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All subjects gave their written consent before sample extraction. Informed consent was obtained from all individual participants included in the study. The corresponding Human Research Ethics Committee from University Cruces Hospital, Comit\u00e9 de \u00c9tica en la Investigaci\u00f3n (CEI) OSI Ezkeraldea-Enkarterri-Cruces approved the entire procedure with the code CEI E22 \/27.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}