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An imbalanced astrocyte activity can therefore have drastic negative impacts on brain development, leading to the onset of severe pathologies. Clinical and pre-clinical studies show alterations in astrocyte cell number, morphology, molecular makeup and astrocyte-dependent processes in different affected brain regions in neurodevelopmental (ND) and neuropsychiatric (NP) disorders. Astrocytes proliferate, differentiate and mature during the critical period of early postnatal brain development, a time window of elevated glia-dependent regulation of a proper balance between synapse formation\/elimination, which is pivotal in refining synaptic connectivity. Therefore, any intrinsic and\/or extrinsic factors altering these processes during the critical period may result in an aberrant synaptic remodeling and onset of mental disorders. The peculiar bridging position of astrocytes between synaptic and vascular compartments further allows them to \u201ccompute\u201d the brain state and consequently secrete factors in the bloodstream, which may serve as diagnostic biomarkers of distinct healthy or disease conditions. Here, we collect recent advancements regarding astrogenesis and astrocyte-mediated regulation of neuronal network remodeling during early postnatal critical periods of brain development, focusing on synapse elimination. We then propose alternative hypotheses for an involvement of aberrancies in these processes in the onset of ND and NP disorders. In light of the well-known differential prevalence of certain brain disorders between males and females, we also discuss putative sex-dependent influences on these neurodevelopmental events. From a translational perspective, understanding age- and sex-dependent astrocyte-specific molecular and functional changes may help to identify biomarkers of distinct cellular (dys)functions in health and disease, favouring the development of diagnostic tools or the selection of tailored treatment options for male\/female patients.<\/jats:p>","DOI":"10.1038\/s41380-024-02534-4","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T04:01:50Z","timestamp":1711684910000},"page":"2821-2833","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Brain stars take the lead during critical periods of early postnatal brain development: relevance of astrocytes in health and mental disorders"],"prefix":"10.1038","volume":"29","author":[{"given":"Eugenia","family":"Vivi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6537-9072","authenticated-orcid":false,"given":"Barbara","family":"Di Benedetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,29]]},"reference":[{"key":"2534_CR1","doi-asserted-by":"publisher","first-page":"14108","DOI":"10.1073\/pnas.0804650106","volume":"106","author":"F Bandeira","year":"2009","unstructured":"Bandeira F, Lent R, Herculano-Houzel S. 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