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RBP is the named inventor on a University of Pittsburgh-owned patent filing related to the combination intervention described in this letter. MLW has served as a statistical consultant for Health Rhythms, Noctem Health, and Sleep Number Bed. SJM is supported through the use of facilities and resources at the Michael E. Debakey VA Medical Center, Houston, Texas, and receives support from The Menninger Clinic. SJM has served as a consultant to Alkermes, Allergan, Almatica, Axsome Therapeutics, Biohaven, BioXcel Therapeutics, Clexio Biosciences, Eleusis, EMA Wellness, Engrail Therapeutics, Greenwich Biosciences, Intra-Cellular Therapies, Janssen, Levo Therapeutics, Neurocrine, Perception Neuroscience, Praxis Precision Medicines, Relmada Therapeutics, Sage Therapeutics, Seelos Therapeutics, and Signant Health. He has received research support from Biohaven Pharmaceuticals, Boehringer-Ingelheim, Merck, Sage Therapeutics, and VistaGen Therapeutics. All other authors report no financial conflicts of interest to disclose.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}