{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:14:37Z","timestamp":1778501677457,"version":"3.51.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1038\/s41380-022-01800-7","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T11:04:26Z","timestamp":1664881466000},"page":"4432-4445","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A causal association of ANKRD37 with human hippocampal volume"],"prefix":"10.1038","volume":"27","author":[{"given":"Jiayuan","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianyou","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3232-5526","authenticated-orcid":false,"given":"Qiaojun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6905-2787","authenticated-orcid":false,"given":"Yan","family":"Dou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinjun","family":"Suo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuhao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yating","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukun","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9121-8296","authenticated-orcid":false,"given":"Wen","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shijie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4595-1144","authenticated-orcid":false,"given":"Tobias","family":"Banaschewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herta","family":"Flor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Grigis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4900-4817","authenticated-orcid":false,"given":"Penny","family":"Gowland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5405-9065","authenticated-orcid":false,"given":"Andreas","family":"Heinz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0111-5996","authenticated-orcid":false,"given":"R\u00fcdiger","family":"Br\u00fchl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0136-0388","authenticated-orcid":false,"given":"Jean-Luc","family":"Martinot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4461-7646","authenticated-orcid":false,"given":"Eric","family":"Artiges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7796-8234","authenticated-orcid":false,"given":"Frauke","family":"Nees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1\u0161","family":"Paus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luise","family":"Poustka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Hohmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9403-6121","authenticated-orcid":false,"given":"Henrik","family":"Walter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pak Chung","family":"Sham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7740-6469","authenticated-orcid":false,"given":"Gunter","family":"Schumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9594-479X","authenticated-orcid":false,"given":"Xudong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3598-3679","authenticated-orcid":false,"given":"Mulin Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5648-5199","authenticated-orcid":false,"given":"Chunshui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"IMAGEN Consortia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frauke","family":"Nees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herta","family":"Flor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1\u0161","family":"Paus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunter","family":"Schumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,10,4]]},"reference":[{"key":"1800_CR1","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1038\/nn.4661","volume":"20","author":"J Lisman","year":"2017","unstructured":"Lisman J, Buzs\u00e1ki G, Eichenbaum H, Nadel L, Ranganath C, Redish AD. Viewpoints: how the hippocampus contributes to memory, navigation and cognition. Nat Neurosci. 2017;20:1434\u201347.","journal-title":"Nat Neurosci"},{"key":"1800_CR2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1101\/lm.037291.114","volume":"22","author":"EJ Kim","year":"2015","unstructured":"Kim EJ, Pellman B, Kim JJ. Stress effects on the hippocampus: a critical review. Learn Mem. 2015;22:411\u20136.","journal-title":"Learn Mem"},{"key":"1800_CR3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000356430","volume":"34","author":"K Moodley","year":"2014","unstructured":"Moodley K, Chan D. The hippocampus in neurodegenerative disease. Front Neurol Neurosci. 2014;34:95\u2013108.","journal-title":"Front Neurol Neurosci"},{"key":"1800_CR4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000356435","volume":"34","author":"A Chatzikonstantinou","year":"2014","unstructured":"Chatzikonstantinou A. Epilepsy and the hippocampus. Front Neurol Neurosci. 2014;34:121\u201342.","journal-title":"Front Neurol Neurosci"},{"key":"1800_CR5","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/mp.2010.80","volume":"16","author":"G MacQueen","year":"2011","unstructured":"MacQueen G, Frodl T. The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research? Mol Psychiatry. 2011;16:252\u201364.","journal-title":"Mol Psychiatry"},{"key":"1800_CR6","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1038\/s41380-020-0853-y","volume":"26","author":"MJ Roeske","year":"2021","unstructured":"Roeske MJ, Konradi C, Heckers S, Lewis AS. Hippocampal volume and hippocampal neuron density, number and size in schizophrenia: a systematic review and meta-analysis of postmortem studies. Mol Psychiatry. 2021;26:3524\u201335.","journal-title":"Mol Psychiatry"},{"key":"1800_CR7","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/S1474-4422(17)30343-5","volume":"16","author":"G Halliday","year":"2017","unstructured":"Halliday G. Pathology and hippocampal atrophy in Alzheimer\u2019s disease. Lancet Neurol. 2017;16:862\u20134.","journal-title":"Lancet Neurol"},{"key":"1800_CR8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.trci.2018.04.007","volume":"4","author":"E Bayram","year":"2018","unstructured":"Bayram E, Caldwell JZ, Banks SJ. Current understanding of magnetic resonance imaging biomarkers and memory in Alzheimer\u2019s disease. Alzheimers Dement (N Y). 2018;4:395\u2013413.","journal-title":"Alzheimers Dement (N Y)"},{"key":"1800_CR9","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1212\/01.wnl.0000344568.09360.31","volume":"72","author":"WJ Henneman","year":"2009","unstructured":"Henneman WJ, Sluimer JD, Barnes J, van der Flier WM, Sluimer IC, Fox NC, et al. Hippocampal atrophy rates in Alzheimer disease: added value over whole brain volume measures. Neurology. 2009;72:999\u20131007.","journal-title":"Neurology"},{"key":"1800_CR10","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1212\/WNL.55.4.484","volume":"55","author":"CR Jack Jr","year":"2000","unstructured":"Jack CR Jr, Petersen RC, Xu Y, O\u2019Brien PC, Smith GE, Ivnik RJ, et al. Rates of hippocampal atrophy correlate with change in clinical status in aging and AD. Neurology. 2000;55:484\u201390.","journal-title":"Neurology"},{"key":"1800_CR11","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/ng.2250","volume":"44","author":"JL Stein","year":"2012","unstructured":"Stein JL, Medland SE, Vasquez AA, Hibar DP, Senstad RE, Winkler AM, et al. Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet. 2012;44:552\u201361.","journal-title":"Nat Genet"},{"key":"1800_CR12","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nature14101","volume":"520","author":"DP Hibar","year":"2015","unstructured":"Hibar DP, Stein JL, Renteria ME, Arias-Vasquez A, Desrivi\u00e8res S, Jahanshad N, et al. Common genetic variants influence human subcortical brain structures. Nature. 2015;520:224\u20139.","journal-title":"Nature"},{"key":"1800_CR13","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s41586-018-0571-7","volume":"562","author":"LT Elliott","year":"2018","unstructured":"Elliott LT, Sharp K, Alfaro-Almagro F, Shi S, Miller KL, Douaud G, et al. Genome-wide association studies of brain imaging phenotypes in UK Biobank. Nature. 2018;562:210\u20136.","journal-title":"Nature"},{"key":"1800_CR14","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nrg2814","volume":"11","author":"RP Alexander","year":"2010","unstructured":"Alexander RP, Fang G, Rozowsky J, Snyder M, Gerstein MB. Annotating non-coding regions of the genome. Nat Rev Genet. 2010;11:559\u201371.","journal-title":"Nat Rev Genet"},{"key":"1800_CR15","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1038\/ng.3959","volume":"49","author":"AJ Jasinska","year":"2017","unstructured":"Jasinska AJ, Zelaya I, Service SK, Peterson CB, Cantor RM, Choi OW, et al. Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate. Nat Genet. 2017;49:1714\u201321.","journal-title":"Nat Genet"},{"key":"1800_CR16","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1038\/npp.2017.91","volume":"42","author":"A Kepa","year":"2017","unstructured":"Kepa A, Martinez Medina L, Erk S, Srivastava DP, Fernandes A, Toro R, et al. Associations of the intellectual disability gene MYT1L with helix\u2013loop\u2013helix gene expression, hippocampus volume and hippocampus activation during memory retrieval. Neuropsychopharmacology. 2017;42:2516\u201326.","journal-title":"Neuropsychopharmacology"},{"key":"1800_CR17","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1038\/s41380-019-0605-z","volume":"26","author":"T Jia","year":"2021","unstructured":"Jia T, Chu C, Liu Y, van Dongen J, Papastergios E, Armstrong NJ, et al. Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group. Mol Psychiatry. 2021;26:3884\u201395.","journal-title":"Mol Psychiatry"},{"key":"1800_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2014-15-5-r73","volume":"15","author":"AF McRae","year":"2014","unstructured":"McRae AF, Powell JE, Henders AK, Bowdler L, Hemani G, Shah S, et al. Contribution of genetic variation to transgenerational inheritance of DNA methylation. Genome Biol. 2014;15:1\u201310.","journal-title":"Genome Biol"},{"key":"1800_CR19","doi-asserted-by":"crossref","first-page":"e00523","DOI":"10.7554\/eLife.00523","volume":"2","author":"M Gutierrez-Arcelus","year":"2013","unstructured":"Gutierrez-Arcelus M, Lappalainen T, Montgomery SB, Buil A, Ongen H, Yurovsky A, et al. Passive and active DNA methylation and the interplay with genetic variation in gene regulation. Elife. 2013;2:e00523.","journal-title":"Elife"},{"key":"1800_CR20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cell.2013.12.019","volume":"156","author":"H Wu","year":"2014","unstructured":"Wu H, Zhang Y. Reversing DNA methylation: mechanisms, genomics, and biological functions. Cell. 2014;156:45\u201368.","journal-title":"Cell"},{"key":"1800_CR21","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1101\/gr.254904.119","volume":"30","author":"LE Blake","year":"2020","unstructured":"Blake LE, Roux J, Hernando-Herraez I, Banovich NE, Perez RG, Hsiao CJ, et al. A comparison of gene expression and DNA methylation patterns across tissues and species. Genome Res. 2020;30:250\u201362.","journal-title":"Genome Res"},{"key":"1800_CR22","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ng.3538","volume":"48","author":"Z Zhu","year":"2016","unstructured":"Zhu Z, Zhang F, Hu H, Bakshi A, Robinson MR, Powell JE, et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet. 2016;48:481\u20137.","journal-title":"Nat Genet"},{"key":"1800_CR23","doi-asserted-by":"crossref","first-page":"e1004383","DOI":"10.1371\/journal.pgen.1004383","volume":"10","author":"C Giambartolomei","year":"2014","unstructured":"Giambartolomei C, Vukcevic D, Schadt EE, Franke L, Hingorani AD, Wallace C, et al. Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet. 2014;10:e1004383.","journal-title":"PLoS Genet"},{"key":"1800_CR24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2156-10-23","volume":"10","author":"J Millstein","year":"2009","unstructured":"Millstein J, Zhang B, Zhu J, Schadt EE. Disentangling molecular relationships with a causal inference test. BMC Genet. 2009;10:1\u201315.","journal-title":"BMC Genet"},{"key":"1800_CR25","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15452","volume":"8","author":"O Delaneau","year":"2017","unstructured":"Delaneau O, Ongen H, Brown AA, Fort A, Panousis NI, Dermitzakis ET. A complete tool set for molecular QTL discovery and analysis. Nat Commun. 2017;8:15452.","journal-title":"Nat Commun"},{"key":"1800_CR26","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2012-13-6-r43","volume":"13","author":"MN Davies","year":"2012","unstructured":"Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S, et al. Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol. 2012;13:R43.","journal-title":"Genome Biol"},{"key":"1800_CR27","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1001\/jamapsychiatry.2016.0144","volume":"73","author":"C Montano","year":"2016","unstructured":"Montano C, Taub MA, Jaffe A, Briem E, Feinberg JI, Trygvadottir R, et al. Association of DNA methylation differences with schizophrenia in an epigenome-wide association study. JAMA Psychiatry. 2016;73:506\u201314.","journal-title":"JAMA Psychiatry"},{"key":"1800_CR28","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-01818-4","volume":"8","author":"H Schulz","year":"2017","unstructured":"Schulz H, Ruppert AK, Herms S, Wolf C, Mirza-Schreiber N, Stegle O, et al. Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus. Nat Commun. 2017;8:1511.","journal-title":"Nat Commun"},{"key":"1800_CR29","doi-asserted-by":"crossref","first-page":"186","DOI":"10.12688\/wellcomeopenres.15555.1","volume":"4","author":"S Burgess","year":"2019","unstructured":"Burgess S, Davey Smith G, Davies NM, Dudbridge F, Gill D, Glymour MM, et al. Guidelines for performing Mendelian randomization investigations. Wellcome Open Res. 2019;4:186.","journal-title":"Wellcome Open Res"},{"key":"1800_CR30","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/mp.2010.4","volume":"15","author":"G Schumann","year":"2010","unstructured":"Schumann G, Loth E, Banaschewski T, Barbot A, Barker G, B\u00fcchel C, et al. The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology. Mol Psychiatry. 2010;15:1128\u201339.","journal-title":"Mol Psychiatry"},{"key":"1800_CR31","doi-asserted-by":"crossref","first-page":"e0121945","DOI":"10.1371\/journal.pone.0121945","volume":"10","author":"B Diedenhofen","year":"2015","unstructured":"Diedenhofen B, Musch J. cocor: a comprehensive solution for the statistical comparison of correlations. PLoS One. 2015;10:e0121945.","journal-title":"PLoS One"},{"key":"1800_CR32","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41593-021-00826-4","volume":"24","author":"SM Smith","year":"2021","unstructured":"Smith SM, Douaud G, Chen W, Hanayik T, Alfaro-Almagro F, Sharp K, et al. An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank. Nat Neurosci. 2021;24:737\u201345.","journal-title":"Nat Neurosci"},{"key":"1800_CR33","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/prot.340170405","volume":"17","author":"P Bork","year":"1993","unstructured":"Bork P. Hundreds of ankyrin\u2010like repeats in functionally diverse proteins: mobile modules that cross phyla horizontally? Proteins. 1993;17:363\u201374.","journal-title":"Proteins"},{"key":"1800_CR34","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1093\/nar\/gkp425","volume":"37","author":"Y Benita","year":"2009","unstructured":"Benita Y, Kikuchi H, Smith AD, Zhang MQ, Chung DC, Xavier RJ, et al. An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. Nucleic Acids Res. 2009;37:4587\u2013602.","journal-title":"Nucleic Acids Res"},{"key":"1800_CR35","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.cell.2013.04.048","volume":"153","author":"MD Galbraith","year":"2013","unstructured":"Galbraith MD, Allen MA, Bensard CL, Wang X, Schwinn MK, Qin B, et al. HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia. Cell. 2013;153:1327\u201339.","journal-title":"Cell"},{"key":"1800_CR36","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.molcel.2010.09.022","volume":"40","author":"AJ Majmundar","year":"2013","unstructured":"Majmundar AJ, Wong WJ, Simon MC. Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell. 2013;40:294\u2013309.","journal-title":"Mol Cell"},{"key":"1800_CR37","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.expneurol.2009.07.033","volume":"223","author":"X Zhang","year":"2010","unstructured":"Zhang X, Le W. Pathological role of hypoxia in Alzheimer\u2019s disease. Exp Neurol. 2010;223:299\u2013303.","journal-title":"Exp Neurol"},{"key":"1800_CR38","doi-asserted-by":"crossref","first-page":"18727","DOI":"10.1073\/pnas.0606298103","volume":"103","author":"X Sun","year":"2006","unstructured":"Sun X, He G, Qing H, Zhou W, Dobie F, Cai F, et al. Hypoxia facilitates Alzheimer\u2019s disease pathogenesis by up-regulating BACE1 gene expression. Proc Natl Acad Sci U S A. 2006;103:18727\u201332.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1800_CR39","doi-asserted-by":"crossref","first-page":"585833","DOI":"10.3389\/fncel.2020.585833","volume":"14","author":"D Lana","year":"2020","unstructured":"Lana D, Ugolini F, Giovannini MG. An Overview on the Differential Interplay Among Neurons\u2013Astrocytes\u2013Microglia in CA1 and CA3 Hippocampus in Hypoxia\/Ischemia. Front Cell Neurosci. 2020;14:585833.","journal-title":"Front Cell Neurosci"},{"key":"1800_CR40","doi-asserted-by":"crossref","first-page":"559074","DOI":"10.3389\/fgene.2020.559074","volume":"11","author":"Y Yasukochi","year":"2020","unstructured":"Yasukochi Y, Shin S, Wakabayashi H, Maeda T. Transcriptomic changes in young Japanese males after exposure to acute hypobaric hypoxia. Front Genet. 2020;11:559074.","journal-title":"Front Genet"},{"key":"1800_CR41","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrg3230","volume":"13","author":"PA Jones","year":"2012","unstructured":"Jones PA. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet. 2012;13:484\u201392.","journal-title":"Nat Rev Genet"},{"key":"1800_CR42","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/nature21373","volume":"543","author":"F Neri","year":"2017","unstructured":"Neri F, Rapelli S, Krepelova A, Incarnato D, Parlato C, Basile G, et al. Intragenic DNA methylation prevents spurious transcription initiation. Nature. 2017;543:72\u201377.","journal-title":"Nature"},{"key":"1800_CR43","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41586-019-1534-3","volume":"573","author":"DN Weinberg","year":"2019","unstructured":"Weinberg DN, Papillon-Cavanagh S, Chen H, Yue Y, Chen X, Rajagopalan KN, et al. The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape. Nature. 2019;573:281\u20136.","journal-title":"Nature"},{"key":"1800_CR44","first-page":"444","volume":"329","author":"H Wu","year":"2010","unstructured":"Wu H, Coskun V, Tao J, Xie W, Ge W, Yoshikawa K, et al. Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Nature. 2010;329:444\u20138.","journal-title":"Nature"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41380-022-01800-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-022-01800-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-022-01800-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T11:14:13Z","timestamp":1680866053000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-022-01800-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,4]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["1800"],"URL":"https:\/\/doi.org\/10.1038\/s41380-022-01800-7","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,4]]},"assertion":[{"value":"24 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}