{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T08:38:51Z","timestamp":1789115931880,"version":"build-2803163510"},"reference-count":93,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K07931"],"award-info":[{"award-number":["20K07931"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K07606"],"award-info":[{"award-number":["22K07606"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22J15573"],"award-info":[{"award-number":["22J15573"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K11891"],"award-info":[{"award-number":["22K11891"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H02843"],"award-info":[{"award-number":["23H02843"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"MEXT | Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJFR215H"],"award-info":[{"award-number":["JPMJFR215H"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1038\/s41380-024-02826-9","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T07:13:56Z","timestamp":1732864436000},"page":"2137-2151","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Adolescent social isolation decreases colonic goblet cells and impairs spatial cognition through the reduction of cystine"],"prefix":"10.1038","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6218-6736","authenticated-orcid":false,"given":"Moeka","family":"Tanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Kunisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imari","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aika","family":"Kosuge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tezuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koyo","family":"Yoshidomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akari","family":"Kagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisayoshi","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruto","family":"Ojika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Tochio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Hirooka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniaki","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Nabeshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3833-4041","authenticated-orcid":false,"given":"Akihiro","family":"Mouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"2826_CR1","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.tics.2015.07.008","volume":"19","author":"D Fuhrmann","year":"2015","unstructured":"Fuhrmann D, Knoll LJ, Blakemore SJ. Adolescence as a Sensitive Period of Brain Development. Trends Cogn Sci. 2015;19:558\u201366.","journal-title":"Trends Cogn Sci"},{"key":"2826_CR2","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.tins.2008.01.004","volume":"31","author":"SL Andersen","year":"2008","unstructured":"Andersen SL, Teicher MH. Stress, sensitive periods and maturational events in adolescent depression. Trends Neurosci. 2008;31:183\u201391.","journal-title":"Trends Neurosci"},{"key":"2826_CR3","doi-asserted-by":"publisher","first-page":"e1001349","DOI":"10.1371\/journal.pmed.1001349","volume":"9","author":"RE Norman","year":"2012","unstructured":"Norman RE, Byambaa M, De R, Butchart A, Scott J, Vos T. The long-term health consequences of child physical abuse, emotional abuse, and neglect: a systematic review and meta-analysis. PLoS Med. 2012;9:e1001349.","journal-title":"PLoS Med"},{"key":"2826_CR4","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1192\/bjp.bp.111.103267","volume":"200","author":"KM Scott","year":"2012","unstructured":"Scott KM, McLaughlin KA, Smith DA, Ellis PM. Childhood maltreatment and DSM-IV adult mental disorders: comparison of prospective and retrospective findings. Br J Psychiatry. 2012;200:469\u201375.","journal-title":"Br J Psychiatry"},{"key":"2826_CR5","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.neubiorev.2017.01.018","volume":"76","author":"AR Burke","year":"2017","unstructured":"Burke AR, McCormick CM, Pellis SM, Lukkes JL. Impact of adolescent social experiences on behavior and neural circuits implicated in mental illnesses. Neurosci Biobehav Rev. 2017;76:280\u2013300.","journal-title":"Neurosci Biobehav Rev"},{"key":"2826_CR6","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.expneurol.2018.09.009","volume":"311","author":"B Wang","year":"2019","unstructured":"Wang B, Wu Q, Lei L, Sun H, Michael N, Zhang X, et al. Long-term social isolation inhibits autophagy activation, induces postsynaptic dysfunctions and impairs spatial memory. Exp Neurol. 2019;311:213\u201324.","journal-title":"Exp Neurol"},{"key":"2826_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2021.147497","volume":"1765","author":"X Zhang","year":"2021","unstructured":"Zhang X, Xun Y, Wang L, Zhang J, Hou W, Ma H, et al. Involvement of the dopamine system in the effect of chronic social isolation during adolescence on social behaviors in male C57 mice. Brain Res. 2021;1765:147497.","journal-title":"Brain Res"},{"key":"2826_CR8","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3892\/br.2020.1363","volume":"13","author":"TK Alshammari","year":"2020","unstructured":"Alshammari TK, Alghamdi HM, Alduhailan HE, Saja MF, Alrasheed NM, Alshammari MA. Examining the central effects of chronic stressful social isolation on rats. Biomed Rep. 2020;13:56.","journal-title":"Biomed Rep"},{"key":"2826_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1054-3","volume":"15","author":"YL Wang","year":"2018","unstructured":"Wang YL, Han QQ, Gong WQ, Pan DH, Wang LZ, Hu W, et al. Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats. J Neuroinflammation. 2018;15:21.","journal-title":"J Neuroinflammation"},{"key":"2826_CR10","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9999146","volume":"2021","author":"R Kolliker-Frers","year":"2021","unstructured":"Kolliker-Frers R, Udovin L, Otero-Losada M, Kobiec T, Herrera MI, Palacios J, et al. Neuroinflammation: An Integrating Overview of Reactive-Neuroimmune Cell Interactions in Health and Disease. Mediators Inflamm. 2021;2021:9999146.","journal-title":"Mediators Inflamm"},{"key":"2826_CR11","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3389\/fcimb.2017.00276","volume":"7","author":"A Tohidpour","year":"2017","unstructured":"Tohidpour A, Morgun AV, Boitsova EB, Malinovskaya NA, Martynova GP, Khilazheva ED, et al. Neuroinflammation and Infection: Molecular Mechanisms Associated with Dysfunction of Neurovascular Unit. Front Cell Infect Microbiol. 2017;7:276.","journal-title":"Front Cell Infect Microbiol"},{"key":"2826_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02368-9","volume":"19","author":"AJ Al Omran","year":"2022","unstructured":"Al Omran AJ, Shao AS, Watanabe S, Zhang Z, Zhang J, Xue C, et al. Social isolation induces neuroinflammation and microglia overactivation, while dihydromyricetin prevents and improves them. J Neuroinflammation. 2022;19:2.","journal-title":"J Neuroinflammation"},{"key":"2826_CR13","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1007\/s00213-016-4218-9","volume":"233","author":"MA Calcia","year":"2016","unstructured":"Calcia MA, Bonsall DR, Bloomfield PS, Selvaraj S, Barichello T, Howes OD. Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness. Psychopharmacology. 2016;233:1637\u201350.","journal-title":"Psychopharmacology"},{"key":"2826_CR14","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.biopsych.2016.12.031","volume":"82","author":"A Burokas","year":"2017","unstructured":"Burokas A, Arboleya S, Moloney RD, Peterson VL, Murphy K, Clarke G, et al. Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice. Biol Psychiatry. 2017;82:472\u201387.","journal-title":"Biol Psychiatry"},{"key":"2826_CR15","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1038\/s41380-020-0651-6","volume":"26","author":"IA Gampierakis","year":"2021","unstructured":"Gampierakis IA, Koutmani Y, Semitekolou M, Morianos I, Polissidis A, Katsouda A, et al. Hippocampal neural stem cells and microglia response to experimental inflammatory bowel disease (IBD). Mol Psychiatry. 2021;26:1248\u201363.","journal-title":"Mol Psychiatry"},{"key":"2826_CR16","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.bbi.2017.10.024","volume":"68","author":"F Dunphy-Doherty","year":"2018","unstructured":"Dunphy-Doherty F, O\u2019Mahony SM, Peterson VL, O\u2019Sullivan O, Crispie F, Cotter PD, et al. Post-weaning social isolation of rats leads to long-term disruption of the gut microbiota-immune-brain axis. Brain Behav Immun. 2018;68:261\u201373.","journal-title":"Brain Behav Immun."},{"key":"2826_CR17","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.bbi.2021.05.028","volume":"96","author":"A Kosuge","year":"2021","unstructured":"Kosuge A, Kunisawa K, Arai S, Sugawara Y, Shinohara K, Iida T, et al. Heat-sterilized Bifidobacterium breve prevents depression-like behavior and interleukin-1beta expression in mice exposed to chronic social defeat stress. Brain Behav Immun. 2021;96:200\u201311.","journal-title":"Brain Behav Immun"},{"key":"2826_CR18","doi-asserted-by":"publisher","first-page":"4123","DOI":"10.1038\/s41380-022-01569-9","volume":"27","author":"Z Li","year":"2022","unstructured":"Li Z, Lai J, Zhang P, Ding J, Jiang J, Liu C, et al. Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression. Mol Psychiatry. 2022;27:4123\u201335.","journal-title":"Mol Psychiatry"},{"key":"2826_CR19","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/nrmicro2538","volume":"9","author":"MA McGuckin","year":"2011","unstructured":"McGuckin MA, Linden SK, Sutton P, Florin TH. Mucin dynamics and enteric pathogens. Nat Rev Microbiol. 2011;9:265\u201378.","journal-title":"Nat Rev Microbiol"},{"key":"2826_CR20","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1053\/gast.2002.36019","volume":"123","author":"JD Soderholm","year":"2002","unstructured":"Soderholm JD, Yang PC, Ceponis P, Vohra A, Riddell R, Sherman PM, et al. Chronic stress induces mast cell-dependent bacterial adherence and initiates mucosal inflammation in rat intestine. Gastroenterology. 2002;123:1099\u2013108.","journal-title":"Gastroenterology"},{"key":"2826_CR21","doi-asserted-by":"publisher","first-page":"505","DOI":"10.5056\/jnm19166","volume":"26","author":"J Lu","year":"2020","unstructured":"Lu J, Shi L, Huang D, Fan W, Li X, Zhu L, et al. Depression and Structural Factors Are Associated With Symptoms in Patients of Irritable Bowel Syndrome With Diarrhea. J Neurogastroenterol Motil. 2020;26:505\u201313.","journal-title":"J Neurogastroenterol Motil"},{"key":"2826_CR22","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1111\/jgh.14021","volume":"33","author":"H Jang","year":"2018","unstructured":"Jang H, Park S, Lee J, Myung JK, Jang WS, Lee SJ, et al. Rebamipide alleviates radiation-induced colitis through improvement of goblet cell differentiation in mice. J Gastroenterol Hepatol. 2018;33:878\u201386.","journal-title":"J Gastroenterol Hepatol"},{"key":"2826_CR23","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1111\/j.1471-4159.2007.05207.x","volume":"105","author":"D Ibi","year":"2008","unstructured":"Ibi D, Takuma K, Koike H, Mizoguchi H, Tsuritani K, Kuwahara Y, et al. Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice. J Neurochem. 2008;105:921\u201332.","journal-title":"J Neurochem"},{"key":"2826_CR24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/cei.12355","volume":"178","author":"JK Byun","year":"2014","unstructured":"Byun JK, Moon SJ, Jhun JY, Kim EK, Park JS, Youn J, et al. Rebamipide attenuates autoimmune arthritis severity in SKG mice via regulation of B cell and antibody production. Clin Exp Immunol. 2014;178:9\u201319.","journal-title":"Clin Exp Immunol"},{"key":"2826_CR25","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1159\/000489825","volume":"73","author":"T Miyakuni","year":"2018","unstructured":"Miyakuni T, Fukatsu K, Ri M, Murakoshi S, Inoue Y, Kurihara S, et al. Cystine and Theanine Improve Survival after Gut Ischemia-Reperfusion. Ann Nutr Metab. 2018;73:131\u20137.","journal-title":"Ann Nutr Metab"},{"key":"2826_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2021.113191","volume":"405","author":"Y Mori","year":"2021","unstructured":"Mori Y, Mouri A, Kunisawa K, Hirakawa M, Kubota H, Kosuge A, et al. Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of alpha7 nicotinic acetylcholine receptors by kynurenic acid. Behav Brain Res. 2021;405:113191.","journal-title":"Behav Brain Res"},{"key":"2826_CR27","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/j.celrep.2019.09.037","volume":"29","author":"Y Koutmani","year":"2019","unstructured":"Koutmani Y, Gampierakis IA, Polissidis A, Ximerakis M, Koutsoudaki PN, Polyzos A, et al. CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus. Cell Rep. 2019;29:932\u201345.e7.","journal-title":"Cell Rep"},{"key":"2826_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18391-x","volume":"8","author":"T Odamaki","year":"2018","unstructured":"Odamaki T, Bottacini F, Kato K, Mitsuyama E, Yoshida K, Horigome A, et al. Genomic diversity and distribution of Bifidobacterium longum subsp. longum across the human lifespan. Sci Rep. 2018;8:85.","journal-title":"Sci Rep"},{"key":"2826_CR29","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nmeth.3869","volume":"13","author":"BJ Callahan","year":"2016","unstructured":"Callahan BJ, McMurdie PJ, Rosen MJ, Han AW, Johnson AJ, Holmes SP. DADA2: High-resolution sample inference from Illumina amplicon data. Nat Methods. 2016;13:581\u20133.","journal-title":"Nat Methods"},{"key":"2826_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-6-r60","volume":"12","author":"N Segata","year":"2011","unstructured":"Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, et al. Metagenomic biomarker discovery and explanation. Genome Biol. 2011;12:R60.","journal-title":"Genome Biol"},{"key":"2826_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-020-00698-y","volume":"13","author":"K Kunisawa","year":"2020","unstructured":"Kunisawa K, Hatanaka N, Shimizu T, Kobayashi K, Osanai Y, Mouri A, et al. Focal loss of the paranodal domain protein Neurofascin155 in the internal capsule impairs cortically induced muscle activity in vivo. Mol Brain. 2020;13:159.","journal-title":"Mol Brain"},{"key":"2826_CR32","doi-asserted-by":"crossref","unstructured":"Pang Z, Chong J, Li S, Xia J. MetaboAnalystR 3.0: Toward an Optimized Workflow for Global Metabolomics. Metabolites. 2020;10:186.","DOI":"10.3390\/metabo10050186"},{"key":"2826_CR33","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1093\/nar\/gkaa1127","volume":"49","author":"O Hahn","year":"2021","unstructured":"Hahn O, Fehlmann T, Zhang H, Munson CN, Vest RT, Borcherding A, et al. CoolMPS for robust sequencing of single-nuclear RNAs captured by droplet-based method. Nucleic Acids Res. 2021;49:e11.","journal-title":"Nucleic Acids Res"},{"key":"2826_CR34","doi-asserted-by":"publisher","DOI":"10.1177\/17448069231169373","volume":"19","author":"LP Zhu","year":"2023","unstructured":"Zhu LP, Xu ML, Yuan BT, Ma LJ, Gao YJ. Chemokine CCL7 mediates trigeminal neuropathic pain via CCR2\/CCR3-ERK pathway in the trigeminal ganglion of mice. Mol Pain. 2023;19:17448069231169373.","journal-title":"Mol Pain"},{"key":"2826_CR35","doi-asserted-by":"crossref","unstructured":"Pawlik K, Ciapala K, Ciechanowska A, Kwiatkowski K, Mika J. Pharmacological Evidence of the Important Roles of CCR1 and CCR3 and Their Endogenous Ligands CCL2\/7\/8 in Hypersensitivity Based on a Murine Model of Neuropathic Pain. Cells. 2022;12:98.","DOI":"10.3390\/cells12010098"},{"key":"2826_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2020.107301","volume":"175","author":"L Niu","year":"2020","unstructured":"Niu L, Luo SS, Xu Y, Wang Z, Luo D, Yang H, et al. The critical role of the hippocampal NLRP3 inflammasome in social isolation-induced cognitive impairment in male mice. Neurobiol Learn Mem. 2020;175:107301.","journal-title":"Neurobiol Learn Mem"},{"key":"2826_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.993132","volume":"16","author":"T Yoshioka","year":"2022","unstructured":"Yoshioka T, Ohashi M, Matsumoto K, Omata T, Hamano T, Yamazaki M, et al. Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice. Front Neurosci. 2022;16:993132.","journal-title":"Front Neurosci"},{"key":"2826_CR38","doi-asserted-by":"crossref","unstructured":"He J, Liu Y, Li J, Zhao Y, Jiang H, Luo S, et al. Intestinal changes in permeability, tight junction and mucin synthesis in a mouse model of Alzheimer\u2019s disease. Int J Mol Med. 2023;52:113.","DOI":"10.3892\/ijmm.2023.5316"},{"key":"2826_CR39","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1083\/jcb.201010127","volume":"192","author":"F Gerbe","year":"2011","unstructured":"Gerbe F, van Es JH, Makrini L, Brulin B, Mellitzer G, Robine S, et al. Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J Cell Biol. 2011;192:767\u201380.","journal-title":"J Cell Biol"},{"key":"2826_CR40","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01172-0","volume":"9","author":"H Shi","year":"2021","unstructured":"Shi H, Ge X, Ma X, Zheng M, Cui X, Pan W, et al. A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites. Microbiome. 2021;9:223.","journal-title":"Microbiome"},{"key":"2826_CR41","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1128\/AEM.01226-07","volume":"74","author":"M Derrien","year":"2008","unstructured":"Derrien M, Collado MC, Ben-Amor K, Salminen S, de Vos WM. The Mucin degrader Akkermansia muciniphila is an abundant resident of the human intestinal tract. Appl Environ Microbiol. 2008;74:1646\u20138.","journal-title":"Appl Environ Microbiol"},{"key":"2826_CR42","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12934-024-02307-2","volume":"23","author":"CY Zhang","year":"2024","unstructured":"Zhang CY, Peng XX, Wu Y, Peng MJ, Liu TH, Tan ZJ. Intestinal mucosal microbiota mediate amino acid metabolism involved in the gastrointestinal adaptability to cold and humid environmental stress in mice. Microb Cell Fact. 2024;23:33.","journal-title":"Microb Cell Fact"},{"key":"2826_CR43","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0998-z","volume":"14","author":"M Wadhwa","year":"2017","unstructured":"Wadhwa M, Prabhakar A, Ray K, Roy K, Kumari P, Jha PK, et al. Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation. J Neuroinflammation. 2017;14:222.","journal-title":"J Neuroinflammation"},{"key":"2826_CR44","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.neuropharm.2018.03.023","volume":"135","author":"Y Gong","year":"2018","unstructured":"Gong Y, Tong L, Yang R, Hu W, Xu X, Wang W, et al. Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation. Neuropharmacology. 2018;135:223\u201333.","journal-title":"Neuropharmacology"},{"key":"2826_CR45","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1038\/s41380-020-0718-4","volume":"26","author":"L Rule","year":"2021","unstructured":"Rule L, Yang J, Watkin H, Hall J, Brydges NM. Environmental enrichment rescues survival and function of adult-born neurons following early life stress. Mol Psychiatry. 2021;26:1898\u2013908.","journal-title":"Mol Psychiatry"},{"key":"2826_CR46","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1126\/science.1202529","volume":"333","author":"RC Paolicelli","year":"2011","unstructured":"Paolicelli RC, Bolasco G, Pagani F, Maggi L, Scianni M, Panzanelli P, et al. Synaptic pruning by microglia is necessary for normal brain development. Science. 2011;333:1456\u20138.","journal-title":"Science"},{"key":"2826_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2022.109249","volume":"220","author":"QQ Han","year":"2022","unstructured":"Han QQ, Shen SY, Chen XR, Pilot A, Liang LF, Zhang JR, et al. Minocycline alleviates abnormal microglial phagocytosis of synapses in a mouse model of depression. Neuropharmacology. 2022;220:109249.","journal-title":"Neuropharmacology"},{"key":"2826_CR48","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1073\/pnas.0708092105","volume":"105","author":"JW Koo","year":"2008","unstructured":"Koo JW, Duman RS. IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc Natl Acad Sci USA. 2008;105:751\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2826_CR49","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.bbi.2021.06.004","volume":"96","author":"BF Osborne","year":"2021","unstructured":"Osborne BF, Beamish SB, Schwarz JM. The effects of early-life immune activation on microglia-mediated neuronal remodeling and the associated ontogeny of hippocampal-dependent learning in juvenile rats. Brain Behav Immun. 2021;96:239\u201355.","journal-title":"Brain Behav Immun"},{"key":"2826_CR50","doi-asserted-by":"publisher","first-page":"2694","DOI":"10.1111\/ejn.14565","volume":"52","author":"N Liu","year":"2020","unstructured":"Liu N, Wang Y, An AY, Banker C, Qian YH, O\u2019Donnell JM. Single housing-induced effects on cognitive impairment and depression-like behavior in male and female mice involve neuroplasticity-related signaling. Eur J Neurosci. 2020;52:2694\u2013704.","journal-title":"Eur J Neurosci"},{"key":"2826_CR51","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.brainres.2015.11.006","volume":"1630","author":"M Ahern","year":"2016","unstructured":"Ahern M, Goodell DJ, Adams J, Bland ST. Brain regional differences in social encounter-induced Fos expression in male and female rats after post-weaning social isolation. Brain Res. 2016;1630:120\u201333.","journal-title":"Brain Res"},{"key":"2826_CR52","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.ynstr.2017.03.001","volume":"7","author":"JA Foster","year":"2017","unstructured":"Foster JA, Rinaman L, Cryan JF. Stress & the gut-brain axis: Regulation by the microbiome. Neurobiol Stress. 2017;7:124\u201336.","journal-title":"Neurobiol Stress"},{"key":"2826_CR53","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.2147\/JIR.S318327","volume":"14","author":"S Yang","year":"2021","unstructured":"Yang S, Yu M. Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity. J Inflamm Res. 2021;14:3171\u201383.","journal-title":"J Inflamm Res"},{"key":"2826_CR54","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.mucimm.2023.06.004","volume":"16","author":"M Taniguchi","year":"2023","unstructured":"Taniguchi M, Okumura R, Matsuzaki T, Nakatani A, Sakaki K, Okamoto S, et al. Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon. Mucosal Immunol. 2023;16:624\u201341.","journal-title":"Mucosal Immunol"},{"key":"2826_CR55","doi-asserted-by":"crossref","unstructured":"Gold A, Danguecan A, Belza C, So S, de Silva N, Avitzur Y, et al. Neurocognitive Functioning in Early School-age Children With Intestinal Failure. J Pediatr Gastroenterol Nutr. 2020;70:225\u201331.","DOI":"10.1097\/MPG.0000000000002500"},{"key":"2826_CR56","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-0716-3076-1_1","volume":"2650","author":"A Bonilla-Diaz","year":"2023","unstructured":"Bonilla-Diaz A, Ordonez-Moran P. Differentiated Epithelial Cells of the Gut. Methods Mol Biol. 2023;2650:3\u201316.","journal-title":"Methods Mol Biol"},{"key":"2826_CR57","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1126\/science.1065718","volume":"294","author":"Q Yang","year":"2001","unstructured":"Yang Q, Bermingham NA, Finegold MJ, Zoghbi HY. Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science. 2001;294:2155\u20138.","journal-title":"Science"},{"key":"2826_CR58","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1053\/j.gastro.2009.06.044","volume":"137","author":"A Gregorieff","year":"2009","unstructured":"Gregorieff A, Stange DE, Kujala P, Begthel H, van den Born M, Korving J, et al. The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium. Gastroenterology. 2009;137:1333\u201345.e1-3.","journal-title":"Gastroenterology"},{"key":"2826_CR59","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1176\/appi.ajp.2018.17121360","volume":"176","author":"N Tay","year":"2019","unstructured":"Tay N, Macare C, Liu Y, Ruggeri B, Jia T, Chu C, et al. Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse. Am J Psychiatry. 2019;176:146\u201355.","journal-title":"Am J Psychiatry"},{"key":"2826_CR60","doi-asserted-by":"publisher","first-page":"5393","DOI":"10.1016\/j.cell.2024.07.019","volume":"187","author":"H Chang","year":"2024","unstructured":"Chang H, Perkins MH, Novaes LS, Qian F, Zhang T, Neckel PH, et al. Stress-sensitive neural circuits change the gut microbiome via duodenal glands. Cell. 2024;187:5393\u2013412.e30.","journal-title":"Cell"},{"key":"2826_CR61","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-023-00468-3","volume":"9","author":"T Zhao","year":"2023","unstructured":"Zhao T, Zhang Y, Nan L, Zhu Q, Wang S, Xie Y, et al. Impact of structurally diverse polysaccharides on colonic mucin O-glycosylation and gut microbiota. NPJ Biofilms Microbiomes. 2023;9:97.","journal-title":"NPJ Biofilms Microbiomes"},{"key":"2826_CR62","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1084\/jem.20180448","volume":"216","author":"J Durack","year":"2019","unstructured":"Durack J, Lynch SV. The gut microbiome: Relationships with disease and opportunities for therapy. J Exp Med. 2019;216:20\u201340.","journal-title":"J Exp Med"},{"key":"2826_CR63","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/nrmicro3552","volume":"14","author":"GP Donaldson","year":"2016","unstructured":"Donaldson GP, Lee SM, Mazmanian SK. Gut biogeography of the bacterial microbiota. Nat Rev Microbiol. 2016;14:20\u201332.","journal-title":"Nat Rev Microbiol"},{"key":"2826_CR64","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3389\/fgene.2015.00081","volume":"6","author":"LE Tailford","year":"2015","unstructured":"Tailford LE, Crost EH, Kavanaugh D, Juge N. Mucin glycan foraging in the human gut microbiome. Front Genet. 2015;6:81.","journal-title":"Front Genet"},{"key":"2826_CR65","doi-asserted-by":"crossref","unstructured":"de la Rubia Orti JE, Moneti C, Serrano-Ballesteros P, Castellano G, Bayona-Babiloni R, Carriqui-Suarez AB, et al. Liposomal Epigallocatechin-3-Gallate for the Treatment of Intestinal Dysbiosis in Children with Autism Spectrum Disorder: A Comprehensive Review. Nutrients. 2023;15:3265.","DOI":"10.3390\/nu15143265"},{"key":"2826_CR66","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.1093\/gerona\/glaa056","volume":"75","author":"S Ahmadi","year":"2020","unstructured":"Ahmadi S, Razazan A, Nagpal R, Jain S, Wang B, Mishra SP, et al. Metformin Reduces Aging-Related Leaky Gut and Improves Cognitive Function by Beneficially Modulating Gut Microbiome\/Goblet Cell\/Mucin Axis. J Gerontol A Biol Sci Med Sci. 2020;75:e9\u2013e21.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2826_CR67","first-page":"5S","volume":"43","author":"T Arakawa","year":"1998","unstructured":"Arakawa T, Kobayashi K, Yoshikawa T, Tarnawski A. Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing. Dig Dis Sci. 1998;43:5S\u201313S.","journal-title":"Dig Dis Sci"},{"key":"2826_CR68","doi-asserted-by":"publisher","first-page":"3194","DOI":"10.1038\/s41380-023-02201-0","volume":"28","author":"M Sato","year":"2023","unstructured":"Sato M, Nakai N, Fujima S, Choe KY, Takumi T. Social circuits and their dysfunction in autism spectrum disorder. Mol Psychiatry. 2023;28:3194\u2013206.","journal-title":"Mol Psychiatry"},{"key":"2826_CR69","doi-asserted-by":"publisher","unstructured":"Tripathi A, Bartosh A, Mata J, Jacks C, Madeshiya AK, Hussein U, et al. Microglial type I interferon signaling mediates chronic stress-induced synapse loss and social behavior deficits. Mol Psychiatry. 2024. https:\/\/doi.org\/10.1038\/s41380-024-02675-6.","DOI":"10.1038\/s41380-024-02675-6"},{"key":"2826_CR70","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1002\/hbm.22239","volume":"35","author":"S Kuhn","year":"2014","unstructured":"Kuhn S, Gallinat J. Segregating cognitive functions within hippocampal formation: a quantitative meta-analysis on spatial navigation and episodic memory. Hum Brain Mapp. 2014;35:1129\u201342.","journal-title":"Hum Brain Mapp"},{"key":"2826_CR71","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/s41586-018-0191-2","volume":"558","author":"T Hainmueller","year":"2018","unstructured":"Hainmueller T, Bartos M. Parallel emergence of stable and dynamic memory engrams in the hippocampus. Nature. 2018;558:292\u20136.","journal-title":"Nature"},{"key":"2826_CR72","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-88397-z","volume":"11","author":"X Liu","year":"2021","unstructured":"Liu X, Zhao F, Liu H, Xie Y, Zhao D, Li C. Transcriptomics and metabolomics reveal the adaption of Akkermansia muciniphila to high mucin by regulating energy homeostasis. Sci Rep. 2021;11:9073.","journal-title":"Sci Rep"},{"key":"2826_CR73","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.bbi.2023.08.009","volume":"114","author":"MA Guzzardi","year":"2023","unstructured":"Guzzardi MA, La Rosa F, Granziera F, Panetta D, Pardo-Tendero M, Barone M, et al. Gut-derived metabolites mediating cognitive development in 5-year-old children: Early-life transplant in mice has lasting effects throughout adulthood. Brain Behav Immun. 2023;114:94\u2013110.","journal-title":"Brain Behav Immun"},{"key":"2826_CR74","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","volume":"19","author":"Y Fan","year":"2021","unstructured":"Fan Y, Pedersen O. Gut microbiota in human metabolic health and disease. Nat Rev Microbiol. 2021;19:55\u201371.","journal-title":"Nat Rev Microbiol"},{"key":"2826_CR75","doi-asserted-by":"publisher","first-page":"e114024","DOI":"10.1371\/journal.pone.0114024","volume":"9","author":"Y Iguchi","year":"2014","unstructured":"Iguchi Y, Kosugi S, Nishikawa H, Lin Z, Minabe Y, Toda S. Repeated exposure of adult rats to transient oxidative stress induces various long-lasting alterations in cognitive and behavioral functions. PLoS One. 2014;9:e114024.","journal-title":"PLoS One"},{"key":"2826_CR76","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.neurobiolaging.2007.09.006","volume":"30","author":"T Maurice","year":"2009","unstructured":"Maurice T, Hippert C, Serratrice N, Dubois G, Jacquet C, Antignac C, et al. Cystine accumulation in the CNS results in severe age-related memory deficits. Neurobiol Aging. 2009;30:987\u20131000.","journal-title":"Neurobiol Aging"},{"key":"2826_CR77","doi-asserted-by":"crossref","unstructured":"Grey MJ, De Luca H, Ward DV, Kreulen IA, Bugda Gwilt K, Foley SE, et al. The epithelial-specific ER stress sensor ERN2\/IRE1beta enables host-microbiota crosstalk to affect colon goblet cell development. J Clin Invest. 2022;132:e153519.","DOI":"10.1172\/JCI153519"},{"key":"2826_CR78","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1111\/j.1476-5381.1996.tb15218.x","volume":"117","author":"A Matton","year":"1996","unstructured":"Matton A, Engelborghs S, Bollengier F, Finne E, Vanhaeist L. Modulating effect of the nootropic drug, piracetam on stress- and subsequent morphine-induced prolactin secretion in male rats. Br J Pharmacol. 1996;117:502\u20136.","journal-title":"Br J Pharmacol"},{"key":"2826_CR79","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1007\/s00726-022-03144-6","volume":"54","author":"Y Su","year":"2022","unstructured":"Su Y, Hessou EP, Colombo E, Belletti G, Moussadik A, Lucas IT, et al. Crystalline structures of L-cysteine and L-cystine: a combined theoretical and experimental characterization. Amino Acids. 2022;54:1123\u201333.","journal-title":"Amino Acids"},{"key":"2826_CR80","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1177\/44.7.8675996","volume":"44","author":"KI Iida","year":"1996","unstructured":"Iida KI, Miyaishi O, Iwata Y, Kozaki KI, Matsuyama M, Saga S. Distinct distribution of protein disulfide isomerase family proteins in rat tissues. J Histochem Cytochem. 1996;44:751\u20139.","journal-title":"J Histochem Cytochem"},{"key":"2826_CR81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/prep.1994.1001","volume":"5","author":"R Noiva","year":"1994","unstructured":"Noiva R. Enzymatic catalysis of disulfide formation. Protein Expr Purif. 1994;5:1\u201313.","journal-title":"Protein Expr Purif"},{"key":"2826_CR82","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.bbr.2008.11.017","volume":"198","author":"O Dean","year":"2009","unstructured":"Dean O, Bush AI, Berk M, Copolov DL, van den Buuse M. Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice. Behav Brain Res. 2009;198:258\u201362.","journal-title":"Behav Brain Res"},{"key":"2826_CR83","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1093\/brain\/awu312","volume":"138","author":"P Mesci","year":"2015","unstructured":"Mesci P, Zaidi S, Lobsiger CS, Millecamps S, Escartin C, Seilhean D, et al. System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice. Brain. 2015;138:53\u201368.","journal-title":"Brain"},{"key":"2826_CR84","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/jnc.13411","volume":"136","author":"MR Minter","year":"2016","unstructured":"Minter MR, Taylor JM, Crack PJ. The contribution of neuroinflammation to amyloid toxicity in Alzheimer\u2019s disease. J Neurochem. 2016;136:457\u201374.","journal-title":"J Neurochem"},{"key":"2826_CR85","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s13238-018-0599-3","volume":"10","author":"N Zhou","year":"2019","unstructured":"Zhou N, Liu K, Sun Y, Cao Y, Yang J. Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition. Protein Cell. 2019;10:87\u2013103.","journal-title":"Protein Cell"},{"key":"2826_CR86","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28043-y","volume":"13","author":"B Cakir","year":"2022","unstructured":"Cakir B, Tanaka Y, Kiral FR, Xiang Y, Dagliyan O, Wang J, et al. Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids. Nat Commun. 2022;13:430.","journal-title":"Nat Commun"},{"key":"2826_CR87","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/nn.3318","volume":"16","author":"K Kierdorf","year":"2013","unstructured":"Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG, et al. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat Neurosci. 2013;16:273\u201380.","journal-title":"Nat Neurosci"},{"key":"2826_CR88","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1038\/s41596-020-00472-3","volume":"16","author":"A Nott","year":"2021","unstructured":"Nott A, Schlachetzki JCM, Fixsen BR, Glass CK. Nuclei isolation of multiple brain cell types for omics interrogation. Nat Protoc. 2021;16:1629\u201346.","journal-title":"Nat Protoc"},{"key":"2826_CR89","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1158\/0008-5472.CAN-12-2989","volume":"73","author":"K Belarbi","year":"2013","unstructured":"Belarbi K, Jopson T, Arellano C, Fike JR, Rosi S. CCR2 deficiency prevents neuronal dysfunction and cognitive impairments induced by cranial irradiation. Cancer Res. 2013;73:1201\u201310.","journal-title":"Cancer Res"},{"key":"2826_CR90","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2019.05.022","volume":"1719","author":"Y Sui","year":"2019","unstructured":"Sui Y, Zhang Y, Dong C, Xu B, Sun X. The small molecular CCR3 antagonist YM344031 attenuates neurodegenerative pathologies and improves learning and memory performance in a mouse model of Alzheimer\u2019s disease. Brain Res. 2019;1719:1\u201310.","journal-title":"Brain Res"},{"key":"2826_CR91","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.mcn.2007.08.017","volume":"37","author":"MP Quinones","year":"2008","unstructured":"Quinones MP, Kalkonde Y, Estrada CA, Jimenez F, Ramirez R, Mahimainathan L, et al. Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt. Mol Cell Neurosci. 2008;37:96\u2013109.","journal-title":"Mol Cell Neurosci"},{"key":"2826_CR92","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1002\/stem.1194","volume":"30","author":"H Long","year":"2012","unstructured":"Long H, Xie R, Xiang T, Zhao Z, Lin S, Liang Z, et al. Autocrine CCL5 signaling promotes invasion and migration of CD133+ ovarian cancer stem-like cells via NF-kappaB-mediated MMP-9 upregulation. Stem Cells. 2012;30:2309\u201319.","journal-title":"Stem Cells"},{"key":"2826_CR93","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1046\/j.1471-4159.2002.01091.x","volume":"82","author":"A Bajetto","year":"2002","unstructured":"Bajetto A, Bonavia R, Barbero S, Schettini G. Characterization of chemokines and their receptors in the central nervous system: physiopathological implications. J Neurochem. 2002;82:1311\u201329.","journal-title":"J Neurochem"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41380-024-02826-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-024-02826-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-024-02826-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T08:03:38Z","timestamp":1789113818000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-024-02826-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,29]]},"references-count":93,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["2826"],"URL":"https:\/\/doi.org\/10.1038\/s41380-024-02826-9","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,29]]},"assertion":[{"value":"22 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}