{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T22:36:23Z","timestamp":1794695783302,"version":"4.9.1"},"reference-count":205,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH118884"],"award-info":[{"award-number":["R01MH118884"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH100616"],"award-info":[{"award-number":["R01MH100616"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH124428"],"award-info":[{"award-number":["R01MH124428"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH107183"],"award-info":[{"award-number":["R01MH107183"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health"},{"name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health"},{"name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric disorders in later life. Previous studies have suggested that ELS can cause profound changes in gene expression through epigenetic mechanisms, which can lead to psychiatric disorders in adulthood; however, studies on epigenetic modifications associated with ELS and psychiatric disorders in adolescents are limited. Moreover, how these epigenetic modifications can lead to psychiatric disorders in adolescents is not fully understood. Commonly, DNA methylation, histone modification, and the regulation of noncoding RNAs have been attributed to the reprogramming of epigenetic profiling associated with ELS. Although only a few studies have attempted to examine epigenetic modifications in adolescents with ELS, existing evidence suggests that there are commonalities and differences in epigenetic profiling between adolescents and adults. In addition, epigenetic modifications are sex-dependent and are influenced by the type of ELS. In this review, we have critically evaluated the current evidence on epigenetic modifications in adolescents with ELS, particularly DNA methylation and the expression of microRNAs in both preclinical models and humans. We have also clarified the impact of ELS on psychiatric disorders in adolescents to predict the development of neuropsychiatric disorders and to prevent and recover these disorders through personalized medicine.<\/jats:p>","DOI":"10.1038\/s41380-022-01907-x","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T02:03:25Z","timestamp":1670983405000},"page":"141-153","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Dissecting early life stress-induced adolescent depression through epigenomic approach"],"prefix":"10.1038","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2263-3477","authenticated-orcid":false,"given":"Shinichiro","family":"Ochi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5359-4717","authenticated-orcid":false,"given":"Yogesh","family":"Dwivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"1907_CR1","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-018-1147-y","volume":"16","author":"MH Teicher","year":"2018","unstructured":"Teicher MH. Childhood trauma and the enduring consequences of forcibly separating children from parents at the United States border. BMC Med. 2018;16:146.","journal-title":"BMC Med"},{"key":"1907_CR2","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1377\/hlthaff.2019.00480","volume":"38","author":"F Rivara","year":"2019","unstructured":"Rivara F, Adhia A, Lyons V, Massey A, Mills B, Morgan E, et al. The effects of violence on health. Health Aff. 2019;38:1622\u20139.","journal-title":"Health Aff"},{"key":"1907_CR3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.chiabu.2015.11.021","volume":"52","author":"R Wade","year":"2016","unstructured":"Wade R, Cronholm PF, Fein JA, Forke CM, Davis MB, Harkins-Schwarz M, et al. Household and community-level Adverse Childhood Experiences and adult health outcomes in a diverse urban population. Child Abus Negl. 2016;52:135\u201345.","journal-title":"Child Abus Negl"},{"key":"1907_CR4","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.amepre.2015.07.022","volume":"50","author":"JA Campbell","year":"2016","unstructured":"Campbell JA, Walker RJ, Egede LE. Associations between adverse childhood experiences, high-risk behaviors, and morbidity in adulthood. Am J Prev Med. 2016;50:344\u201352.","journal-title":"Am J Prev Med"},{"key":"1907_CR5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.chiabu.2015.08.017","volume":"51","author":"KA Ports","year":"2016","unstructured":"Ports KA, Ford DC, Merrick MT. Adverse childhood experiences and sexual victimization in adulthood. Child Abus Negl. 2016;51:313\u201322.","journal-title":"Child Abus Negl"},{"key":"1907_CR6","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/s41380-019-0597-8","volume":"25","author":"L Allen","year":"2020","unstructured":"Allen L, Dwivedi Y. MicroRNA mediators of early life stress vulnerability to depression and suicidal behavior. Mol Psychiatry. 2020;25:308\u201320.","journal-title":"Mol Psychiatry"},{"key":"1907_CR7","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.2105\/AJPH.2011.300636","volume":"102","author":"CS Widom","year":"2012","unstructured":"Widom CS, Czaja SJ, Bentley T, Johnson MS. A prospective investigation of physical health outcomes in abused and neglected children: new findings from a 30-year follow-up. Am J Public Health. 2012;102:1135\u201344.","journal-title":"Am J Public Health"},{"key":"1907_CR8","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.metabol.2015.08.019","volume":"64","author":"H Huang","year":"2015","unstructured":"Huang H, Yan P, Shan Z, Chen S, Li M, Luo C, et al. Adverse childhood experiences and risk of type 2 diabetes: a systematic review and meta-analysis. Metabolism. 2015;64:1408\u201318.","journal-title":"Metabolism."},{"key":"1907_CR9","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.schres.2014.07.011","volume":"159","author":"S Shah","year":"2014","unstructured":"Shah S, Mackinnon A, Galletly C, Carr V, McGrath JJ, Stain HJ, et al. Prevalence and impact of childhood abuse in people with a psychotic illness. Data from the second Australian national survey of psychosis. Schizophr Res. 2014;159:20\u201326.","journal-title":"Schizophr Res"},{"key":"1907_CR10","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1001\/jama.286.24.3089","volume":"286","author":"SR Dube","year":"2001","unstructured":"Dube SR, Anda RF, Felitti VJ, Chapman DP, Williamson DF, Giles WH. Childhood abuse, household dysfunction, and the risk of attempted suicide throughout the life span: findings from the Adverse Childhood Experiences Study. JAMA. 2001;286:3089\u201396.","journal-title":"JAMA."},{"key":"1907_CR11","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.psychres.2013.07.004","volume":"210","author":"L Ferraz","year":"2013","unstructured":"Ferraz L, Portella MJ, V\u00e1llez M, Guti\u00e9rrez F, Mart\u00edn-Blanco A, Mart\u00edn-Santos R, et al. Hostility and childhood sexual abuse as predictors of suicidal behaviour in borderline personality disorder. Psychiatry Res. 2013;210:980\u20135.","journal-title":"Psychiatry Res"},{"key":"1907_CR12","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/cch.12351","volume":"42","author":"E Fuller-Thomson","year":"2016","unstructured":"Fuller-Thomson E, Baird SL, Dhrodia R, Brennenstuhl S. The association between adverse childhood experiences (ACEs) and suicide attempts in a population\u2010based study. Child Care Heal Dev. 2016;42:725\u201334.","journal-title":"Child Care Heal Dev"},{"key":"1907_CR13","doi-asserted-by":"crossref","first-page":"e2434","DOI":"10.1097\/MD.0000000000002434","volume":"95","author":"H Liang","year":"2016","unstructured":"Liang H, Olsen J, Yuan W, Cnattingus S, Vestergaard M, Obel C, et al. Early life bereavement and schizophrenia. Medicine. 2016;95:e2434.","journal-title":"Medicine."},{"key":"1907_CR14","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.chiabu.2017.03.016","volume":"69","author":"MT Merrick","year":"2017","unstructured":"Merrick MT, Ports KA, Ford DC, Afifi TO, Gershoff ET, Grogan-Kaylor A. Unpacking the impact of adverse childhood experiences on adult mental health. Child Abus Negl. 2017;69:10\u201319.","journal-title":"Child Abus Negl"},{"key":"1907_CR15","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1590\/2237-6089-2017-0101","volume":"40","author":"SL de Bach","year":"2018","unstructured":"de Bach SL, Molina MAL, Jansen K, da Silva RA, de Souza LDM. Suicide risk and childhood trauma in individuals diagnosed with posttraumatic stress disorder. Trends Psychiatry Psychother. 2018;40:253\u20137.","journal-title":"Trends Psychiatry Psychother"},{"key":"1907_CR16","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jad.2018.02.034","volume":"234","author":"E Obikane","year":"2018","unstructured":"Obikane E, Shinozaki T, Takagi D, Kawakami N. Impact of childhood abuse on suicide-related behavior: Analysis using marginal structural models. J Affect Disord. 2018;234:224\u201330.","journal-title":"J Affect Disord"},{"key":"1907_CR17","doi-asserted-by":"crossref","first-page":"112730","DOI":"10.1016\/j.psychres.2019.112730","volume":"285","author":"I Alberdi-Paramo","year":"2019","unstructured":"Alberdi-Paramo I, Saiz-Gonzalez MD, Diaz-Marsa M, Carrasco-Perera JL. Bullying and childhood trauma events as predictive factors of suicidal behavior in borderline personality disorder: preliminary findings. Psychiatry Res. 2019;285:112730.","journal-title":"Psychiatry Res"},{"key":"1907_CR18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/cch.12617","volume":"45","author":"MP Thompson","year":"2019","unstructured":"Thompson MP, Kingree JB, Lamis D. Associations of adverse childhood experiences and suicidal behaviors in adulthood in a U.S. nationally representative sample. Child Care Heal Dev. 2019;45:121\u20138.","journal-title":"Child Care Heal Dev"},{"key":"1907_CR19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jpsychires.2018.02.001","volume":"99","author":"QX Ng","year":"2018","unstructured":"Ng QX, Yong BZJ, Ho CYX, Lim DY, Yeo W-S. Early life sexual abuse is associated with increased suicide attempts: An update meta-analysis. J Psychiatr Res. 2018;99:129\u201341.","journal-title":"J Psychiatr Res"},{"key":"1907_CR20","doi-asserted-by":"crossref","first-page":"538172","DOI":"10.3389\/fpsyt.2020.538172","volume":"11","author":"FD Santo","year":"2020","unstructured":"Santo FD, Carballo JJ, Velasco A, Jim\u00e9nez-Trevi\u00f1o L, Rodr\u00edguez-Revuelta J, Mart\u00ednez-Cao C, et al. The Mediating role of impulsivity in the relationship between suicidal behavior and early traumatic experiences in depressed subjects. Front Psychiatry. 2020;11:538172.","journal-title":"Front Psychiatry"},{"key":"1907_CR21","doi-asserted-by":"crossref","first-page":"113411","DOI":"10.1016\/j.psychres.2020.113411","volume":"293","author":"CR Prokopez","year":"2020","unstructured":"Prokopez CR, Vallejos M, Farinola R, Alberio G, Caporusso GB, Cozzarin LG, et al. The history of multiple adverse childhood experiences in patients with schizophrenia is associated with more severe symptomatology and suicidal behavior with gender-specific characteristics. Psychiatry Res. 2020;293:113411.","journal-title":"Psychiatry Res"},{"key":"1907_CR22","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S2215-0366(19)30525-5","volume":"7","author":"S O\u2019Neill","year":"2020","unstructured":"O\u2019Neill S, O\u2019Connor RC. Suicide in Northern Ireland: epidemiology, risk factors, and prevention. Lancet Psychiatry. 2020;7:538\u201346.","journal-title":"Lancet Psychiatry"},{"key":"1907_CR23","doi-asserted-by":"crossref","first-page":"1874600","DOI":"10.1080\/20008198.2021.1874600","volume":"12","author":"S Gloger","year":"2021","unstructured":"Gloger S, Mart\u00ednez P, Behn A, Chac\u00f3n MV, Cottin M, de Medina DD, et al. Population-attributable risk of adverse childhood experiences for high suicide risk, psychiatric admissions, and recurrent depression, in depressed outpatients. Eur J Psychotraumatol. 2021;12:1874600.","journal-title":"Eur J Psychotraumatol"},{"key":"1907_CR24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/acps.13401","volume":"145","author":"DG Laroche","year":"2022","unstructured":"Laroche DG, Godin O, Belzeaux R, M\u2019Bailara K, Loftus J, Courtet P, et al. Association between childhood maltreatment and the clinical course of bipolar disorders: a survival analysis of mood recurrences. Acta Psychiat Scand. 2022;145:373\u201383.","journal-title":"Acta Psychiat Scand"},{"key":"1907_CR25","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0749-3797(98)00017-8","volume":"14","author":"VJ Felitti","year":"1998","unstructured":"Felitti VJ, Anda RF, Nordenberg D, Williamson DF, Spitz AM, Edwards V, et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. Am J Prev Med. 1998;14:245\u201358.","journal-title":"Am J Prev Med"},{"key":"1907_CR26","doi-asserted-by":"crossref","first-page":"104993","DOI":"10.1016\/j.chiabu.2021.104993","volume":"115","author":"RH Kappel","year":"2021","unstructured":"Kappel RH, Livingston MD, Patel SN, Villaveces A, Massetti GM. Prevalence of adverse childhood experiences (ACEs) and associated health risks and risk behaviors among young women and men in Honduras. Child Abus Negl. 2021;115:104993.","journal-title":"Child Abus Negl"},{"key":"1907_CR27","doi-asserted-by":"crossref","unstructured":"Johnson RM, Hill AV, Jones VC, Powell TW, Dean LT, Gilreath TD. Racial\/ethnic inequities in adverse childhood experiences and selected health-related behaviors and problems among Maryland adolescents. Health Promot Pract. 2021:15248399211008238.","DOI":"10.1177\/15248399211008238"},{"key":"1907_CR28","doi-asserted-by":"crossref","first-page":"e1003031","DOI":"10.1371\/journal.pmed.1003031","volume":"17","author":"LC Houtepen","year":"2020","unstructured":"Houtepen LC, Heron J, Suderman MJ, Fraser A, Chittleborough CR, Howe LD. Associations of adverse childhood experiences with educational attainment and adolescent health and the role of family and socioeconomic factors: A prospective cohort study in the U.K. Plos Med. 2020;17:e1003031.","journal-title":"Plos Med"},{"key":"1907_CR29","doi-asserted-by":"crossref","first-page":"104705","DOI":"10.1016\/j.chiabu.2020.104705","volume":"109","author":"M-C Lee","year":"2020","unstructured":"Lee M-C, Huang N, Chen C-Y. Effects of childhood adversity trajectories on mental health outcomes in late adolescence: The buffering role of parenting practices in Taiwan. Child Abus Negl. 2020;109:104705.","journal-title":"Child Abus Negl"},{"key":"1907_CR30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jadohealth.2020.01.005","volume":"67","author":"C Cohrdes","year":"2020","unstructured":"Cohrdes C, Mauz E. Self-efficacy and emotional stability buffer negative effects of adverse childhood experiences on young adult health-related quality of life. J Adolesc Health. 2020;67:93\u2013100.","journal-title":"J Adolesc Health"},{"key":"1907_CR31","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/smi.2761","volume":"34","author":"C Karatekin","year":"2018","unstructured":"Karatekin C. Adverse childhood experiences (ACEs), Stress and mental health in college students. Stress Health. 2018;34:36\u201345.","journal-title":"Stress Health"},{"key":"1907_CR32","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.acap.2014.09.010","volume":"15","author":"R Thompson","year":"2015","unstructured":"Thompson R, Flaherty EG, English DJ, Litrownik AJ, Dubowitz H, Kotch JB, et al. Trajectories of adverse childhood experiences and self-reported health at age 18. Acad Pediatr. 2015;15:503\u20139.","journal-title":"Acad Pediatr"},{"key":"1907_CR33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.pediatrneurol.2021.04.004","volume":"121","author":"M Anto","year":"2021","unstructured":"Anto M, Jaffee S, Tietjen G, Mendizabal A, Szperka C. Adverse childhood experiences and frequent headache by adolescent self-report. Pediatr Neurol. 2021;121:51\u201355.","journal-title":"Pediatr Neurol"},{"key":"1907_CR34","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/ACI.0000000000000421","volume":"18","author":"MJ Rosa","year":"2018","unstructured":"Rosa MJ, Lee AG, Wright RJ. Evidence establishing a link between prenatal and early-life stress and asthma development. Curr Opin Allergy Clin Immunol. 2018;18:148\u201358.","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"1907_CR35","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.jadohealth.2020.08.024","volume":"68","author":"T Lensch","year":"2021","unstructured":"Lensch T, Clements-Nolle K, Oman RF, Evans WP, Lu M, Yang W. Adverse childhood experiences and suicidal behaviors among youth: The buffering influence of family communication and school connectedness. J Adolesc Health. 2021;68:945\u201352.","journal-title":"J Adolesc Health"},{"key":"1907_CR36","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1001\/jamapsychiatry.2021.0480","volume":"78","author":"L Polanco-Roman","year":"2021","unstructured":"Polanco-Roman L, Alvarez K, Corbeil T, Scorza P, Wall M, Gould MS, et al. Association of childhood adversities with suicide ideation and attempts in Puerto Rican young adults. JAMA Psychiatry. 2021;78:896\u2013902.","journal-title":"JAMA Psychiatry"},{"key":"1907_CR37","doi-asserted-by":"crossref","first-page":"11743","DOI":"10.1177\/0886260519900976","volume":"36","author":"K Clements-Nolle","year":"2021","unstructured":"Clements-Nolle K, Lensch T, Yang Y, Martin H, Peek J, Yang W. Attempted suicide among adolescents in military families: The mediating role of adverse childhood experiences. J Interpers Violence. 2021;36:11743\u201354.","journal-title":"J Interpers Violence"},{"key":"1907_CR38","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1017\/S0954579420000553","volume":"33","author":"JI Meza","year":"2021","unstructured":"Meza JI, Owens EB, Hinshaw SP. Childhood predictors and moderators of lifetime risk of self-harm in girls with and without attention-deficit\/hyperactivity disorder. Dev Psychopathol. 2021;33:1351\u201367.","journal-title":"Dev Psychopathol"},{"key":"1907_CR39","doi-asserted-by":"crossref","first-page":"670246","DOI":"10.3389\/fpsyt.2021.670246","volume":"12","author":"AW T\u00f6rnblom","year":"2021","unstructured":"T\u00f6rnblom AW, Sorjonen K, Runeson B, Rydelius P-A. Life events and coping strategies among young people who died by suicide or sudden violent death. Front Psychiatry. 2021;12:670246.","journal-title":"Front Psychiatry"},{"key":"1907_CR40","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jad.2021.02.045","volume":"285","author":"S Li","year":"2021","unstructured":"Li S, Wang S, Gao X, Jiang Z, Xu H, Zhang S, et al. Patterns of adverse childhood experiences and suicidal behaviors in adolescents: A four-province study in China. J Affect Disord. 2021;285:69\u201376.","journal-title":"J Affect Disord"},{"key":"1907_CR41","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jaac.2020.07.908","volume":"60","author":"B Geselowitz","year":"2021","unstructured":"Geselowitz B, Whalen DJ, Tillman R, Barch DM, Luby JL, Vogel A. Preschool age predictors of adolescent borderline personality symptoms. J Am Acad Child Adolesc Psychiatry. 2021;60:612\u201322.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"1907_CR42","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1017\/S0033291719004136","volume":"51","author":"EM McMahon","year":"2021","unstructured":"McMahon EM, Corcoran P, Keeley H, Clarke M, Coughlan H, Wasserman D, et al. Risk and protective factors for psychotic experiences in adolescence: a population-based study. Psychol Med. 2021;51:1220\u20138.","journal-title":"Psychol Med"},{"key":"1907_CR43","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/jcop.22560","volume":"50","author":"SA Aytur","year":"2022","unstructured":"Aytur SA, Carlino S, Bernard F, West K, Dobrzycki V, Malik R. Social\u2010ecological theory, substance misuse, adverse childhood experiences, and adolescent suicidal ideation: applications for community-academic partnerships. J Community Psychol. 2022;50:265\u201384.","journal-title":"J Community Psychol"},{"key":"1907_CR44","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jadohealth.2020.05.044","volume":"68","author":"B-KE Kim","year":"2021","unstructured":"Kim B-KE, Gilman AB, Thompson N, Leon JD. Statewide trends of trauma history, suicidality, and mental health among youth entering the juvenile justice system. J Adolesc Health. 2021;68:300\u20137.","journal-title":"J Adolesc Health"},{"key":"1907_CR45","doi-asserted-by":"crossref","first-page":"4718","DOI":"10.3390\/ijerph17134718","volume":"17","author":"Z Jia","year":"2020","unstructured":"Jia Z, Wen X, Chen F, Zhu H, Li C, Lin Y, et al. Cumulative exposure to adverse childhood experience: Depressive symptoms, suicide intensions and suicide plans among senior high school students in Nanchang city of China. Int J Environ Res Public Health. 2020;17:4718.","journal-title":"Int J Environ Res Public Health"},{"key":"1907_CR46","doi-asserted-by":"crossref","first-page":"102134","DOI":"10.1016\/j.ajp.2020.102134","volume":"53","author":"TT Thai","year":"2020","unstructured":"Thai TT, Cao PLT, Kim LX, Tran DP, Bui MB, Bui HHT. The effect of adverse childhood experiences on depression, psychological distress and suicidal thought in Vietnamese adolescents: Findings from multiple cross-sectional studies. Asian J Psychiatry. 2020;53:102134.","journal-title":"Asian J Psychiatry"},{"key":"1907_CR47","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1001\/jamapsychiatry.2017.3788","volume":"75","author":"E Bj\u00f6rkenstam","year":"2018","unstructured":"Bj\u00f6rkenstam E, Hjern A, Bj\u00f6rkenstam C, Kosidou K. Association of cumulative childhood adversity and adolescent violent offending with suicide in early adulthood. JAMA Psychiatry. 2018;75:185\u201393.","journal-title":"JAMA Psychiatry"},{"key":"1907_CR48","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jadohealth.2015.03.001","volume":"57","author":"L Cluver","year":"2015","unstructured":"Cluver L, Orkin M, Boyes ME, Sherr L. Child and adolescent suicide attempts, suicidal behavior, and adverse childhood experiences in South Africa: a prospective study. J Adolesc Health. 2015;57:52\u201359.","journal-title":"J Adolesc Health"},{"key":"1907_CR49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jad.2015.08.034","volume":"187","author":"JG Stewart","year":"2015","unstructured":"Stewart JG, Kim JC, Esposito EC, Gold J, Nock MK, Auerbach RP. Predicting suicide attempts in depressed adolescents: clarifying the role of disinhibition and childhood sexual abuse. J Affect Disord. 2015;187:27\u201334.","journal-title":"J Affect Disord"},{"key":"1907_CR50","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jad.2015.09.006","volume":"190","author":"MR Infurna","year":"2016","unstructured":"Infurna MR, Reichl C, Parzer P, Schimmenti A, Bifulco A, Kaess M. Associations between depression and specific childhood experiences of abuse and neglect: a meta-analysis. J Affect Disord. 2016;190:47\u201355.","journal-title":"J Affect Disord"},{"key":"1907_CR51","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.jaac.2019.10.011","volume":"59","author":"J LeMoult","year":"2020","unstructured":"LeMoult J, Humphreys KL, Tracy A, Hoffmeister J-A, Ip E, Gotlib IH. Meta-analysis: exposure to early life stress and risk for depression in childhood and adolescence. J Am Acad Child Adolesc Psychiatry. 2020;59:842\u201355.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"1907_CR52","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s12529-020-09913-5","volume":"27","author":"TJ Grigsby","year":"2020","unstructured":"Grigsby TJ, Rogers CJ, Albers LD, Benjamin SM, Lust K, Eisenberg ME, et al. Adverse childhood experiences and health indicators in a young adult, college student sample: differences by gender. Int J Behav Med. 2020;27:660\u20137.","journal-title":"Int J Behav Med"},{"key":"1907_CR53","first-page":"1389","volume":"16","author":"G Serafini","year":"2012","unstructured":"Serafini G, Pompili M, Innamorati M, Gentile G, Borro M, Lamis DA, et al. Gene variants with suicidal risk in a sample of subjects with chronic migraine and affective temperamental dysregulation. Eur Rev Med Pharm Sci. 2012;16:1389\u201398.","journal-title":"Eur Rev Med Pharm Sci"},{"key":"1907_CR54","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1017\/S0033291706008646","volume":"36","author":"MW Enns","year":"2006","unstructured":"Enns MW, Cox BJ, Afifi TO, Graaf RD, Have MT, Sareen J. Childhood adversities and risk for suicidal ideation and attempts: a longitudinal population-based study. Psychol Med. 2006;36:1769\u201378.","journal-title":"Psychol Med"},{"key":"1907_CR55","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/15299732.2015.989648","volume":"16","author":"JD Ford","year":"2015","unstructured":"Ford JD, G\u00f3mez JM. Self-injury and suicidality: the impact of trauma and dissociation. J Trauma Dissociation. 2015;16:225\u201331.","journal-title":"J Trauma Dissociation"},{"key":"1907_CR56","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1192\/bjp.bp.109.074716","volume":"197","author":"R Bruffaerts","year":"2010","unstructured":"Bruffaerts R, Demyttenaere K, Borges G, Haro JM, Chiu WT, Hwang I, et al. Childhood adversities as risk factors for onset and persistence of suicidal behaviour. Br J Psychiatry. 2010;197:20\u201327.","journal-title":"Br J Psychiatry"},{"key":"1907_CR57","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1017\/S0033291716002336","volume":"47","author":"SA Stansfeld","year":"2017","unstructured":"Stansfeld SA, Clark C, Smuk M, Power C, Davidson T, Rodgers B. Childhood adversity and midlife suicidal ideation. Psychol Med. 2017;47:327\u201340.","journal-title":"Psychol Med"},{"key":"1907_CR58","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0140-6736(20)30621-8","volume":"396","author":"NH Rod","year":"2020","unstructured":"Rod NH, Bengtsson J, Budtz-J\u00f8rgensen E, Clipet-Jensen C, Taylor-Robinson D, Andersen A-MN, et al. Trajectories of childhood adversity and mortality in early adulthood: a population-based cohort study. Lancet. 2020;396:489\u201397.","journal-title":"Lancet"},{"key":"1907_CR59","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1001\/archpsyc.1996.01830060096013","volume":"53","author":"JR Davidson","year":"1996","unstructured":"Davidson JR, Hughes DC, George LK, Blazer DG. The association of sexual assault and attempted suicide within the community. Arch Gen Psychiatry. 1996;53:550\u20135.","journal-title":"Arch Gen Psychiatry"},{"key":"1907_CR60","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1017\/S0033291701004329","volume":"31","author":"BE Molnar","year":"2001","unstructured":"Molnar BE, Berkman LF, Buka SL. Psychopathology, childhood sexual abuse and other childhood adversities: relative links to subsequent suicidal behaviour in the US. Psychol Med. 2001;31:965\u201377.","journal-title":"Psychol Med"},{"key":"1907_CR61","doi-asserted-by":"crossref","first-page":"946","DOI":"10.2105\/AJPH.2007.120253","volume":"98","author":"TO Afifi","year":"2008","unstructured":"Afifi TO, Enns MW, Cox BJ, Asmundson GJG, Stein MB, Sareen J. Population attributable fractions of psychiatric disorders and suicide ideation and attempts associated with adverse childhood experiences. Am J Public Health. 2008;98:946\u201352.","journal-title":"Am J Public Health"},{"key":"1907_CR62","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1176\/appi.ajp.158.8.1215","volume":"158","author":"A Roy","year":"2001","unstructured":"Roy A. Characteristics of cocaine-dependent patients who attempt suicide. Am J Psychiatry. 2001;158:1215\u20139.","journal-title":"Am J Psychiatry"},{"key":"1907_CR63","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/00005053-200102000-00008","volume":"189","author":"A Roy","year":"2001","unstructured":"Roy A. Childhood trauma and attempted suicide in alcoholics. J Nerv Ment Dis. 2001;189:120\u20131.","journal-title":"J Nerv Ment Dis"},{"key":"1907_CR64","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/da.20243","volume":"24","author":"M Sarchiapone","year":"2007","unstructured":"Sarchiapone M, Carli V, Cuomo C, Roy A. Childhood trauma and suicide attempts in patients with unipolar depression. Depress Anxiety. 2007;24:268\u201372.","journal-title":"Depress Anxiety"},{"key":"1907_CR65","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.psc.2008.02.002","volume":"31","author":"BS Brodsky","year":"2008","unstructured":"Brodsky BS, Stanley B. Adverse childhood experiences and suicidal behavior. Psychiatr Clin N Am. 2008;31:223\u201335.","journal-title":"Psychiatr Clin N Am"},{"key":"1907_CR66","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1176\/appi.ajp.2013.12070957","volume":"170","author":"MH Teicher","year":"2013","unstructured":"Teicher MH, Samson JA. Childhood maltreatment and psychopathology: a case for ecophenotypic variants as clinically and neurobiologically distinct subtypes. Am J Psychiatry. 2013;170:1114\u201333.","journal-title":"Am J Psychiatry"},{"key":"1907_CR67","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.psychres.2017.06.082","volume":"256","author":"C Zatti","year":"2017","unstructured":"Zatti C, Rosa V, Barros A, Valdivia L, Calegaro VC, Freitas LH, et al. Childhood trauma and suicide attempt: a meta-analysis of longitudinal studies from the last decade. Psychiatry Res. 2017;256:353\u20138.","journal-title":"Psychiatry Res"},{"key":"1907_CR68","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.annepidem.2021.04.015","volume":"60","author":"JT Carbone","year":"2021","unstructured":"Carbone JT, Jackson DB, Holzer KJ, Vaughn MG. Childhood adversity, suicidality, and non-suicidal self-injury among children and adolescents admitted to emergency departments. Ann Epidemiol. 2021;60:21\u201327.","journal-title":"Ann Epidemiol"},{"key":"1907_CR69","doi-asserted-by":"crossref","first-page":"101961","DOI":"10.1016\/j.ajp.2020.101961","volume":"49","author":"S Wang","year":"2020","unstructured":"Wang S, Xu H, Li S, Jiang Z, Wan Y. Sex differences in the determinants of suicide attempt among adolescents in China. Asian J Psychiatr. 2020;49:101961.","journal-title":"Asian J Psychiatr"},{"key":"1907_CR70","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.neubiorev.2020.12.033","volume":"128","author":"B Roy","year":"2021","unstructured":"Roy B, Dwivedi Y. Modeling endophenotypes of suicidal behavior in animals. Neurosci Biobehav Rev. 2021;128:819\u201327.","journal-title":"Neurosci Biobehav Rev"},{"key":"1907_CR71","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neubiorev.2016.10.031","volume":"72","author":"B Roy","year":"2017","unstructured":"Roy B, Dwivedi Y. Understanding epigenetic architecture of suicide neurobiology: a critical perspective. Neurosci Biobehav Rev. 2017;72:10\u201327.","journal-title":"Neurosci Biobehav Rev"},{"key":"1907_CR72","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jagp.2012.10.026","volume":"21","author":"Y Dwivedi","year":"2013","unstructured":"Dwivedi Y. Involvement of brain-derived neurotrophic factor in late-life depression. Am J Geriatr Psychiatry. 2013;21:433\u201349.","journal-title":"Am J Geriatr Psychiatry"},{"key":"1907_CR73","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.psyneuen.2015.02.017","volume":"56","author":"S Simsek","year":"2015","unstructured":"Simsek S, Uysal C, Kaplan I, Yuksel T, Aktas H. BDNF and cortisol levels in children with or without posttraumatic stress disorder after sustaining sexual abuse. Psychoneuroendocrinology. 2015;56:45\u201351.","journal-title":"Psychoneuroendocrinology."},{"key":"1907_CR74","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jad.2017.10.024","volume":"227","author":"M Zhao","year":"2018","unstructured":"Zhao M, Chen L, Yang J, Han D, Fang D, Qiu X, et al. BDNF Val66Met polymorphism, life stress and depression: A meta-analysis of gene-environment interaction. J Affect Disord. 2018;227:226\u201335.","journal-title":"J Affect Disord"},{"key":"1907_CR75","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1111\/jcpp.12099","volume":"54","author":"J Chen","year":"2013","unstructured":"Chen J, Li X, McGue M. The interacting effect of the BDNF Val66Met polymorphism and stressful life events on adolescent depression is not an artifact of gene-environment correlation: evidence from a longitudinal twin study. J Child Psychol Psychiatry. 2013;54:1066\u201373.","journal-title":"J Child Psychol Psychiatry"},{"key":"1907_CR76","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jad.2011.02.001","volume":"132","author":"CS Carver","year":"2011","unstructured":"Carver CS, Johnson SL, Joormann J, LeMoult J, Cuccaro ML. Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis. J Affect Disord. 2011;132:89\u201393.","journal-title":"J Affect Disord"},{"key":"1907_CR77","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/YPG.0000000000000107","volume":"25","author":"T Rimay","year":"2015","unstructured":"Rimay T, Benak I, Kiss E, Baji I, Feher A, Juhasz A, et al. BDNF Val66Met polymorphism and stressful life events in melancholic childhood-onset depression. Psychiatr Genet. 2015;25:249\u201355.","journal-title":"Psychiatr Genet"},{"key":"1907_CR78","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.biopsych.2005.10.026","volume":"59","author":"J Kaufman","year":"2006","unstructured":"Kaufman J, Yang B-Z, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, et al. Brain-derived neurotrophic Factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biol Psychiatry. 2006;59:673\u201380.","journal-title":"Biol Psychiatry"},{"key":"1907_CR79","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10964-015-0378-x","volume":"45","author":"L Zhang","year":"2016","unstructured":"Zhang L, Li Z, Chen J, Li X, Zhang J, Belsky J. The BDNF Val66Met polymorphism interacts with maternal parenting influencing adolescent depressive symptoms: Evidence of differential susceptibility model. J Youth Adolesc. 2016;45:471\u201383.","journal-title":"J Youth Adolesc"},{"key":"1907_CR80","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.physbeh.2017.05.018","volume":"179","author":"M Fan","year":"2017","unstructured":"Fan M, Li RH, Hu MS, Xiao LY, Zhou XD, Ran MS, et al. Association of Val66Met polymorphism at brain derived neurotrophic factor gene with depression among Chinese adolescents after Wenchuan earthquake: An 18months longitudinal study. Physiol Behav. 2017;179:16\u201322.","journal-title":"Physiol Behav"},{"key":"1907_CR81","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.euroneuro.2013.01.010","volume":"23","author":"E Comasco","year":"2013","unstructured":"Comasco E, \u00c5slund C, Oreland L, Nilsson KW. Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression: a replication study. Eur Neuropsychopharmacol. 2013;23:1300\u20136.","journal-title":"Eur Neuropsychopharmacol"},{"key":"1907_CR82","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/brb3.220","volume":"4","author":"CS Cruz-Fuentes","year":"2014","unstructured":"Cruz-Fuentes CS, Benjet C, Mart\u00ednez-Levy GA, P\u00e9rez-Molina A, Briones-Velasco M, Su\u00e1rez-Gonz\u00e1lez J. BDNF Met66 modulates the cumulative effect of psychosocial childhood adversities on major depression in adolescents. Brain Behav. 2014;4:290\u20137.","journal-title":"Brain Behav"},{"key":"1907_CR83","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jad.2011.09.043","volume":"136","author":"CS Perea","year":"2012","unstructured":"Perea CS, Paternina AC, Gomez Y, Lattig MC. Negative affectivity moderated by BDNF and stress response. J Affect Disord. 2012;136:767\u201374.","journal-title":"J Affect Disord"},{"key":"1907_CR84","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/j.1601-183X.2012.00843.x","volume":"11","author":"J Chen","year":"2012","unstructured":"Chen J, Li X, McGue M. Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression. Genes Brain Behav. 2012;11:958\u201365.","journal-title":"Genes Brain Behav"},{"key":"1907_CR85","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.jad.2013.07.024","volume":"151","author":"AML Greca","year":"2013","unstructured":"Greca AML, Lai BS, Joormann J, Auslander BB, Short MA. Children\u2019s risk and resilience following a natural disaster: Genetic vulnerability, posttraumatic stress, and depression. J Affect Disord. 2013;151:860\u20137.","journal-title":"J Affect Disord"},{"key":"1907_CR86","doi-asserted-by":"crossref","DOI":"10.1186\/1753-2000-7-10","volume":"7","author":"S Agnafors","year":"2013","unstructured":"Agnafors S, Comasco E, Bladh M, Sydsj\u00f6 G, DeKeyser L, Oreland L, et al. Effect of gene, environment and maternal depressive symptoms on pre-adolescence behavior problems - a longitudinal study. Child Adolesc Psychiatry Ment Health. 2013;7:10.","journal-title":"Child Adolesc Psychiatry Ment Health"},{"key":"1907_CR87","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.psychres.2017.08.092","volume":"258","author":"J Valderrama","year":"2017","unstructured":"Valderrama J, Miranda R. Early life stress predicts negative urgency through brooding, depending on 5-HTTLPR genotype: A pilot study with 6-month follow-up examining suicide ideation. Psychiatry Res. 2017;258:481\u20137.","journal-title":"Psychiatry Res"},{"key":"1907_CR88","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s10519-009-9285-9","volume":"39","author":"C \u00c5slund","year":"2009","unstructured":"\u00c5slund C, Leppert J, Comasco E, Nordquist N, Oreland L, Nilsson KW. Impact of the interaction between the 5HTTLPR polymorphism and maltreatment on adolescent depression. A population-based study. Behav Genet. 2009;39:524\u201331.","journal-title":"Behav Genet"},{"key":"1907_CR89","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jpsychires.2014.08.022","volume":"59","author":"A Bortoluzzi","year":"2014","unstructured":"Bortoluzzi A, Salum GA, Blaya C, Silveira PP, Grassi-Oliveira R, da Rosa ED, et al. Mineralocorticoid receptor genotype moderates the association between physical neglect and serum BDNF. J Psychiatr Res. 2014;59:8\u201313.","journal-title":"J Psychiatr Res"},{"key":"1907_CR90","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.psyneuen.2016.07.206","volume":"72","author":"J Isaksson","year":"2016","unstructured":"Isaksson J, Comasco E, \u00c5slund C, Rehn M, Tuvblad C, Andershed H, et al. Associations between the FKBP5 haplotype, exposure to violence and anxiety in females. Psychoneuroendocrinology. 2016;72:196\u2013204.","journal-title":"Psychoneuroendocrinology."},{"key":"1907_CR91","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jad.2017.08.066","volume":"225","author":"Q Wang","year":"2018","unstructured":"Wang Q, Shelton RC, Dwivedi Y. Interaction between early-life stress and FKBP5 gene variants in major depressive disorder and posttraumatic stress disorder: a systematic review and meta-analysis. J Affect Disord. 2018;225:422\u20138.","journal-title":"J Affect Disord"},{"key":"1907_CR92","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jad.2018.02.005","volume":"234","author":"S Mistry","year":"2018","unstructured":"Mistry S, Harrison JR, Smith DJ, Escott-Price V, Zammit S. The use of polygenic risk scores to identify phenotypes associated with genetic risk of bipolar disorder and depression: a systematic review. J Affect Disord. 2018;234:148\u201355.","journal-title":"J Affect Disord"},{"key":"1907_CR93","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10964-020-01353-4","volume":"50","author":"SA Nelemans","year":"2021","unstructured":"Nelemans SA, Boks M, Lin B, Oldehinkel T, van Lier P, Branje S, et al. Polygenic risk for major depression interacts with parental criticism in predicting adolescent depressive symptom development. J Youth Adolesc. 2021;50:159\u201376.","journal-title":"J Youth Adolesc"},{"key":"1907_CR94","doi-asserted-by":"crossref","first-page":"543893","DOI":"10.3389\/fpsyt.2020.543893","volume":"11","author":"Y Yoshino","year":"2020","unstructured":"Yoshino Y, Dwivedi Y. Non-coding RNAs in psychiatric disorders and suicidal behavior. Front Psychiatry. 2020;11:543893.","journal-title":"Front Psychiatry"},{"key":"1907_CR95","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jpsychires.2017.02.005","volume":"89","author":"B Roy","year":"2017","unstructured":"Roy B, Shelton RC, Dwivedi Y. DNA methylation and expression of stress related genes in PBMC of MDD patients with and without serious suicidal ideation. J Psychiatr Res. 2017;89:115\u201324.","journal-title":"J Psychiatr Res"},{"key":"1907_CR96","volume":"7","author":"B Roy","year":"2017","unstructured":"Roy B, Wang Q, Palkovits M, Faludi G, Dwivedi Y. Altered miRNA expression network in locus coeruleus of depressed suicide subjects. Sci Rep. 2017;7:4387.","journal-title":"Sci Rep"},{"key":"1907_CR97","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jad.2017.08.087","volume":"233","author":"R Belzeaux","year":"2018","unstructured":"Belzeaux R, Lin R, Ju C, Chay M-A, Fiori LM, Lutz P-E, et al. Transcriptomic and epigenomic biomarkers of antidepressant response. J Affect Disord. 2018;233:36\u201344.","journal-title":"J Affect Disord"},{"key":"1907_CR98","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jad.2019.04.049","volume":"252","author":"P Misra","year":"2019","unstructured":"Misra P, Liu S, Meng X. What DNA methylation modifications and\/or genetic variations interact with childhood maltreatment in the development of depression: a systematic review. J Affect Disord. 2019;252:325\u201333.","journal-title":"J Affect Disord"},{"key":"1907_CR99","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2174\/1389202919666171229145656","volume":"19","author":"L Stenz","year":"2018","unstructured":"Stenz L, Schechter DS, Serpa SR, Paoloni-Giacobino A. Intergenerational transmission of DNA methylation signatures associated with early life stress. Curr Genomics. 2018;19:665\u201375.","journal-title":"Curr Genomics"},{"key":"1907_CR100","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.psyneuen.2017.12.007","volume":"92","author":"EJ Wolf","year":"2018","unstructured":"Wolf EJ, Maniates H, Nugent N, Maihofer AX, Armstrong D, Ratanatharathorn A, et al. Traumatic stress and accelerated DNA methylation age: a meta-analysis. Psychoneuroendocrinology. 2018;92:123\u201334.","journal-title":"Psychoneuroendocrinology."},{"key":"1907_CR101","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.semcdb.2017.09.033","volume":"77","author":"SB Burns","year":"2018","unstructured":"Burns SB, Szyszkowicz JK, Luheshi GN, Lutz P-E, Turecki G. Plasticity of the epigenome during early-life stress. Semin Cell Dev Biol. 2018;77:115\u201332.","journal-title":"Semin Cell Dev Biol"},{"key":"1907_CR102","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1146\/annurev-pharmtox-010611-134540","volume":"53","author":"V Vialou","year":"2013","unstructured":"Vialou V, Feng J, Robison AJ, Nestler EJ. Epigenetic mechanisms of depression and antidepressant action. Annu Rev Pharm Toxicol. 2013;53:59\u201387.","journal-title":"Annu Rev Pharm Toxicol"},{"key":"1907_CR103","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/bs.irn.2020.08.004","volume":"156","author":"E Dong","year":"2021","unstructured":"Dong E, Pandey SC. Prenatal stress induced chromatin remodeling and risk of psychopathology in adulthood. Int Rev Neurobiol. 2021;156:185\u2013215.","journal-title":"Int Rev Neurobiol"},{"key":"1907_CR104","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.nbd.2009.12.026","volume":"39","author":"PO McGowan","year":"2010","unstructured":"McGowan PO, Szyf M. The epigenetics of social adversity in early life: implications for mental health outcomes. Neurobiol Dis. 2010;39:66\u201372.","journal-title":"Neurobiol Dis"},{"key":"1907_CR105","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41580-019-0159-6","volume":"20","author":"MVC Greenberg","year":"2019","unstructured":"Greenberg MVC, Bourc\u2019his D. The diverse roles of DNA methylation in mammalian development and disease. Nat Rev Mol Cell Biol. 2019;20:590\u2013607.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1907_CR106","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jad.2020.03.062","volume":"271","author":"J Chiarella","year":"2020","unstructured":"Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, et al. DNA methylation differences in stress-related genes, functional connectivity and gray matter volume in depressed and healthy adolescents. J Affect Disord. 2020;271:160\u20138.","journal-title":"J Affect Disord"},{"key":"1907_CR107","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-021-01601-6","volume":"11","author":"E Raffetti","year":"2021","unstructured":"Raffetti E, Melas PA, Landgren AJ, Andersson F, Forsell Y, Lavebratt C, et al. DNA methylation of the glucocorticoid receptor gene predicts substance use in adolescence: longitudinal data from over 1000 young individuals. Transl Psychiatry. 2021;11:477.","journal-title":"Transl Psychiatry"},{"key":"1907_CR108","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-020-00984-2","volume":"10","author":"R Roberson-Nay","year":"2020","unstructured":"Roberson-Nay R, Lapato DM, Wolen AR, Lancaster EE, Webb BT, Verhulst B, et al. An epigenome-wide association study of early-onset major depression in monozygotic twins. Transl Psychiatry. 2020;10:301.","journal-title":"Transl Psychiatry"},{"key":"1907_CR109","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s11064-018-2519-6","volume":"43","author":"FF Masrour","year":"2018","unstructured":"Masrour FF, Peeri M, Azarbayjani MA, Hosseini M-J. Voluntary exercise during adolescence mitigated negative the effects of maternal separation stress on the depressive-like behaviors of adult male rats: Role of NMDA receptors. Neurochem Res. 2018;43:1067\u201374.","journal-title":"Neurochem Res"},{"key":"1907_CR110","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1007\/s12035-016-0043-8","volume":"54","author":"A Lesse","year":"2017","unstructured":"Lesse A, Rether K, Gr\u00f6ger N, Braun K, Bock J. Chronic postnatal stress induces depressive-like behavior in male mice and programs second-hit stress-induced gene expression patterns of OxtR and AvpR1a in adulthood. Mol Neurobiol. 2017;54:4813\u20139.","journal-title":"Mol Neurobiol"},{"key":"1907_CR111","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1038\/npp.2015.134","volume":"40","author":"P Ganguly","year":"2015","unstructured":"Ganguly P, Holland FH, Brenhouse HC. Functional uncoupling NMDAR NR2A subunit from PSD-95 in the prefrontal cortex: effects on behavioral dysfunction and parvalbumin loss after early-life stress. Neuropsychopharmacology. 2015;40:2666\u201375.","journal-title":"Neuropsychopharmacology."},{"key":"1907_CR112","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.neuroscience.2010.08.063","volume":"171","author":"JW Jahng","year":"2010","unstructured":"Jahng JW, Ryu V, Yoo SB, Noh SJ, Kim JY, Lee JH. Mesolimbic dopaminergic activity responding to acute stress is blunted in adolescent rats that experienced neonatal maternal separation. Neuroscience. 2010;171:144\u201352.","journal-title":"Neuroscience."},{"key":"1907_CR113","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.psyneuen.2016.04.016","volume":"71","author":"R Grassi-Oliveira","year":"2016","unstructured":"Grassi-Oliveira R, Honeycutt JA, Holland FH, Ganguly P, Brenhouse HC. Cognitive impairment effects of early life stress in adolescents can be predicted with early biomarkers: Impacts of sex, experience, and cytokines. Psychoneuroendocrinology. 2016;71:19\u201330.","journal-title":"Psychoneuroendocrinology."},{"key":"1907_CR114","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fnmol.2019.00074","volume":"12","author":"I Jaric","year":"2019","unstructured":"Jaric I, Rocks D, Cham H, Herchek A, Kundakovic M. Sex and estrous cycle effects on anxiety- and depression-related phenotypes in a two-hit developmental stress model. Front Mol Neurosci. 2019;12:74.","journal-title":"Front Mol Neurosci"},{"key":"1907_CR115","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000339162","volume":"34","author":"MP Leussis","year":"2012","unstructured":"Leussis MP, Freund N, Brenhouse HC, Thompson BS, Andersen SL. Depressive-like behavior in adolescents after maternal separation: sex differences, controllability, and GABA. Dev Neurosci. 2012;34:210\u20137.","journal-title":"Dev Neurosci"},{"key":"1907_CR116","doi-asserted-by":"crossref","first-page":"100256","DOI":"10.1016\/j.ynstr.2020.100256","volume":"13","author":"Y Liu","year":"2020","unstructured":"Liu Y, Wang Z, Zhang X, Li S, Wu W, Li X, et al. A sex-dependent delayed maturation of visual plasticity induced by adverse experiences in early childhood. Neurobiol Stress. 2020;13:100256.","journal-title":"Neurobiol Stress"},{"key":"1907_CR117","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3389\/fpsyt.2018.00471","volume":"9","author":"R Wang","year":"2018","unstructured":"Wang R, Wang W, Xu J, Liu D, Jiang H, Pan F. Dynamic effects of early adolescent stress on depressive-like behaviors and expression of cytokines and JMJD3 in the prefrontal cortex and hippocampus of rats. Front Psychiatry. 2018;9:471.","journal-title":"Front Psychiatry"},{"key":"1907_CR118","volume":"7","author":"J-H Deng","year":"2017","unstructured":"Deng J-H, Yan W, Han Y, Chen C, Meng S-Q, Sun C-Y, et al. Predictable chronic mild stress during adolescence promotes fear memory extinction in adulthood. Sci Rep. 2017;7:7857.","journal-title":"Sci Rep"},{"key":"1907_CR119","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.bbrc.2012.03.035","volume":"420","author":"X Yang","year":"2012","unstructured":"Yang X, Ewald ER, Huo Y, Tamashiro KL, Salvatori R, Sawa A, et al. Glucocorticoid-induced loss of DNA methylation in non-neuronal cells and potential involvement of DNMT1 in epigenetic regulation of Fkbp5. Biochem Biophys Res Commun. 2012;420:570\u20135.","journal-title":"Biochem Biophys Res Commun"},{"key":"1907_CR120","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41593-021-00814-8","volume":"24","author":"H Kronman","year":"2021","unstructured":"Kronman H, Torres-Berr\u00edo A, Sidoli S, Issler O, Godino A, Ramakrishnan A, et al. Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons. Nat Neurosci. 2021;24:667\u201376.","journal-title":"Nat Neurosci"},{"key":"1907_CR121","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13072-021-00405-8","volume":"14","author":"E Fitzgerald","year":"2021","unstructured":"Fitzgerald E, Sinton MC, Wernig-Zorc S, Morton NM, Holmes MC, Boardman JP, et al. Altered hypothalamic DNA methylation and stress-induced hyperactivity following early life stress. Epigenetics Chromatin. 2021;14:31.","journal-title":"Epigenetics Chromatin"},{"key":"1907_CR122","volume":"11","author":"MK Seo","year":"2021","unstructured":"Seo MK, Lee JG, Park SW. Early life stress induces age-dependent epigenetic changes in p11 gene expression in male mice. Sci Rep. 2021;11:10663.","journal-title":"Sci Rep"},{"key":"1907_CR123","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jpsychires.2016.09.010","volume":"83","author":"CAM Cecil","year":"2016","unstructured":"Cecil CAM, Smith RG, Walton E, Mill J, McCrory EJ, Viding E. Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability. J Psychiatr Res. 2016;83:184\u201394.","journal-title":"J Psychiatr Res"},{"key":"1907_CR124","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2014.75","volume":"4","author":"V Nieratschker","year":"2014","unstructured":"Nieratschker V, Massart R, Gilles M, Luoni A, Suderman MJ, Krumm B, et al. MORC1 exhibits cross-species differential methylation in association with early life stress as well as genome-wide association with MDD. Transl Psychiatry. 2014;4:e429.","journal-title":"Transl Psychiatry"},{"key":"1907_CR125","doi-asserted-by":"crossref","first-page":"e12201","DOI":"10.1371\/journal.pone.0012201","volume":"5","author":"AM Devlin","year":"2010","unstructured":"Devlin AM, Brain U, Austin J, Oberlander TF. Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth. PLoS ONE. 2010;5:e12201.","journal-title":"PLoS ONE"},{"key":"1907_CR126","doi-asserted-by":"crossref","first-page":"853","DOI":"10.4161\/epi.21180","volume":"7","author":"C Mulligan","year":"2012","unstructured":"Mulligan C, D\u2019Errico N, Stees J, Hughes D. Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight. Epigenetics. 2012;7:853\u20137.","journal-title":"Epigenetics."},{"key":"1907_CR127","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.jpsychires.2013.03.009","volume":"47","author":"T Hompes","year":"2013","unstructured":"Hompes T, Izzi B, Gellens E, Morreels M, Fieuws S, Pexsters A, et al. Investigating the influence of maternal cortisol and emotional state during pregnancy on the DNA methylation status of the glucocorticoid receptor gene (NR3C1) promoter region in cord blood. J Psychiatr Res. 2013;47:880\u201391.","journal-title":"J Psychiatr Res"},{"key":"1907_CR128","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1093\/scan\/nsw051","volume":"11","author":"E Unternaehrer","year":"2016","unstructured":"Unternaehrer E, Bolten M, Nast I, Staehli S, Meyer AH, Dempster E, et al. Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation. Soc Cogn Affect Neurosci. 2016;11:1460\u201370.","journal-title":"Soc Cogn Affect Neurosci"},{"key":"1907_CR129","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.euroneuro.2020.08.008","volume":"39","author":"FHP Lesemann","year":"2020","unstructured":"Lesemann FHP, Spencer H, Montoya ER, Kraaijenvanger EJ, He Y, Branje S, et al. Methylation of oxytocin related genes and early life trauma together shape the N170 response to human faces. Eur Neuropsychopharmacol. 2020;39:19\u201328.","journal-title":"Eur Neuropsychopharmacol"},{"key":"1907_CR130","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/pcn.13183","volume":"75","author":"S Nishitani","year":"2021","unstructured":"Nishitani S, Suzuki S, Ochiai K, Yao A, Fujioka T, Fujisawa TX, et al. Altered epigenetic clock in children exposed to maltreatment. Psychiatry Clin Neurosci. 2021;75:110\u20132.","journal-title":"Psychiatry Clin Neurosci"},{"key":"1907_CR131","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-022-01269-9","volume":"14","author":"JA Sumner","year":"2022","unstructured":"Sumner JA, Gambazza S, Gao X, Baccarelli AA, Uddin M, McLaughlin KA. Epigenetics of early-life adversity in youth: cross-sectional and longitudinal associations. Clin Epigenetics. 2022;14:48.","journal-title":"Clin Epigenetics"},{"key":"1907_CR132","doi-asserted-by":"crossref","first-page":"104604","DOI":"10.1016\/j.psyneuen.2020.104604","volume":"114","author":"DJ Grasso","year":"2020","unstructured":"Grasso DJ, Drury S, Briggs-Gowan M, Johnson A, Ford J, Lapidus G, et al. Adverse childhood experiences, posttraumatic stress, and FKBP5 methylation patterns in postpartum women and their newborn infants. Psychoneuroendocrinology. 2020;114:104604.","journal-title":"Psychoneuroendocrinology."},{"key":"1907_CR133","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2017.153","volume":"7","author":"F Serpeloni","year":"2017","unstructured":"Serpeloni F, Radtke K, de Assis SG, Henning F, N\u00e4tt D, Elbert T. Grandmaternal stress during pregnancy and DNA methylation of the third generation: an epigenome-wide association study. Transl Psychiatry. 2017;7:e1202.","journal-title":"Transl Psychiatry"},{"key":"1907_CR134","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.jaac.2013.12.025","volume":"53","author":"N Weder","year":"2014","unstructured":"Weder N, Zhang H, Jensen K, Yang BZ, Simen A, Jackowski A, et al. Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry. J Am Acad Child Adolesc Psychiatry. 2014;53:417\u2013424. e5","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"1907_CR135","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.jad.2020.03.120","volume":"272","author":"T Saito","year":"2020","unstructured":"Saito T, Shinozaki G, Koga M, Tanichi M, Takeshita S, Nakagawa R, et al. Effect of interaction between a specific subtype of child abuse and the FKBP5 rs1360780 SNP on DNA methylation among patients with bipolar disorder. J Affect Disord. 2020;272:417\u201322.","journal-title":"J Affect Disord"},{"key":"1907_CR136","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.amepre.2012.10.012","volume":"44","author":"B-Z Yang","year":"2013","unstructured":"Yang B-Z, Zhang H, Ge W, Weder N, Douglas-Palumberi H, Perepletchikova F, et al. Child abuse and epigenetic mechanisms of disease risk. Am J Prev Med. 2013;44:101\u20137.","journal-title":"Am J Prev Med"},{"key":"1907_CR137","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.63","volume":"5","author":"KM Radtke","year":"2015","unstructured":"Radtke KM, Schauer M, Gunter HM, Ruf-Leuschner M, Sill J, Meyer A, et al. Epigenetic modifications of the glucocorticoid receptor gene are associated with the vulnerability to psychopathology in childhood maltreatment. Transl Psychiatry. 2015;5:e571.","journal-title":"Transl Psychiatry"},{"key":"1907_CR138","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1038\/s41386-018-0157-y","volume":"43","author":"J Kaufman","year":"2018","unstructured":"Kaufman J, Wymbs NF, Montalvo-Ortiz JL, Orr C, Albaugh MD, Althoff R, et al. Methylation in OTX2 and related genes, maltreatment, and depression in children. Neuropsychopharmacology. 2018;43:2204\u201311.","journal-title":"Neuropsychopharmacology."},{"key":"1907_CR139","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-018-0169-8","volume":"8","author":"P Efstathopoulos","year":"2018","unstructured":"Efstathopoulos P, Andersson F, Melas PA, Yang LL, Villaescusa JC, R\u0215egg J, et al. NR3C1 hypermethylation in depressed and bullied adolescents. Transl Psychiatry. 2018;8:121.","journal-title":"Transl Psychiatry"},{"key":"1907_CR140","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.biopsych.2018.09.008","volume":"85","author":"JA Sumner","year":"2019","unstructured":"Sumner JA, Colich NL, Uddin M, Armstrong D, McLaughlin KA. Early experiences of threat, but not deprivation, are associated with accelerated biological aging in children and adolescents. Biol Psychiatry. 2019;85:268\u201378.","journal-title":"Biol Psychiatry"},{"key":"1907_CR141","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3389\/fgene.2019.00269","volume":"10","author":"F Serpeloni","year":"2019","unstructured":"Serpeloni F, Radtke KM, Hecker T, Sill J, Vukojevic V, Assis SGde, et al. Does prenatal stress shape postnatal resilience? - An epigenome-wide study on violence and mental health in humans. Front Genet. 2019;10:269.","journal-title":"Front Genet"},{"key":"1907_CR142","doi-asserted-by":"crossref","first-page":"867","DOI":"10.3389\/fcell.2020.00867","volume":"8","author":"M Li","year":"2020","unstructured":"Li M, Fu X, Xie W, Guo W, Li B, Cui R, et al. Effect of early life stress on the epigenetic profiles in depression. Front Cell Dev Biol. 2020;8:867.","journal-title":"Front Cell Dev Biol"},{"key":"1907_CR143","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","volume":"173","author":"DP Bartel","year":"2018","unstructured":"Bartel DP. Metazoan MicroRNAs. Cell. 2018;173:20\u201351.","journal-title":"Cell."},{"key":"1907_CR144","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neures.2012.04.001","volume":"73","author":"G Serafini","year":"2012","unstructured":"Serafini G, Pompili M, Innamorati M, Giordano G, Montebovi F, Sher L, et al. The role of microRNAs in synaptic plasticity, major affective disorders and suicidal behavior. Neurosci Res. 2012;73:179\u201390.","journal-title":"Neurosci Res"},{"key":"1907_CR145","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrm3838","volume":"15","author":"M Ha","year":"2014","unstructured":"Ha M, Kim VN. Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol. 2014;15:509\u201324.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1907_CR146","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.bbamcr.2010.06.013","volume":"1803","author":"F Wahid","year":"2010","unstructured":"Wahid F, Shehzad A, Khan T, Kim YY. MicroRNAs: synthesis, mechanism, function, and recent clinical trials. Biochim Biophys Acta. 2010;1803:1231\u201343.","journal-title":"Biochim Biophys Acta"},{"key":"1907_CR147","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1038\/s41380-022-01476-z","volume":"27","author":"S Yoon","year":"2022","unstructured":"Yoon S, Kim SE, Ko Y, Jeong GH, Lee KH, Lee J, et al. Differential expression of MicroRNAs in Alzheimer\u2019s disease: a systematic review and meta-analysis. Mol Psychiatry. 2022;27:2405\u201313.","journal-title":"Mol Psychiatry"},{"key":"1907_CR148","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s11011-022-00918-5","volume":"37","author":"H Sabaie","year":"2022","unstructured":"Sabaie H, Gharesouran J, Asadi MR, Farhang S, Ahangar NK, Brand S, et al. Downregulation of miR-185 is a common pathogenic event in 22q11.2 deletion syndrome-related and idiopathic schizophrenia. Metab Brain Dis. 2022;37:1175\u201384.","journal-title":"Metab Brain Dis"},{"key":"1907_CR149","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.biopsych.2021.08.013","volume":"91","author":"EJ Kyzar","year":"2021","unstructured":"Kyzar EJ, Bohnsack JP, Pandey SC. Current and future perspectives of noncoding RNAs in brain function and neuropsychiatric disease. Biol Psychiatry. 2021;91:183\u201393.","journal-title":"Biol Psychiatry"},{"key":"1907_CR150","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.euroneuro.2021.12.005","volume":"55","author":"C Pisanu","year":"2022","unstructured":"Pisanu C, Severino G, Toma ID, Dierssen M, Fusar-Poli P, Gennarelli M, et al. Transcriptional biomarkers of response to pharmacological treatments in severe mental disorders: a systematic review. Eur Neuropsychopharmacol. 2022;55:112\u201357.","journal-title":"Eur Neuropsychopharmacol"},{"key":"1907_CR151","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.biopsych.2014.12.009","volume":"78","author":"M Geaghan","year":"2015","unstructured":"Geaghan M, Cairns MJ. MicroRNA and posttranscriptional dysregulation in psychiatry. Biol Psychiatry. 2015;78:231\u20139.","journal-title":"Biol Psychiatry"},{"key":"1907_CR152","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.semcdb.2021.04.011","volume":"118","author":"A Morgunova","year":"2021","unstructured":"Morgunova A, Flores C. MicroRNA regulation of prefrontal cortex development and psychiatric risk in adolescence. Semin Cell Dev Biol. 2021;118:83\u201391.","journal-title":"Semin Cell Dev Biol"},{"key":"1907_CR153","doi-asserted-by":"crossref","first-page":"6203","DOI":"10.3390\/ijms21176203","volume":"21","author":"M Ragusa","year":"2020","unstructured":"Ragusa M, Santagati M, Mirabella F, Lauretta G, Cirnigliaro M, Brex D, et al. Potential associations among alteration of salivary miRNAs, saliva microbiome structure, and cognitive impairments in autistic children. Int J Mol Sci. 2020;21:6203.","journal-title":"Int J Mol Sci"},{"key":"1907_CR154","doi-asserted-by":"crossref","first-page":"114252","DOI":"10.1016\/j.psychres.2021.114252","volume":"305","author":"S Gupta","year":"2021","unstructured":"Gupta S, Guleria RS, Szabo YZ. MicroRNAs as biomarker and novel therapeutic target for posttraumatic stress disorder in veterans. Psychiatry Res. 2021;305:114252.","journal-title":"Psychiatry Res"},{"key":"1907_CR155","doi-asserted-by":"crossref","first-page":"108984","DOI":"10.1016\/j.neuropharm.2022.108984","volume":"208","author":"L Ye","year":"2022","unstructured":"Ye L, Xiao X, Xu Y, Zheng C, Chen S, Luo T, et al. Prelimbic cortex miR-34a contributes to (2R,6R)-hydroxynorketamine-mediated antidepressant-relevant actions. Neuropharmacology. 2022;208:108984.","journal-title":"Neuropharmacology."},{"key":"1907_CR156","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.biopsych.2022.03.012","volume":"92","author":"J Sun","year":"2022","unstructured":"Sun J, Zhang X, Cong Q, Chen D, Yi Z, Huang H, et al. miR143-3p-mediated neuregulin-1-dependent mitochondrial dysfunction contributes to olanzapine resistance in refractory schizophrenia. Biol Psychiatry. 2022;92:419\u201333.","journal-title":"Biol Psychiatry"},{"key":"1907_CR157","doi-asserted-by":"crossref","first-page":"771103","DOI":"10.3389\/fnmol.2021.771103","volume":"14","author":"D Zeng","year":"2021","unstructured":"Zeng D, He S, Zhao N, Hu M, Gao J, Yu Y, et al. Promoter hypomethylation of miR-124 gene is associated with major depressive disorder. Front Mol Neurosci. 2021;14:771103.","journal-title":"Front Mol Neurosci"},{"key":"1907_CR158","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jpsychires.2022.02.007","volume":"148","author":"S Zhou","year":"2022","unstructured":"Zhou S, Chen R, She Y, Liu X, Zhao H, Li C, et al. A new perspective on depression and neuroinflammation: Non-coding RNA. J Psychiatr Res. 2022;148:293\u2013306.","journal-title":"J Psychiatr Res"},{"key":"1907_CR159","doi-asserted-by":"crossref","first-page":"1987655","DOI":"10.1080\/20008198.2021.1987655","volume":"12","author":"E Maffioletti","year":"2021","unstructured":"Maffioletti E, Bocchio-Chiavetto L, Perusi G, Silva RC, Sacco C, Bazzanella R, et al. Inflammation-related microRNAs are involved in stressful life events exposure and in trauma-focused psychotherapy in treatment-resistant depressed patients. Eur J Psychotraumatol. 2021;12:1987655.","journal-title":"Eur J Psychotraumatol"},{"key":"1907_CR160","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.3390\/biomedicines9111659","volume":"9","author":"MA Ortega","year":"2021","unstructured":"Ortega MA, Alvarez-Mon MA, Garc\u00eda-Montero C, Fraile-Martinez O, Lahera G, Monserrat J, et al. MicroRNAs as critical biomarkers of major depressive disorder: a comprehensive perspective. Biomedicines. 2021;9:1659.","journal-title":"Biomedicines."},{"key":"1907_CR161","doi-asserted-by":"publisher","unstructured":"Ran L, Kong Y, Xiang J, Zeng Q, Zhang C, Shi L, et al. Serum extracellular vesicle microRNA dysregulation and childhood trauma in adolescents with major depressive disorder. Bosnian J Basic Med. 2022. https:\/\/doi.org\/10.17305\/bjbms.2022.7110.","DOI":"10.17305\/bjbms.2022.7110"},{"key":"1907_CR162","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15497","volume":"8","author":"JP Lopez","year":"2017","unstructured":"Lopez JP, Fiori LM, Cruceanu C, Lin R, Labonte B, Cates HM, et al. MicroRNAs 146a\/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK\/Wnt-system genes. Nat Commun. 2017;8:15497.","journal-title":"Nat Commun"},{"key":"1907_CR163","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jchemneu.2011.04.002","volume":"42","author":"Y Dwivedi","year":"2011","unstructured":"Dwivedi Y. Evidence demonstrating role of microRNAs in the etiopathology of major depression. J Chem Neuroanat. 2011;42:142\u201356.","journal-title":"J Chem Neuroanat"},{"key":"1907_CR164","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jad.2018.07.075","volume":"240","author":"Y Dwivedi","year":"2018","unstructured":"Dwivedi Y. MicroRNAs in depression and suicide: recent insights and future perspectives. J Affect Disord. 2018;240:146\u201354.","journal-title":"J Affect Disord"},{"key":"1907_CR165","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.euroneuro.2020.06.004","volume":"40","author":"Y Yoshino","year":"2020","unstructured":"Yoshino Y, Roy B, Dwivedi Y. Altered miRNA landscape of the anterior cingulate cortex is associated with potential loss of key neuronal functions in depressed brain. Eur Neuropsychopharmacol. 2020;40:70\u201384.","journal-title":"Eur Neuropsychopharmacol"},{"key":"1907_CR166","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/npp.2016.175","volume":"42","author":"B Roy","year":"2017","unstructured":"Roy B, Dunbar M, Shelton RC, Dwivedi Y. Identification of microRNA-124-3p as a putative epigenetic signature of major depressive disorder. Neuropsychopharmacology. 2017;42:864\u201375.","journal-title":"Neuropsychopharmacology."},{"key":"1907_CR167","doi-asserted-by":"crossref","first-page":"9759","DOI":"10.1007\/s11033-022-07461-7","volume":"49","author":"S Rahmani","year":"2022","unstructured":"Rahmani S, Kadkhoda S, Ghafouri-Fard S. Synaptic plasticity and depression: the role of miRNAs dysregulation. Mol Biol Rep. 2022;49:9759\u201365.","journal-title":"Mol Biol Rep"},{"key":"1907_CR168","doi-asserted-by":"crossref","first-page":"e86469","DOI":"10.1371\/journal.pone.0086469","volume":"9","author":"NR Smalheiser","year":"2014","unstructured":"Smalheiser NR, Lugli G, Zhang H, Rizavi H, Cook EH, Dwivedi Y. Expression of microRNAs and other small RNAs in prefrontal cortex in schizophrenia, bipolar disorder and depressed subjects. PLoS ONE. 2014;9:e86469.","journal-title":"PLoS ONE"},{"key":"1907_CR169","doi-asserted-by":"crossref","first-page":"e33201","DOI":"10.1371\/journal.pone.0033201","volume":"7","author":"NR Smalheiser","year":"2012","unstructured":"Smalheiser NR, Lugli G, Rizavi HS, Torvik VI, Turecki G, Dwivedi Y. MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects. PLoS ONE. 2012;7:e33201.","journal-title":"PLoS ONE"},{"key":"1907_CR170","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1017\/S1461145710001628","volume":"14","author":"NR Smalheiser","year":"2011","unstructured":"Smalheiser NR, Lugli G, Rizavi HS, Zhang H, Torvik VI, Pandey GN, et al. MicroRNA expression in rat brain exposed to repeated inescapable shock: differential alterations in learned helplessness vs. non-learned helplessness. Int J Neuropsychopharmacol. 2011;14:1315\u201325.","journal-title":"Int J Neuropsychopharmacol"},{"key":"1907_CR171","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1111\/j.1460-9568.2008.06218.x","volume":"27","author":"S Uchida","year":"2008","unstructured":"Uchida S, Nishida A, Hara K, Kamemoto T, Suetsugi M, Fujimoto M, et al. Characterization of the vulnerability to repeated stress in Fischer\u2003344 rats: possible involvement of microRNA\u2010mediated down\u2010regulation of the glucocorticoid receptor. Eur J Neurosci. 2008;27:2250\u201361.","journal-title":"Eur J Neurosci"},{"key":"1907_CR172","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.neuroscience.2009.11.057","volume":"165","author":"H Kawashima","year":"2010","unstructured":"Kawashima H, Numakawa T, Kumamaru E, Adachi N, Mizuno H, Ninomiya M, et al. Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression. Neuroscience. 2010;165:1301\u201311.","journal-title":"Neuroscience."},{"key":"1907_CR173","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.mce.2012.10.025","volume":"365","author":"A Grieco","year":"2013","unstructured":"Grieco A, Rzeczkowska P, Alm C, Palmert MR. Investigation of peripubertal expression of Lin28a and Lin28b in C57BL\/6 female mice. Mol Cell Endocrinol. 2013;365:241\u20138.","journal-title":"Mol Cell Endocrinol"},{"key":"1907_CR174","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1210\/en.2012-2006","volume":"154","author":"S Sangiao-Alvarellos","year":"2013","unstructured":"Sangiao-Alvarellos S, Manfredi-Lozano M, Ruiz-Pino F, Navarro VM, S\u00e1nchez-Garrido MA, Leon S, et al. Changes in hypothalamic expression of the Lin28\/let-7 system and related microRNAs during postnatal maturation and after experimental manipulations of puberty. Endocrinology. 2013;154:942\u201355.","journal-title":"Endocrinology."},{"key":"1907_CR175","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/cr.2008.282","volume":"18","author":"X Chen","year":"2008","unstructured":"Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 2008;18:997\u20131006.","journal-title":"Cell Res"},{"key":"1907_CR176","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3233\/JAD-2008-14103","volume":"14","author":"JP Cogswell","year":"2008","unstructured":"Cogswell JP, Ward J, Taylor IA, Waters M, Shi Y, Cannon B, et al. Identification of miRNA changes in Alzheimer\u2019s disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis. 2008;14:27\u201341.","journal-title":"J Alzheimers Dis"},{"key":"1907_CR177","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1373\/clinchem.2010.147405","volume":"56","author":"JA Weber","year":"2010","unstructured":"Weber JA, Baxter DH, Zhang S, Huang DY, Huang KH, Lee MJ, et al. The microRNA spectrum in 12 body fluids. Clin Chem. 2010;56:1733\u201341.","journal-title":"Clin Chem"},{"key":"1907_CR178","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s10571-013-9940-9","volume":"33","author":"X-F Jin","year":"2013","unstructured":"Jin X-F, Wu N, Wang L, Li J. Circulating MicroRNAs: a novel class of potential biomarkers for diagnosing and prognosing central nervous system diseases. Cell Mol Neurobiol. 2013;33:601\u201313.","journal-title":"Cell Mol Neurobiol"},{"key":"1907_CR179","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fncel.2014.00075","volume":"8","author":"E Maffioletti","year":"2014","unstructured":"Maffioletti E, Tardito D, Gennarelli M, Bocchio-Chiavetto L. Micro spies from the brain to the periphery: new clues from studies on microRNAs in neuropsychiatric disorders. Front Cell Neurosci. 2014;8:75.","journal-title":"Front Cell Neurosci"},{"key":"1907_CR180","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2012.112","volume":"2","author":"R Belzeaux","year":"2012","unstructured":"Belzeaux R, Bergon A, Jeanjean V, Loriod B, Formisano-Tr\u00e9ziny C, Verrier L, et al. Responder and nonresponder patients exhibit different peripheral transcriptional signatures during major depressive episode. Transl Psychiatry. 2012;2:e185.","journal-title":"Transl Psychiatry"},{"key":"1907_CR181","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.euroneuro.2012.06.013","volume":"23","author":"L Bocchio-Chiavetto","year":"2013","unstructured":"Bocchio-Chiavetto L, Maffioletti E, Bettinsoli P, Giovannini C, Bignotti S, Tardito D, et al. Blood microRNA changes in depressed patients during antidepressant treatment. Eur Neuropsychopharmacol. 2013;23:602\u201311.","journal-title":"Eur Neuropsychopharmacol"},{"key":"1907_CR182","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/ijnp\/pyx034","volume":"20","author":"LM Fiori","year":"2017","unstructured":"Fiori LM, Lopez JP, Richard-Devantoy S, Berlim M, Chachamovich E, Jollant F, et al. Investigation of miR-1202, miR-135a, and miR-16 in major depressive disorder and antidepressant response. Int J Neuropsychophrmacol. 2017;20:619\u201323.","journal-title":"Int J Neuropsychophrmacol"},{"key":"1907_CR183","doi-asserted-by":"crossref","first-page":"e7212","DOI":"10.1590\/1414-431x20187212","volume":"51","author":"W-H Kuang","year":"2018","unstructured":"Kuang W-H, Dong Z-Q, Tian L-T, Li J. MicroRNA-451a, microRNA-34a-5p, and microRNA-221-3p as predictors of response to antidepressant treatment. Braz J Med Biol Res. 2018;51:e7212.","journal-title":"Braz J Med Biol Res"},{"key":"1907_CR184","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.bpsgos.2021.05.009","volume":"1","author":"LA McKibben","year":"2021","unstructured":"McKibben LA, Dwivedi Y. MicroRNA regulates early-life stress-induced depressive behavior via serotonin signaling in a sex-dependent manner in the prefrontal cortex of rats. Biol Psychiatry Glob Open Sci. 2021;1:180\u20139.","journal-title":"Biol Psychiatry Glob Open Sci"},{"key":"1907_CR185","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-021-08003-4","volume":"22","author":"LA McKibben","year":"2021","unstructured":"McKibben LA, Dwivedi Y. Early life and adult stress promote sex dependent changes in hypothalamic miRNAs and environmental enrichment prevents stress-induced miRNA and gene expression changes in rats. BMC Genomics. 2021;22:701.","journal-title":"BMC Genomics"},{"key":"1907_CR186","doi-asserted-by":"crossref","first-page":"6831","DOI":"10.1074\/jbc.RA119.012047","volume":"295","author":"L Guo","year":"2020","unstructured":"Guo L, Zhu Z, Wang G, Cui S, Shen M, Song Z, et al. microRNA-15b contributes to depression-like behavior in mice by affecting synaptic protein levels and function in the nucleus accumbens. J Biol Chem. 2020;295:6831\u201348.","journal-title":"J Biol Chem"},{"key":"1907_CR187","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/gbb.12197","volume":"14","author":"J Prados","year":"2015","unstructured":"Prados J, Stenz L, Courtet P, Prada P, Nicastro R, Adouan W, et al. Borderline personality disorder and childhood maltreatment: a genome\u2010wide methylation analysis. Genes Brain Behav. 2015;14:177\u201388.","journal-title":"Genes Brain Behav"},{"key":"1907_CR188","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.schres.2018.07.030","volume":"205","author":"N Cattane","year":"2019","unstructured":"Cattane N, Mora C, Lopizzo N, Borsini A, Maj C, Pedrini L, et al. Identification of a miRNAs signature associated with exposure to stress early in life and enhanced vulnerability for schizophrenia: New insights for the key role of miR-125b-1-3p in neurodevelopmental processes. Schizophr Res. 2019;205:63\u201375.","journal-title":"Schizophr Res"},{"key":"1907_CR189","doi-asserted-by":"crossref","DOI":"10.1186\/1755-8794-7-13","volume":"7","author":"M Suderman","year":"2014","unstructured":"Suderman M, Borghol N, Pappas JJ, Pereira SMP, Pembrey M, Hertzman C, et al. Childhood abuse is associated with methylation of multiple loci in adult DNA. BMC Med Genomics. 2014;7:13.","journal-title":"BMC Med Genomics"},{"key":"1907_CR190","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40479-015-0029-6","volume":"2","author":"H Dukal","year":"2015","unstructured":"Dukal H, Frank J, Lang M, Treutlein J, Gilles M, Wolf IA, et al. Newborn females show higher stress- and genotype-independent methylation of SLC6A4 than males. Borderline Personal Disord Emot Dysregul. 2015;2:8.","journal-title":"Borderline Personal Disord Emot Dysregul"},{"key":"1907_CR191","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/08039488.2019.1613446","volume":"73","author":"E Wikenius","year":"2019","unstructured":"Wikenius E, Myhre AM, Page CM, Moe V, Smith L, Heiervang ER, et al. Prenatal maternal depressive symptoms and infant DNA methylation: a longitudinal epigenome-wide study. Nord J Psychiatry. 2019;73:257\u201363.","journal-title":"Nord J Psychiatry"},{"key":"1907_CR192","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-019-0653-x","volume":"11","author":"A Cardenas","year":"2019","unstructured":"Cardenas A, Faleschini S, Hidalgo AC, Rifas-Shiman SL, Baccarelli AA, DeMeo DL, et al. Prenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood. Clin Epigenetics. 2019;11:56.","journal-title":"Clin Epigenetics"},{"key":"1907_CR193","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1196\/annals.1364.057","volume":"1071","author":"JD Coplan","year":"2006","unstructured":"Coplan JD, Smith ELP, Altemus M, Mathew SJ, Perera T, Kral JG, et al. Maternal-infant response to variable foraging demand in nonhuman primates. Ann N Y Acad Sci. 2006;1071:525\u201333.","journal-title":"Ann N Y Acad Sci"},{"key":"1907_CR194","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0165-3806(98)00143-6","volume":"111","author":"HJ van Oers","year":"1998","unstructured":"van Oers HJ, de Kloet ER, Levine S. Early vs. late maternal deprivation differentially alters the endocrine and hypothalamic responses to stress. Dev Brain Res. 1998;111:245\u201352.","journal-title":"Dev Brain Res"},{"key":"1907_CR195","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.nbd.2011.09.005","volume":"45","author":"A Levine","year":"2012","unstructured":"Levine A, Worrell TR, Zimnisky R, Schmauss C. Early life stress triggers sustained changes in histone deacetylase expression and histone H4 modifications that alter responsiveness to adolescent antidepressant treatment. Neurobiol Dis. 2012;45:488\u201398.","journal-title":"Neurobiol Dis"},{"key":"1907_CR196","doi-asserted-by":"crossref","first-page":"172973","DOI":"10.1016\/j.pbb.2020.172973","volume":"196","author":"GI Elmer","year":"2020","unstructured":"Elmer GI, Tapocik JD, Mayo CL, Zanos P, Gould TD. Ketamine metabolite (2R,6R)-hydroxynorketamine reverses behavioral despair produced by adolescent trauma. Pharmacol Biochem Behav. 2020;196:172973.","journal-title":"Pharmacol Biochem Behav"},{"key":"1907_CR197","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/acps.13420","volume":"145","author":"AL Wrobel","year":"2022","unstructured":"Wrobel AL, K\u00f6hler\u2010Forsberg O, Sylvia LG, Russell SE, Dean OM, Cotton SM, et al. Childhood trauma and treatment outcomes during mood\u2010stabilising treatment with lithium or quetiapine among outpatients with bipolar disorder. Acta Psychiat Scand. 2022;145:615\u201327.","journal-title":"Acta Psychiat Scand"},{"key":"1907_CR198","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s00702-016-1570-1","volume":"123","author":"N Gr\u00f6ger","year":"2016","unstructured":"Gr\u00f6ger N, Matas E, Gos T, Lesse A, Poeggel G, Braun K, et al. The transgenerational transmission of childhood adversity: behavioral, cellular, and epigenetic correlates. J Neural Transm. 2016;123:1037\u201352.","journal-title":"J Neural Transm"},{"key":"1907_CR199","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.tig.2019.12.001","volume":"36","author":"L Duempelmann","year":"2020","unstructured":"Duempelmann L, Skribbe M, B\u00fchler M. Small RNAs in the transgenerational inheritance of epigenetic information. Trends Genet. 2020;36:203\u201314.","journal-title":"Trends Genet"},{"key":"1907_CR200","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1146\/annurev-clinpsy-071519-113915","volume":"16","author":"SH Goodman","year":"2020","unstructured":"Goodman SH. Intergenerational transmission of depression. Annu Rev Clin Psychol. 2020;16:213\u201338.","journal-title":"Annu Rev Clin Psychol"},{"key":"1907_CR201","doi-asserted-by":"crossref","DOI":"10.1186\/s12915-020-00780-w","volume":"18","author":"EA O\u2019Brien","year":"2020","unstructured":"O\u2019Brien EA, Ensbey KS, Day BW, Baldock PA, Barry G. Direct evidence for transport of RNA from the mouse brain to the germline and offspring. BMC Biol. 2020;18:45.","journal-title":"BMC Biol"},{"key":"1907_CR202","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41431-020-00726-4","volume":"29","author":"AP Monaco","year":"2021","unstructured":"Monaco AP. An epigenetic, transgenerational model of increased mental health disorders in children, adolescents and young adults. Eur J Hum Genet. 2021;29:387\u201395.","journal-title":"Eur J Hum Genet"},{"key":"1907_CR203","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/epigenomes6020012","volume":"6","author":"GS Lee","year":"2022","unstructured":"Lee GS, Conine CC. The transmission of intergenerational epigenetic information by sperm microRNAs. Epigenomes. 2022;6:12.","journal-title":"Epigenomes"},{"key":"1907_CR204","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jaac.2017.03.001","volume":"56","author":"C Buss","year":"2017","unstructured":"Buss C, Entringer S, Moog NK, Toepfer P, Fair DA, Simhan HN, et al. Intergenerational transmission of maternal childhood maltreatment exposure: Implications for fetal brain development. J Am Acad Child Adolesc Psychiatry. 2017;56:373\u201382.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"1907_CR205","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/FBP.0000000000000057","volume":"25","author":"CR Lewis","year":"2014","unstructured":"Lewis CR, Olive MF. Early-life stress interactions with the epigenome: potential mechanisms driving vulnerability toward psychiatric illness. Behav Pharmacol. 2014;25:341\u201351.","journal-title":"Behav Pharmacol"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41380-022-01907-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-022-01907-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-022-01907-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T17:52:40Z","timestamp":1701539560000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-022-01907-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,14]]},"references-count":205,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["1907"],"URL":"https:\/\/doi.org\/10.1038\/s41380-022-01907-x","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,14]]},"assertion":[{"value":"16 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}