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Professor Ole A Andreassen has received personal fees from Lundbeck and Sunovion and has served as a consultant for Cortechs.ai. Dr Inmaculada Baeza has received personal fees from Angelini Pharma, Janssen Pharmaceuticals, and Otsuka-Lundbeck. Professor Bj\u00f8rn H. Ebdrup is part of the Advisory Board of Boehringer Ingelheim, Lundbeck Pharma, and Orion Pharma; and has received lecture fees from Boehringer Ingelheim, Otsuka Pharma Scandinavia AB, and Lundbeck Pharma. Professor Paolo Fusar-Poli received grants from Lundbeck; personal fees from Angelini Pharma and Menarini Group; and nonfinancial support from Boehringer Ingelheim. Professor Birte Yding Glenth\u00f8j has been the leader of a Lundbeck Foundation Centre of Excellence for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) (January 2009 \u2013 December 2021), which was partially financed by an independent grant from the Lundbeck Foundation based on international review and partially financed by the Mental Health Services in the Capital Region of Denmark, the University of Copenhagen, and other foundations. All grants are the property of the Mental Health Services in the Capital Region of Denmark and administrated by them. Dr Louise Birkedal Glenth\u00f8j has received support from the TrygFoundation; the Danish Research Council on Independent Research; the Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS. Professor Kiyoto Kasai has received grants from Novartis, Astellas, Merck Sharp and Dohme, Eli Lily and Company, Dainippon-Sumitomo Corporation, Eisai, Otsuka, Shionogi, Ono, Tanabe-Mitsubishi, and Takeda; personal fees from Otsuka, Fuji-Film, Yoshitomi, Kyowa, Janssen Pharmaceuticals, Astellas, Meiji Seika Pharma, Sumitomo Dainippon Pharma, and Takeda; and serves on the funding committees of Takeda Science Foundation and Astellas. Dr Shinsuke Koike has received grants from Agency for Medical Research and Development, Japan Society for the Promotion of Science, the Naito Foundation, and Takeda Science Foundation. Professor Daniel H Mathalon has served as a consultant to Boehringer Ingelheim and Neurocrine. Professor Takahiro Nemoto has received personal fees from Astellas, Eisai, Janssen Pharmaceuticals, Meiji Seika Pharma, Sumitomo Dainippon Pharma, and Takeda. Professor Christos Pantelis has received honoraria for talks at educational meetings and has served on an advisory board for Lundbeck, Australia Pty Ltd.. Dr Francisco Reyes-Madrigal has received speaker fees from Janssen (Johnson & Johnson). Professor Wulf R\u00f6ssler is supported by the Zurich Program for Sustainable Development of Mental Health Services (ZInEP). The donor had no further role in the experimental design, collection, analysis, interpretation of data, writing, and submitting this article for publication. Professor Michio Suzuki had received personal fees from Nakagawa Hospital. Professor Peter J Uhlhaas has received grants from Lundbeck and Eli Lilly UK. Professor Paul M Thompson receives partial research support from Biogen, Inc., for research unrelated to this manuscript. Dr Jimmy Lee has received grants from the Singapore Ministry of Health\u2019s National Medical Research Council; honoraria from Otsuka Pharmaceuticals, Sumitomo Pharmaceuticals, Lundbeck Singapore and Janssen Pharmaceuticals. Other authors have no conflict of interest to declare that are relevant to the content of this article.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All methods were performed in accordance with the relevant guidelines and regulations. All 31 sites obtained local institutional review board approval. The Institutional Review Board (IRB) at the Boston Children\u2019s Hospital also approved the ENIGMA-CHR Repository (IRB-P00043549). Written informed consent was obtained from every participant, or from the participant\u2019s guardian for minors. All studies were conducted in accordance with the Declaration of Helsinki [\n                      \n                      ].","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}