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This unique neuroanatomical structure is comprised of arachnoid villi stemming from frond-like surface projections\u2014that protrude into the lumen of the four cerebral ventricles\u2014providing a key source of nutrients to the brain parenchyma in addition to serving as a \u2018sink\u2019 for central nervous system metabolic waste. In fact, the functions of the CP are often described as being analogous to those of the liver and kidney. Beyond forming a barrier\/interface between the blood and CSF compartments, the CP has been identified as a modulator of leukocyte trafficking, inflammation, cognition, circadian rhythm and the gut brain-axis. In recent years, advances in molecular biology techniques and neuroimaging along with the use of sophisticated animal models have played an integral role in shaping our understanding of how the CP\u2013CSF system changes in relation to the maturation of neural circuits during critical periods of brain development. In this article we provide an ontogenetic perspective of the CP and review the experimental evidence implicating this structure in the pathophysiology of neurodevelopmental and neuropsychiatric disorders.<\/jats:p>","DOI":"10.1038\/s41380-022-01623-6","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T03:03:00Z","timestamp":1653534180000},"page":"3573-3582","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Deconstructing the functional neuroanatomy of the choroid plexus: an ontogenetic perspective for studying neurodevelopmental and neuropsychiatric disorders"],"prefix":"10.1038","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8630-3082","authenticated-orcid":false,"given":"Byron K. 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