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This work was supported in part by NIH grants: AG027224 and MH116046 (RAS), MH125235 and MH118497 (MLM), and P01AG14449 (MDI). RAS, JMK, PF, BCM, LW, and MLM are listed inventors on pending patent 63404994 filed by the University of Pittsburgh Innovation Institute. The methods of treating, preventing, or reducing dendritic spine density loss in a subject by administering one or a combination of the ten drugs listed in Fig.\u00a0\n                      \n                      , or a pharmaceutically acceptable salt, prodrug, or derivative thereof, are protected by the patent.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"All methods were conducted in accordance with the University of Pittsburgh\u2019s Committee for Oversight in Research Involving Decedents (ID 474) and the International Review Board for Biomedical Research (ID 19080015). 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