{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:28:20Z","timestamp":1792618100967,"version":"4.5.0"},"reference-count":84,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000049","name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["R01-AG049953"],"award-info":[{"award-number":["R01-AG049953"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging"},{"name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging"},{"name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging"},{"name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging"},{"DOI":"10.13039\/100014400","name":"Fujirebio Diagnostics","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014400","id-type":"DOI","asserted-by":"crossref"}]},{"name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging"},{"name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging"},{"DOI":"10.13039\/100000030","name":"U.S. Department of Health & Human Services | Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["200-2011-39361"],"award-info":[{"award-number":["200-2011-39361"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging"},{"DOI":"10.13039\/100000050","name":"U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01-HL134320"],"award-info":[{"award-number":["R01-HL134320"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging"},{"name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the development of cognitive impairment in aging are not well understood. To determine whether plasma proteins linked to inflammatory diet predict future cognitive impairment, we applied high-throughput proteomic assays to plasma samples from a subset (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091528) of Women\u2019s Health Initiative Memory Study (WHIMS) participants (mean [SD] baseline age, 71.3 [SD 3.8] years). Results provide insights into how inflammatory nutritional patterns are associated with an immune-related proteome and identify a group of proteins (CXCL10, CCL3, HGF, OPG, CDCP1, NFATC3, ITGA11) related to future cognitive impairment over a 14-year follow-up period. Several of these inflammatory diet proteins were also associated with dementia risk across two external cohorts (ARIC, ESTHER), correlated with plasma biomarkers of Alzheimer\u2019s disease (AD) pathology (A\u03b2\n                    <jats:sub>42\/40<\/jats:sub>\n                    ) and\/or neurodegeneration (NfL), and related to an MRI-defined index of neurodegenerative brain atrophy in a separate cohort (BLSA). In addition to evaluating their biological relevance, assessing their potential role in AD, and characterizing their immune-tissue\/cell-specific expression, we leveraged published RNA-seq results to examine how the in vitro regulation of genes encoding these candidate proteins might be altered in response to an immune challenge. Our findings indicate how dietary patterns with higher inflammatory potential relate to plasma levels of immunologically relevant proteins and highlight the molecular mediators which predict subsequent risk for age-related cognitive impairment.\n                  <\/jats:p>","DOI":"10.1038\/s41380-023-01975-7","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T07:04:07Z","timestamp":1675407847000},"page":"1599-1609","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Plasma proteins related to inflammatory diet predict future cognitive impairment"],"prefix":"10.1038","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1029-4423","authenticated-orcid":false,"given":"Michael R.","family":"Duggan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-9102","authenticated-orcid":false,"given":"Lauren","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongsheng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9550-5818","authenticated-orcid":false,"given":"Gulzar N.","family":"Daya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9464-1551","authenticated-orcid":false,"given":"Abhay","family":"Moghekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Rapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aladdin H.","family":"Shadyab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginny","family":"Natale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longjian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Snetselaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruin","family":"Moaddel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey M.","family":"Rebholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie M.","family":"Ballantyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Resnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6273-1613","authenticated-orcid":false,"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5989-9853","authenticated-orcid":false,"given":"Keenan A.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"1975_CR1","doi-asserted-by":"publisher","first-page":"113207","DOI":"10.1016\/j.bbr.2021.113207","volume":"405","author":"MR Duggan","year":"2021","unstructured":"Duggan MR, Parikh V. Microglia and modifiable life factors: Potential contributions to cognitive resilience in aging. Behav Brain Res. 2021;405:113207.","journal-title":"Behav Brain Res"},{"key":"1975_CR2","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/geronb\/gbu031","volume":"69","author":"C Franceschi","year":"2014","unstructured":"Franceschi C, Campisi J. Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases. J Gerontology. 2014;69:S4\u2013S9.","journal-title":"J Gerontology"},{"key":"1975_CR3","doi-asserted-by":"publisher","first-page":"493","DOI":"10.2174\/1567205015666180101145619","volume":"15","author":"Y Gu","year":"2018","unstructured":"Gu Y, Manly JJ, Mayeux RP, Brickman AM. An Inflammation-related Nutrient Pattern is Associated with Both Brain and Cognitive Measures in a Multiethnic Elderly Population. Curr Alzheimer Res. 2018;15:493\u2013501.","journal-title":"Curr Alzheimer Res"},{"key":"1975_CR4","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s13668-019-0271-4","volume":"8","author":"AM McGrattan","year":"2019","unstructured":"McGrattan AM, McGuinness B, McKinley MC, Kee F, Passmore P, Woodside JV, et al. Diet and Inflammation in Cognitive Ageing and Alzheimer\u2019s Disease. Curr Nutr Rep. 2019;8:53\u201365.","journal-title":"Curr Nutr Rep"},{"key":"1975_CR5","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1007\/s12603-019-1221-y","volume":"23","author":"J Corley","year":"2019","unstructured":"Corley J, Shivappa N, H\u00e9bert JR, Starr JM, Deary IJ. Associations between Dietary Inflammatory Index Scores and Inflammatory Biomarkers among Older Adults in the Lothian Birth Cohort 1936 Study. J Nutr Health Aging. 2019;23:628\u201336.","journal-title":"J Nutr Health Aging"},{"key":"1975_CR6","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1017\/S1368980013002565","volume":"17","author":"N Shivappa","year":"2014","unstructured":"Shivappa N, Steck SE, Hurley TG, Hussey JR, Ma Y, Ockene IS, et al. A population-based dietary inflammatory index predicts levels of C-reactive protein in the Seasonal Variation of Blood Cholesterol Study (SEASONS). Public Health Nutr. 2014;17:1825\u201333.","journal-title":"Public Health Nutr"},{"key":"1975_CR7","doi-asserted-by":"crossref","unstructured":"Shivappa N, Hebert JR, Marcos A, Diaz LE, Gomez S, Nova E, et al. Association between dietary inflammatory index and inflammatory markers in the HELENA study. Mol Nutr Food Res. 2017;61:1600707.","DOI":"10.1002\/mnfr.201600707"},{"key":"1975_CR8","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1017\/S000711451400395X","volume":"113","author":"N Shivappa","year":"2015","unstructured":"Shivappa N, H\u00e9bert JR, Rietzschel ER, De Buyzere ML, Langlois M, Debruyne E, et al. Associations between dietary inflammatory index and inflammatory markers in the Asklepios Study. Br J Nutr. 2015;113:665\u201371.","journal-title":"Br J Nutr"},{"key":"1975_CR9","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1017\/S1368980013002115","volume":"17","author":"N Shivappa","year":"2014","unstructured":"Shivappa N, Steck SE, Hurley TG, Hussey JR, H\u00e9bert JR. Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutr. 2014;17:1689\u201396.","journal-title":"Public Health Nutr"},{"key":"1975_CR10","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.annepidem.2015.03.009","volume":"25","author":"FK Tabung","year":"2015","unstructured":"Tabung FK, Steck SE, Zhang J, Ma Y, Liese AD, Agalliu I, et al. Construct validation of the dietary inflammatory index among postmenopausal women. Ann Epidemiol. 2015;25:398\u2013405.","journal-title":"Ann Epidemiol"},{"key":"1975_CR11","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1017\/S0007114517003804","volume":"119","author":"E Frith","year":"2018","unstructured":"Frith E, Shivappa N, Mann JR, H\u00e9bert JR, Wirth MD, Loprinzi PD. Dietary inflammatory index and memory function: population-based national sample of elderly Americans. Br J Nutr. 2018;119:552\u20138.","journal-title":"Br J Nutr"},{"key":"1975_CR12","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1007\/s00394-016-1211-3","volume":"56","author":"E Kesse-Guyot","year":"2017","unstructured":"Kesse-Guyot E, Assmann KE, Andreeva VA, Touvier M, Neufcourt L, Shivappa N, et al. Long-term association between the dietary inflammatory index and cognitive functioning: findings from the SU.VI.MAX study. Eur J Nutr. 2017;56:1647\u201355.","journal-title":"Eur J Nutr"},{"key":"1975_CR13","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.nut.2018.02.026","volume":"55-56","author":"D Shin","year":"2018","unstructured":"Shin D, Kwon SC, Kim MH, Lee KW, Choi SY, Shivappa N, et al. Inflammatory potential of diet is associated with cognitive function in an older adult Korean population. Nutrition. 2018;55-56:56\u201362.","journal-title":"Nutrition"},{"key":"1975_CR14","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.jalz.2017.04.004","volume":"13","author":"KM Hayden","year":"2017","unstructured":"Hayden KM, Beavers DP, Steck SE, Hebert JR, Tabung FK, Shivappa N, et al. The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women\u2019s Health Initiative Memory Study. Alzheimers Dement. 2017;13:1187\u201396.","journal-title":"Alzheimers Dement"},{"key":"1975_CR15","doi-asserted-by":"publisher","first-page":"e2381","DOI":"10.1212\/WNL.0000000000012973","volume":"97","author":"S Charisis","year":"2021","unstructured":"Charisis S, Ntanasi E, Yannakoulia M, Anastasiou CA, Kosmidis MH, Dardiotis E, et al. Diet Inflammatory Index and Dementia Incidence. Neurology. 2021;97:e2381\u2013e2391.","journal-title":"Neurology"},{"key":"1975_CR16","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.1001\/jama.289.20.2651","volume":"289","author":"SA Shumaker","year":"2003","unstructured":"Shumaker SA, Legault C, Rapp SR, Thal L, Wallace RB, Ockene JK, et al. Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women\u2019s Health Initiative Memory Study: a randomized controlled trial. Jama. 2003;289:2651\u201362.","journal-title":"Jama"},{"key":"1975_CR17","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.1001\/jama.289.20.2663","volume":"289","author":"SR Rapp","year":"2003","unstructured":"Rapp SR, Espeland MA, Shumaker SA, Henderson VW, Brunner RL, Manson JE, et al. Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women\u2019s Health Initiative Memory Study: a randomized controlled trial. Jama. 2003;289:2663\u201372.","journal-title":"Jama"},{"key":"1975_CR18","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1001\/jama.291.24.2947","volume":"291","author":"SA Shumaker","year":"2004","unstructured":"Shumaker SA, Legault C, Kuller L, Rapp SR, Thal L, Lane DS, et al. Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women\u2019s Health Initiative Memory Study. Jama. 2004;291:2947\u201358.","journal-title":"Jama"},{"key":"1975_CR19","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.1001\/jama.291.24.2959","volume":"291","author":"MA Espeland","year":"2004","unstructured":"Espeland MA, Rapp SR, Shumaker SA, Brunner R, Manson JE, Sherwin BB, et al. Conjugated equine estrogens and global cognitive function in postmenopausal women: Women\u2019s Health Initiative Memory Study. Jama. 2004;291:2959\u201368.","journal-title":"Jama"},{"key":"1975_CR20","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1001\/jama.291.14.1701","volume":"291","author":"GL Anderson","year":"2004","unstructured":"Anderson GL, Limacher M, Assaf AR, Bassford T, Beresford SA, Black H, et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women\u2019s Health Initiative randomized controlled trial. Jama. 2004;291:1701\u201312.","journal-title":"Jama"},{"key":"1975_CR21","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0197-2456(97)00078-0","volume":"19","author":"Design of the Women\u2019s Health Initiative clinical trial and observational study.","year":"1998","unstructured":"Design of the Women\u2019s Health Initiative clinical trial and observational study. The Women\u2019s Health Initiative Study Group. Control Clin Trials. 1998;19:61\u2013109.","journal-title":"Control Clin Trials"},{"key":"1975_CR22","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/S0197-2456(98)00038-5","volume":"19","author":"SA Shumaker","year":"1998","unstructured":"Shumaker SA, Reboussin BA, Espeland MA, Rapp SR, McBee WL, Dailey M, et al. The Women\u2019s Health Initiative Memory Study (WHIMS): a trial of the effect of estrogen therapy in preventing and slowing the progression of dementia. Control Clin Trials. 1998;19:604\u201321.","journal-title":"Control Clin Trials"},{"key":"1975_CR23","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/S1047-2797(98)00055-6","volume":"9","author":"RE Patterson","year":"1999","unstructured":"Patterson RE, Kristal AR, Tinker LF, Carter RA, Bolton MP, Agurs-Collins T. Measurement characteristics of the Women\u2019s Health Initiative food frequency questionnaire. Ann Epidemiol. 1999;9:178\u201387.","journal-title":"Ann Epidemiol"},{"key":"1975_CR24","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1016\/S1047-2797(03)00043-7","volume":"13","author":"GL Anderson","year":"2003","unstructured":"Anderson GL, Manson J, Wallace R, Lund B, Hall D, Davis S, et al. Implementation of the Women\u2019s Health Initiative study design. Ann Epidemiol. 2003;13:S5\u201317.","journal-title":"Ann Epidemiol"},{"key":"1975_CR25","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/0895-4356(90)90099-B","volume":"43","author":"G Block","year":"1990","unstructured":"Block G, Woods M, Potosky A, Clifford C. Validation of a self-administered diet history questionnaire using multiple diet records. J Clin Epidemiol. 1990;43:1327\u201335.","journal-title":"J Clin Epidemiol"},{"key":"1975_CR26","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1097\/00001648-199001000-00013","volume":"1","author":"G Block","year":"1990","unstructured":"Block G, Hartman AM, Naughton D. A reduced dietary questionnaire: development and validation. Epidemiology. 1990;1:58\u201364.","journal-title":"Epidemiology"},{"key":"1975_CR27","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.jand.2020.11.004","volume":"121","author":"F Zabetian-Targhi","year":"2021","unstructured":"Zabetian-Targhi F, Srikanth VK, Smith KJ, Oddy PhDW, Beare R, Moran C, et al. Associations Between the Dietary Inflammatory Index, Brain Volume, Small Vessel Disease, and Global Cognitive Function. J Acad Nutr Diet. 2021;121:915\u201324 e913.","journal-title":"J Acad Nutr Diet"},{"key":"1975_CR28","doi-asserted-by":"crossref","unstructured":"Ferreira M, Cronj\u00e9 HT, van Zyl T, Bondonno NP, Pieters M. The association between an energy-adjusted dietary inflammatory index and inflammation in rural and urban Black South Africans. Public Health Nutr 2021;25:1\u201329.","DOI":"10.1017\/S136898002100505X"},{"key":"1975_CR29","doi-asserted-by":"crossref","unstructured":"Kotemori A, Sawada N, Iwasaki M, Yamaji T, Shivappa N, Hebert JR, et al. Dietary Inflammatory Index Is Associated With Inflammation in Japanese Men. Front Nutr. 2021;8:604296.","DOI":"10.3389\/fnut.2021.604296"},{"key":"1975_CR30","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.3390\/nu11061213","volume":"11","author":"P Rafiee","year":"2019","unstructured":"Rafiee P, Shivappa N, H\u00e9bert JR, Jaafari Nasab S, Bahrami A, Hekmatdoost A, et al. Dietary Inflammatory Index and Odds of Colorectal Cancer and Colorectal Adenomatous Polyps in a Case-Control Study from Iran. Nutrients. 2019;11:1213.","journal-title":"Nutrients"},{"key":"1975_CR31","doi-asserted-by":"publisher","first-page":"e95192","DOI":"10.1371\/journal.pone.0095192","volume":"9","author":"E Assarsson","year":"2014","unstructured":"Assarsson E, Lundberg M, Holmquist G, Bj\u00f6rkesten J, Thorsen SB, Ekman D, et al. Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability. PLoS One. 2014;9:e95192.","journal-title":"PLoS One"},{"key":"1975_CR32","doi-asserted-by":"publisher","first-page":"e102","DOI":"10.1093\/nar\/gkr424","volume":"39","author":"M Lundberg","year":"2011","unstructured":"Lundberg M, Eriksson A, Tran B, Assarsson E, Fredriksson S. Homogeneous antibody-based proximity extension assays provide sensitive and specific detection of low-abundant proteins in human blood. Nucleic Acids Res. 2011;39:e102.","journal-title":"Nucleic Acids Res"},{"key":"1975_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64636-7","volume":"10","author":"SM Figarska","year":"2020","unstructured":"Figarska SM, Rigdon J, Ganna A, Elmst\u00e5hl S, Lind L, Gardner CD, et al. Proteomic profiles before and during weight loss: Results from randomized trial of dietary intervention. Sci Rep. 2020;10:7913.","journal-title":"Sci Rep"},{"key":"1975_CR34","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s13195-022-01063-y","volume":"14","author":"K Trares","year":"2022","unstructured":"Trares K, Bhardwaj M, Perna L, Stocker H, Petrera A, Hauck SM, et al. Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study. Alzheimers Res Ther. 2022;14:128.","journal-title":"Alzheimers Res Ther"},{"key":"1975_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81705-7","volume":"11","author":"NC Cullen","year":"2021","unstructured":"Cullen NC, M\u00e4larstig AN, Stomrud E, Hansson O, Mattsson-Carlgren N. Accelerated inflammatory aging in Alzheimer\u2019s disease and its relation to amyloid, tau, and cognition. Sci Rep. 2021;11:1965.","journal-title":"Sci Rep"},{"key":"1975_CR36","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1212\/WNL.56.9.1133","volume":"56","author":"RC Petersen","year":"2001","unstructured":"Petersen RC, Stevens JC, Ganguli M, Tangalos EG, Cummings JL, DeKosky ST. Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2001;56:1133\u201342.","journal-title":"Neurology"},{"key":"1975_CR37","unstructured":"American Psychiatric Publishing. Diagnostic and statistical manual of mental disorders, 4th ed. Arlington, VA, US: American Psychiatric Publishing, Inc.:; 1994. xxvii, 886-xxvii, p. 886."},{"key":"1975_CR38","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s43587-021-00064-0","volume":"1","author":"KA Walker","year":"2021","unstructured":"Walker KA, Chen J, Zhang J, Fornage M, Yang Y, Zhou L, et al. Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk. Nat Aging. 2021;1:473\u201389.","journal-title":"Nat Aging"},{"key":"1975_CR39","unstructured":"Shock NW, Greulich RC, Aremberg D, Costa PT, Lakatta EG, Tobin JD. Normal human aging: The Baltimore longitudinal study of aging. Washington, D.C.: National Institutes of Health; 1984."},{"key":"1975_CR40","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1001\/jamaoto.2019.1610","volume":"145","author":"NM Armstrong","year":"2019","unstructured":"Armstrong NM, An Y, Doshi J, Erus G, Ferrucci L, Davatzikos C, et al. Association of Midlife Hearing Impairment With Late-Life Temporal Lobe Volume Loss. JAMA Otolaryngol Head Neck Surg. 2019;145:794\u2013802.","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"1975_CR41","doi-asserted-by":"publisher","first-page":"117289","DOI":"10.1016\/j.neuroimage.2020.117289","volume":"223","author":"NM Armstrong","year":"2020","unstructured":"Armstrong NM, An Y, Shin JJ, Williams OA, Doshi J, Erus G, et al. Associations between cognitive and brain volume changes in cognitively normal older adults. Neuroimage. 2020;223:117289.","journal-title":"Neuroimage"},{"key":"1975_CR42","doi-asserted-by":"publisher","first-page":"e2117416","DOI":"10.1001\/jamanetworkopen.2021.17416","volume":"4","author":"V Varadaraj","year":"2021","unstructured":"Varadaraj V, Munoz B, Deal JA, An Y, Albert MS, Resnick SM, et al. Association of Vision Impairment With Cognitive Decline Across Multiple Domains in Older Adults. JAMA Netw Open. 2021;4:e2117416\u2013e2117416.","journal-title":"JAMA Netw Open"},{"key":"1975_CR43","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1093\/brain\/awp091","volume":"132","author":"C Davatzikos","year":"2009","unstructured":"Davatzikos C, Xu F, An Y, Fan Y, Resnick SM. Longitudinal progression of Alzheimer\u2019s-like patterns of atrophy in normal older adults: the SPARE-AD index. Brain. 2009;132:2026\u201335.","journal-title":"Brain"},{"key":"1975_CR44","doi-asserted-by":"publisher","first-page":"2322.e2319","DOI":"10.1016\/j.neurobiolaging.2010.05.023","volume":"32","author":"C Davatzikos","year":"2011","unstructured":"Davatzikos C, Bhatt P, Shaw LM, Batmanghelich KN, Trojanowski JQ. Prediction of MCI to AD conversion, via MRI, CSF biomarkers, and pattern classification. Neurobiol Aging. 2011;32:2322.e2319\u20132327.","journal-title":"Neurobiol Aging"},{"key":"1975_CR45","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1109\/TMI.2006.886812","volume":"26","author":"Y Fan","year":"2006","unstructured":"Fan Y, Shen D, Gur RC, Gur RE, Davatzikos C. COMPARE: classification of morphological patterns using adaptive regional elements. IEEE Trans Med imaging. 2006;26:93\u2013105.","journal-title":"IEEE Trans Med imaging"},{"key":"1975_CR46","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/BF00994018","volume":"20","author":"C Cortes","year":"1995","unstructured":"Cortes C, Vapnik V. Support-vector networks. Mach Learn. 1995;20:273\u201397.","journal-title":"Mach Learn"},{"key":"1975_CR47","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.nicl.2013.11.010","volume":"4","author":"X Da","year":"2014","unstructured":"Da X, Toledo JB, Zee J, Wolk DA, Xie SX, Ou Y, et al. Integration and relative value of biomarkers for prediction of MCI to AD progression: spatial patterns of brain atrophy, cognitive scores, APOE genotype and CSF biomarkers. NeuroImage: Clin. 2014;4:164\u201373.","journal-title":"NeuroImage: Clin"},{"key":"1975_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2051-5960-2-26","volume":"2","author":"JB Toledo","year":"2014","unstructured":"Toledo JB, Weiner MW, Wolk DA, Da X, Chen K, Arnold SE, et al. Neuronal injury biomarkers and prognosis in ADNI subjects with normal cognition. Acta neuropathol Commun. 2014;2:1\u20139.","journal-title":"Acta neuropathol Commun"},{"key":"1975_CR49","doi-asserted-by":"crossref","unstructured":"Vapnik V. The nature of statistical learning theory. Berlin: Springer science & business media; 1999.","DOI":"10.1007\/978-1-4757-3264-1"},{"key":"1975_CR50","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06885-7","volume":"7","author":"AJ Ahola","year":"2017","unstructured":"Ahola AJ, Lassenius MI, Forsblom C, Harjutsalo V, Lehto M, Groop P-H. Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity. Sci Rep. 2017;7:6511.","journal-title":"Sci Rep"},{"key":"1975_CR51","doi-asserted-by":"publisher","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","volume":"150","author":"AS Levey","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150:604\u201312.","journal-title":"Ann Intern Med"},{"key":"1975_CR52","doi-asserted-by":"publisher","first-page":"173","DOI":"10.5808\/GI.2016.14.4.173","volume":"14","author":"CH Lee","year":"2016","unstructured":"Lee CH, Cook S, Lee JS, Han B. Comparison of Two Meta-Analysis Methods: Inverse-Variance-Weighted Average and Weighted Sum of Z-Scores. Genomics Inf. 2016;14:173\u201380.","journal-title":"Genomics Inf"},{"key":"1975_CR53","doi-asserted-by":"publisher","first-page":"n1804","DOI":"10.1136\/bmj.n1804","volume":"374","author":"M Kivim\u00e4ki","year":"2021","unstructured":"Kivim\u00e4ki M, Walker KA, Pentti J, Nyberg ST, Mars N, Vahtera J, et al. Cognitive stimulation in the workplace, plasma proteins, and risk of dementia: three analyses of population cohort studies. Bmj. 2021;374:n1804.","journal-title":"Bmj"},{"key":"1975_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27164-0","volume":"12","author":"M Pietzner","year":"2021","unstructured":"Pietzner M, Wheeler E, Carrasco-Zanini J, Kerrison ND, Oerton E, Koprulu M, et al. Synergistic insights into human health from aptamer- and antibody-based proteomic profiling. Nat Commun. 2021;12:6822.","journal-title":"Nat Commun"},{"key":"1975_CR55","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.jacc.2004.03.039","volume":"44","author":"C Chrysohoou","year":"2004","unstructured":"Chrysohoou C, Panagiotakos DB, Pitsavos C, Das UN, Stefanadis C. Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study. J Am Coll Cardiol. 2004;44:152\u20138.","journal-title":"J Am Coll Cardiol"},{"key":"1975_CR56","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1002\/oby.20239","volume":"21","author":"C Richard","year":"2013","unstructured":"Richard C, Couture P, Desroches S, Lamarche B. Effect of the Mediterranean diet with and without weight loss on markers of inflammation in men with metabolic syndrome. Obesity. 2013;21:51\u201357.","journal-title":"Obesity"},{"key":"1975_CR57","doi-asserted-by":"crossref","unstructured":"Sureda A, Bibiloni MDM, Julibert A, Bouzas C, Argelich E, Llompart I, et al. Adherence to the Mediterranean Diet and Inflammatory Markers. Nutrients. 2018;10:10010062.","DOI":"10.3390\/nu10010062"},{"key":"1975_CR58","doi-asserted-by":"crossref","unstructured":"Ellegaard Nielsen J, Sofie Pedersen K, Vesterg\u00e5rd K, Georgiana Maltesen R, Christiansen G, Lundbye-Christensen S, et al. Novel Blood-Derived Extracellular Vesicle-Based Biomarkers in Alzheimer\u2019s Disease Identified by Proximity Extension Assay. Biomedicines. 2020;8:8070199.","DOI":"10.3390\/biomedicines8070199"},{"key":"1975_CR59","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-019-0795-2","volume":"7","author":"CD Whelan","year":"2019","unstructured":"Whelan CD, Mattsson N, Nagle MW, Vijayaraghavan S, Hyde C, Janelidze S, et al. Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer\u2019s disease. Acta Neuropathol Commun. 2019;7:169.","journal-title":"Acta Neuropathol Commun"},{"key":"1975_CR60","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1002\/alz.12419","volume":"18","author":"JV Lindbohm","year":"2022","unstructured":"Lindbohm JV, Mars N, Walker KA, Singh-Manoux A, Livingston G, Brunner EJ, et al. Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies. Alzheimers Dement. 2022;18:612\u201324.","journal-title":"Alzheimers Dement"},{"key":"1975_CR61","doi-asserted-by":"publisher","first-page":"629","DOI":"10.3233\/JAD-201565","volume":"81","author":"G Bostr\u00f6m","year":"2021","unstructured":"Bostr\u00f6m G, Freyhult E, Virhammar J, Alcolea D, Tumani H, Otto M, et al. Different Inflammatory Signatures in Alzheimer\u2019s Disease and Frontotemporal Dementia Cerebrospinal Fluid. J Alzheimers Dis. 2021;81:629\u201340.","journal-title":"J Alzheimers Dis"},{"key":"1975_CR62","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/alz.12369","volume":"18","author":"Y Jiang","year":"2022","unstructured":"Jiang Y, Zhou X, Ip FC, Chan P, Chen Y, Lai NC, et al. Large\u2010scale plasma proteomic profiling identifies a high\u2010performance biomarker panel for Alzheimer\u2019s disease screening and staging. Alzheimer\u2019s Dement. 2022;18:88\u2013102.","journal-title":"Alzheimer\u2019s Dement"},{"key":"1975_CR63","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1136\/jnnp-2017-316201","volume":"88","author":"KSP Lai","year":"2017","unstructured":"Lai KSP, Liu CS, Rau A, Lanct\u00f4t KL, K\u00f6hler CA, Pakosh M, et al. Peripheral inflammatory markers in Alzheimer\u2019s disease: a systematic review and meta-analysis of 175 studies. J Neurol Neurosurg Psychiatry. 2017;88:876\u201382.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1975_CR64","doi-asserted-by":"crossref","first-page":"e12183","DOI":"10.1002\/trc2.12183","volume":"7","author":"J Samuelsson","year":"2021","unstructured":"Samuelsson J, Kern S, Zetterberg H, Blennow K, Rothenberg E, Wallengren O, et al. A Western\u2010style dietary pattern is associated with cerebrospinal fluid biomarker levels for preclinical Alzheimer\u2019s disease\u2014A population\u2010based cross\u2010sectional study among 70\u2010year\u2010olds. Alzheimer\u2019s Dement. 2021;7:e12183.","journal-title":"Alzheimer\u2019s Dement"},{"key":"1975_CR65","doi-asserted-by":"publisher","first-page":"e2920","DOI":"10.1212\/WNL.0000000000012067","volume":"96","author":"T Ballarini","year":"2021","unstructured":"Ballarini T, Melo van Lent D, Brunner J, Schr\u00f6der A, Wolfsgruber S, Altenstein S, et al. Mediterranean Diet, Alzheimer Disease Biomarkers and Brain Atrophy in Old Age. Neurology. 2021;96:e2920\u20132932.","journal-title":"Neurology"},{"key":"1975_CR66","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1001\/archneurol.2011.125","volume":"68","author":"JL Bayer-Carter","year":"2011","unstructured":"Bayer-Carter JL, Green PS, Montine TJ, VanFossen B, Baker LD, Watson GS, et al. Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment. Arch Neurol. 2011;68:743\u201352.","journal-title":"Arch Neurol"},{"key":"1975_CR67","doi-asserted-by":"publisher","first-page":"e038179","DOI":"10.1002\/alz.038179","volume":"16","author":"EH Thijssen","year":"2020","unstructured":"Thijssen EH, Verberk IM, Stoops E, Boxer AL, Teunissen CE. Amyloid, pTau, NfL, and GFAP as biomarkers for Alzheimer\u2019s disease: Clinical study results of AD blood biomarkers. Alzheimer\u2019s Dement. 2020;16:e038179.","journal-title":"Alzheimer\u2019s Dement"},{"key":"1975_CR68","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-89749-5","volume":"11","author":"C Delaby","year":"2021","unstructured":"Delaby C, Julian A, Page G, Ragot S, Lehmann S, Paccalin M. NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline. Sci Rep. 2021;11:10283.","journal-title":"Sci Rep"},{"key":"1975_CR69","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1567-4","volume":"16","author":"P Chatterjee","year":"2019","unstructured":"Chatterjee P, Zetterberg H, Goozee K, Lim CK, Jacobs KR, Ashton NJ, et al. Plasma neurofilament light chain and amyloid-\u03b2 are associated with the kynurenine pathway metabolites in preclinical Alzheimer\u2019s disease. J Neuroinflamm. 2019;16:186.","journal-title":"J Neuroinflamm"},{"key":"1975_CR70","doi-asserted-by":"publisher","first-page":"e87","DOI":"10.1016\/S2666-7568(20)30061-1","volume":"2","author":"IMW Verberk","year":"2021","unstructured":"Verberk IMW, Laarhuis MB, van den Bosch KA, Ebenau JL, van Leeuwenstijn M, Prins ND, et al. Serum markers glial fibrillary acidic protein and neurofilament light for prognosis and monitoring in cognitively normal older people: a prospective memory clinic-based cohort study. Lancet Healthy Longev. 2021;2:e87\u2013e95.","journal-title":"Lancet Healthy Longev"},{"key":"1975_CR71","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24220-7","volume":"12","author":"WT Hu","year":"2021","unstructured":"Hu WT, Ozturk T, Kollhoff A, Wharton W, Christina Howell J, Weiner M, et al. Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer\u2019s disease. Nat Commun. 2021;12:4001.","journal-title":"Nat Commun"},{"key":"1975_CR72","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/S1474-4422(22)00027-8","volume":"21","author":"E Morenas-Rodr\u00edguez","year":"2022","unstructured":"Morenas-Rodr\u00edguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Su\u00e1rez-Calvet M, et al. Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer\u2019s disease: a longitudinal observational study. Lancet Neurol. 2022;21:329\u201341.","journal-title":"Lancet Neurol"},{"key":"1975_CR73","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1001\/jamaneurol.2021.3671","volume":"78","author":"AL Benedet","year":"2021","unstructured":"Benedet AL, Mil\u00e0-Alom\u00e0 M, Vrillon A, Ashton NJ, Pascoal TA, Lussier F, et al. Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum. JAMA Neurol. 2021;78:1471\u201383.","journal-title":"JAMA Neurol"},{"key":"1975_CR74","doi-asserted-by":"publisher","first-page":"e584","DOI":"10.1038\/tp.2015.78","volume":"5","author":"SJ Kiddle","year":"2015","unstructured":"Kiddle SJ, Steves CJ, Mehta M, Simmons A, Xu X, Newhouse S, et al. Plasma protein biomarkers of Alzheimer\u2019s disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes. Transl Psychiatry. 2015;5:e584\u2013e584.","journal-title":"Transl Psychiatry"},{"key":"1975_CR75","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.jalz.2013.09.016","volume":"10","author":"M Sattlecker","year":"2014","unstructured":"Sattlecker M, Kiddle SJ, Newhouse S, Proitsi P, Nelson S, Williams S, et al. Alzheimer\u2019s disease biomarker discovery using SOMAscan multiplexed protein technology. Alzheimer\u2019s Dement. 2014;10:724\u201334.","journal-title":"Alzheimer\u2019s Dement"},{"key":"1975_CR76","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/j.1365-2990.2010.01089.x","volume":"36","author":"M M\u00fcller","year":"2010","unstructured":"M\u00fcller M, Carter S, Hofer MJ, Campbell IL. Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity\u2013a tale of conflict and conundrum. Neuropathol Appl Neurobiol. 2010;36:368\u201387.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"1975_CR77","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1172\/JCI66771","volume":"125","author":"M Krauthausen","year":"2015","unstructured":"Krauthausen M, Kummer MP, Zimmermann J, Reyes-Irisarri E, Terwel D, Bulic B, et al. CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer\u2019s disease model. J Clin Investig. 2015;125:365\u201378.","journal-title":"J Clin Investig"},{"key":"1975_CR78","doi-asserted-by":"publisher","first-page":"3377","DOI":"10.1007\/s00394-022-02892-1","volume":"61","author":"SR Millar","year":"2022","unstructured":"Millar SR, Navarro P, Harrington JM, Shivappa N, H\u00e9bert JR, Perry IJ, et al. Dietary score associations with markers of chronic low-grade inflammation: a cross-sectional comparative analysis of a middle- to older-aged population. Eur J Nutr. 2022;61:3377\u201390.","journal-title":"Eur J Nutr"},{"key":"1975_CR79","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.3390\/nu10121896","volume":"10","author":"Y Tomata","year":"2018","unstructured":"Tomata Y, Shivappa N, Zhang S, Nurrika D, Tanji F, Sugawara Y, et al. Dietary Inflammatory Index and Disability-Free Survival in Community-Dwelling Older Adults. Nutrients. 2018;10:1896.","journal-title":"Nutrients"},{"key":"1975_CR80","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1093\/eurpub\/ckx060","volume":"28","author":"N Shivappa","year":"2018","unstructured":"Shivappa N, Schneider A, H\u00e9bert JR, Koenig W, Peters A, Thorand B. Association between dietary inflammatory index, and cause-specific mortality in the MONICA\/KORA Augsburg Cohort Study. Eur J Public Health. 2018;28:167\u201372.","journal-title":"Eur J Public Health"},{"key":"1975_CR81","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1093\/aje\/kwg091","volume":"158","author":"V Kipnis","year":"2003","unstructured":"Kipnis V, Subar AF, Midthune D, Freedman LS, Ballard-Barbash R, Troiano RP, et al. Structure of dietary measurement error: results of the OPEN biomarker study. Am J Epidemiol. 2003;158:14\u201321. discussion 22-16","journal-title":"Am J Epidemiol"},{"key":"1975_CR82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cyto.2004.08.008","volume":"30","author":"GY Ho","year":"2005","unstructured":"Ho GY, Xue XN, Burk RD, Kaplan RC, Cornell E, Cushman M. Variability of serum levels of tumor necrosis factor-alpha, interleukin 6, and soluble interleukin 6 receptor over 2 years in young women. Cytokine. 2005;30:1\u20136.","journal-title":"Cytokine"},{"key":"1975_CR83","doi-asserted-by":"publisher","first-page":"2100170","DOI":"10.1002\/pmic.202100170","volume":"22","author":"DE Haslam","year":"2022","unstructured":"Haslam DE, Li J, Dillon ST, Gu X, Cao Y, Zeleznik OA, et al. Stability and reproducibility of proteomic profiles in epidemiological studies: comparing the Olink and SOMAscan platforms. PROTEOMICS. 2022;22:2100170.","journal-title":"PROTEOMICS"},{"key":"1975_CR84","doi-asserted-by":"publisher","first-page":"889647","DOI":"10.3389\/fneur.2022.889647","volume":"13","author":"BC Carlyle","year":"2022","unstructured":"Carlyle BC, Kitchen RR, Mattingly Z, Celia AM, Trombetta BA, Das S, et al. Technical Performance Evaluation of Olink Proximity Extension Assay for Blood-Based Biomarker Discovery in Longitudinal Studies of Alzheimer\u2019s Disease. Front Neurol. 2022;13:889647.","journal-title":"Front Neurol"}],"updated-by":[{"DOI":"10.1038\/s41380-023-02007-0","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000}}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41380-023-01975-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-023-01975-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-023-01975-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:21:16Z","timestamp":1701822076000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-023-01975-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,3]]},"references-count":84,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["1975"],"URL":"https:\/\/doi.org\/10.1038\/s41380-023-01975-7","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,3]]},"assertion":[{"value":"8 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2023","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41380-023-02007-0","URL":"https:\/\/doi.org\/10.1038\/s41380-023-02007-0","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Supported in part by a grant from Fujirebio Diagnostics Inc awarded to AM. All other authors have no conflicts of interest to declare.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}