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HJG has received travel grants and speakers honoraria from Fresenius Medical Care, Neuraxpharm, Servier and Janssen Cilag as well as research funding from Fresenius Medical Care. PMT and NJ received a research grant from Biogen, Inc., unrelated to the topic of this paper. DJS received research grants and\/or consultancy honoraria from Lundbeck and Sun.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}