{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:59:41Z","timestamp":1740124781180,"version":"3.37.3"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1038\/s41380-024-02480-1","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T12:03:11Z","timestamp":1708344191000},"page":"2050-2058","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Processing speed mediates the relationship between DDR1 and psychosocial functioning in euthymic patients with bipolar disorder presenting psychotic symptoms"],"prefix":"10.1038","volume":"29","author":[{"given":"Selena","family":"Aranda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erick J.","family":"Canales-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma","family":"Verdolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3039-0022","authenticated-orcid":false,"given":"Esteban","family":"Sep\u00falveda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6064-3620","authenticated-orcid":false,"given":"Antonio","family":"Juli\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Marsal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2187-4033","authenticated-orcid":false,"given":"Julio","family":"Bobes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar A.","family":"S\u00e1iz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paz","family":"Garc\u00eda-Portilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6231-6524","authenticated-orcid":false,"given":"Jose M.","family":"Mench\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Crespo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Gonz\u00e1lez-Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3382-4754","authenticated-orcid":false,"given":"Celso","family":"Arango","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Sierra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Sanju\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith","family":"Pomarol-Clotet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-0053","authenticated-orcid":false,"given":"Eduard","family":"Vieta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1887-5919","authenticated-orcid":false,"given":"Elisabet","family":"Vilella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"2480_CR1","doi-asserted-by":"publisher","first-page":"18008","DOI":"10.1038\/nrdp.2018.8","volume":"4","author":"E Vieta","year":"2018","unstructured":"Vieta E, Berk M, Schulze T, Carvalho A, Suppes T, Calabrese J, et al. Bipolar disorders. Nat Rev Dis Prim. 2018;4:18008.","journal-title":"Nat Rev Dis Prim"},{"key":"2480_CR2","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/s41380-019-0634-7","volume":"25","author":"FJA Gordovez","year":"2020","unstructured":"Gordovez FJA, McMahon FJ. The genetics of bipolar disorder. Mol Psychiatry. 2020;25:544\u201359.","journal-title":"Mol Psychiatry"},{"key":"2480_CR3","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/s41588-019-0397-8","volume":"51","author":"EA Stahl","year":"2019","unstructured":"Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, et al. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat Genet. 2019;51:793\u2013803. https:\/\/pubmed.ncbi.nlm.nih.gov\/31043756.","journal-title":"Nat Genet"},{"key":"2480_CR4","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/s41588-021-00857-4","volume":"53","author":"N Mullins","year":"2021","unstructured":"Mullins N, Forstner AJ, O\u2019Connell KS, Coombes B, Coleman JRI, Qiao Z, et al. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nat Genet. 2021;53:817\u201329. https:\/\/pubmed.ncbi.nlm.nih.gov\/34002096\/.","journal-title":"Nat Genet"},{"key":"2480_CR5","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/s41380-020-0782-9","volume":"26","author":"C Zhang","year":"2021","unstructured":"Zhang C, Xiao X, Li T, Li M. Translational genomics and beyond in bipolar disorder. Mol Psychiatry. 2021;26:186\u2013202. https:\/\/pubmed.ncbi.nlm.nih.gov\/32424235\/.","journal-title":"Mol Psychiatry"},{"key":"2480_CR6","first-page":"363","volume":"39","author":"JK M\u00fcller","year":"2016","unstructured":"M\u00fcller JK, Leweke FM. Bipolar disorder: clinical overview. Med Monatsschr Pharm. 2016;39:363\u20139. https:\/\/pubmed.ncbi.nlm.nih.gov\/29956510\/.","journal-title":"Med Monatsschr Pharm"},{"key":"2480_CR7","doi-asserted-by":"publisher","first-page":"eaap8757","DOI":"10.1126\/science.aap8757","volume":"360","author":"V Anttila","year":"2018","unstructured":"Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, et al. Analysis of shared heritability in common disorders of the brain. Science. 2018;360:eaap8757.","journal-title":"Science"},{"key":"2480_CR8","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1038\/nature08185","volume":"460","author":"SM Purcell","year":"2009","unstructured":"Purcell SM, Wray NR, Stone JL, Visscher PM, O\u2019Donovan MC, Sullivan PF, et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature. 2009;460:748\u201352. https:\/\/pubmed.ncbi.nlm.nih.gov\/19571811\/.","journal-title":"Nature"},{"key":"2480_CR9","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s12031-008-9151-x","volume":"38","author":"N Franco-Pons","year":"2009","unstructured":"Franco-Pons N, Tom\u00e0s J, Roig B, Auladell C, Martorell L, Vilella E. Discoidin domain receptor 1, a tyrosine kinase receptor, is upregulated in an experimental model of remyelination and during oligodendrocyte differentiation in vitro. J Mol Neurosci. 2009;38:2\u201311.","journal-title":"J Mol Neurosci"},{"key":"2480_CR10","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.neuroscience.2006.02.033","volume":"140","author":"N Franco-Pons","year":"2006","unstructured":"Franco-Pons N, Virgos C, Vogel WF, Ure\u00f1a JM, Soriano E, del Rio JA, et al. Expression of discoidin domain receptor 1 during mouse brain development follows the progress of myelination. Neuroscience. 2006;140:463\u201375.","journal-title":"Neuroscience"},{"key":"2480_CR11","doi-asserted-by":"publisher","first-page":"118483","DOI":"10.1016\/j.bbamcr.2019.04.010","volume":"1866","author":"E Vilella","year":"2019","unstructured":"Vilella E, Gas C, Garcia-Ruiz B, Rivera FJ. Expression of DDR1 in the CNS and in myelinating oligodendrocytes. Biochim. Biophys. Acta Mol Cell Res. 2019;1866:118483.","journal-title":"Biochim. Biophys. Acta Mol Cell Res"},{"key":"2480_CR12","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.brainres.2010.03.099","volume":"1336","author":"B Roig","year":"2010","unstructured":"Roig B, Franco-Pons N, Martorell L, Tom\u00e0s J, Vogel WF, Vilella E. Expression of the tyrosine kinase discoidin domain receptor 1 (DDR1) in human central nervous system myelin. Brain Res. 2010;1336:22\u20139.","journal-title":"Brain Res"},{"key":"2480_CR13","doi-asserted-by":"publisher","first-page":"e2309","DOI":"10.1002\/brb3.2309","volume":"11","author":"G Muntan\u00e9","year":"2021","unstructured":"Muntan\u00e9 G, Chillida M, Aranda S, Navarro A, Vilella E. Coexpression of the discoidin domain receptor 1 gene with oligodendrocyte-related and schizophrenia risk genes in the developing and adult human brain. Brain Behav. 2021;11:e2309. https:\/\/pubmed.ncbi.nlm.nih.gov\/34323026\/.","journal-title":"Brain Behav"},{"key":"2480_CR14","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/s41588-018-0059-2","volume":"50","author":"A Pardi\u00f1as","year":"2018","unstructured":"Pardi\u00f1as A, Holmans P, Pocklington A, Escott-Price V, Ripke S, Carrera N, et al. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nat Genet. 2018;50:381\u20139. https:\/\/pubmed.ncbi.nlm.nih.gov\/29483656\/.","journal-title":"Nat Genet"},{"key":"2480_CR15","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.jpsychires.2012.02.018","volume":"46","author":"B Roig","year":"2012","unstructured":"Roig B, Abasolo N, Moyano S, Martorell L, Vilella E. Increased expression of the spliced DDR1c isoform in brain tissues from schizophrenia patients. J Psychiatr Res. 2012;46:825\u20137.","journal-title":"J Psychiatr Res"},{"key":"2480_CR16","doi-asserted-by":"publisher","first-page":"845","DOI":"10.2217\/epi-2021-0006","volume":"13","author":"B Garcia-Ruiz","year":"2021","unstructured":"Garcia-Ruiz B, De Moura MC, Muntan\u00e9 G, Martorell L, Bosch E, Esteller M, et al. DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes. Epigenomics. 2021;13:845\u201358. https:\/\/www.futuremedicine.com\/doi\/10.2217\/epi-2021-0006.","journal-title":"Epigenomics"},{"key":"2480_CR17","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jpsychires.2018.12.021","volume":"110","author":"C Gas","year":"2019","unstructured":"Gas C, Canales-Rodr\u00edguez EJ, Radua J, Abasolo N, Cort\u00e9s MJ, Salvad\u00f3 E, et al. Discoidin domain receptor 1 gene variants are associated with decreased white matter fractional anisotropy and decreased processing speed in schizophrenia. J Psychiatr Res. 2019;110:74\u201382. https:\/\/doi.org\/10.1016\/j.jpsychires.2018.12.021.","journal-title":"J Psychiatr Res"},{"key":"2480_CR18","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jpsychires.2022.12.020","volume":"158","author":"C Gas","year":"2023","unstructured":"Gas C, Ayesa R, V\u00e1zquez-Bourgon J, Crespo-Facorro B, Garc\u00eda-Gavil\u00e1n J, Labad J, et al. Cross-sectional and longitudinal assessment of the association between DDR1 variants and processing speed in patients with early psychosis and healthy controls. J Psychiatr Res. 2023;158:49\u201355. https:\/\/pubmed.ncbi.nlm.nih.gov\/36571911\/.","journal-title":"J Psychiatr Res"},{"key":"2480_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.rpsm.2018.10.001","volume":"12","author":"E Salagre","year":"2019","unstructured":"Salagre E, Arango C, Artigas F, Ayuso-Mateos JL, Bernardo M, Castro-Fornieles J, et al. CIBERSAM: Ten years of collaborative translational research in mental disorders. Rev Psiquiatr Salud Ment. 2019;12:1\u20138. https:\/\/pubmed.ncbi.nlm.nih.gov\/30416047\/.","journal-title":"Rev Psiquiatr Salud Ment"},{"key":"2480_CR20","doi-asserted-by":"publisher","first-page":"6927","DOI":"10.1093\/hmg\/ddu398","volume":"23","author":"A Juli\u00e0","year":"2014","unstructured":"Juli\u00e0 A, Dom\u00e8nech E, Chaparro M, Garc\u00eda-S\u00e1nchez V, Gomoll\u00f3n F, Pan\u00e9s J, et al. A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis. Hum Mol Genet. 2014;23:6927\u201334.","journal-title":"Hum Mol Genet"},{"key":"2480_CR21","doi-asserted-by":"crossref","unstructured":"Canales-Rodr\u00edguez EJ, Verdolini N, Alonso-Lana S, Torres ML, Panicalli F, Argila-Plaza I, et al. Widespread intra-axonal signal fraction abnormalities in bipolar disorder from multicompartment diffusion MRI: Sensitivity to diagnosis, association with clinical features and pharmacologic treatment. Hum Brain Mapp. 2023. https:\/\/pubmed.ncbi.nlm.nih.gov\/37357976\/.","DOI":"10.1002\/hbm.26405"},{"key":"2480_CR22","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","volume":"23","author":"M Hamilton","year":"1960","unstructured":"Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56\u201362.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2480_CR23","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1192\/bjp.133.5.429","volume":"133","author":"RC Young","year":"1978","unstructured":"Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry. 1978;133:429\u201335.","journal-title":"Br J Psychiatry"},{"key":"2480_CR24","unstructured":"Wechsler D. WAIS-III Administration and scoring manual. Am Psychol Assoc. 1997."},{"key":"2480_CR25","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","volume":"21","author":"JC Barrett","year":"2005","unstructured":"Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinforma. 2005;21:263\u20135. https:\/\/pubmed.ncbi.nlm.nih.gov\/15297300\/.","journal-title":"Bioinforma"},{"key":"2480_CR26","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MAR, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81:559\u201375. https:\/\/pubmed.ncbi.nlm.nih.gov\/17701901\/.","journal-title":"Am J Hum Genet"},{"key":"2480_CR27","unstructured":"First MB, Spitzer RL, Gibbon M, Williams JB. Structured Clinical Interview For DSM-IV Axis I Disorders. New York: New York State Psychiatric Institute: Biometrics Research Department; 1997."},{"key":"2480_CR28","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.schres.2010.11.016","volume":"128","author":"JJ Gomar","year":"2011","unstructured":"Gomar JJ, Ortiz-Gil J, McKenna PJ, Salvador R, Sans-Sansa B, Sarr\u00f3 S, et al. Validation of the Word Accentuation Test (TAP) as a means of estimating premorbid IQ in Spanish speakers. Schizophr Res. 2011;128:175\u20136.","journal-title":"Schizophr Res"},{"key":"2480_CR29","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1745-0179-3-5","volume":"3","author":"AR Rosa","year":"2007","unstructured":"Rosa AR, S\u00e1nchez-Moreno J, Mart\u00ednez-Aran A, Salamero M, Torrent C, Reinares M, et al. Validity and reliability of the Functioning Assessment Short Test (FAST) in bipolar disorder. Clin Pr Epidemiol Ment Health. 2007;3:5. https:\/\/pubmed.ncbi.nlm.nih.gov\/17555558\/.","journal-title":"Clin Pr Epidemiol Ment Health"},{"key":"2480_CR30","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.euroneuro.2021.02.007","volume":"47","author":"S Amoretti","year":"2021","unstructured":"Amoretti S, Mezquida G, Rosa AR, Bioque M, Cuesta MJ, Pina-Camacho L, et al. The functioning assessment short test (FAST) applied to first-episode psychosis: Psychometric properties and severity thresholds. Eur Neuropsychopharmacol. 2021;47:98\u2013111. https:\/\/pubmed.ncbi.nlm.nih.gov\/33658165\/.","journal-title":"Eur Neuropsychopharmacol"},{"key":"2480_CR31","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1111\/j.1399-5618.2010.00830.x","volume":"12","author":"LN Yatham","year":"2010","unstructured":"Yatham LN, Torres IJ, Malhi GS, Frangou S, Glahn DC, Bearden CE, et al. The International Society for Bipolar Disorders-Battery for Assessment of Neurocognition (ISBD-BANC). Bipolar Disord. 2010;12:351\u201363. https:\/\/pubmed.ncbi.nlm.nih.gov\/20636632\/.","journal-title":"Bipolar Disord"},{"key":"2480_CR32","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/bdi.12514","volume":"19","author":"E Jim\u00e9nez","year":"2017","unstructured":"Jim\u00e9nez E, Sol\u00e9 B, Arias B, Mitjans M, Varo C, Reinares M, et al. Impact of childhood trauma on cognitive profile in bipolar disorder. Bipolar Disord. 2017;19:363\u201374. https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/bdi.12514.","journal-title":"Bipolar Disord"},{"key":"2480_CR33","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.neuroimage.2016.06.002","volume":"139","author":"E Kaden","year":"2016","unstructured":"Kaden E, Kelm ND, Carson RP, Does MD, Alexander DC. Multi-compartment microscopic diffusion imaging. Neuroimage. 2016;139:346\u201359.","journal-title":"Neuroimage"},{"key":"2480_CR34","doi-asserted-by":"publisher","first-page":"11","DOI":"10.5334\/jors.160","volume":"5","author":"Q Yu","year":"2017","unstructured":"Yu Q, Li B. mma: An R Package for Mediation Analysis with Multiple Mediators. J Open Res Softw. 2017;5:11. https:\/\/openresearchsoftware.metajnl.com\/articles\/10.5334\/jors.160.","journal-title":"J Open Res Softw"},{"key":"2480_CR35","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.sste.2017.02.001","volume":"21","author":"Q Yu","year":"2017","unstructured":"Yu Q, Scribner RA, Leonardi C, Zhang L, Park C, Chen L, et al. Exploring racial disparity in obesity: A mediation analysis considering geo-coded environmental factors. Spat Spatiotemporal Epidemiol. 2017;21:13\u201323.","journal-title":"Spat Spatiotemporal Epidemiol"},{"key":"2480_CR36","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jad.2009.05.014","volume":"121","author":"CM Bonn\u00edn","year":"2010","unstructured":"Bonn\u00edn CM, Mart\u00ednez-Ar\u00e1n A, Torrent C, Pacchiarotti I, Rosa AR, Franco C, et al. Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: a long-term, follow-up study. J Affect Disord. 2010;121:156\u201360. https:\/\/pubmed.ncbi.nlm.nih.gov\/19505727\/.","journal-title":"J Affect Disord"},{"key":"2480_CR37","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","volume":"62","author":"M Jenkinson","year":"2012","unstructured":"Jenkinson M, Beckmann CF, Behrens TE, Woolrich MW, Smith SM. Fsl. NeuroImage. 2012;62:782\u201390.","journal-title":"NeuroImage"},{"key":"2480_CR38","doi-asserted-by":"publisher","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","volume":"23","author":"SM Smith","year":"2004","unstructured":"Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TEJ, Johansen-Berg H, et al. Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage. 2004;23:S208\u201319.","journal-title":"Neuroimage"},{"key":"2480_CR39","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.neuroimage.2008.03.061","volume":"44","author":"SM Smith","year":"2009","unstructured":"Smith SM, Nichols TE. Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage. 2009;44:83\u201398.","journal-title":"Neuroimage"},{"key":"2480_CR40","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1038\/sj.mp.4001995","volume":"12","author":"B Roig","year":"2007","unstructured":"Roig B, Virgos C, Franco N, Martorell L, Valero J, Costas J, et al. The discoidin domain receptor 1 as a novel susceptibility gene for schizophrenia. Mol Psychiatry. 2007;12:833\u201341. https:\/\/pubmed.ncbi.nlm.nih.gov\/17440435\/.","journal-title":"Mol Psychiatry"},{"key":"2480_CR41","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1192\/bjp.bp.109.073429","volume":"196","author":"N Craddock","year":"2010","unstructured":"Craddock N, Owen MJ. The Kraepelinian dichotomy - going, going\u2026 but still not gone. Br J Psychiatry. 2010;196:92\u20135. https:\/\/pubmed.ncbi.nlm.nih.gov\/20118450\/.","journal-title":"Br J Psychiatry"},{"key":"2480_CR42","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1093\/schbul\/sbm053","volume":"33","author":"MJ Owen","year":"2007","unstructured":"Owen MJ, Craddock N, Jablensky A. The genetic deconstruction of psychosis. Schizophr Bull. 2007;33:905\u201311. https:\/\/pubmed.ncbi.nlm.nih.gov\/17551090\/.","journal-title":"Schizophr Bull"},{"key":"2480_CR43","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1503\/jpn.170076","volume":"43","author":"AJ Lynham","year":"2018","unstructured":"Lynham AJ, Hubbard L, Tansey KE, Hamshere ML, Legge SE, Owen MJ, et al. Examining cognition across the bipolar\/schizophrenia diagnostic spectrum. J Psychiatry Neurosci. 2018;43:245.","journal-title":"J Psychiatry Neurosci"},{"key":"2480_CR44","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1093\/schbul\/sbp034","volume":"37","author":"C Simonsen","year":"2011","unstructured":"Simonsen C, Sundet K, Vaskinn A, Birkenaes AB, Engh JA, F\u00e6rden A, et al. Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group. Schizophr Bull. 2011;37:73\u201383. https:\/\/pubmed.ncbi.nlm.nih.gov\/19443616\/.","journal-title":"Schizophr Bull"},{"key":"2480_CR45","doi-asserted-by":"publisher","first-page":"16237","DOI":"10.4088\/JCP.10m06025yel","volume":"72","author":"LL Hua","year":"2011","unstructured":"Hua LL, Wilens TE, Martelon MK, Wong P, Wozniak J, Biederman J. Psychosocial Functioning, Familiality, and Psychiatric Comorbidity in Bipolar Youth With and Without Psychotic Features. J Clin Psychiatry. 2011;72:16237. https:\/\/www.psychiatrist.com\/jcp\/mental\/child\/psychosocial-functioning-familiality-psychiatric-comorbidity.","journal-title":"J Clin Psychiatry"},{"key":"2480_CR46","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/j.1600-0447.2010.01590.x","volume":"122","author":"KE Burdick","year":"2010","unstructured":"Burdick KE, Goldberg JF, Harrow M. Neurocognitive dysfunction and psychosocial outcome in patients with bipolar I disorder at 15-year follow-up. Acta Psychiatr Scand. 2010;122:499\u2013506. https:\/\/pubmed.ncbi.nlm.nih.gov\/20637012\/.","journal-title":"Acta Psychiatr Scand"},{"key":"2480_CR47","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.euroneuro.2022.12.005","volume":"68","author":"E Bora","year":"2023","unstructured":"Bora E, Verim B, Akgul O, Ild\u0131z A, Ceylan D, Alptekin K, et al. Clinical and developmental characteristics of cognitive subgroups in a transdiagnostic sample of schizophrenia spectrum disorders and bipolar disorder. Eur Neuropsychopharmacol. 2023;68:47\u201356. https:\/\/pubmed.ncbi.nlm.nih.gov\/36640733\/.","journal-title":"Eur Neuropsychopharmacol"},{"key":"2480_CR48","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/labinvest.3700692","volume":"88","author":"AM Meyer Zum Gottesberge","year":"2008","unstructured":"Meyer Zum Gottesberge AM, Gross O, Becker-Lendzian U, Massing T, Vogel WF. Inner ear defects and hearing loss in mice lacking the collagen receptor DDR1. Lab Invest. 2008;88:27\u201337. https:\/\/pubmed.ncbi.nlm.nih.gov\/18026164\/.","journal-title":"Lab Invest"},{"key":"2480_CR49","doi-asserted-by":"publisher","first-page":"dev200636","DOI":"10.1242\/dev.200636","volume":"149","author":"MM Corty","year":"2022","unstructured":"Corty MM, Hulegaard AL, Hill JQ, Sheehan AE, Aicher SA, Freeman MR. Discoidin domain receptor regulates ensheathment, survival and caliber of peripheral axons. Development. 2022;149:dev200636. https:\/\/pubmed.ncbi.nlm.nih.gov\/36355066\/.","journal-title":"Development"},{"key":"2480_CR50","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1101\/gr.229102","volume":"12","author":"WJ Kent","year":"2002","unstructured":"Kent WJ, Sugnet CW, Furey TS, Roskin KM, Pringle TH, Zahler AM, et al. The human genome browser at UCSC. Genome Res. 2002;12:996\u20131006. https:\/\/pubmed.ncbi.nlm.nih.gov\/12045153\/.","journal-title":"Genome Res"},{"key":"2480_CR51","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1111\/j.1471-4159.2011.07580.x","volume":"120","author":"B Roig","year":"2012","unstructured":"Roig B, Moyano S, Martorell L, Costas J, Vilella E. The Discoidin domain receptor 1 gene has a functional A2RE sequence. J Neurochem. 2012;120:408\u201318.","journal-title":"J Neurochem"},{"key":"2480_CR52","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1093\/hmg\/ddaa177","volume":"29","author":"AJ Fowler","year":"2020","unstructured":"Fowler AJ, Hebron M, Balaraman K, Shi W, Missner AA, Greenzaid JD, et al. Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases. Hum Mol Genet. 2020;29:2882.","journal-title":"Hum Mol Genet"},{"key":"2480_CR53","doi-asserted-by":"publisher","first-page":"105870","DOI":"10.1016\/j.psyneuen.2022.105870","volume":"144","author":"MT Fard","year":"2022","unstructured":"Fard MT, Savage KM, Stough CK. Peripheral inflammation marker relationships to cognition in healthy older adults - A systematic review. Psychoneuroendocrinology. 2022;144:105870. https:\/\/pubmed.ncbi.nlm.nih.gov\/35908534\/.","journal-title":"Psychoneuroendocrinology"},{"key":"2480_CR54","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.euroneuro.2021.06.008","volume":"53","author":"KE Burdick","year":"2021","unstructured":"Burdick KE, Millett CE. Cognitive heterogeneity is a key predictor of differential functional outcome in patients with bipolar disorder. Eur Neuropsychopharmacol. 2021;53:4.","journal-title":"Eur Neuropsychopharmacol"},{"key":"2480_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00406-016-0765-7","volume":"267","author":"C Arango","year":"2017","unstructured":"Arango C. Candidate gene associations studies in psychiatry: time to move forward. Eur Arch Psychiatry Clin Neurosci. 2017;267:1\u20132. https:\/\/pubmed.ncbi.nlm.nih.gov\/28070643\/.","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"2480_CR56","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.euroneuro.2021.09.011","volume":"54","author":"A Bjertrup","year":"2022","unstructured":"Bjertrup A, Macoveanu J, Laurent H, Moszkowicz M, Finnegan MK, Egmose I, et al. Reduced prefrontal cortex response to own vs. unknown emotional infant faces in mothers with bipolar disorder. Eur Neuropsychopharmacol. 2022;54:7\u201320.","journal-title":"Eur Neuropsychopharmacol"},{"key":"2480_CR57","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.euroneuro.2023.03.001","volume":"71","author":"L Ilzarbe","year":"2023","unstructured":"Ilzarbe L, Vieta E. The elephant in the room: Medication as confounder. Eur Neuropsychopharmacol. 2023;71:6\u20138. https:\/\/pubmed.ncbi.nlm.nih.gov\/36931073\/.","journal-title":"Eur Neuropsychopharmacol"},{"key":"2480_CR58","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nrg2579","volume":"10","author":"HJ Cordell","year":"2009","unstructured":"Cordell HJ. Detecting gene-gene interactions that underlie human diseases. Nat Rev Genet Nat Rev Genet. 2009;10:392\u2013404.","journal-title":"Nat Rev Genet Nat Rev Genet"},{"key":"2480_CR59","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1159\/000073735","volume":"56","author":"JH Moore","year":"2003","unstructured":"Moore JH. The ubiquitous nature of epistasis in determining susceptibility to common human diseases. : Hum Heredity Hum Hered. 2003;56:73\u201382.","journal-title":": Hum Heredity Hum Hered"},{"key":"2480_CR60","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1521\/psyc.2013.76.3.295","volume":"76","author":"DP Eisenberg","year":"2013","unstructured":"Eisenberg DP, Kleinman J, Berman KF. Epistasis and complex neuropsychiatric phenotypes. Psychiatry. 2013;76:295\u20137.","journal-title":"Psychiatry"},{"key":"2480_CR61","doi-asserted-by":"publisher","DOI":"10.1186\/s13040-017-0139-3","volume":"10","author":"JH Moore","year":"2017","unstructured":"Moore JH, Andrews PC, Olson RS, Carlson SE, Larock CR, Bulhoes MJ, et al. Grid-based stochastic search for hierarchical gene-gene interactions in population-based genetic studies of common human diseases. BioData Min. 2017;10:19.","journal-title":"BioData Min"},{"key":"2480_CR62","doi-asserted-by":"publisher","unstructured":"Matthews LJ, Turkheimer E. Three legs of the missing heritability problem. 2022. Available from: https:\/\/doi.org\/10.1016\/j.shpsa.2022.04.004.","DOI":"10.1016\/j.shpsa.2022.04.004"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41380-024-02480-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-024-02480-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-024-02480-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T11:08:28Z","timestamp":1726744108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-024-02480-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,19]]},"references-count":62,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["2480"],"URL":"https:\/\/doi.org\/10.1038\/s41380-024-02480-1","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"type":"print","value":"1359-4184"},{"type":"electronic","value":"1476-5578"}],"subject":[],"published":{"date-parts":[[2024,2,19]]},"assertion":[{"value":"28 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Eduard V has received grants and served as consultant, advisor, or CME speaker (unrelated to this work) for the following entities: AB-Biotics, Abbott, AbbVie, Angelini, Biogen, Compass, Dainippon Sumitomo Pharma, Ferrer, Gedeon Richter, Glaxo Smith-Kline, GH Research, Janssen, Lundbeck, Otsuka, Sage, Sanofi-Aventis, Sunovion, Takeda, and Viatris. AGP has received grants and served as a consultant, advisor or CME speaker for the following entities: Janssen-Cilag, Lundbeck, Otsuka, Pfizer, Sanofi-Aventis, Alter, Angelini, Exeltis, Novartis, Rovi, Takeda, the Spanish Ministry of Science and Innovation (CIBERSAM), the Ministry of Science (Carlos III Institute), the Basque Government, and the European Framework Program of Research. The other authors have no conflicts of interest to disclose. CA received support from the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (ISCIII), co-financed by the European Union, and ERDF Funds from the European Commission, \u201cA way of making Europe\u201d, financed by the European Union - NextGenerationEU (PMP21\/00051), PI19\/01024, CIBERSAM, Madrid Regional Government (B2017\/BMD-3740 AGES-CM-2), European Union Structural Funds, European Union Seventh Framework Program, European Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking: Project PRISM-2 (Grant agreement No.101034377), Project AIMS-2-TRIALS (Grant agreement No. 777394), Horizon Europe, the National Institute of Mental Health of the National Institutes of Health under Award Number 1U01MH124639\u201301 (Project ProNET) and Award Number 5P50MH115846\u201303 (project FEP-CAUSAL), Fundaci\u00f3n Familia Alonso, and Fundaci\u00f3n Alicia Koplowitz.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}