{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:37:13Z","timestamp":1788781033537,"version":"build-2803163510"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1038\/s41380-025-03026-9","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T14:04:57Z","timestamp":1746194697000},"page":"3175-3187","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Retinoic acid-mediated homeostatic plasticity drives cell type-specific CP-AMPAR accumulation in nucleus accumbens core and incubation of cocaine craving"],"prefix":"10.1038","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8199-9133","authenticated-orcid":false,"given":"Eun-Kyung","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2292-439X","authenticated-orcid":false,"given":"Amanda M.","family":"Wunsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9129-3432","authenticated-orcid":false,"given":"Marina E.","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"3026_CR1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/BF02245266","volume":"107","author":"RNRS Ehrman","year":"1992","unstructured":"Ehrman RNRS, Childress AR, O\u2019Brien CP. Conditioned responses to cocaine-related stimuli in cocaine abuse patients. Psychopharmacology (Berl). 1992;107:523\u2013520.","journal-title":"Psychopharmacology (Berl)"},{"issue":"Suppl 1","key":"3026_CR2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.neuropharm.2004.06.027","volume":"47","author":"L Lu","year":"2004","unstructured":"Lu L, Grimm JW, Hope BT, Shaham Y. Incubation of cocaine craving after withdrawal: a review of preclinical data. Neuropharmacology. 2004;47(Suppl 1):214\u201326.","journal-title":"Neuropharmacology"},{"key":"3026_CR3","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1001\/jamapsychiatry.2016.2181","volume":"73","author":"MA Parvaz","year":"2016","unstructured":"Parvaz MA, Moeller SJ, Goldstein RZ. Incubation of Cue-Induced craving in adults addicted to cocaine measured by electroencephalography. JAMA Psychiatry. 2016;73:1127\u201334.","journal-title":"JAMA Psychiatry"},{"key":"3026_CR4","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.tins.2011.06.001","volume":"34","author":"CL Pickens","year":"2011","unstructured":"Pickens CL, Airavaara M, Theberge F, Fanous S, Hope BT, Shaham Y. Neurobiology of the incubation of drug craving. Trends Neurosci. 2011;34:411\u201320.","journal-title":"Trends Neurosci"},{"key":"3026_CR5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nrn.2016.39","volume":"17","author":"ME Wolf","year":"2016","unstructured":"Wolf ME. Synaptic mechanisms underlying persistent cocaine craving. Nat Rev Neurosci. 2016;17:351\u201365.","journal-title":"Nat Rev Neurosci"},{"key":"3026_CR6","doi-asserted-by":"crossref","unstructured":"Chow JJ, Pitts, KM, Negishi, K, Madangopal, R, Dong, Y, Wolf, ME, et al. Neurobiology of the incubation of drug craving: an update. Pharmacol Rev. 2025;77:100022.","DOI":"10.1016\/j.pharmr.2024.100022"},{"key":"3026_CR7","first-page":"72","volume":"5","author":"ME Wolf","year":"2012","unstructured":"Wolf ME, Tseng KY. Calcium-permeable AMPA receptors in the VTA and nucleus accumbens after cocaine exposure: when, how, and why? Front Mol Neurosci. 2012;5:72.","journal-title":"Front Mol Neurosci"},{"key":"3026_CR8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev-pharmtox-061724-080548","volume":"65","author":"ME Wolf","year":"2025","unstructured":"Wolf ME. Targeting neuroplasticity in substance use disorders: implications for therapeutics. Annu Rev Pharmacol Toxicol. 2025;65:259\u201380.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"3026_CR9","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature06995","volume":"454","author":"KL Conrad","year":"2008","unstructured":"Conrad KL, Tseng KY, Uejima JL, Reimers JM, Heng LJ, Shaham Y, et al. Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving. Nature. 2008;454:118\u201321.","journal-title":"Nature"},{"key":"3026_CR10","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.neuron.2007.06.001","volume":"54","author":"JT Isaac","year":"2007","unstructured":"Isaac JT, Ashby MC, McBain CJ. The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity. Neuron. 2007;54:859\u201371.","journal-title":"Neuron"},{"key":"3026_CR11","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.conb.2006.05.012","volume":"16","author":"S Cull-Candy","year":"2006","unstructured":"Cull-Candy S, Kelly L, Farrant M. Regulation of Ca2+-permeable AMPA receptors: synaptic plasticity and beyond. Curr Opin Neurobiol. 2006;16:288\u201397.","journal-title":"Curr Opin Neurobiol"},{"key":"3026_CR12","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/nn.2763","volume":"14","author":"M Mameli","year":"2011","unstructured":"Mameli M, Bellone C, Brown MT, Luscher C. Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area. Nat Neurosci. 2011;14:414\u20136.","journal-title":"Nat Neurosci"},{"key":"3026_CR13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nn.3590","volume":"17","author":"JA Loweth","year":"2014","unstructured":"Loweth JA, Scheyer AF, Milovanovic M, LaCrosse AL, Flores-Barrera E, Werner CT, et al. Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving. Nat Neurosci. 2014;17:73\u201380.","journal-title":"Nat Neurosci"},{"key":"3026_CR14","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.biopsych.2022.05.008","volume":"92","author":"AB Kawa","year":"2022","unstructured":"Kawa AB, Hwang EK, Funke JR, Zhou H, Costa-Mattioli M, Wolf ME. Positive allosteric modulation of mGlu1 reverses cocaine-induced behavioral and synaptic plasticity through the integrated stress response and Oligophrenin-1. Biol Psychiatry. 2022;92:871\u20139.","journal-title":"Biol Psychiatry"},{"key":"3026_CR15","doi-asserted-by":"crossref","first-page":"a005736","DOI":"10.1101\/cshperspect.a005736","volume":"4","author":"G Turrigiano","year":"2012","unstructured":"Turrigiano G. Homeostatic synaptic plasticity: local and global mechanisms for stabilizing neuronal function. Cold Spring Harb Perspect Biol. 2012;4:a005736.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"3026_CR16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neuropharm.2012.12.004","volume":"78","author":"L Chen","year":"2014","unstructured":"Chen L, Lau AG, Sarti F. Synaptic retinoic acid signaling and homeostatic synaptic plasticity. Neuropharmacology. 2014;78:3\u201312.","journal-title":"Neuropharmacology"},{"key":"3026_CR17","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nrn2212","volume":"8","author":"M Maden","year":"2007","unstructured":"Maden M. Retinoic acid in the development, regeneration and maintenance of the nervous system. Nat Rev Neurosci. 2007;8:755\u201365.","journal-title":"Nat Rev Neurosci"},{"key":"3026_CR18","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.cell.2008.09.002","volume":"134","author":"G Duester","year":"2008","unstructured":"Duester G. Retinoic acid synthesis and signaling during early organogenesis. Cell. 2008;134:921\u201331.","journal-title":"Cell"},{"key":"3026_CR19","first-page":"119","volume":"9","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Kong F, Crofton EJ, Dragosljvich SN, Sinha M, Li D, et al. Transcriptomics of environmental enrichment reveals a role for retinoic acid signaling in addiction. Front Mol Neurosci. 2016;9:119.","journal-title":"Front Mol Neurosci"},{"key":"3026_CR20","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108398","volume":"183","author":"EJ Crofton","year":"2021","unstructured":"Crofton EJ, Nenov MN, Zhang Y, Tapia CM, Donnelly J, Koshy S, et al. Topographic transcriptomics of the nucleus accumbens shell: Identification and validation of fatty acid binding protein 5 as target for cocaine addiction. Neuropharmacology. 2021;183:108398.","journal-title":"Neuropharmacology"},{"key":"3026_CR21","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.biopsych.2018.04.009","volume":"84","author":"DM Walker","year":"2018","unstructured":"Walker DM, Cates HM, Loh YE, Purushothaman I, Ramakrishnan A, Cahill KM, et al. Cocaine self-administration alters transcriptome-wide responses in the Brain\u2019s reward circuitry. Biol Psychiatry. 2018;84:867\u201380.","journal-title":"Biol Psychiatry"},{"key":"3026_CR22","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.neuron.2023.02.013","volume":"111","author":"A Godino","year":"2023","unstructured":"Godino A, Salery M, Durand-de Cuttoli R, Estill MS, Holt LM, Futamura R, et al. Transcriptional control of nucleus accumbens neuronal excitability by retinoid X receptor alpha tunes sensitivity to drug rewards. Neuron. 2023;111:1453\u201367.","journal-title":"Neuron"},{"key":"3026_CR23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.brainres.2008.06.073","volume":"1227","author":"H Huang","year":"2008","unstructured":"Huang H, Wei H, Zhang X, Chen K, Li Y, Qu P, et al. Changes in the expression and subcellular localization of RARalpha in the rat hippocampus during postnatal development. Brain Res. 2008;1227:26\u201333.","journal-title":"Brain Res"},{"key":"3026_CR24","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.neuron.2008.08.012","volume":"60","author":"J Aoto","year":"2008","unstructured":"Aoto J, Nam CI, Poon MM, Ting P, Chen L. Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity. Neuron. 2008;60:308\u201320.","journal-title":"Neuron"},{"key":"3026_CR25","doi-asserted-by":"crossref","first-page":"16015","DOI":"10.1073\/pnas.0804801105","volume":"105","author":"B Maghsoodi","year":"2008","unstructured":"Maghsoodi B, Poon MM, Nam CI, Aoto J, Ting P, Chen L. Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity. Proc Natl Acad Sci USA. 2008;105:16015\u201320.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3026_CR26","doi-asserted-by":"crossref","first-page":"17764","DOI":"10.1523\/JNEUROSCI.3964-11.2011","volume":"31","author":"HL Wang","year":"2011","unstructured":"Wang HL, Zhang Z, Hintze M, Chen L. Decrease in calcium concentration triggers neuronal retinoic acid synthesis during homeostatic synaptic plasticity. J Neurosci. 2011;31:17764\u201371.","journal-title":"J Neurosci"},{"key":"3026_CR27","doi-asserted-by":"crossref","first-page":"E5744","DOI":"10.1073\/pnas.1510239112","volume":"112","author":"KL Arendt","year":"2015","unstructured":"Arendt KL, Zhang Z, Ganesan S, Hintze M, Shin MM, Tang Y, et al. Calcineurin mediates homeostatic synaptic plasticity by regulating retinoic acid synthesis. Proc Natl Acad Sci USA. 2015;112:E5744\u20135752.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3026_CR28","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/cr.2017.132","volume":"28","author":"X Xu","year":"2018","unstructured":"Xu X, Li C, Gao X, Xia K, Guo H, Li Y, et al. Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders. Cell Res. 2018;28:48\u201368.","journal-title":"Cell Res"},{"key":"3026_CR29","doi-asserted-by":"crossref","first-page":"20303","DOI":"10.1073\/pnas.0807740105","volume":"105","author":"MM Poon","year":"2008","unstructured":"Poon MM, Chen L. Retinoic acid-gated sequence-specific translational control by RARalpha. Proc Natl Acad Sci USA. 2008;105:20303\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3026_CR30","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fnmol.2012.00016","volume":"5","author":"F Sarti","year":"2012","unstructured":"Sarti F, Schroeder J, Aoto J, Chen L. Conditional RARalpha knockout mice reveal acute requirement for retinoic acid and RARalpha in homeostatic plasticity. Front Mol Neurosci. 2012;5:16.","journal-title":"Front Mol Neurosci"},{"key":"3026_CR31","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0163-19.2019","volume":"6","author":"JR Pettibone","year":"2019","unstructured":"Pettibone JR, Yu JY, Derman RC, Faust TW, Hughes ED, Filipiak WE, et al. Knock-in rat lines with cre recombinase at the dopamine D1 and adenosine 2a receptor loci. eNeuro. 2019;6:ENEURO.0163-19.2019.","journal-title":"eNeuro"},{"key":"3026_CR32","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0006-8993(03)03165-2","volume":"986","author":"AA Alcantara","year":"2003","unstructured":"Alcantara AA, Chen V, Herring BE, Mendenhall JM, Berlanga ML. Localization of dopamine D2 receptors on cholinergic interneurons of the dorsal striatum and nucleus accumbens of the rat. Brain Res. 2003;986:22\u201329.","journal-title":"Brain Res"},{"key":"3026_CR33","doi-asserted-by":"crossref","DOI":"10.1111\/adb.13237","volume":"27","author":"B Wong","year":"2022","unstructured":"Wong B, Zimbelman AR, Milovanovic M, Wolf ME, Stefanik MT. GluA2-lacking AMPA receptors in the nucleus accumbens core and shell contribute to the incubation of oxycodone craving in male rats. Addict Biol. 2022;27:e13237.","journal-title":"Addict Biol"},{"key":"3026_CR34","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1523\/JNEUROSCI.2412-17.2018","volume":"38","author":"CT Werner","year":"2018","unstructured":"Werner CT, Stefanik MT, Milovanovic M, Caccamise A, Wolf ME. Protein translation in the nucleus accumbens is dysregulated during cocaine withdrawal and required for expression of incubation of cocaine craving. J Neurosci. 2018;38:2683\u201397.","journal-title":"J Neurosci"},{"key":"3026_CR35","doi-asserted-by":"crossref","first-page":"14536","DOI":"10.1523\/JNEUROSCI.3625-11.2011","volume":"31","author":"JE McCutcheon","year":"2011","unstructured":"McCutcheon JE, Loweth JA, Ford KA, Marinelli M, Wolf ME, Tseng KY. Group I mGluR activation reverses cocaine-induced accumulation of calcium-permeable AMPA receptors in nucleus accumbens synapses via a protein kinase C-dependent mechanism. J Neurosci. 2011;31:14536\u201341.","journal-title":"J Neurosci"},{"key":"3026_CR36","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0480-22.2023","volume":"10","author":"JR Funke","year":"2023","unstructured":"Funke JR, Hwang EK, Wunsch AM, Baker R, Engeln KA, Murray CH, et al. Persistent neuroadaptations in the nucleus accumbens core accompany incubation of methamphetamine craving in male and female rats. eNeuro. 2023;10:ENEURO.0480-22.2023.","journal-title":"eNeuro"},{"key":"3026_CR37","doi-asserted-by":"publisher","unstructured":"Kawa AB, Hashimoto JG, Beutler MM, Guizzetti M, Wolf ME. Changes in nucleus accumbens core translatome accompanying incubation of cocaine craving. Neuropsychopharmacology. 2025. Available from: https:\/\/doi.org\/10.1038\/s41386-025-02112-4.","DOI":"10.1038\/s41386-025-02112-4"},{"key":"3026_CR38","doi-asserted-by":"crossref","first-page":"9144","DOI":"10.1523\/JNEUROSCI.2252-05.2005","volume":"25","author":"AC Boudreau","year":"2005","unstructured":"Boudreau AC, Wolf ME. Behavioral sensitization to cocaine is associated with increased AMPA receptor surface expression in the nucleus accumbens. J Neurosci. 2005;25:9144\u201351.","journal-title":"J Neurosci"},{"key":"3026_CR39","first-page":"17","volume":"5","author":"HK Lee","year":"2012","unstructured":"Lee HK. Ca-permeable AMPA receptors in homeostatic synaptic plasticity. Front Mol Neurosci. 2012;5:17.","journal-title":"Front Mol Neurosci"},{"key":"3026_CR40","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1523\/JNEUROSCI.4940-13.2014","volume":"34","author":"AF Scheyer","year":"2014","unstructured":"Scheyer AF, Wolf ME, Tseng KY. A protein synthesis-dependent mechanism sustains calcium-permeable AMPA receptor transmission in nucleus accumbens synapses during withdrawal from cocaine self-administration. J Neurosci. 2014;34:3095\u20133100.","journal-title":"J Neurosci"},{"key":"3026_CR41","doi-asserted-by":"crossref","first-page":"10454","DOI":"10.1523\/JNEUROSCI.1133-18.2018","volume":"38","author":"LR Zhong","year":"2018","unstructured":"Zhong LR, Chen X, Park E, Sudhof TC, Chen L. Retinoic acid receptor RARalpha-dependent synaptic signaling mediates homeostatic synaptic plasticity at the inhibitory synapses of mouse visual cortex. J Neurosci. 2018;38:10454\u201366.","journal-title":"J Neurosci"},{"key":"3026_CR42","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1523\/JNEUROSCI.3028-17.2018","volume":"38","author":"E Park","year":"2018","unstructured":"Park E, Tjia M, Zuo Y, Chen L. Postnatal ablation of synaptic retinoic acid signaling impairs cortical information processing and sensory discrimination in mice. J Neurosci. 2018;38:5277\u201388.","journal-title":"J Neurosci"},{"key":"3026_CR43","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1016\/j.neuron.2022.09.027","volume":"110","author":"B Cao","year":"2022","unstructured":"Cao B, Scherrer G, Chen L. Spinal cord retinoic acid receptor signaling gates mechanical hypersensitivity in neuropathic pain. Neuron. 2022;110:4108\u20134124.e6.","journal-title":"Neuron"},{"key":"3026_CR44","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109918","volume":"37","author":"K Suzuki","year":"2021","unstructured":"Suzuki K, Kim JW, Nosyreva E, Kavalali ET, Monteggia LM. Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action. Cell Rep. 2021;37:109918.","journal-title":"Cell Rep"},{"key":"3026_CR45","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.1073\/pnas.1820690116","volume":"116","author":"YT Hsu","year":"2019","unstructured":"Hsu YT, Li J, Wu D, Sudhof TC, Chen L. Synaptic retinoic acid receptor signaling mediates mTOR-dependent metaplasticity that controls hippocampal learning. Proc Natl Acad Sci USA. 2019;116:7113\u201322.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3026_CR46","volume":"10","author":"M Lenz","year":"2021","unstructured":"Lenz M, Kruse P, Eichler A, Straehle J, Beck J, Deller T, et al. All-trans retinoic acid induces synaptic plasticity in human cortical neurons. eLife. 2021;10:e63026.","journal-title":"eLife"},{"key":"3026_CR47","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/JES.0b013e3182798a95","volume":"41","author":"CA Goodman","year":"2013","unstructured":"Goodman CA, Hornberger TA. Measuring protein synthesis with SUnSET: a valid alternative to traditional techniques? Exerc Sport Sci Rev. 2013;41:107\u201315.","journal-title":"Exerc Sport Sci Rev"},{"key":"3026_CR48","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.biopsych.2018.02.012","volume":"84","author":"MT Stefanik","year":"2018","unstructured":"Stefanik MT, Milovanovic M, Werner CT, Spainhour JCG, Wolf ME. Withdrawal from cocaine self-administration alters the regulation of protein translation in the nucleus accumbens. Biol Psychiatry. 2018;84:223\u201332.","journal-title":"Biol Psychiatry"},{"key":"3026_CR49","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1111\/ejn.14151","volume":"50","author":"JA Loweth","year":"2019","unstructured":"Loweth JA, Reimers JM, Caccamise A, Stefanik MT, Woo KKY, Chauhan NM, et al. mGlu1 tonically regulates levels of calcium-permeable AMPA receptors in cultured nucleus accumbens neurons through retinoic acid signaling and protein translation. Eur J Neurosci. 2019;50:2590\u2013601.","journal-title":"Eur J Neurosci"},{"key":"3026_CR50","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba4221","volume":"6","author":"KE Savell","year":"2020","unstructured":"Savell KE, Tuscher JJ, Zipperly ME, Duke CG, Phillips RA 3rd, Bauman AJ, et al. A dopamine-induced gene expression signature regulates neuronal function and cocaine response. Sci Adv. 2020;6:eaba4221.","journal-title":"Sci Adv"},{"key":"3026_CR51","volume":"125","author":"RA Phillips 3rd","year":"2023","unstructured":"Phillips RA 3rd, Tuscher JJ, Fitzgerald ND, Wan E, Zipperly ME, Duke CG, et al. Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine. Mol Cell Neurosci. 2023;125:103849.","journal-title":"Mol Cell Neurosci"},{"key":"3026_CR52","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1038\/s41593-021-00938-x","volume":"24","author":"R Chen","year":"2021","unstructured":"Chen R, Blosser TR, Djekidel MN, Hao J, Bhattacherjee A, Chen W, et al. Decoding molecular and cellular heterogeneity of mouse nucleus accumbens. Nat Neurosci. 2021;24:1757\u201371.","journal-title":"Nat Neurosci"},{"key":"3026_CR53","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.biopsych.2018.04.019","volume":"84","author":"C Barrientos","year":"2018","unstructured":"Barrientos C, Knowland D, Wu MMJ, Lilascharoen V, Huang KW, Malenka RC, et al. Cocaine-induced structural plasticity in input regions to distinct cell types in nucleus accumbens. Biol Psychiatry. 2018;84:893\u2013904.","journal-title":"Biol Psychiatry"},{"key":"3026_CR54","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3389\/fnana.2018.00084","volume":"12","author":"Z Li","year":"2018","unstructured":"Li Z, Chen Z, Fan G, Li A, Yuan J, Xu T. Cell-type-specific afferent innervation of the nucleus accumbens core and shell. Front Neuroanat. 2018;12:84.","journal-title":"Front Neuroanat"},{"key":"3026_CR55","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neuron.2017.09.019","volume":"96","author":"DA Burke","year":"2017","unstructured":"Burke DA, Rotstein HG, Alvarez VA. Striatal local circuitry: a new framework for lateral inhibition. Neuron. 2017;96:267\u201384.","journal-title":"Neuron"},{"key":"3026_CR56","doi-asserted-by":"crossref","DOI":"10.3389\/fnsyn.2021.799274","volume":"13","author":"MC Allichon","year":"2021","unstructured":"Allichon MC, Ortiz V, Pousinha P, Andrianarivelo A, Petitbon A, Heck N, et al. Cell-type-specific adaptions in striatal medium-sized spiny neurons and their roles in behavioral responses to drugs of abuse. Front Synaptic Neurosci. 2021;13:799274.","journal-title":"Front Synaptic Neurosci"},{"key":"3026_CR57","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.brainres.2018.10.009","volume":"1713","author":"S Bariselli","year":"2019","unstructured":"Bariselli S, Fobbs WC, Creed MC, Kravitz AV. A competitive model for striatal action selection. Brain Res. 2019;1713:70\u201379.","journal-title":"Brain Res"},{"key":"3026_CR58","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1002\/1873-3468.14727","volume":"597","author":"AV Domingues","year":"2023","unstructured":"Domingues AV, Rodrigues AJ, Soares-Cunha C. A novel perspective on the role of nucleus accumbens neurons in encoding associative learning. FEBS Lett. 2023;597:2601\u201310.","journal-title":"FEBS Lett"},{"key":"3026_CR59","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.1523\/JNEUROSCI.1039-08.2008","volume":"28","author":"J Bertran-Gonzalez","year":"2008","unstructured":"Bertran-Gonzalez J, Bosch C, Maroteaux M, Matamales M, Herve D, Valjent E, et al. Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol. J Neurosci. 2008;28:5671\u201385.","journal-title":"J Neurosci"},{"key":"3026_CR60","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fnana.2014.00014","volume":"8","author":"RJ Oude Ophuis","year":"2014","unstructured":"Oude Ophuis RJ, Boender AJ, van Rozen AJ, Adan RA. Cannabinoid, melanocortin and opioid receptor expression on DRD1 and DRD2 subpopulations in rat striatum. Front Neuroanat. 2014;8:14.","journal-title":"Front Neuroanat"},{"key":"3026_CR61","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.neuron.2014.08.023","volume":"83","author":"YY Ma","year":"2014","unstructured":"Ma YY, Lee BR, Wang X, Guo C, Liu L, Cui R, et al. Bidirectional modulation of incubation of cocaine craving by silent synapse-based remodeling of prefrontal cortex to accumbens projections. Neuron. 2014;83:1453\u201367.","journal-title":"Neuron"},{"key":"3026_CR62","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/syn.890140110","volume":"14","author":"RP Hammer Jr","year":"1993","unstructured":"Hammer RP Jr, Pires WS, Markou A, Koob GF. Withdrawal following cocaine self-administration decreases regional cerebral metabolic rate in critical brain reward regions. Synapse. 1993;14:73\u201380.","journal-title":"Synapse"},{"key":"3026_CR63","doi-asserted-by":"crossref","first-page":"8004","DOI":"10.1523\/JNEUROSCI.1413-06.2006","volume":"26","author":"W Sun","year":"2006","unstructured":"Sun W, Rebec GV. Repeated cocaine self-administration alters processing of cocaine-related information in rat prefrontal cortex. J Neurosci. 2006;26:8004\u20138.","journal-title":"J Neurosci"},{"key":"3026_CR64","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1038\/npp.2011.129","volume":"36","author":"A Gozzi","year":"2011","unstructured":"Gozzi A, Tessari M, Dacome L, Agosta F, Lepore S, Lanzoni A, et al. Neuroimaging evidence of altered fronto-cortical and striatal function after prolonged cocaine self-administration in the rat. Neuropsychopharmacology. 2011;36:2431\u201340.","journal-title":"Neuropsychopharmacology"},{"key":"3026_CR65","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s00213-003-1676-7","volume":"172","author":"DJ Macey","year":"2004","unstructured":"Macey DJ, Rice WN, Freedland CS, Whitlow CT, Porrino LJ. Patterns of functional activity associated with cocaine self-administration in the rat change over time. Psychopharmacology (Berl). 2004;172:384\u201392.","journal-title":"Psychopharmacology (Berl)"},{"key":"3026_CR66","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1089\/brain.2014.0264","volume":"4","author":"H Lu","year":"2014","unstructured":"Lu H, Zou Q, Chefer S, Ross TJ, Vaupel DB, Guillem K, et al. Abstinence from cocaine and sucrose self-administration reveals altered mesocorticolimbic circuit connectivity by resting state MRI. Brain Connect. 2014;4:499\u2013510.","journal-title":"Brain Connect"},{"key":"3026_CR67","doi-asserted-by":"crossref","DOI":"10.1016\/j.addicn.2023.100097","volume":"7","author":"ML Ngbokoli","year":"2023","unstructured":"Ngbokoli ML, Douton JE, Carelli RM. Prelimbic cortex and nucleus accumbens core resting state signaling dynamics as a biomarker for cocaine seeking behaviors. Addict Neurosci. 2023;7:100097.","journal-title":"Addict Neurosci"},{"key":"3026_CR68","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1038\/npp.2017.109","volume":"42","author":"C Nicolas","year":"2017","unstructured":"Nicolas C, Tauber C, Lepelletier FX, Chalon S, Belujon P, Galineau L, et al. Longitudinal changes in brain metabolic activity after withdrawal from escalation of cocaine self-administration. Neuropsychopharmacology. 2017;42:1981\u201390.","journal-title":"Neuropsychopharmacology"},{"key":"3026_CR69","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-76182-3","volume":"10","author":"N Cannella","year":"2020","unstructured":"Cannella N, Cosa-Linan A, Takahashi T, Weber-Fahr W, Spanagel R. Cocaine addicted rats show reduced neural activity as revealed by manganese-enhanced MRI. Sci Rep. 2020;10:19353.","journal-title":"Sci Rep"},{"key":"3026_CR70","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1111\/ejn.12381","volume":"38","author":"ES Calipari","year":"2013","unstructured":"Calipari ES, Beveridge TJ, Jones SR, Porrino LJ. Withdrawal from extended-access cocaine self-administration results in dysregulated functional activity and altered locomotor activity in rats. Eur J Neurosci. 2013;38:3749\u201357.","journal-title":"Eur J Neurosci"},{"key":"3026_CR71","doi-asserted-by":"crossref","first-page":"8262","DOI":"10.1523\/JNEUROSCI.0406-21.2021","volume":"41","author":"DT Christian","year":"2021","unstructured":"Christian DT, Stefanik MT, Bean LA, Loweth JA, Wunsch AM, Funke JR, et al. GluN3-containing NMDA receptors in the rat nucleus accumbens core contribute to incubation of cocaine craving. J Neurosci. 2021;41:8262\u201377.","journal-title":"J Neurosci"},{"key":"3026_CR72","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pneurobio.2010.01.004","volume":"91","author":"MA Henson","year":"2010","unstructured":"Henson MA, Roberts AC, Perez-Otano I, Philpot BD. Influence of the NR3A subunit on NMDA receptor functions. Prog Neurobiol. 2010;91:23\u201337.","journal-title":"Prog Neurobiol"},{"key":"3026_CR73","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.tins.2011.11.010","volume":"35","author":"S Pachernegg","year":"2012","unstructured":"Pachernegg S, Strutz-Seebohm N, Hollmann M. GluN3 subunit-containing NMDA receptors: not just one-trick ponies. Trends Neurosci. 2012;35:240\u20139.","journal-title":"Trends Neurosci"},{"key":"3026_CR74","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn3504","volume":"14","author":"P Paoletti","year":"2013","unstructured":"Paoletti P, Bellone C, Zhou Q. NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease. Nat Rev Neurosci. 2013;14:383\u2013400.","journal-title":"Nat Rev Neurosci"},{"key":"3026_CR75","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrn.2016.92","volume":"17","author":"I Perez-Otano","year":"2016","unstructured":"Perez-Otano I, Larsen RS, Wesseling JF. Emerging roles of GluN3-containing NMDA receptors in the CNS. Nat Rev Neurosci. 2016;17:623\u201335.","journal-title":"Nat Rev Neurosci"},{"key":"3026_CR76","doi-asserted-by":"crossref","first-page":"e40898","DOI":"10.1371\/journal.pone.0040898","volume":"7","author":"CR Ferrario","year":"2012","unstructured":"Ferrario CR, Goussakov I, Stutzmann GE, Wolf ME. Withdrawal from cocaine self-administration alters NMDA receptor-mediated Ca2+ entry in nucleus accumbens dendritic spines. PLoS ONE. 2012;7:e40898.","journal-title":"PLoS ONE"},{"key":"3026_CR77","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1098\/rstb.2008.2270","volume":"363","author":"M Kano","year":"2008","unstructured":"Kano M, Hashimoto K, Tabata T. Type-1 metabotropic glutamate receptor in cerebellar Purkinje cells: a key molecule responsible for long-term depression, endocannabinoid signalling and synapse elimination. Philos Trans R Soc Lond B Biol Sci. 2008;363:2173\u201386.","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"3026_CR78","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.tins.2010.06.003","volume":"33","author":"ME Wolf","year":"2010","unstructured":"Wolf ME. The bermuda triangle of cocaine-induced neuroadaptations. Trends Neurosci. 2010;33:391\u20138.","journal-title":"Trends Neurosci"},{"key":"3026_CR79","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbr.2010.07.039","volume":"216","author":"YH Huang","year":"2011","unstructured":"Huang YH, Schluter OM, Dong Y. Cocaine-induced homeostatic regulation and dysregulation of nucleus accumbens neurons. Behav Brain Res. 2011;216:9\u201318.","journal-title":"Behav Brain Res"},{"key":"3026_CR80","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nrn3877","volume":"16","author":"S Kourrich","year":"2015","unstructured":"Kourrich S, Calu DJ, Bonci A. Intrinsic plasticity: an emerging player in addiction. Nat Rev Neurosci. 2015;16:173\u201384.","journal-title":"Nat Rev Neurosci"},{"key":"3026_CR81","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1523\/JNEUROSCI.3291-17.2018","volume":"38","author":"J Wang","year":"2018","unstructured":"Wang J, Ishikawa M, Yang Y, Otaka M, Kim JY, Gardner GR, et al. Cascades of homeostatic dysregulation promote incubation of cocaine craving. J Neurosci. 2018;38:4316\u201328.","journal-title":"J Neurosci"},{"key":"3026_CR82","doi-asserted-by":"crossref","first-page":"9275","DOI":"10.1523\/JNEUROSCI.1559-21.2021","volume":"41","author":"WJ Wright","year":"2021","unstructured":"Wright WJ, Dong Y. Silent synapses in cocaine-associated memory and beyond. J Neurosci. 2021;41:9275\u201385.","journal-title":"J Neurosci"},{"key":"3026_CR83","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/s41386-023-01580-w","volume":"48","author":"Y He","year":"2023","unstructured":"He Y, Wang J, Li KL, Wang YQ, Freyberg Z, Dong Y. Membrane excitability of nucleus accumbens neurons gates the incubation of cocaine craving. Neuropsychopharmacology. 2023;48:1318\u201327.","journal-title":"Neuropsychopharmacology"},{"key":"3026_CR84","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1038\/npp.2016.52","volume":"41","author":"PA Neumann","year":"2016","unstructured":"Neumann PA, Wang Y, Yan Y, Wang Y, Ishikawa M, Cui R, et al. Cocaine-induced synaptic alterations in thalamus to nucleus accumbens projection. Neuropsychopharmacology. 2016;41:2399\u2013410.","journal-title":"Neuropsychopharmacology"},{"key":"3026_CR85","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1523\/JNEUROSCI.1907-22.2022","volume":"43","author":"EE Boxer","year":"2023","unstructured":"Boxer EE, Kim J, Dunn B, Aoto J. Ventral subiculum inputs to nucleus accumbens medial shell preferentially innervate D2R medium spiny neurons and contain calcium permeable AMPARs. J Neurosci. 2023;43:1166\u201377.","journal-title":"J Neurosci"},{"key":"3026_CR86","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/nn.3533","volume":"16","author":"BR Lee","year":"2013","unstructured":"Lee BR, Ma YY, Huang YH, Wang X, Otaka M, Ishikawa M, et al. Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving. Nat Neurosci. 2013;16:1644\u201351.","journal-title":"Nat Neurosci"},{"key":"3026_CR87","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nature13257","volume":"509","author":"V Pascoli","year":"2014","unstructured":"Pascoli V, Terrier J, Espallergues J, Valjent E, O\u2019Connor EC, Luscher C. Contrasting forms of cocaine-evoked plasticity control components of relapse. Nature. 2014;509:459\u201364.","journal-title":"Nature"},{"key":"3026_CR88","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/npp.2015.345","volume":"41","author":"J Terrier","year":"2015","unstructured":"Terrier J, Luscher C, Pascoli V. Cell-type specific insertion of GluA2-lacking AMPARs with cocaine exposure leading to sensitization, cue-induced seeking, and incubation of craving. Neuropsychopharmacology. 2015;41:1779\u201389.","journal-title":"Neuropsychopharmacology"},{"key":"3026_CR89","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1007\/s00213-024-06612-x","volume":"241","author":"AM Wunsch","year":"2024","unstructured":"Wunsch AM, Hwang EK, Funke JR, Baker R, Moutier A, Milovanovic M, et al. Retinoic acid-mediated homeostatic plasticity in the nucleus accumbens core contributes to incubation of cocaine craving. Psychopharmacology (Berl). 2024;241:1983\u20132001.","journal-title":"Psychopharmacology (Berl)"},{"key":"3026_CR90","volume":"10","author":"GL Powell","year":"2020","unstructured":"Powell GL, Vannan A, Bastle RM, Wilson MA, Dell\u2019Orco M, Perrone-Bizzozero NI, et al. Environmental enrichment during forced abstinence from cocaine self-administration opposes gene network expression changes associated with the incubation effect. Sci Rep. 2020;10:11291.","journal-title":"Sci Rep"},{"key":"3026_CR91","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2021.108585","volume":"221","author":"A Vannan","year":"2021","unstructured":"Vannan A, Powell GL, Dell\u2019Orco M, Wilson MA, Perrone-Bizzozero NI, Neisewander JL. microRNA regulation related to the protective effects of environmental enrichment against cocaine-seeking behavior. Drug Alcohol Depend. 2021;221:108585.","journal-title":"Drug Alcohol Depend"},{"key":"3026_CR92","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neulet.2010.12.036","volume":"490","author":"CR Ferrario","year":"2011","unstructured":"Ferrario CR, Loweth JA, Milovanovic M, Wang X, Wolf ME. Distribution of AMPA receptor subunits and TARPs in synaptic and extrasynaptic membranes of the adult rat nucleus accumbens. Neurosci Lett. 2011;490:180\u20134.","journal-title":"Neurosci Lett"},{"key":"3026_CR93","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.neuropharm.2011.01.021","volume":"61","author":"CR Ferrario","year":"2011","unstructured":"Ferrario CR, Loweth JA, Milovanovic M, Ford KA, Galinanes GL, Heng LJ, et al. Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca2+-permeable AMPA receptors during the incubation of cocaine craving. Neuropharmacology. 2011;61:1141\u201351.","journal-title":"Neuropharmacology"},{"key":"3026_CR94","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41386-024-02030-x","volume":"50","author":"X Liu","year":"2025","unstructured":"Liu X, Huang Y, Mu L, Friedman V, Kelly TJ, Hu Y, et al. Epac2-mediated synaptic insertion of Ca2+-permeable AMPARs in the nucleus accumbens contributes to incubation of cocaine craving. Neuropsychopharmacology. 2025;50:620\u20139.","journal-title":"Neuropsychopharmacology"},{"key":"3026_CR95","doi-asserted-by":"crossref","first-page":"11440","DOI":"10.1523\/JNEUROSCI.1710-13.2013","volume":"33","author":"F Sarti","year":"2013","unstructured":"Sarti F, Zhang Z, Schroeder J, Chen L. Rapid suppression of inhibitory synaptic transmission by retinoic acid. J Neurosci. 2013;33:11440\u201350.","journal-title":"J Neurosci"},{"key":"3026_CR96","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.conb.2018.08.010","volume":"54","author":"J Li","year":"2019","unstructured":"Li J, Park E, Zhong LR, Chen L. Homeostatic synaptic plasticity as a metaplasticity mechanism - a molecular and cellular perspective. Curr Opin Neurobiol. 2019;54:44\u201353.","journal-title":"Curr Opin Neurobiol"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41380-025-03026-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-025-03026-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-025-03026-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T02:59:36Z","timestamp":1750647576000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-025-03026-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,2]]},"references-count":96,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["3026"],"URL":"https:\/\/doi.org\/10.1038\/s41380-025-03026-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.09.12.611703","asserted-by":"object"}]},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,2]]},"assertion":[{"value":"13 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Dr. Wolf and OHSU have a financial interest in Eleutheria Pharmaceuticals LLC, a company that may have a commercial interest in results related to the research described herein. This potential conflict of interest has been reviewed and managed by Oregon Health & Science University. The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Studies were performed in accordance with the relevant guidelines and regulations. All animal experiments and procedures were approved by the Institutional Animal Care and Use Committee of Oregon Health & Science University (protocol number TR03_IP00001792).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}