1350_CR2","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1093\/hmg\/10.10.1049","volume":"10","author":"NR Jana","year":"2001","unstructured":"Jana NR, Zemskov EA, Wang G, Nukina N. Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release. Hum Mol Genet. 2001;10:1049\u201359.","journal-title":"Hum Mol Genet"},{"key":"1350_CR3","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","volume":"90","author":"SW Davies","year":"1997","unstructured":"Davies SW, Turmaine M, Cozens BA, DiFiglia M, Sharp AH, Ross CA, et al. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell. 1997;90:537\u201348.","journal-title":"Cell"},{"key":"1350_CR4","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s00401-016-1582-9","volume":"132","author":"I Jeon","year":"2016","unstructured":"Jeon I, Cicchetti F, Cisbani G, Lee S, Li E, Bae J, et al. Human-to-mouse prion-like propagation of mutant huntingtin protein. Acta Neuropathol. 2016;132:577\u201392.","journal-title":"Acta Neuropathol"},{"key":"1350_CR5","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1172\/JCI80743","volume":"125","author":"EJ Wild","year":"2015","unstructured":"Wild EJ, Boggio R, Langbehn D, Robertson N, Haider S, Miller JR, et al. Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington\u2019s disease patients. J Clin Investig. 2015;125:1979\u201386.","journal-title":"J Clin Investig"},{"key":"1350_CR6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1002\/ana.24174","volume":"76","author":"F Cicchetti","year":"2014","unstructured":"Cicchetti F, Lacroix S, Cisbani G, Vallieres N, Saint-Pierre M, St-Amour I, et al. Mutant huntingtin is present in neuronal grafts in Huntington disease patients. Ann Neurol. 2014;76:31\u201342.","journal-title":"Ann Neurol"},{"key":"1350_CR7","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/j.jasms.2007.04.012","volume":"18","author":"X Liu","year":"2007","unstructured":"Liu X, Valentine SJ, Plasencia MD, Trimpin S, Naylor S, Clemmer DE. Mapping the human plasma proteome by SCX-LC-IMS-MS. J Am Soc Mass Spectrom. 2007;18:1249\u201364.","journal-title":"J Am Soc Mass Spectrom"},{"key":"1350_CR8","doi-asserted-by":"publisher","first-page":"2522","DOI":"10.1523\/JNEUROSCI.19-07-02522.1999","volume":"19","author":"CA Gutekunst","year":"1999","unstructured":"Gutekunst CA, Li SH, Yi H, Mulroy JS, Kuemmerle S, Jones R, et al. Nuclear and neuropil aggregates in Huntington\u2019s disease: relationship to neuropathology. J Neurosci. 1999;19:2522\u201334.","journal-title":"J Neurosci"},{"key":"1350_CR9","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/B978-0-12-381328-2.00014-6","volume":"98","author":"A Reiner","year":"2011","unstructured":"Reiner A, Dragatsis I, Dietrich P. Genetics and neuropathology of Huntington\u2019s disease. Int Rev Neurobiol. 2011;98:325\u201372.","journal-title":"Int Rev Neurobiol"},{"key":"1350_CR10","doi-asserted-by":"crossref","unstructured":"Vonsattel JP, Keller C, Del Pilar Amaya M. Neuropathology of Huntington\u2019s disease. Handb Clin Neurol. 2008;89:599\u2013618.","DOI":"10.1016\/S0072-9752(07)01256-0"},{"key":"1350_CR11","doi-asserted-by":"publisher","first-page":"421","DOI":"10.2217\/nmt.12.34","volume":"2","author":"C Tang","year":"2012","unstructured":"Tang C, Feigin A. Monitoring Huntington\u2019s disease progression through preclinical and early stages. Neurodegenerative Dis Manag. 2012;2:421\u201335.","journal-title":"Neurodegenerative Dis Manag"},{"key":"1350_CR12","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1002\/ana.25354","volume":"84","author":"A Maxan","year":"2018","unstructured":"Maxan A, Mason S, Saint-Pierre M, Smith E, Ho A, Harrower T, et al. Outcome of cell suspension allografts in a patient with Huntington\u2019s disease. Ann. Neurol. 2018;84:950\u20136.","journal-title":"Ann. Neurol."},{"key":"1350_CR13","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1038\/nn.3761","volume":"17","author":"E Pecho-Vrieseling","year":"2014","unstructured":"Pecho-Vrieseling E, Rieker C, Fuchs S, Bleckmann D, Esposito MS, Botta P, et al. Transneuronal propagation of mutant huntingtin contributes to non-cell autonomous pathology in neurons. Nat Neurosci. 2014;17:1064\u201372.","journal-title":"Nat Neurosci"},{"key":"1350_CR14","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1038\/mp.2015.81","volume":"20","author":"Z Tan","year":"2015","unstructured":"Tan Z, Dai W, van Erp TG, Overman J, Demuro A, Digman MA, et al. Huntington\u2019s disease cerebrospinal fluid seeds aggregation of mutant huntingtin. Mol Psychiatry. 2015;20:1286\u201393.","journal-title":"Mol Psychiatry"},{"key":"1350_CR15","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.molcel.2018.07.032","volume":"71","author":"A Ast","year":"2018","unstructured":"Ast A, Buntru A, Schindler F, Hasenkopf R, Schulz A, Brusendorf L, et al. mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington\u2019s Disease. Mol Cell. 2018;71:675\u201388.","journal-title":"Mol Cell"},{"key":"1350_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-8-559","volume":"8","author":"M Imran","year":"2011","unstructured":"Imran M, Mahmood S. An overview of human prion diseases. Virol J. 2011;8:559.","journal-title":"Virol J"},{"key":"1350_CR17","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/j.1423-0410.2006.00833.x","volume":"91","author":"PE Hewitt","year":"2006","unstructured":"Hewitt PE, Llewelyn CA, Mackenzie J, Will RG. Creutzfeldt-Jakob disease and blood transfusion: results of the UK Transfusion Medicine Epidemiological Review study. Vox Sang. 2006;91:221\u201330.","journal-title":"Vox Sang"},{"key":"1350_CR18","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0928-8244(98)00020-0","volume":"21","author":"JW Ironside","year":"1998","unstructured":"Ironside JW. Neuropathological findings in new variant CJD and experimental transmission of BSE. FEMS Immunol Med Microbiol. 1998;21:91\u201395.","journal-title":"FEMS Immunol Med Microbiol"},{"key":"1350_CR19","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/S0022-510X(98)00226-3","volume":"160","author":"CJ Lang","year":"1998","unstructured":"Lang CJ, Heckmann JG, Neundorfer B. Creutzfeldt-Jakob disease via dural and corneal transplants. J Neurol Sci. 1998;160:128\u201339.","journal-title":"J Neurol Sci"},{"key":"1350_CR20","doi-asserted-by":"publisher","first-page":"E10","DOI":"10.3171\/2016.5.FOCUS15126","volume":"41","author":"DJ Bonda","year":"2016","unstructured":"Bonda DJ, Manjila S, Mehndiratta P, Khan F, Miller BR, Onwuzulike K, et al. Human prion diseases: surgical lessons learned from iatrogenic prion transmission. Neurosurg Focus. 2016;41:E10.","journal-title":"Neurosurg Focus"},{"key":"1350_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000339318","volume":"39","author":"J de Pedro Cuesta","year":"2012","unstructured":"de Pedro Cuesta J, Ruiz Tovar M, Ward H, Calero M, Smith A, Verduras CA, et al. Sensitivity to biases of case-control studies on medical procedures, particularly surgery and blood transfusion, and risk of Creutzfeldt-Jakob disease. Neuroepidemiology. 2012;39:1\u201318.","journal-title":"Neuroepidemiology"},{"key":"1350_CR22","doi-asserted-by":"crossref","unstructured":"Rieux M, Alpaugh M, Sciacca G, Saint-Pierre M, Masnata M, Denis HL, et al. Shedding a new light on Huntington\u2019s disease: how blood can both propagate and ameliorate disease pathology. Mol Psychiatry. 2020:1-23.","DOI":"10.1038\/s41380-020-0850-1"},{"key":"1350_CR23","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1038\/mp.2017.204","volume":"23","author":"XL Bu","year":"2018","unstructured":"Bu XL, Xiang Y, Jin WS, Wang J, Shen LL, Huang ZL, et al. Blood-derived amyloid-beta protein induces Alzheimer\u2019s disease pathologies. Mol Psychiatry. 2018;23:1948\u201356.","journal-title":"Mol Psychiatry"},{"key":"1350_CR24","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1002\/mds.27842","volume":"34","author":"SM Sundaram","year":"2019","unstructured":"Sundaram SM, Garg P. The gut-brain axis in Parkinson\u2019s disease: a focus on the transport of alpha-Synuclein. Mov Disord. 2019;34:1479.","journal-title":"Mov Disord"},{"key":"1350_CR25","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","volume":"24","author":"H Braak","year":"2003","unstructured":"Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson\u2019s disease. Neurobiol Aging. 2003;24:197\u2013211.","journal-title":"Neurobiol Aging"},{"key":"1350_CR26","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s00401-016-1538-0","volume":"131","author":"M Brahic","year":"2016","unstructured":"Brahic M, Bousset L, Bieri G, Melki R, Gitler AD. Axonal transport and secretion of fibrillar forms of alpha-synuclein, Abeta42 peptide and HTTExon 1. Acta Neuropathol. 2016;131:539\u201348.","journal-title":"Acta Neuropathol"},{"key":"1350_CR27","doi-asserted-by":"publisher","first-page":"4192","DOI":"10.1002\/hbm.24695","volume":"40","author":"GR Poudel","year":"2019","unstructured":"Poudel GR, Harding IH, Egan GF, Georgiou-Karistianis N. Network spread determines severity of degeneration and disconnection in Huntington\u2019s disease. Hum Brain Mapp. 2019;40:4192\u2013201.","journal-title":"Hum Brain Mapp"},{"key":"1350_CR28","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.neuron.2011.08.033","volume":"72","author":"LA Volpicelli-Daley","year":"2011","unstructured":"Volpicelli-Daley LA, Luk KC, Patel TP, Tanik SA, Riddle DM, Stieber A, et al. Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron. 2011;72:57\u201371.","journal-title":"Neuron"},{"key":"1350_CR29","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1002\/ana.23747","volume":"72","author":"EC Freundt","year":"2012","unstructured":"Freundt EC, Maynard N, Clancy EK, Roy S, Bousset L, Sourigues Y, et al. Neuron-to-neuron transmission of alpha-synuclein fibrils through axonal transport. Ann Neurol. 2012;72:517\u201324.","journal-title":"Ann Neurol"},{"key":"1350_CR30","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1074\/jbc.M112.394528","volume":"288","author":"JW Wu","year":"2013","unstructured":"Wu JW, Herman M, Liu L, Simoes S, Acker CM, Figueroa H, et al. Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons. J Biol Chem. 2013;288:1856\u201370.","journal-title":"J Biol Chem"},{"key":"1350_CR31","doi-asserted-by":"publisher","first-page":"104951","DOI":"10.1016\/j.nbd.2020.104951","volume":"141","author":"A Maxan","year":"2020","unstructured":"Maxan A, Sciacca G, Alpaugh M, Tao Z, Breger L, Dehay B, et al. Use of adeno-associated virus-mediated delivery of mutant huntingtin to study the spreading capacity of the protein in mice and non-human primates. Neurobiol Dis. 2020;141:104951.","journal-title":"Neurobiol Dis"},{"key":"1350_CR32","doi-asserted-by":"publisher","first-page":"E5427","DOI":"10.1073\/pnas.1516217112","volume":"112","author":"DT Babcock","year":"2015","unstructured":"Babcock DT, Ganetzky B. Transcellular spreading of huntingtin aggregates in the Drosophila brain. Proc Natl Acad Sci USA. 2015;112:E5427\u20135433.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1350_CR33","doi-asserted-by":"publisher","first-page":"e58499","DOI":"10.7554\/eLife.58499","volume":"9","author":"KM Donnelly","year":"2020","unstructured":"Donnelly KM, DeLorenzo OR, Zaya AD, Pisano GE, Thu WM, Luo L, et al. Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses. Elife. 2020;9:e58499.","journal-title":"Elife"},{"key":"1350_CR34","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1007\/s00401-019-01973-6","volume":"137","author":"M Masnata","year":"2019","unstructured":"Masnata M, Sciacca G, Maxan A, Bousset L, Denis HL, Lauruol F, et al. Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms. Acta Neuropathol. 2019;137:981\u20131001.","journal-title":"Acta Neuropathol"},{"key":"1350_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7768","volume":"6","author":"MMP Pearce","year":"2015","unstructured":"Pearce MMP, Spartz EJ, Hong W, Luo L, Kopito RR. Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain. Nat Commun. 2015;6:6768.","journal-title":"Nat Commun"},{"key":"1350_CR36","doi-asserted-by":"publisher","first-page":"104941","DOI":"10.1016\/j.nbd.2020.104941","volume":"141","author":"P Gosset","year":"2020","unstructured":"Gosset P, Maxan A, Alpaugh M, Breger L, Dehay B, Tao Z, et al. Evidence for the spread of human-derived mutant huntingtin protein in mice and non-human primates. Neurobiol Dis. 2020;141:104941.","journal-title":"Neurobiol Dis"},{"key":"1350_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15119-w","volume":"11","author":"I Choi","year":"2020","unstructured":"Choi I, Zhang Y, Seegobin SP, Pruvost M, Wang Q, Purtell K, et al. Microglia clear neuron-released alpha-synuclein via selective autophagy and prevent neurodegeneration. Nat Commun. 2020;11:1386.","journal-title":"Nat Commun"},{"key":"1350_CR38","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1016\/j.jmb.2019.12.041","volume":"432","author":"K Sung","year":"2020","unstructured":"Sung K, Jimenez-Sanchez M. Autophagy in Astrocytes and its Implications in Neurodegeneration. J Mol Biol. 2020;432:2605\u201321.","journal-title":"J Mol Biol"},{"key":"1350_CR39","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s40478-020-00943-4","volume":"8","author":"PS Mishra","year":"2020","unstructured":"Mishra PS, Boutej H, Soucy G, Bareil C, Kumar S, Picher-Martel V, et al. Transmission of ALS pathogenesis by the cerebrospinal fluid. Acta Neuropathol Commun. 2020;8:65.","journal-title":"Acta Neuropathol Commun"},{"key":"1350_CR40","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ab.2009.08.001","volume":"395","author":"A Weiss","year":"2009","unstructured":"Weiss A, Abramowski D, Bibel M, Bodner R, Chopra V, DiFiglia M, et al. Single-step detection of mutant huntingtin in animal and human tissues: a bioassay for Huntington\u2019s disease. Anal Biochem. 2009;395:8\u201315.","journal-title":"Anal Biochem"},{"key":"1350_CR41","doi-asserted-by":"publisher","first-page":"eaat7108","DOI":"10.1126\/scitranslmed.aat7108","volume":"10","author":"LM Byrne","year":"2018","unstructured":"Byrne LM, Rodrigues FB, Johnson EB, Wijeratne PA, De Vita E, Alexander DC, et al. Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington\u2019s disease. Sci Transl Med. 2018;10:eaat7108.","journal-title":"Sci Transl Med."},{"key":"1350_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77164-1","volume":"10","author":"CYD Lee","year":"2020","unstructured":"Lee CYD, Wang N, Shen K, Stricos M, Langfelder P, Cheon KH, et al. Disease-related Huntingtin seeding activities in cerebrospinal fluids of Huntington\u2019s disease patients. Sci Rep. 2020;10:20295.","journal-title":"Sci Rep"},{"key":"1350_CR43","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1523\/JNEUROSCI.1865-20.2020","volume":"41","author":"NS Caron","year":"2021","unstructured":"Caron NS, Banos R, Yanick C, Aly AE, Byrne LM, Smith ED, et al. Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease. J Neurosci. 2021;41:780\u201396.","journal-title":"J Neurosci"},{"key":"1350_CR44","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1083\/jcb.201807068","volume":"218","author":"M Sharma","year":"2019","unstructured":"Sharma M, Subramaniam S. Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion. J Cell Biol. 2019;218:1972\u201393.","journal-title":"J Cell Biol"},{"key":"1350_CR45","first-page":"3678","volume":"126","author":"M Costanzo","year":"2013","unstructured":"Costanzo M, Abounit S, Marzo L, Danckaert A, Chamoun Z, Roux P, et al. Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes. J Cell Sci. 2013;126:3678\u201385.","journal-title":"J Cell Sci"},{"key":"1350_CR46","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1083\/jcb.201211138","volume":"200","author":"G Raposo","year":"2013","unstructured":"Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013;200:373\u201383.","journal-title":"J Cell Biol"},{"key":"1350_CR47","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.1007\/s00018-011-0689-3","volume":"68","author":"B Gyorgy","year":"2011","unstructured":"Gyorgy B, Szabo TG, Pasztoi M, Pal Z, Misjak P, Aradi B, et al. Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell Mol Life Sci. 2011;68:2667\u201388.","journal-title":"Cell Mol Life Sci"},{"key":"1350_CR48","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nrd3978","volume":"12","author":"ELA S","year":"2013","unstructured":"S ELA, Mager I, Breakefield XO, Wood MJ. Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov. 2013;12:347\u201357.","journal-title":"Nat Rev Drug Discov"},{"key":"1350_CR49","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13024-016-0143-y","volume":"12","author":"Y Wang","year":"2017","unstructured":"Wang Y, Balaji V, Kaniyappan S, Kruger L, Irsen S, Tepper K, et al. The release and trans-synaptic transmission of Tau via exosomes. Mol Neurodegener. 2017;12:5.","journal-title":"Mol Neurodegener"},{"key":"1350_CR50","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1002\/path.2145","volume":"211","author":"LJ Vella","year":"2007","unstructured":"Vella LJ, Sharples RA, Lawson VA, Masters CL, Cappai R, Hill AF. Packaging of prions into exosomes is associated with a novel pathway of PrP processing. J Pathol. 2007;211:582\u201390.","journal-title":"J Pathol"},{"key":"1350_CR51","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s00401-018-1868-1","volume":"136","author":"M Sardar Sinha","year":"2018","unstructured":"Sardar Sinha M, Ansell-Schultz A, Civitelli L, Hildesjo C, Larsson M, Lannfelt L, et al. Alzheimer\u2019s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers. Acta Neuropathol. 2018;136:41\u201356.","journal-title":"Acta Neuropathol"},{"key":"1350_CR52","doi-asserted-by":"publisher","first-page":"eaau4543","DOI":"10.1126\/scisignal.aau4543","volume":"12","author":"DS Harischandra","year":"2019","unstructured":"Harischandra DS, Rokad D, Neal ML, Ghaisas S, Manne S, Sarkar S, et al. Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of alpha-synuclein. Sci Signal. 2019;12:eaau4543.","journal-title":"Sci Signal."},{"key":"1350_CR53","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3389\/fnins.2017.00149","volume":"11","author":"JKT Wang","year":"2017","unstructured":"Wang JKT, Langfelder P, Horvath S, Palazzolo MJ. Exosomes and Homeostatic Synaptic Plasticity Are Linked to Each other and to Huntington\u2019s, Parkinson\u2019s, and Other Neurodegenerative Diseases by Database-Enabled Analyses of Comprehensively Curated Datasets. Front Neurosci. 2017;11:149.","journal-title":"Front Neurosci"},{"key":"1350_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01115-6","volume":"7","author":"J Deng","year":"2017","unstructured":"Deng J, Koutras C, Donnelier J, Alshehri M, Fotouhi M, Girard M, et al. Neurons Export Extracellular Vesicles Enriched in Cysteine String Protein and Misfolded Protein Cargo. Sci Rep. 2017;7:956.","journal-title":"Sci Rep"},{"key":"1350_CR55","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1016\/j.bbamcr.2016.05.005","volume":"1863","author":"L Diaz-Hidalgo","year":"2016","unstructured":"Diaz-Hidalgo L, Altuntas S, Rossin F, D\u2019Eletto M, Marsella C, Farrace MG, et al. Transglutaminase type 2-dependent selective recruitment of proteins into exosomes under stressful cellular conditions. Biochim Biophys Acta. 2016;1863:2084\u201392.","journal-title":"Biochim Biophys Acta"},{"key":"1350_CR56","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1007\/s00415-018-9022-5","volume":"265","author":"HL Denis","year":"2018","unstructured":"Denis HL, Lamontagne-Proulx J, St-Amour I, Mason SL, Weiss A, Chouinard S, et al. Platelet-derived extracellular vesicles in Huntington\u2019s disease. J Neurol. 2018;265:2704\u201312.","journal-title":"J Neurol"},{"key":"1350_CR57","doi-asserted-by":"publisher","first-page":"3702","DOI":"10.1093\/hmg\/ddq285","volume":"19","author":"MY Heng","year":"2010","unstructured":"Heng MY, Duong DK, Albin RL, Tallaksen-Greene SJ, Hunter JM, Lesort MJ, et al. Early autophagic response in a novel knock-in model of Huntington disease. Hum Mol Genet. 2010;19:3702\u201320.","journal-title":"Hum Mol Genet"},{"key":"1350_CR58","doi-asserted-by":"publisher","first-page":"9000","DOI":"10.1523\/JNEUROSCI.0118-17.2017","volume":"37","author":"K Trajkovic","year":"2017","unstructured":"Trajkovic K, Jeong H, Krainc D. Mutant Huntingtin Is Secreted via a Late Endosomal\/Lysosomal Unconventional Secretory Pathway. J Neurosci : Off J Soc Neurosci. 2017;37:9000\u201312.","journal-title":"J Neurosci : Off J Soc Neurosci"},{"key":"1350_CR59","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/7854_2014_354","volume":"22","author":"HJ Waldvogel","year":"2015","unstructured":"Waldvogel HJ, Kim EH, Tippett LJ, Vonsattel JP, Faull RL. The Neuropathology of Huntington\u2019s Disease. Curr Top Behav Neurosci. 2015;22:33\u201380.","journal-title":"Curr Top Behav Neurosci"},{"key":"1350_CR60","first-page":"1158","volume":"74","author":"DR Jones","year":"2015","unstructured":"Jones DR, Delenclos M, Baine AT, DeTure M, Murray ME, Dickson DW, et al. Transmission of Soluble and Insoluble alpha-Synuclein to Mice. J Neuropathol Exp Neurol. 2015;74:1158\u201369.","journal-title":"J Neuropathol Exp Neurol"},{"key":"1350_CR61","doi-asserted-by":"publisher","first-page":"10323","DOI":"10.1073\/pnas.1408900111","volume":"111","author":"JC Watts","year":"2014","unstructured":"Watts JC, Condello C, Stohr J, Oehler A, Lee J, DeArmond SJ, et al. Serial propagation of distinct strains of Abeta prions from Alzheimer\u2019s disease patients. Proc Natl Acad Sci USA. 2014;111:10323\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1350_CR62","doi-asserted-by":"publisher","first-page":"585896","DOI":"10.3389\/fbioe.2020.585896","volume":"8","author":"LM Ascari","year":"2020","unstructured":"Ascari LM, Rocha SC, Goncalves PB, Vieira T, Cordeiro Y. Challenges and Advances in Antemortem Diagnosis of Human Transmissible Spongiform Encephalopathies. Front Bioeng Biotechnol. 2020;8:585896.","journal-title":"Front Bioeng Biotechnol"},{"key":"1350_CR63","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1093\/brain\/awab061","volume":"144","author":"N Van Den Berge","year":"2021","unstructured":"Van Den Berge N, Ferreira N, Mikkelsen TW, Alstrup AKO, Tamguney G, Karlsson P, et al. Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats. Brain. 2021;144:1853\u201368.","journal-title":"Brain"},{"key":"1350_CR64","doi-asserted-by":"publisher","first-page":"eaaw6404","DOI":"10.1126\/sciadv.aaw6404","volume":"5","author":"S Wegmann","year":"2019","unstructured":"Wegmann S, Bennett RE, Delorme L, Robbins AB, Hu M, McKenzie D, et al. Experimental evidence for the age dependence of tau protein spread in the brain. Sci Adv. 2019;5:eaaw6404.","journal-title":"Sci Adv"},{"key":"1350_CR65","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s40478-019-0860-x","volume":"7","author":"J Moron-Oset","year":"2019","unstructured":"Moron-Oset J, Super T, Esser J, Isaacs AM, Gronke S, Partridge L. Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain. Acta Neuropathol Commun. 2019;7:209.","journal-title":"Acta Neuropathol Commun"},{"key":"1350_CR66","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61757-x","volume":"10","author":"J Courte","year":"2020","unstructured":"Courte J, Bousset L, Boxberg YV, Villard C, Melki R, Peyrin JM. The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding. Sci Rep. 2020;10:4895.","journal-title":"Sci Rep"},{"key":"1350_CR67","doi-asserted-by":"publisher","first-page":"3493","DOI":"10.1007\/s00415-021-10418-8","volume":"68","author":"M Alpaugh","year":"2021","unstructured":"Alpaugh M, Cicchetti F. Huntington\u2019s disease: lessons from prion disorders. J Neurol. 2021;68:3493\u2013504.","journal-title":"J Neurol."},{"key":"1350_CR68","doi-asserted-by":"publisher","first-page":"743","DOI":"10.3233\/JAD-170298","volume":"59","author":"G Manassero","year":"2017","unstructured":"Manassero G, Guglielmotto M, Monteleone D, Vasciaveo V, Butenko O, Tamagno E, et al. Dual Mechanism of Toxicity for Extracellular Injection of Tau Oligomers versus Monomers in Human Tau Mice. J Alzheimers Dis. 2017;59:743\u201351.","journal-title":"J Alzheimers Dis"},{"key":"1350_CR69","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1093\/brain\/awt037","volume":"136","author":"M Masuda-Suzukake","year":"2013","unstructured":"Masuda-Suzukake M, Nonaka T, Hosokawa M, Oikawa T, Arai T, Akiyama H, et al. Prion-like spreading of pathological alpha-synuclein in brain. Brain. 2013;136:1128\u201338.","journal-title":"Brain"},{"key":"1350_CR70","doi-asserted-by":"publisher","first-page":"3815","DOI":"10.1073\/pnas.1516546113","volume":"113","author":"D Pinotsi","year":"2016","unstructured":"Pinotsi D, Michel CH, Buell AK, Laine RF, Mahou P, Dobson CM, et al. Nanoscopic insights into seeding mechanisms and toxicity of alpha-synuclein species in neurons. Proc Natl Acad Sci USA. 2016;113:3815\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1350_CR71","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/bpa.12734","volume":"30","author":"N Katzmarski","year":"2020","unstructured":"Katzmarski N, Ziegler-Waldkirch S, Scheffler N, Witt C, Abou-Ajram C, Nuscher B, et al. Abeta oligomers trigger and accelerate Abeta seeding. Brain Pathol. 2020;30:36\u201345.","journal-title":"Brain Pathol"},{"key":"1350_CR72","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.neuron.2016.02.003","volume":"89","author":"F Saudou","year":"2016","unstructured":"Saudou F, Humbert S. The Biology of Huntingtin. Neuron. 2016;89:910\u201326.","journal-title":"Neuron"},{"key":"1350_CR73","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1016\/j.febslet.2015.05.041","volume":"589","author":"OA Morozova","year":"2015","unstructured":"Morozova OA, Gupta S, Colby DW. Prefibrillar huntingtin oligomers isolated from HD brain potently seed amyloid formation. FEBS Lett. 2015;589:1897\u2013903.","journal-title":"FEBS Lett"},{"key":"1350_CR74","doi-asserted-by":"publisher","first-page":"2894","DOI":"10.1016\/j.bpj.2012.04.050","volume":"102","author":"L Pieri","year":"2012","unstructured":"Pieri L, Madiona K, Bousset L, Melki R. Fibrillar alpha-synuclein and huntingtin exon 1 assemblies are toxic to the cells. Biophys J. 2012;102:2894\u2013905.","journal-title":"Biophys J"},{"key":"1350_CR75","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00401-020-02201-2","volume":"142","author":"HHC Lau","year":"2020","unstructured":"Lau HHC, Ingelsson M, Watts JC. The existence of Abeta strains and their potential for driving phenotypic heterogeneity in Alzheimer\u2019s disease. Acta Neuropathol. 2020;142:17\u201339.","journal-title":"Acta Neuropathol."},{"key":"1350_CR76","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1073\/pnas.1221891110","volume":"110","author":"K Sathasivam","year":"2013","unstructured":"Sathasivam K, Neueder A, Gipson TA, Landles C, Benjamin AC, Bondulich MK, et al. Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease. Proc Natl Acad Sci USA. 2013;110:2366\u201370.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1350_CR77","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1093\/hmg\/ddu504","volume":"24","author":"BA Barbaro","year":"2015","unstructured":"Barbaro BA, Lukacsovich T, Agrawal N, Burke J, Bornemann DJ, Purcell JM, et al. Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington\u2019s disease. Hum Mol Genet. 2015;24:913\u201325.","journal-title":"Hum Mol Genet"},{"key":"1350_CR78","doi-asserted-by":"publisher","first-page":"682172","DOI":"10.3389\/fnins.2021.682172","volume":"15","author":"F Schindler","year":"2021","unstructured":"Schindler F, Praedel N, Neuendorf N, Kunz S, Schnoegl S, Mason MA, et al. Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington\u2019s Disease Knock-in Mice. Front Neurosci. 2021;15:682172.","journal-title":"Front Neurosci"},{"key":"1350_CR79","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1001\/jamaneurol.2019.2368","volume":"76","author":"DR Langbehn","year":"2019","unstructured":"Langbehn DR, Stout JC, Gregory S, Mills JA, Durr A, Leavitt BR, et al. Association of CAG Repeats With Long-term Progression in Huntington Disease. JAMA Neurol. 2019;76:1375\u201385.","journal-title":"JAMA Neurol."},{"key":"1350_CR80","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1111\/j.1750-3639.1997.tb00894.x","volume":"7","author":"BT Koshy","year":"1997","unstructured":"Koshy BT, Zoghbi HY. The CAG\/polyglutamine tract diseases: gene products and molecular pathogenesis. Brain Pathol. 1997;7:927\u201342.","journal-title":"Brain Pathol"},{"key":"1350_CR81","doi-asserted-by":"publisher","first-page":"4604","DOI":"10.1073\/pnas.96.8.4604","volume":"96","author":"E Scherzinger","year":"1999","unstructured":"Scherzinger E, Sittler A, Schweiger K, Heiser V, Lurz R, Hasenbank R, et al. Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington\u2019s disease pathology. Proc Natl Acad Sci USA. 1999;96:4604\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1350_CR82","doi-asserted-by":"publisher","first-page":"321","DOI":"10.5607\/en.2017.26.6.321","volume":"26","author":"DK Kim","year":"2017","unstructured":"Kim DK, Cho KW, Ahn WJ, Perez-Acuna D, Jeong H, Lee HJ, et al. Cell-to-cell Transmission of Polyglutamine Aggregates in C. elegans. Exp Neurobiol. 2017;26:321\u20138.","journal-title":"Exp Neurobiol"},{"key":"1350_CR83","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.1038\/s41380-020-00999-7","volume":"26","author":"A de Rus Jacquet","year":"2021","unstructured":"de Rus Jacquet A, Denis HL, Cicchetti F, Alpaugh M. Current and future applications of induced pluripotent stem cell-based models to study pathological proteins in neurodegenerative disorders. Mol Psychiatry. 2021;26:2685\u2013706.","journal-title":"Mol Psychiatry."},{"key":"1350_CR84","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","volume":"15","author":"Y Hou","year":"2019","unstructured":"Hou Y, Dan X, Babbar M, Wei Y, Hasselbalch SG, Croteau DL, et al. Ageing as a risk factor for neurodegenerative disease. Nat Rev Neurol. 2019;15:565\u201381.","journal-title":"Nat Rev Neurol"},{"key":"1350_CR85","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/S1474-4422(20)30143-5","volume":"19","author":"RI Scahill","year":"2020","unstructured":"Scahill RI, Zeun P, Osborne-Crowley K, Johnson EB, Gregory S, Parker C, et al. Biological and clinical characteristics of gene carriers far from predicted onset in the Huntington\u2019s disease Young Adult Study (HD-YAS): a cross-sectional analysis. Lancet Neurol. 2020;19:502\u201312.","journal-title":"Lancet Neurol"},{"key":"1350_CR86","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.conb.2019.11.008","volume":"61","author":"K Del Tredici","year":"2020","unstructured":"Del Tredici K, Braak H. To stage, or not to stage. Curr Opin Neurobiol. 2020;61:10\u201322.","journal-title":"Curr Opin Neurobiol"},{"key":"1350_CR87","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0304-3940(94)90239-9","volume":"170","author":"A Nitta","year":"1994","unstructured":"Nitta A, Itoh A, Hasegawa T, Nabeshima T. beta-Amyloid protein-induced Alzheimer\u2019s disease animal model. Neurosci Lett. 1994;170:63\u201366.","journal-title":"Neurosci Lett"},{"key":"1350_CR88","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/S0006-8993(01)02704-4","volume":"912","author":"S Nakamura","year":"2001","unstructured":"Nakamura S, Murayama N, Noshita T, Annoura H, Ohno T. Progressive brain dysfunction following intracerebroventricular infusion of beta(1-42)-amyloid peptide. Brain Res. 2001;912:128\u201336.","journal-title":"Brain Res"},{"key":"1350_CR89","doi-asserted-by":"publisher","first-page":"6186","DOI":"10.1093\/hmg\/ddv335","volume":"24","author":"AI Ramsingh","year":"2015","unstructured":"Ramsingh AI, Manley K, Rong Y, Reilly A, Messer A. Transcriptional dysregulation of inflammatory\/immune pathways after active vaccination against Huntington\u2019s disease. Hum Mol Genet. 2015;24:6186\u201397.","journal-title":"Hum Mol Genet"},{"key":"1350_CR90","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/S1525-0016(03)00063-7","volume":"7","author":"TW Miller","year":"2003","unstructured":"Miller TW, Shirley TL, Wolfgang WJ, Kang X, Messer A. DNA vaccination against mutant huntingtin ameliorates the HDR6\/2 diabetic phenotype. Mol Ther. 2003;7:572\u20139.","journal-title":"Mol Ther"},{"key":"1350_CR91","doi-asserted-by":"publisher","first-page":"104943","DOI":"10.1016\/j.nbd.2020.104943","volume":"141","author":"S Bartl","year":"2020","unstructured":"Bartl S, Oueslati A, Southwell AL, Siddu A, Parth M, David LS, et al. Inhibiting cellular uptake of mutant huntingtin using a monoclonal antibody: Implications for the treatment of Huntington\u2019s disease. Neurobiol Dis. 2020;141:104943.","journal-title":"Neurobiol Dis"},{"key":"1350_CR92","doi-asserted-by":"crossref","unstructured":"Bartl S, Xie Y, Potluri N, Gordon B, Willenberg A, Balazs K, et al. In vivo targeting and reduction of mtHTT protein by passive immunization with the monoclonal antibody C6-17. CHDI2021;poster I09;36.","DOI":"10.1136\/jnnp-2021-EHDN.123"},{"key":"1350_CR93","doi-asserted-by":"publisher","first-page":"eaat8462","DOI":"10.1126\/scitranslmed.aat8462","volume":"11","author":"A Aoyagi","year":"2019","unstructured":"Aoyagi A, Condello C, Stohr J, Yue W, Rivera BM, Lee JC, et al. Abeta and tau prion-like activities decline with longevity in the Alzheimer\u2019s disease human brain. Sci Transl Med. 2019;11:eaat8462.","journal-title":"Sci Transl Med."},{"key":"1350_CR94","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1038\/s41591-020-0938-9","volume":"26","author":"S Dujardin","year":"2020","unstructured":"Dujardin S, Commins C, Lathuiliere A, Beerepoot P, Fernandes AR, Kamath TV, et al. Tau molecular diversity contributes to clinical heterogeneity in Alzheimer\u2019s disease. Nat Med. 2020;26:1256\u201363.","journal-title":"Nat Med"},{"key":"1350_CR95","doi-asserted-by":"publisher","first-page":"41452","DOI":"10.1074\/jbc.M303354200","volume":"278","author":"A Busch","year":"2003","unstructured":"Busch A, Engemann S, Lurz R, Okazawa H, Lehrach H, Wanker EE. Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington\u2019s disease. J Biol Chem. 2003;278:41452\u201361.","journal-title":"J Biol Chem"},{"key":"1350_CR96","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.1021\/acs.biochem.7b00138","volume":"56","author":"JM Isas","year":"2017","unstructured":"Isas JM, Langen A, Isas MC, Pandey NK, Siemer AB. Formation and Structure of Wild Type Huntingtin Exon-1 Fibrils. Biochemistry. 2017;56:3579\u201386.","journal-title":"Biochemistry"},{"key":"1350_CR97","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/s41586-020-1984-7","volume":"578","author":"M Shahnawaz","year":"2020","unstructured":"Shahnawaz M, Mukherjee A, Pritzkow S, Mendez N, Rabadia P, Liu X, et al. Discriminating alpha-synuclein strains in Parkinson\u2019s disease and multiple system atrophy. Nature. 2020;578:273\u20137.","journal-title":"Nature"},{"key":"1350_CR98","doi-asserted-by":"publisher","first-page":"9679","DOI":"10.1073\/pnas.0812083106","volume":"106","author":"Y Nekooki-Machida","year":"2009","unstructured":"Nekooki-Machida Y, Kurosawa M, Nukina N, Ito K, Oda T, Tanaka M. Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity. Proc Natl Acad Sci USA. 2009;106:9679\u201384.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1350_CR99","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3233\/JHD-200429","volume":"10","author":"DG Monckton","year":"2021","unstructured":"Monckton DG. The Contribution of Somatic Expansion of the CAG Repeat to Symptomatic Development in Huntington\u2019s Disease: A Historical Perspective. J Huntingt Dis. 2021;10:7\u201333.","journal-title":"J Huntingt Dis"},{"key":"1350_CR100","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01510-z","volume":"7","author":"A Neueder","year":"2017","unstructured":"Neueder A, Landles C, Ghosh R, Howland D, Myers RH, Faull RLM, et al. The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington\u2019s disease patients. Sci Rep. 2017;7:1307.","journal-title":"Sci Rep"},{"key":"1350_CR101","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/s41586-020-2156-5","volume":"580","author":"JN Rauch","year":"2020","unstructured":"Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, et al. LRP1 is a master regulator of tau uptake and spread. Nature. 2020;580:381\u20135.","journal-title":"Nature"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41380-021-01350-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-021-01350-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-021-01350-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T01:05:15Z","timestamp":1675818315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-021-01350-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,28]]},"references-count":101,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["1350"],"URL":"https:\/\/doi.org\/10.1038\/s41380-021-01350-4","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,28]]},"assertion":[{"value":"28 October 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}