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S.I. also serves as the President of the Institute for Research on Productive Aging (Japan) and a co-CEO of LongGen Bioscience (Japan). S.I.\u2019s External Professional Activities (EPAs) have already been reported to, and a potential conflict of interest has been properly resolved through the Washington University Conflict of Interest Committee. The other authors have no Competing Financial or Non-Financial Interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All animal procedures, including the ones on live animals, were approved by the Washington University Institutional Animal Care and Use Committee (WU IACUC) and were in accordance with National Institutes of Health guidelines. The animal protocol numbers approved by WU IACUC were 22-0007 and 24-0384 for the Imai lab and 20-0139 and 23-0261 for the McCall lab. This study did not involve any human subjects, and therefore no informed consent for publication is necessary.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}