{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:16:16Z","timestamp":1790702176573,"version":"4.1.0"},"reference-count":99,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated the relationship between emotion processing and resting-state functional connectivity (rs-FC) of the brain networks in frontotemporal lobar degeneration (FTLD). Eighty FTLD patients (including cases with behavioral variant of frontotemporal dementia, primary progressive aphasia, progressive supranuclear palsy syndrome, motor neuron disease) and 65 healthy controls underwent rs-functional MRI. Emotion processing was tested using the Comprehensive Affect Testing System (CATS). In patients and controls, correlations were investigated between each emotion construct and rs-FC changes within critical networks. Mean rs-FC of the clusters significantly associated with CATS scoring were compared among FTLD groups. FTLD patients had pathological CATS scores compared with controls. In controls, increased rs-FC of the cerebellar and visuo-associative networks correlated with better scores in emotion-matching and discrimination tasks, respectively; while decreased rs-FC of the visuo-spatial network was related with better performance in the affect-matching and naming. In FTLD, the associations between rs-FC and CATS scores involved more brain regions, such as orbitofrontal and middle frontal gyri within anterior networks (i.e., salience and default-mode), parietal and somatosensory regions within visuo-spatial and sensorimotor networks, caudate and thalamus within basal-ganglia network. Rs-FC changes associated with CATS were similar among all FTLD groups. In FTLD compared to controls, the pattern of rs-FC associated with emotional processing involves a larger number of brain regions, likely due to functional specificity loss and compensatory attempts. These associations were similar across all FTLD groups, suggesting a common physiopathological mechanism of emotion processing breakdown, regardless the clinical presentation and pattern of atrophy.<\/jats:p>","DOI":"10.1038\/s41380-022-01612-9","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T20:08:55Z","timestamp":1653077335000},"page":"4809-4821","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Resting state functional brain networks associated with emotion processing in frontotemporal lobar degeneration"],"prefix":"10.1038","volume":"27","author":[{"given":"Elisa","family":"Canu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Calderaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Castelnovo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Basaia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Antonietta","family":"Magno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilo","family":"Riva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Magnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Caso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Caroppo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Prioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2125-2886","authenticated-orcid":false,"given":"Cristina","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"Pain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Mora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Tremolizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildebrando","family":"Appollonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Poletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Silani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5485-0479","authenticated-orcid":false,"given":"Massimo","family":"Filippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Agosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,20]]},"reference":[{"key":"1612_CR1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1037\/h0030377","volume":"17","author":"P Ekman","year":"1971","unstructured":"Ekman P, Friesen WV. Constants across cultures in the face and emotion. J Pers Soc Psychol. 1971;17:124\u20139.","journal-title":"J Pers Soc Psychol"},{"key":"1612_CR2","unstructured":"Ekman P. Pictures of facial affect. Consulting Psychologists Press; Palo Alto, CA, 1976."},{"key":"1612_CR3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.neuropsychologia.2014.11.022","volume":"67","author":"LD Oliver","year":"2015","unstructured":"Oliver LD, Mitchell DG, Dziobek I, MacKinley J, Coleman K, Rankin KP, et al. Parsing cognitive and emotional empathy deficits for negative and positive stimuli in frontotemporal dementia. Neuropsychologia. 2015;67:14\u201326.","journal-title":"Neuropsychologia."},{"key":"1612_CR4","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3233\/JAD-141854","volume":"44","author":"O Piguet","year":"2015","unstructured":"Piguet O, Leyton CE, Gleeson LD, Hoon C, Hodges JR. Memory and emotion processing performance contributes to the diagnosis of non-semantic primary progressive aphasia syndromes. J Alzheimer\u2019s Dis: JAD. 2015;44:541\u20137.","journal-title":"J Alzheimer\u2019s Dis: JAD"},{"key":"1612_CR5","doi-asserted-by":"crossref","first-page":"e67457","DOI":"10.1371\/journal.pone.0067457","volume":"8","author":"F Kumfor","year":"2013","unstructured":"Kumfor F, Irish M, Hodges JR, Piguet O. Discrete Neural Correlates for the Recognition of Negative Emotions: Insights from Frontotemporal Dementia. PloS One. 2013;8:e67457.","journal-title":"PloS One"},{"key":"1612_CR6","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","volume":"134","author":"K Rascovsky","year":"2011","unstructured":"Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, et al. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain. 2011;134:2456\u201377.","journal-title":"Brain."},{"key":"1612_CR7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cortex.2016.11.012","volume":"88","author":"E Bora","year":"2017","unstructured":"Bora E. Meta-analysis of social cognition in amyotrophic lateral sclerosis. Cortex. 2017;88:1\u20137.","journal-title":"Cortex."},{"key":"1612_CR8","doi-asserted-by":"crossref","first-page":"102803","DOI":"10.1016\/j.nicl.2021.102803","volume":"32","author":"V Castelnovo","year":"2021","unstructured":"Castelnovo V, Canu E, Magno MA, Basaia S, Riva N, Poletti B, et al. Impaired recognition of disgust in amyotrophic lateral sclerosis is related to basal ganglia involvement. NeuroImage Clin. 2021;32:102803.","journal-title":"NeuroImage Clin"},{"key":"1612_CR9","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s00415-020-10096-y","volume":"268","author":"LC Jiskoot","year":"2021","unstructured":"Jiskoot LC, Poos JM, Vollebergh ME, Franzen S, van Hemmen J, Papma JM, et al. Emotion recognition of morphed facial expressions in presymptomatic and symptomatic frontotemporal dementia, and Alzheimer\u2019s dementia. J Neurol. 2021;268:102\u201313.","journal-title":"J Neurol"},{"key":"1612_CR10","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.cortex.2020.08.023","volume":"133","author":"LL Russell","year":"2020","unstructured":"Russell LL, Greaves CV, Bocchetta M, Nicholas J, Convery RS, Moore K, et al. Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort. Cortex. 2020;133:384\u201398.","journal-title":"Cortex."},{"key":"1612_CR11","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nrn2889","volume":"11","author":"M Tamietto","year":"2010","unstructured":"Tamietto M, de Gelder B. Neural bases of the non-conscious perception of emotional signals. Nat Rev Neurosci. 2010;11:697\u2013709.","journal-title":"Nat Rev Neurosci"},{"key":"1612_CR12","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.nicl.2015.06.005","volume":"8","author":"LE Downey","year":"2015","unstructured":"Downey LE, Mahoney CJ, Buckley AH, Golden HL, Henley SM, Schmitz N, et al. White matter tract signatures of impaired social cognition in frontotemporal lobar degeneration. NeuroImage Clin. 2015;8:640\u201351.","journal-title":"NeuroImage Clin"},{"key":"1612_CR13","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1017\/S1355617712001300","volume":"18","author":"M Bertoux","year":"2012","unstructured":"Bertoux M, Volle E, Funkiewiez A, de Souza LC, Leclercq D, Dubois B. Social Cognition and Emotional Assessment (SEA) is a marker of medial and orbital frontal functions: a voxel-based morphometry study in behavioral variant of frontotemporal degeneration. J Int Neuropsychol Soc. 2012;18:972\u201385.","journal-title":"J Int Neuropsychol Soc"},{"key":"1612_CR14","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/brain\/awz204","volume":"142","author":"CR Marshall","year":"2019","unstructured":"Marshall CR, Hardy CJD, Russell LL, Bond RL, Sivasathiaseelan H, Greaves C, et al. The functional neuroanatomy of emotion processing in frontotemporal dementias. Brain: a J Neurol. 2019;142:2873\u201387.","journal-title":"Brain: a J Neurol"},{"key":"1612_CR15","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","volume":"76","author":"ML Gorno-Tempini","year":"2011","unstructured":"Gorno-Tempini ML, Hillis AE, Weintraub S, Kertesz A, Mendez M, Cappa SF, et al. Classification of primary progressive aphasia and its variants. Neurology. 2011;76:1006\u201314.","journal-title":"Neurology."},{"key":"1612_CR16","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/mds.26987","volume":"32","author":"GU Hoglinger","year":"2017","unstructured":"Hoglinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE, et al. Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria. Mov Disord. 2017;32:853\u201364.","journal-title":"Mov Disord"},{"key":"1612_CR17","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","volume":"1","author":"BR Brooks","year":"2000","unstructured":"Brooks BR, Miller RG, Swash M, Munsat TL, World Federation of Neurology Research Group on Motor Neuron D. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Mot Neuron Disord. 2000;1:293\u20139.","journal-title":"Amyotroph Lateral Scler Other Mot Neuron Disord"},{"key":"1612_CR18","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/brain\/115.2.495","volume":"115","author":"CE Pringle","year":"1992","unstructured":"Pringle CE, Hudson AJ, Munoz DG, Kiernan JA, Brown WF, Ebers GC. Primary lateral sclerosis. Clinical features, neuropathology and diagnostic criteria. Brain. 1992;115:495\u2013520.","journal-title":"Brain"},{"key":"1612_CR19","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1093\/brain\/awg117","volume":"126","author":"RM van den Berg-Vos","year":"2003","unstructured":"van den Berg-Vos RM, Visser J, Franssen H, de Visser M, de Jong JM, Kalmijn S, et al. Sporadic lower motor neuron disease with adult onset: classification of subtypes. Brain 2003;126:1036\u201347.","journal-title":"Brain"},{"key":"1612_CR20","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2174\/1567205016666190725150836","volume":"16","author":"R Santangelo","year":"2019","unstructured":"Santangelo R, Dell\u2019Edera A, Sala A, Cecchetti G, Masserini F, Caso F, et al. The CSF p-tau181\/Abeta42 Ratio Offers a Good Accuracy \u201cIn Vivo\u201d in the Differential Diagnosis of Alzheimer\u2019s Dementia. Curr Alzheimer Res. 2019;16:587\u201395.","journal-title":"Curr Alzheimer Res"},{"key":"1612_CR21","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/brain\/awn234","volume":"131","author":"DS Knopman","year":"2008","unstructured":"Knopman DS, Kramer JH, Boeve BF, Caselli RJ, Graff-Radford NR, Mendez MF, et al. Development of methodology for conducting clinical trials in frontotemporal lobar degeneration. Brain. 2008;131:2957\u201368.","journal-title":"Brain."},{"key":"1612_CR22","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1001\/jama.1963.03060120024016","volume":"185","author":"S Katz","year":"1963","unstructured":"Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of Illness in the Aged. The Index of Adl: A Standardized Measure of Biological and Psychosocial Function. JAMA. 1963;185:914\u20139.","journal-title":"JAMA."},{"key":"1612_CR23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","volume":"9","author":"MP Lawton","year":"1969","unstructured":"Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9:179\u201386.","journal-title":"Gerontologist."},{"key":"1612_CR24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-510X(99)00210-5","volume":"169","author":"JM Cedarbaum","year":"1999","unstructured":"Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, et al. The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci. 1999;169:13\u201321.","journal-title":"J Neurol Sci"},{"key":"1612_CR25","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1212\/WNL.53.5.1051","volume":"53","author":"CM Ellis","year":"1999","unstructured":"Ellis CM, Simmons A, Jones DK, Bland J, Dawson JM, Horsfield MA, et al. Diffusion tensor MRI assesses corticospinal tract damage in ALS. Neurology. 1999;53:1051\u20138.","journal-title":"Neurology."},{"key":"1612_CR26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1212\/01.wnl.0000194316.91908.8a","volume":"66","author":"F Kimura","year":"2006","unstructured":"Kimura F, Fujimura C, Ishida S, Nakajima H, Furutama D, Uehara H, et al. Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS. Neurology. 2006;66:265\u20137.","journal-title":"Neurology."},{"key":"1612_CR27","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1212\/01.wnl.0000243812.25517.87","volume":"67","author":"PH Gordon","year":"2006","unstructured":"Gordon PH, Cheung YK. Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS. Neurology. 2006;67:1314\u20135.","journal-title":"Neurology."},{"key":"1612_CR28","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1136\/jnnp-2015-310998","volume":"87","author":"J Labra","year":"2016","unstructured":"Labra J, Menon P, Byth K, Morrison S, Vucic S. Rate of disease progression: a prognostic biomarker in ALS. J Neurol Neurosurg Psychiatry. 2016;87:628\u201332.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1612_CR29","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/ene.13957","volume":"26","author":"F Agosta","year":"2019","unstructured":"Agosta F, Spinelli EG, Riva N, Fontana A, Basaia S, Canu E, et al. Survival prediction models in motor neuron disease. Eur J Neurol. 2019;26:1143\u201352.","journal-title":"Eur J Neurol"},{"key":"1612_CR30","doi-asserted-by":"crossref","unstructured":"Froming K, Levy MSS, Ekman P. The comprehensive affect testing system. Psychology Software, Inc; Gainesville, FL: 2006.","DOI":"10.1037\/t06823-000"},{"key":"1612_CR31","doi-asserted-by":"crossref","first-page":"e402","DOI":"10.1212\/WNL.0000000000013123","volume":"98","author":"C Cividini","year":"2021","unstructured":"Cividini C, Basaia S, Spinelli EG, Canu E, Castelnovo V, Riva N, et al. Amyotrophic Lateral Sclerosis-Frontotemporal Dementia: Shared and Divergent Neural Correlates Across the Clinical Spectrum. Neurology. 2021;98:e402\u2013e415","journal-title":"Neurology"},{"key":"1612_CR32","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein MF, Folstein SE, McHugh PR. \u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189\u201398.","journal-title":"J Psychiatr Res"},{"key":"1612_CR33","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s10072-005-0443-4","volume":"26","author":"I Appollonio","year":"2005","unstructured":"Appollonio I, Leone M, Isella V, Piamarta F, Consoli T, Villa ML, et al. The Frontal Assessment Battery (FAB): normative values in an Italian population sample. Neurol Sci. 2005;26:108\u201316.","journal-title":"Neurol Sci"},{"key":"1612_CR34","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1159\/000117297","volume":"36","author":"GA Carlesimo","year":"1996","unstructured":"Carlesimo GA, Caltagirone C, Gainotti G. The Mental Deterioration Battery: normative data, diagnostic reliability and qualitative analyses of cognitive impairment. The Group for the Standardization of the Mental Deterioration Battery. Eur Neurol. 1996;36:378\u201384.","journal-title":"Eur Neurol"},{"key":"1612_CR35","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/BF02333660","volume":"8","author":"A Orsini","year":"1987","unstructured":"Orsini A, Grossi D, Capitani E, Laiacona M, Papagno C, Vallar G. Verbal and spatial immediate memory span: normative data from 1355 adults and 1112 children. Ital J Neurol Sci. 1987;8:539\u201348.","journal-title":"Ital J Neurol Sci"},{"key":"1612_CR36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuropsychologia.2010.10.026","volume":"49","author":"KL Possin","year":"2011","unstructured":"Possin KL, Laluz VR, Alcantar OZ, Miller BL, Kramer JH. Distinct neuroanatomical substrates and cognitive mechanisms of figure copy performance in Alzheimer\u2019s disease and behavioral variant frontotemporal dementia. Neuropsychologia. 2011;49:43\u20138.","journal-title":"Neuropsychologia."},{"key":"1612_CR37","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s10072-012-1130-x","volume":"34","author":"M Monaco","year":"2013","unstructured":"Monaco M, Costa A, Caltagirone C, Carlesimo GA. Forward and backward span for verbal and visuo-spatial data: standardization and normative data from an Italian adult population. Neurol Sci. 2013;34:749\u201354.","journal-title":"Neurol Sci"},{"key":"1612_CR38","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1076\/jcen.26.2.246.28087","volume":"26","author":"P Caffarra","year":"2004","unstructured":"Caffarra P, Vezzadini G, Dieci F, Zonato F, Venneri A. Modified Card Sorting Test: normative data. J Clin Exp Neuropsychol. 2004;26:246\u201350.","journal-title":"J Clin Exp Neuropsychol"},{"key":"1612_CR39","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1007\/s10072-015-2281-3","volume":"36","author":"A Dodich","year":"2015","unstructured":"Dodich A, Cerami C, Canessa N, Crespi C, Iannaccone S, Marcone A, et al. A novel task assessing intention and emotion attribution: Italian standardization and normative data of the Story-based Empathy Task. Neurol Sci. 2015;36:1907\u201312.","journal-title":"Neurol Sci"},{"key":"1612_CR40","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/brain\/85.4.665","volume":"85","author":"E De Renzi","year":"1962","unstructured":"De Renzi E, Vignolo LA. The token test: A sensitive test to detect receptive disturbances in aphasics. Brain. 1962;85:665\u201378.","journal-title":"Brain."},{"key":"1612_CR41","first-page":"477","volume":"47","author":"G Novelli","year":"1986","unstructured":"Novelli G, Laiacona M, Papagno C, Vallar G, Capitani E, Cappa SF. Three clinical tests to research and rate the lexical performance of normal subjects. Arch Psicol Neurol Psichiatr. 1986;47:477\u2013506.","journal-title":"Arch Psicol Neurol Psichiatr"},{"key":"1612_CR42","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1212\/WNL.44.12.2308","volume":"44","author":"JL Cummings","year":"1994","unstructured":"Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology. 1994;44:2308\u201314.","journal-title":"Neurology."},{"key":"1612_CR43","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s10072-007-0791-3","volume":"28","author":"A Alberici","year":"2007","unstructured":"Alberici A, Geroldi C, Cotelli M, Adorni A, Calabria M, Rossi G, et al. The Frontal Behavioural Inventory (Italian version) differentiates frontotemporal lobar degeneration variants from Alzheimer\u2019s disease. Neurol Sci. 2007;28:80\u20136.","journal-title":"Neurol Sci"},{"key":"1612_CR44","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/21678421.2020.1867179","volume":"22","author":"V Castelnovo","year":"2021","unstructured":"Castelnovo V, Canu E, Riva N, Poletti B, Cividini C, Fontana A, et al. Progression of cognitive and behavioral disturbances in motor neuron diseases assessed using standard and computer-based batteries. Amyotroph lateral Scler frontotemporal degeneration. 2021;22:223\u201336.","journal-title":"Amyotroph lateral Scler frontotemporal degeneration"},{"key":"1612_CR45","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cortex.2018.11.025","volume":"113","author":"E Canu","year":"2018","unstructured":"Canu E, Agosta F, Imperiale F, Fontana A, Caso F, Spinelli EG, et al. Added value of multimodal MRI to the clinical diagnosis of primary progressive aphasia variants. Cortex. 2018;113:58\u201366.","journal-title":"Cortex."},{"key":"1612_CR46","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","volume":"4","author":"AT Beck","year":"1961","unstructured":"Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561\u201371.","journal-title":"Arch Gen Psychiatry"},{"key":"1612_CR47","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","volume":"38","author":"J Ashburner","year":"2007","unstructured":"Ashburner J. A fast diffeomorphic image registration algorithm. Neuroimage. 2007;38:95\u2013113.","journal-title":"Neuroimage."},{"key":"1612_CR48","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41380-018-0067-8","volume":"25","author":"M Filippi","year":"2020","unstructured":"Filippi M, Basaia S, Canu E, Imperiale F, Magnani G, Falautano M, et al. Changes in functional and structural brain connectome along the Alzheimer\u2019s disease continuum. Mol Psychiatry. 2020;25:230\u20139.","journal-title":"Mol Psychiatry"},{"key":"1612_CR49","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1002\/hbm.24997","volume":"41","author":"E Canu","year":"2020","unstructured":"Canu E, Agosta F, Tomic A, Sarasso E, Petrovic I, Piramide N, et al. Breakdown of the affective-cognitive network in functional dystonia. Hum Brain Mapp. 2020;41:3059\u201376.","journal-title":"Hum Brain Mapp"},{"key":"1612_CR50","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neuroimage.2015.02.064","volume":"112","author":"RHR Pruim","year":"2015","unstructured":"Pruim RHR, Mennes M, van Rooij D, Llera A, Buitelaar JK, Beckmann CF. ICA-AROMA: A robust ICA-based strategy for removing motion artifacts from fMRI data. NeuroImage. 2015;112:267\u201377.","journal-title":"NeuroImage."},{"key":"1612_CR51","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuroimage.2009.06.060","volume":"48","author":"DN Greve","year":"2009","unstructured":"Greve DN, Fischl B. Accurate and robust brain image alignment using boundary-based registration. Neuroimage. 2009;48:63\u201372.","journal-title":"Neuroimage."},{"key":"1612_CR52","unstructured":"Andersson JL, Jenkinson M, Smith S. Non-linear registration, aka spatial normalisation. Technical Report. FMRIB Centre, Oxford: United Kingdom; 2007."},{"key":"1612_CR53","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1098\/rstb.2005.1634","volume":"360","author":"CF Beckmann","year":"2005","unstructured":"Beckmann CF, DeLuca M, Devlin JT, Smith SM. Investigations into resting-state connectivity using independent component analysis. Philos Trans R Soc Lond B Biol Sci. 2005;360:1001\u201313.","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"1612_CR54","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/cercor\/bhr099","volume":"22","author":"WR Shirer","year":"2012","unstructured":"Shirer WR, Ryali S, Rykhlevskaia E, Menon V, Greicius MD. Decoding subject-driven cognitive states with whole-brain connectivity patterns. Cereb Cortex. 2012;22:158\u201365.","journal-title":"Cereb Cortex"},{"key":"1612_CR55","doi-asserted-by":"crossref","first-page":"7209","DOI":"10.1073\/pnas.0811879106","volume":"106","author":"N Filippini","year":"2009","unstructured":"Filippini N, MacIntosh BJ, Hough MG, Goodwin GM, Frisoni GB, Smith SM, et al. Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele. Proc Natl Acad Sci USA. 2009;106:7209\u201314.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1612_CR56","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.cortex.2011.04.012","volume":"48","author":"F Agosta","year":"2012","unstructured":"Agosta F, Canu E, Sarro L, Comi G, Filippi M. Neuroimaging findings in frontotemporal lobar degeneration spectrum of disorders. Cortex. 2012;48:389\u2013413.","journal-title":"Cortex."},{"key":"1612_CR57","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1136\/jnnp-2017-317443","volume":"89","author":"F Agosta","year":"2018","unstructured":"Agosta F, Caso F, Jecmenica-Lukic M, Petrovic IN, Valsasina P, Meani A, et al. Tracking brain damage in progressive supranuclear palsy: a longitudinal MRI study. J Neurol Neurosurg Psychiatry. 2018;89:696\u2013701.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1612_CR58","doi-asserted-by":"crossref","first-page":"e1594","DOI":"10.1212\/WNL.0000000000012702","volume":"97","author":"EG Spinelli","year":"2021","unstructured":"Spinelli EG, Ghirelli A, Basaia S, Cividini C, Riva N, Canu E, et al. Structural MRI Signatures in Genetic Presentations of the Frontotemporal Dementia\/Motor Neuron Disease Spectrum. Neurology. 2021;97:e1594\u2013e607.","journal-title":"Neurology."},{"key":"1612_CR59","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.cortex.2009.11.008","volume":"46","author":"CJ Stoodley","year":"2010","unstructured":"Stoodley CJ, Schmahmann JD. Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing. Cortex. 2010;46:831\u201344.","journal-title":"Cortex."},{"key":"1612_CR60","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s12311-015-0649-9","volume":"14","author":"P Strata","year":"2015","unstructured":"Strata P. The emotional cerebellum. Cerebellum. 2015;14:570\u20137.","journal-title":"Cerebellum."},{"key":"1612_CR61","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/brain\/121.4.561","volume":"121","author":"JD Schmahmann","year":"1998","unstructured":"Schmahmann JD, Sherman JC. The cerebellar cognitive affective syndrome. Brain. 1998;121:561\u201379.","journal-title":"Brain."},{"key":"1612_CR62","doi-asserted-by":"crossref","first-page":"8929","DOI":"10.1523\/JNEUROSCI.1450-08.2008","volume":"28","author":"D Pitcher","year":"2008","unstructured":"Pitcher D, Garrido L, Walsh V, Duchaine BC. Transcranial magnetic stimulation disrupts the perception and embodiment of facial expressions. J Neurosci. 2008;28:8929\u201333.","journal-title":"J Neurosci"},{"key":"1612_CR63","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3389\/fnhum.2013.00692","volume":"7","author":"B Harry","year":"2013","unstructured":"Harry B, Williams MA, Davis C, Kim J. Emotional expressions evoke a differential response in the fusiform face area. Front Hum Neurosci. 2013;7:692.","journal-title":"Front Hum Neurosci"},{"key":"1612_CR64","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nrn1724","volume":"6","author":"AJ Calder","year":"2005","unstructured":"Calder AJ, Young AW. Understanding the recognition of facial identity and facial expression. Nat Rev Neurosci. 2005;6:641\u201351.","journal-title":"Nat Rev Neurosci"},{"key":"1612_CR65","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1073\/pnas.0800489105","volume":"105","author":"F Hadj-Bouziane","year":"2008","unstructured":"Hadj-Bouziane F, Bell AH, Knusten TA, Ungerleider LG, Tootell RB. Perception of emotional expressions is independent of face selectivity in monkey inferior temporal cortex. Proc Natl Acad Sci USA. 2008;105:5591\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1612_CR66","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1080\/17470919.2011.620779","volume":"6","author":"F Kumfor","year":"2011","unstructured":"Kumfor F, Miller L, Lah S, Hsieh S, Savage S, Hodges JR, et al. Are you really angry? The effect of intensity on facial emotion recognition in frontotemporal dementia. Soc Neurosci. 2011;6:502\u201314.","journal-title":"Soc Neurosci"},{"key":"1612_CR67","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1155\/2012\/683052","volume":"25","author":"LA Miller","year":"2012","unstructured":"Miller LA, Hsieh S, Lah S, Savage S, Hodges JR, Piguet O. One size does not fit all: face emotion processing impairments in semantic dementia, behavioural-variant frontotemporal dementia and Alzheimer\u2019s disease are mediated by distinct cognitive deficits. Behav Neurol. 2012;25:53\u201360.","journal-title":"Behav Neurol"},{"key":"1612_CR68","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3988\/jcn.2016.12.3.295","volume":"12","author":"SI Oh","year":"2016","unstructured":"Oh SI, Oh KW, Kim HJ, Park JS, Kim SH. Impaired Perception of Emotional Expression in Amyotrophic Lateral Sclerosis. J Clin Neurol. 2016;12:295\u2013300.","journal-title":"J Clin Neurol"},{"key":"1612_CR69","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/WNN.0b013e31804c700b","volume":"20","author":"EK Zimmerman","year":"2007","unstructured":"Zimmerman EK, Eslinger PJ, Simmons Z, Barrett AM. Emotional perception deficits in amyotrophic lateral sclerosis. Cogn Behav Neurol. 2007;20:79\u201382.","journal-title":"Cogn Behav Neurol"},{"key":"1612_CR70","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1136\/jnnp.2008.155846","volume":"80","author":"BC Ghosh","year":"2009","unstructured":"Ghosh BC, Rowe JB, Calder AJ, Hodges JR, Bak TH. Emotion recognition in progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 2009;80:1143\u20135.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1612_CR71","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1093\/brain\/aws128","volume":"135","author":"BC Ghosh","year":"2012","unstructured":"Ghosh BC, Calder AJ, Peers PV, Lawrence AD, Acosta-Cabronero J, Pereira JM, et al. Social cognitive deficits and their neural correlates in progressive supranuclear palsy. Brain. 2012;135:2089\u2013102.","journal-title":"Brain."},{"key":"1612_CR72","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s11065-012-9201-6","volume":"22","author":"F Kumfor","year":"2012","unstructured":"Kumfor F, Piguet O. Disturbance of emotion processing in frontotemporal dementia: a synthesis of cognitive and neuroimaging findings. Neuropsychol Rev. 2012;22:280\u201397.","journal-title":"Neuropsychol Rev"},{"key":"1612_CR73","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/scan\/nsaa060","volume":"15","author":"CL Brown","year":"2020","unstructured":"Brown CL, Hua AY, De Coster L, Sturm VE, Kramer JH, Rosen HJ, et al. Comparing two facets of emotion perception across multiple neurodegenerative diseases. Soc Cogn Affect Neurosci. 2020;15:511\u201322.","journal-title":"Soc Cogn Affect Neurosci"},{"key":"1612_CR74","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1523\/JNEUROSCI.5587-06.2007","volume":"27","author":"WW Seeley","year":"2007","unstructured":"Seeley WW, Menon V, Schatzberg AF, Keller J, Glover GH, Kenna H, et al. Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci. 2007;27:2349\u201356.","journal-title":"J Neurosci"},{"key":"1612_CR75","first-page":"571","volume":"3","author":"ML Meyer","year":"2012","unstructured":"Meyer ML, Lieberman MD. Social working memory: neurocognitive networks and directions for future research. Front Psychol. 2012;3:571.","journal-title":"Front Psychol"},{"key":"1612_CR76","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1176\/appi.neuropsych.23.1.74","volume":"23","author":"PJ Eslinger","year":"2011","unstructured":"Eslinger PJ, Moore P, Anderson C, Grossman M. Social cognition, executive functioning, and neuroimaging correlates of empathic deficits in frontotemporal dementia. J Neuropsychiatry Clin Neurosci. 2011;23:74\u201382.","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"1612_CR77","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1093\/brain\/awn314","volume":"132","author":"CM Kipps","year":"2009","unstructured":"Kipps CM, Nestor PJ, Acosta-Cabronero J, Arnold R, Hodges JR. Understanding social dysfunction in the behavioural variant of frontotemporal dementia: the role of emotion and sarcasm processing. Brain. 2009;132:592\u2013603.","journal-title":"Brain."},{"key":"1612_CR78","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1093\/brain\/awl254","volume":"129","author":"KP Rankin","year":"2006","unstructured":"Rankin KP, Gorno-Tempini ML, Allison SC, Stanley CM, Glenn S, Weiner MW, et al. Structural anatomy of empathy in neurodegenerative disease. Brain. 2006;129:2945\u201356.","journal-title":"Brain."},{"key":"1612_CR79","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1093\/brain\/awf225","volume":"125","author":"HJ Rosen","year":"2002","unstructured":"Rosen HJ, Perry RJ, Murphy J, Kramer JH, Mychack P, Schuff N, et al. Emotion comprehension in the temporal variant of frontotemporal dementia. Brain. 2002;125:2286\u201395.","journal-title":"Brain."},{"key":"1612_CR80","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1196\/annals.1401.025","volume":"1121","author":"IV Viskontas","year":"2007","unstructured":"Viskontas IV, Possin KL, Miller BL. Symptoms of frontotemporal dementia provide insights into orbitofrontal cortex function and social behavior. Ann N. Y Acad Sci. 2007;1121:528\u201345.","journal-title":"Ann N. Y Acad Sci"},{"key":"1612_CR81","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0010-9452(08)70024-8","volume":"38","author":"D Tranel","year":"2002","unstructured":"Tranel D, Bechara A, Denburg NL. Asymmetric functional roles of right and left ventromedial prefrontal cortices in social conduct, decision-making, and emotional processing. Cortex. 2002;38:589\u2013612.","journal-title":"Cortex."},{"key":"1612_CR82","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1093\/brain\/awg168","volume":"126","author":"J Hornak","year":"2003","unstructured":"Hornak J, Bramham J, Rolls ET, Morris RG, O\u2019Doherty J, Bullock PR, et al. Changes in emotion after circumscribed surgical lesions of the orbitofrontal and cingulate cortices. Brain. 2003;126:1691\u2013712.","journal-title":"Brain."},{"key":"1612_CR83","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1176\/jnp.17.1.66","volume":"17","author":"LW Mah","year":"2005","unstructured":"Mah LW, Arnold MC, Grafman J. Deficits in social knowledge following damage to ventromedial prefrontal cortex. J Neuropsychiatry Clin Neurosci. 2005;17:66\u201374.","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"1612_CR84","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1001\/archneurol.2007.38","volume":"65","author":"WW Seeley","year":"2008","unstructured":"Seeley WW, Crawford R, Rascovsky K, Kramer JH, Weiner M, Miller BL, et al. Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementia. Arch Neurol. 2008;65:249\u201355.","journal-title":"Arch Neurol"},{"key":"1612_CR85","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.1002\/hbm.23322","volume":"37","author":"J Jastorff","year":"2016","unstructured":"Jastorff J, De Winter FL, Van den Stock J, Vandenberghe R, Giese MA, Vandenbulcke M. Functional dissociation between anterior temporal lobe and inferior frontal gyrus in the processing of dynamic body expressions: Insights from behavioral variant frontotemporal dementia. Hum Brain Mapp. 2016;37:4472\u201386.","journal-title":"Hum Brain Mapp"},{"key":"1612_CR86","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1073\/pnas.062381899","volume":"99","author":"JR Gray","year":"2002","unstructured":"Gray JR, Braver TS, Raichle ME. Integration of emotion and cognition in the lateral prefrontal cortex. Proc Natl Acad Sci USA. 2002;99:4115\u201320.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1612_CR87","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fneur.2018.00402","volume":"9","author":"AY Hua","year":"2018","unstructured":"Hua AY, Sible IJ, Perry DC, Rankin KP, Kramer JH, Miller BL, et al. Enhanced Positive Emotional Reactivity Undermines Empathy in Behavioral Variant Frontotemporal Dementia. Front Neurol. 2018;9:402.","journal-title":"Front Neurol"},{"key":"1612_CR88","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1093\/brain\/awt185","volume":"136","author":"F Kumfor","year":"2013","unstructured":"Kumfor F, Irish M, Hodges JR, Piguet O. The orbitofrontal cortex is involved in emotional enhancement of memory: evidence from the dementias. Brain. 2013;136:2992\u20133003.","journal-title":"Brain."},{"key":"1612_CR89","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuroimage.2003.09.038","volume":"21","author":"KR Leslie","year":"2004","unstructured":"Leslie KR, Johnson-Frey SH, Grafton ST. Functional imaging of face and hand imitation: towards a motor theory of empathy. Neuroimage. 2004;21:601\u20137.","journal-title":"Neuroimage."},{"key":"1612_CR90","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neuroimage.2008.08.014","volume":"43","author":"L Nummenmaa","year":"2008","unstructured":"Nummenmaa L, Hirvonen J, Parkkola R, Hietanen JK. Is emotional contagion special? An fMRI study on neural systems for affective and cognitive empathy. Neuroimage. 2008;43:571\u201380.","journal-title":"Neuroimage."},{"key":"1612_CR91","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/scan\/nsaa076","volume":"15","author":"JE Pierce","year":"2020","unstructured":"Pierce JE, Peron J. The basal ganglia and the cerebellum in human emotion. Soc Cogn Affect Neurosci. 2020;15:599\u2013613.","journal-title":"Soc Cogn Affect Neurosci"},{"key":"1612_CR92","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.3389\/fpsyg.2019.02638","volume":"10","author":"C Wagenbreth","year":"2019","unstructured":"Wagenbreth C, Kuehne M, Heinze HJ, Zaehle T. Deep Brain Stimulation of the Subthalamic Nucleus Influences Facial Emotion Recognition in Patients With Parkinson\u2019s Disease: A Review. Front Psychol. 2019;10:2638.","journal-title":"Front Psychol"},{"key":"1612_CR93","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1093\/brain\/awn084","volume":"131","author":"F Le Jeune","year":"2008","unstructured":"Le Jeune F, Peron J, Biseul I, Fournier S, Sauleau P, Drapier S, et al. Subthalamic nucleus stimulation affects orbitofrontal cortex in facial emotion recognition: a PET study. Brain. 2008;131:1599\u2013608.","journal-title":"Brain."},{"key":"1612_CR94","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bandc.2016.04.009","volume":"106","author":"G Mattavelli","year":"2016","unstructured":"Mattavelli G, Rosanova M, Casali AG, Papagno C, Romero Lauro LJ. Timing of emotion representation in right and left occipital region: Evidence from combined TMS-EEG. Brain Cogn. 2016;106:13\u201322.","journal-title":"Brain Cogn"},{"key":"1612_CR95","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1474-4422(14)70324-2","volume":"14","author":"JD Rohrer","year":"2015","unstructured":"Rohrer JD, Nicholas JM, Cash DM, van Swieten J, Dopper E, Jiskoot L, et al. Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis. Lancet Neurol. 2015;14:253\u201362.","journal-title":"Lancet Neurol"},{"key":"1612_CR96","doi-asserted-by":"crossref","DOI":"10.1038\/srep40252","volume":"7","author":"K Loewe","year":"2017","unstructured":"Loewe K, Machts J, Kaufmann J, Petri S, Heinze HJ, Borgelt C, et al. Widespread temporo-occipital lobe dysfunction in amyotrophic lateral sclerosis. Sci Rep. 2017;7:40252.","journal-title":"Sci Rep"},{"key":"1612_CR97","doi-asserted-by":"crossref","first-page":"e42816","DOI":"10.1371\/journal.pone.0042816","volume":"7","author":"F Agosta","year":"2012","unstructured":"Agosta F, Valsasina P, Riva N, Copetti M, Messina MJ, Prelle A, et al. The cortical signature of amyotrophic lateral sclerosis. PloS One. 2012;7:e42816.","journal-title":"PloS One"},{"key":"1612_CR98","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1007\/s00259-013-2667-5","volume":"41","author":"A Cistaro","year":"2014","unstructured":"Cistaro A, Pagani M, Montuschi A, Calvo A, Moglia C, Canosa A, et al. The metabolic signature of C9ORF72-related ALS: FDG PET comparison with nonmutated patients. Eur J Nucl Med Mol Imaging. 2014;41:844\u201352.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1612_CR99","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.neuropsychologia.2011.12.022","volume":"50","author":"ME Kret","year":"2012","unstructured":"Kret ME, De Gelder B. A review on sex differences in processing emotional signals. Neuropsychologia. 2012;50:1211\u201321.","journal-title":"Neuropsychologia."}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41380-022-01612-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-022-01612-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-022-01612-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T10:54:40Z","timestamp":1680864880000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-022-01612-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,20]]},"references-count":99,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["1612"],"URL":"https:\/\/doi.org\/10.1038\/s41380-022-01612-9","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,20]]},"assertion":[{"value":"7 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"EC receives or has received research supports form the Italian Ministry of Health; DC, VC, SB, MAM, NR, GM, FC, PC, SP, CV, DP, GM, LT, IA, and BP have nothing to disclose; VS received compensation for consulting services and\/or speaking activities from AveXis, Cytokinetics and Italfarmaco; and receives or has received research supports form the Italian Ministry of Health, AriSLA, and E-Rare Joint Transnational Call; Prof. Filippi is Editor-in-Chief of the <i>Journal of Neurology<\/i>, Associate Editor of <i>Human Brain Mapping<\/i>, Associate Editor of <i>Radiology<\/i>, and Associate Editor of <i>Neurological Sciences<\/i>; received compensation for consulting services and\/or speaking activities from Alexion, Almirall, Bayer, Biogen, Celgene, Eli Lilly, Genzyme, Merck-Serono, Novartis, Roche, Sanofi, Takeda, and Teva Pharmaceutical Industries; and receives research support from Biogen Idec, Merck-Serono, Novartis, Roche, Teva Pharmaceutical Industries, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, and ARiSLA (Fondazione Italiana di Ricerca per la SLA); F. Agosta is Associate Editor of <i>NeuroImage: Clinical<\/i>, has received speaker honoraria from Roche and Biogen Idec, and receives or has received research supports from the Italian Ministry of Health, AriSLA (Fondazione Italiana di Ricerca per la SLA), Foundation Research on Alzheimer Disease and the European Research Council.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}