{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:40:59Z","timestamp":1787740859261,"version":"build-2784847793"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000026","name":"U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA047967"],"award-info":[{"award-number":["R01DA047967"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R21DA040777"],"award-info":[{"award-number":["R21DA040777"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"name":"U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1038\/s41380-022-01448-3","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T14:03:17Z","timestamp":1643119397000},"page":"2136-2145","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["TAAR1 regulates drug-induced reinstatement of cocaine-seeking via negatively modulating CaMKII\u03b1 activity in the NAc"],"prefix":"10.1038","volume":"27","author":[{"given":"Jianfeng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Robert","family":"Seaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Manz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3152-737X","authenticated-orcid":false,"given":"Bernard","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2738-6834","authenticated-orcid":false,"given":"Jimmy","family":"Vu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred J.","family":"Robison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Neve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4224-3866","authenticated-orcid":false,"given":"Brad A.","family":"Grueter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6927-9236","authenticated-orcid":false,"given":"David","family":"Dietz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4749-0767","authenticated-orcid":false,"given":"Jun-Xu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"1448_CR1","doi-asserted-by":"publisher","first-page":"10867","DOI":"10.1523\/JNEUROSCI.1821-17.2017","volume":"37","author":"Y Dong","year":"2017","unstructured":"Dong Y, Taylor JR, Wolf ME, Shaham Y. Circuit and synaptic plasticity mechanisms of drug relapse. J Neurosci. 2017;37:10867\u201376.","journal-title":"J Neurosci"},{"key":"1448_CR2","doi-asserted-by":"publisher","first-page":"eaax1532","DOI":"10.1126\/sciadv.aax1532","volume":"5","author":"KM Kampman","year":"2019","unstructured":"Kampman KM. The treatment of cocaine use disorder. Sci Adv. 2019;5:eaax1532.","journal-title":"Sci Adv"},{"key":"1448_CR3","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s10571-020-00792-8","volume":"40","author":"J Liu","year":"2020","unstructured":"Liu J, Wu R, Li JX. TAAR1 and psychostimulant addiction. Cell Mol Neurobiol. 2020;40:229\u201338.","journal-title":"Cell Mol Neurobiol"},{"key":"1448_CR4","doi-asserted-by":"publisher","first-page":"3403","DOI":"10.1111\/bph.15061","volume":"177","author":"J Liu","year":"2020","unstructured":"Liu J, Johnson B, Wu R, Seaman R Jr., Vu J, Zhu Q, et al. TAAR1 agonists attenuate extended-access cocaine self-administration and yohimbine-induced reinstatement of cocaine-seeking. Br J Pharm. 2020;177:3403\u201314.","journal-title":"Br J Pharm"},{"key":"1448_CR5","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1080\/14728222.2018.1480723","volume":"22","author":"MD Schwartz","year":"2018","unstructured":"Schwartz MD, Canales JJ, Zucchi R, Espinoza S, Sukhanov I, Gainetdinov RR. Trace amine-associated receptor 1: a multimodal therapeutic target for neuropsychiatric diseases. Expert Opin Ther Targets. 2018;22:513\u201326.","journal-title":"Expert Opin Ther Targets"},{"key":"1448_CR6","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.pharmthera.2007.06.007","volume":"116","author":"DK Grandy","year":"2007","unstructured":"Grandy DK. Trace amine-associated receptor 1-Family archetype or iconoclast? Pharm Ther. 2007;116:355\u201390.","journal-title":"Pharm Ther"},{"key":"1448_CR7","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1038\/npp.2014.88","volume":"39","author":"Y Pei","year":"2014","unstructured":"Pei Y, Lee J, Leo D, Gainetdinov RR, Hoener MC, Canales JJ. Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking. Neuropsychopharmacology. 2014;39:2299\u2013308.","journal-title":"Neuropsychopharmacology"},{"key":"1448_CR8","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1038\/npp.2014.91","volume":"39","author":"DA Thorn","year":"2014","unstructured":"Thorn DA, Jing L, Qiu Y, Gancarz-Kausch AM, Galuska CM, Dietz DM, et al. Effects of the trace amine-associated receptor 1 agonist RO5263397 on abuse-related effects of cocaine in rats. Neuropsychopharmacology. 2014;39:2309\u201316.","journal-title":"Neuropsychopharmacology"},{"key":"1448_CR9","doi-asserted-by":"publisher","first-page":"8485","DOI":"10.1073\/pnas.1103029108","volume":"108","author":"FG Revel","year":"2011","unstructured":"Revel FG, Moreau JL, Gainetdinov RR, Bradaia A, Sotnikova TD, Mory R, et al. TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. Proc Natl Acad Sci USA. 2011;108:8485\u201390.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1448_CR10","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1038\/npp.2012.109","volume":"37","author":"FG Revel","year":"2012","unstructured":"Revel FG, Meyer CA, Bradaia A, Jeanneau K, Calcagno E, Andre CB, et al. Brain-specific overexpression of trace amine-associated receptor 1 alters monoaminergic neurotransmission and decreases sensitivity to amphetamine. Neuropsychopharmacology. 2012;37:2580\u201392.","journal-title":"Neuropsychopharmacology"},{"key":"1448_CR11","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.neuropharm.2014.02.007","volume":"81","author":"D Leo","year":"2014","unstructured":"Leo D, Mus L, Espinoza S, Hoener MC, Sotnikova TD, Gainetdinov RR. Taar1-mediated modulation of presynaptic dopaminergic neurotransmission: role of D2 dopamine autoreceptors. Neuropharmacology. 2014;81:283\u201391.","journal-title":"Neuropharmacology"},{"key":"1448_CR12","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1523\/JNEUROSCI.2006-16.2016","volume":"37","author":"JF Liu","year":"2017","unstructured":"Liu JF, Siemian JN, Seaman R Jr., Zhang Y, Li JX. Role of TAAR1 within the subregions of the mesocorticolimbic dopaminergic system in cocaine-seeking behavior. J Neurosci. 2017;37:882\u201392.","journal-title":"J Neurosci"},{"key":"1448_CR13","doi-asserted-by":"publisher","first-page":"645","DOI":"10.3389\/fphar.2018.00645","volume":"9","author":"S Espinoza","year":"2018","unstructured":"Espinoza S, Leo D, Sotnikova TD, Shahid M, Kaariainen TM, Gainetdinov RR. Biochemical and functional characterization of the trace amine-associated receptor 1 (TAAR1) agonist RO5263397. Front Pharm. 2018;9:645.","journal-title":"Front Pharm"},{"key":"1448_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14472-z","volume":"7","author":"A Asif-Malik","year":"2017","unstructured":"Asif-Malik A, Hoener MC, Canales JJ. Interaction between the trace amine-associated receptor 1 and the dopamine D2 receptor controls cocaine\u2019s neurochemical actions. Sci Rep. 2017;7:13901.","journal-title":"Sci Rep."},{"key":"1448_CR15","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.pharmthera.2017.07.002","volume":"180","author":"MD Berry","year":"2017","unstructured":"Berry MD, Gainetdinov RR, Hoener MC, Shahid M. Pharmacology of human trace amine-associated receptors: therapeutic opportunities and challenges. Pharm Ther. 2017;180:161\u201380.","journal-title":"Pharm Ther"},{"key":"1448_CR16","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1016\/j.euroneuro.2015.08.011","volume":"25","author":"A Harmeier","year":"2015","unstructured":"Harmeier A, Obermueller S, Meyer CA, Revel FG, Buchy D, Chaboz S, et al. Trace amine-associated receptor 1 activation silences GSK3beta signaling of TAAR1 and D2R heteromers. Eur Neuropsychopharmacol. 2015;25:2049\u201361.","journal-title":"Eur Neuropsychopharmacol"},{"key":"1448_CR17","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1124\/mol.111.073304","volume":"80","author":"S Espinoza","year":"2011","unstructured":"Espinoza S, Salahpour A, Masri B, Sotnikova TD, Messa M, Barak LS, et al. Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor. Mol Pharm. 2011;80:416\u201325.","journal-title":"Mol Pharm"},{"key":"1448_CR18","doi-asserted-by":"publisher","first-page":"3189","DOI":"10.3390\/ijms22063189","volume":"22","author":"W Jia","year":"2021","unstructured":"Jia W, Kawahata I, Cheng A, Fukunaga K. The role of CaMKII and ERK signaling in addiction. Int J Mol Sci. 2021;22:3189.","journal-title":"Int J Mol Sci"},{"key":"1448_CR19","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/nn2054","volume":"11","author":"SM Anderson","year":"2008","unstructured":"Anderson SM, Famous KR, Sadri-Vakili G, Kumaresan V, Schmidt HD, Bass CE, et al. CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking. Nat Neurosci. 2008;11:344\u201353.","journal-title":"Nat Neurosci"},{"key":"1448_CR20","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/npp.2013.299","volume":"39","author":"X Liu","year":"2014","unstructured":"Liu X, Liu Y, Zhong P, Wilkinson B, Qi J, Olsen CM, et al. CaMKII activity in the ventral tegmental area gates cocaine-induced synaptic plasticity in the nucleus accumbens. Neuropsychopharmacology. 2014;39:989\u201399.","journal-title":"Neuropsychopharmacology"},{"key":"1448_CR21","doi-asserted-by":"publisher","first-page":"11894","DOI":"10.1523\/JNEUROSCI.2397-17.2017","volume":"37","author":"CE Burgdorf","year":"2017","unstructured":"Burgdorf CE, Schierberl KC, Lee AS, Fischer DK, Van Kempen TA, Mudragel V, et al. Extinction of contextual cocaine memories requires Cav1.2 within D1R-expressing cells and recruits hippocampal Cav1.2-dependent signaling mechanisms. J Neurosci. 2017;37:11894\u2013911.","journal-title":"J Neurosci"},{"key":"1448_CR22","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1038\/npp.2015.65","volume":"40","author":"S Espinoza","year":"2015","unstructured":"Espinoza S, Lignani G, Caffino L, Maggi S, Sukhanov I, Leo D, et al. TAAR1 modulates cortical glutamate NMDA receptor function. Neuropsychopharmacology. 2015;40:2217\u201327.","journal-title":"Neuropsychopharmacology"},{"key":"1448_CR23","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1038\/s41386-018-0017-9","volume":"43","author":"JF Liu","year":"2018","unstructured":"Liu JF, Seaman R Jr., Siemian JN, Bhimani R, Johnson B, Zhang Y, et al. Role of trace amine-associated receptor 1 in nicotine\u2019s behavioral and neurochemical effects. Neuropsychopharmacology. 2018;43:2435\u201344.","journal-title":"Neuropsychopharmacology"},{"key":"1448_CR24","unstructured":"Paxinos G, Watson C The rat brain in stereotaxic coordinates (Elsevier Academic, Amsterdam), 7th Edition. 2014."},{"key":"1448_CR25","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1038\/npp.2013.319","volume":"39","author":"AJ Robison","year":"2014","unstructured":"Robison AJ, Vialou V, Sun HS, Labonte B, Golden SA, Dias C, et al. Fluoxetine epigenetically alters the CaMKIIalpha promoter in nucleus accumbens to regulate DeltaFosB binding and antidepressant effects. Neuropsychopharmacology. 2014;39:1178\u201386.","journal-title":"Neuropsychopharmacology"},{"key":"1448_CR26","doi-asserted-by":"publisher","first-page":"4295","DOI":"10.1523\/JNEUROSCI.5192-12.2013","volume":"33","author":"AJ Robison","year":"2013","unstructured":"Robison AJ, Vialou V, Mazei-Robison M, Feng J, Kourrich S, Collins M, et al. Behavioral and structural responses to chronic cocaine require a feedforward loop involving DeltaFosB and calcium\/calmodulin-dependent protein kinase II in the nucleus accumbens shell. J Neurosci. 2013;33:4295\u2013307.","journal-title":"J Neurosci"},{"key":"1448_CR27","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1038\/mp.2017.219","volume":"23","author":"W Yan","year":"2018","unstructured":"Yan W, Liu JF, Han Y, Zhang W, Luo YX, Xue YX, et al. Protein kinase Mzeta in medial prefrontal cortex mediates depressive-like behavior and antidepressant response. Mol Psychiatry. 2018;23:1878\u201391.","journal-title":"Mol Psychiatry"},{"key":"1448_CR28","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1038\/npp.2014.42","volume":"39","author":"N Chai","year":"2014","unstructured":"Chai N, Liu JF, Xue YX, Yang C, Yan W, Wang HM, et al. Delayed noradrenergic activation in the dorsal hippocampus promotes the long-term persistence of extinguished fear. Neuropsychopharmacology. 2014;39:1933\u201345.","journal-title":"Neuropsychopharmacology"},{"key":"1448_CR29","doi-asserted-by":"publisher","first-page":"8865","DOI":"10.1073\/pnas.1705974114","volume":"114","author":"DT Kashima","year":"2017","unstructured":"Kashima DT, Grueter BA. Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior. Proc Natl Acad Sci USA. 2017;114:8865\u201370.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1448_CR30","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1523\/JNEUROSCI.3091-16.2016","volume":"37","author":"D Caprioli","year":"2017","unstructured":"Caprioli D, Venniro M, Zhang M, Bossert JM, Warren BL, Hope BT, et al. Role of dorsomedial striatum neuronal ensembles in incubation of methamphetamine craving after voluntary abstinence. J Neurosci. 2017;37:1014\u201327.","journal-title":"J Neurosci"},{"key":"1448_CR31","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.neubiorev.2010.01.013","volume":"35","author":"ME Wolf","year":"2010","unstructured":"Wolf ME, Ferrario CR. AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine. Neurosci Biobehav Rev. 2010;35:185\u2013211.","journal-title":"Neurosci Biobehav Rev"},{"key":"1448_CR32","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.1038\/s41380-019-0484-3","volume":"25","author":"C Soares-Cunha","year":"2020","unstructured":"Soares-Cunha C, de Vasconcelos NAP, Coimbra B, Domingues AV, Silva JM, Loureiro-Campos E, et al. Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion. Mol Psychiatry. 2020;25:3241\u201355.","journal-title":"Mol Psychiatry"},{"key":"1448_CR33","doi-asserted-by":"publisher","first-page":"20081","DOI":"10.1073\/pnas.0906522106","volume":"106","author":"A Bradaia","year":"2009","unstructured":"Bradaia A, Trube G, Stalder H, Norcross RD, Ozmen L, Wettstein JG, et al. The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system. Proc Natl Acad Sci USA. 2009;106:20081\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1448_CR34","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s10571-019-00721-4","volume":"40","author":"IS Zhukov","year":"2020","unstructured":"Zhukov IS, Kubarskaya LG, Tissen IY, Kozlova AA, Dagayev SG, Kashuro VA, et al. Minimal age-related alterations in behavioral and hematological parameters in trace amine-associated receptor 1 (TAAR1) knockout mice. Cell Mol Neurobiol. 2020;40:273\u201382.","journal-title":"Cell Mol Neurobiol"},{"key":"1448_CR35","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3389\/fnins.2016.00148","volume":"10","author":"Y Pei","year":"2016","unstructured":"Pei Y, Asif-Malik A, Canales JJ. Trace amines and the trace amine-associated receptor 1: pharmacology, neurochemistry, and clinical implications. Front Neurosci. 2016;10:148.","journal-title":"Front Neurosci"},{"key":"1448_CR36","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/mp.2012.57","volume":"18","author":"FG Revel","year":"2013","unstructured":"Revel FG, Moreau JL, Pouzet B, Mory R, Bradaia A, Buchy D, et al. A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Mol Psychiatry. 2013;18:543\u201356.","journal-title":"Mol Psychiatry"},{"key":"1448_CR37","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.biopsych.2012.05.014","volume":"72","author":"FG Revel","year":"2012","unstructured":"Revel FG, Moreau JL, Gainetdinov RR, Ferragud A, Velazquez-Sanchez C, Sotnikova TD, et al. Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics. Biol Psychiatry. 2012;72:934\u201342.","journal-title":"Biol Psychiatry"},{"key":"1448_CR38","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1111\/j.1471-4159.2010.07109.x","volume":"116","author":"GM Miller","year":"2011","unstructured":"Miller GM. The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity. J Neurochem. 2011;116:164\u201376.","journal-title":"J Neurochem"},{"key":"1448_CR39","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1038\/s41380-019-0469-2","volume":"26","author":"SM Underhill","year":"2021","unstructured":"Underhill SM, Hullihen PD, Chen J, Fenollar-Ferrer C, Rizzo MA, Ingram SL, et al. Amphetamines signal through intracellular TAAR1 receptors coupled to Galpha13 and GalphaS in discrete subcellular domains. Mol Psychiatry. 2021;26:1208\u201323.","journal-title":"Mol Psychiatry"},{"key":"1448_CR40","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1023\/A:1007019030595","volume":"20","author":"L Vinade","year":"2000","unstructured":"Vinade L, Dosemeci A. Regulation of the phosphorylation state of the AMPA receptor GluR1 subunit in the postsynaptic density. Cell Mol Neurobiol. 2000;20:451\u201363.","journal-title":"Cell Mol Neurobiol"},{"key":"1448_CR41","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1471-4159.2008.05748.x","volume":"108","author":"Y Liu","year":"2009","unstructured":"Liu Y, Sun QA, Chen Q, Lee TH, Huang Y, Wetsel WC, et al. Targeting inhibition of GluR1 Ser845 phosphorylation with an RNA aptamer that blocks AMPA receptor trafficking. J Neurochem. 2009;108:147\u201357.","journal-title":"J Neurochem"},{"key":"1448_CR42","doi-asserted-by":"publisher","first-page":"3206","DOI":"10.1523\/JNEUROSCI.4514-08.2009","volume":"29","author":"JS Park","year":"2009","unstructured":"Park JS, Voitenko N, Petralia RS, Guan X, Xu JT, Steinberg JP, et al. Persistent inflammation induces GluR2 internalization via NMDA receptor-triggered PKC activation in dorsal horn neurons. J Neurosci. 2009;29:3206\u201319.","journal-title":"J Neurosci"},{"key":"1448_CR43","doi-asserted-by":"publisher","first-page":"987","DOI":"10.3389\/fphar.2017.00987","volume":"8","author":"G Rutigliano","year":"2017","unstructured":"Rutigliano G, Accorroni A, Zucchi R. The case for TAAR1 as a modulator of central nervous system function. Front Pharm. 2017;8:987.","journal-title":"Front Pharm"},{"key":"1448_CR44","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1124\/jpet.107.132647","volume":"324","author":"L Lindemann","year":"2008","unstructured":"Lindemann L, Meyer CA, Jeanneau K, Bradaia A, Ozmen L, Bluethmann H, et al. Trace amine-associated receptor 1 modulates dopaminergic activity. J Pharm Exp Ther. 2008;324:948\u201356.","journal-title":"J Pharm Exp Ther"},{"key":"1448_CR45","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.pnpbp.2015.05.014","volume":"63","author":"Y Pei","year":"2015","unstructured":"Pei Y, Mortas P, Hoener MC, Canales JJ. Selective activation of the trace amine-associated receptor 1 decreases cocaine\u2019s reinforcing efficacy and prevents cocaine-induced changes in brain reward thresholds. Prog Neuropsychopharmacol Biol Psychiatry. 2015;63:70\u20135.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"1448_CR46","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1017\/S1461145714000509","volume":"17","author":"I Sukhanov","year":"2014","unstructured":"Sukhanov I, Espinoza S, Yakovlev DS, Hoener MC, Sotnikova TD, Gainetdinov RR. TAAR1-dependent effects of apomorphine in mice. Int J Neuropsychopharmacol. 2014;17:1683\u201393.","journal-title":"Int J Neuropsychopharmacol"},{"key":"1448_CR47","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00418-019-01791-7","volume":"152","author":"MS Pitts","year":"2019","unstructured":"Pitts MS, McShane JN, Hoener MC, Christian SL, Berry MD. TAAR1 levels and sub-cellular distribution are cell line but not breast cancer subtype specific. Histochem Cell Biol. 2019;152:155\u201366.","journal-title":"Histochem Cell Biol"},{"key":"1448_CR48","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3389\/fphar.2018.00329","volume":"9","author":"I Sukhanov","year":"2018","unstructured":"Sukhanov I, Dorofeikova M, Dolgorukova A, Dorotenko A, Gainetdinov RR. Trace amine-associated receptor 1 modulates the locomotor and sensitization effects of nicotine. Front Pharm. 2018;9:329.","journal-title":"Front Pharm"},{"key":"1448_CR49","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1111\/bph.15335","volume":"178","author":"J Liu","year":"2021","unstructured":"Liu J, Seaman R Jr., Johnson B, Wu R, Vu J, Tian J, et al. Activation of trace amine-associated receptor 1 selectively attenuates the reinforcing effects of morphine. Br J Pharm. 2021;178:933\u201345.","journal-title":"Br J Pharm"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41380-022-01448-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-022-01448-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-022-01448-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T01:03:45Z","timestamp":1667783025000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-022-01448-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,25]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["1448"],"URL":"https:\/\/doi.org\/10.1038\/s41380-022-01448-3","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,25]]},"assertion":[{"value":"31 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}