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The proteomics data were submitted to MassIVE (accession number MSV000095679) and ProteomeXchange (accession number PXD055114).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data sharing statement"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The generation of the mutant, using CRISPR\/Cas9 technology, was performed with the ethical approval of the Italian Ministry of Health (approval n\u00b0 584\/2019-PR), in accordance with the European Union\u2019s Directive 2010\/63\/EU on the protection of animals used for scientific purposes, under the supervision of the University of Pisa Animal Care and Use Committee, and in compliance with the 3R principles.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}}]}}