{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:38:02Z","timestamp":1793162282909,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Identifying brain alterations associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding their development and improving early intervention and prevention. The ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium analyzed neuroimaging data harmonized across sites to examine brain morphology associated with STBs in youth. We performed analyses in three separate stages, in samples ranging from most to least homogeneous in terms of suicide assessment instrument and mental disorder. First, in a sample of 577 young people with mood disorders, in which STBs were assessed with the Columbia Suicide Severity Rating Scale (C-SSRS). Second, in a sample of young people with mood disorders, in which STB were assessed using different instruments, MRI metrics were compared among healthy controls without STBs (HC;\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009519), clinical controls with a mood disorder but without STBs (CC;\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009246) and young people with current suicidal ideation (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009223). In separate analyses, MRI metrics were compared among HCs (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009253), CCs (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009217), and suicide attempters (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200964). Third, in a larger transdiagnostic sample with various assessment instruments (HC\u2009=\u2009606; CC\u2009=\u2009419; Ideation\u2009=\u2009289; HC\u2009=\u2009253; CC\u2009=\u2009432; Attempt=91). In the homogeneous C-SSRS sample, surface area of the frontal pole was lower in young people with mood disorders and a history of actual suicide attempts (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009163) than those without a lifetime suicide attempt (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009323; FDR-\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.035, Cohen\u2019s\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.34). No associations with suicidal ideation were found. When examining more heterogeneous samples, we did not observe significant associations. Lower frontal pole surface area may represent a vulnerability for a (non-interrupted and non-aborted) suicide attempt; however, more research is needed to understand the nature of its relationship to suicide risk.\n                  <\/jats:p>","DOI":"10.1038\/s41380-022-01734-0","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T08:10:47Z","timestamp":1662624647000},"page":"4550-4560","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium"],"prefix":"10.1038","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6003-5227","authenticated-orcid":false,"given":"Laura S.","family":"van 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The BMC operates an early-intervention youth service at Camperdown under contract to headspace. He is the Chief Scientific Advisor to, and a 5% equity shareholder in, InnoWell Pty Ltd. deliver the $30M Australian Government-funded Project Synergy (2017\u201320; a 3-year program forInnoWell was formed by the University of Sydney (45% equity) and PwC (Australia; 45% equity) to the transformation of mental health services) and to lead the transformation of mental health services internationally through the use of innovative technologies. ETCL has previously received salary support for the effort in kind from a Janssen-sponsored study at the University of Texas at Austin. JCS has received research grants from Compass, Alkermes, and Allergan; and has served as a consultant for Pfizer, Sunovion, Sanofi, Johnson & Johnson, Livanova, and Boehringer Ingelheim. NJ and PMT received partial grant support from Biogen, Inc. for research unrelated to this manuscript. 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