{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:42:51Z","timestamp":1793763771506,"version":"4.6.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["24AARFD-1243899"],"award-info":[{"award-number":["24AARFD-1243899"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARFD-22-923814"],"award-info":[{"award-number":["AARFD-22-923814"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARFD-23-1150249"],"award-info":[{"award-number":["AARFD-23-1150249"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARFD-24-1313939"],"award-info":[{"award-number":["AARFD-24-1313939"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["24AACSF-1200375"],"award-info":[{"award-number":["24AACSF-1200375"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARFD-22-974627"],"award-info":[{"award-number":["AARFD-22-974627"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.951210\/2024-00"],"award-info":[{"award-number":["88887.951210\/2024-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"McGill University Faculty of Medicine student fellowship, and the Colin J Adair foundation fellowship"},{"DOI":"10.13039\/100000049","name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["5R01AG073267"],"award-info":[{"award-number":["5R01AG073267"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["5R01AG075336"],"award-info":[{"award-number":["5R01AG075336"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1038\/s41380-025-03400-7","type":"journal-article","created":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T05:18:12Z","timestamp":1765689492000},"page":"2472-2480","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["In vivo-measured Lewy body pathology is associated with neuropsychiatric symptoms across the Alzheimer\u2019s disease continuum"],"prefix":"10.1038","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4890-8451","authenticated-orcid":false,"given":"Douglas Teixeira","family":"Leffa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Povala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2134-9829","authenticated-orcid":false,"given":"Pamela C. L.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2183-1551","authenticated-orcid":false,"given":"Jo\u00e3o Pedro","family":"Ferrari-Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Bauer-Negrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Scarpatto","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4488-763X","authenticated-orcid":false,"given":"Livia","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firoza Z.","family":"Lussier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4237-4565","authenticated-orcid":false,"given":"Marina Scop","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2338-4495","authenticated-orcid":false,"given":"Carolina","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7378-3830","authenticated-orcid":false,"given":"Cristiano Schaffer","family":"Aguzzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur C.","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Therriault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9116-1376","authenticated-orcid":false,"given":"Pedro","family":"Rosa-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana L.","family":"Tudorascu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5349-0053","authenticated-orcid":false,"given":"Eduardo R.","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2212-3373","authenticated-orcid":false,"given":"Bruna","family":"Bellaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharick A.","family":"Pascoal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,14]]},"reference":[{"key":"3400_CR1","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1093\/brain\/awaa438","volume":"144","author":"JL Robinson","year":"2021","unstructured":"Robinson JL, Richardson H, Xie SX, Suh E, Van Deerlin VM, Alfaro B, et al. The development and convergence of co-pathologies in Alzheimer\u2019s disease. Brain. 2021;144:953\u201362.","journal-title":"Brain"},{"key":"3400_CR2","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","volume":"14","author":"MA DeTure","year":"2019","unstructured":"DeTure MA, Dickson DW. The neuropathological diagnosis of Alzheimer\u2019s disease. Mol Neurodegener. 2019;14:32.","journal-title":"Mol Neurodegener"},{"key":"3400_CR3","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S1474-4422(19)30153-X","volume":"19","author":"J-P Taylor","year":"2020","unstructured":"Taylor J-P, McKeith IG, Burn DJ, Boeve BF, Weintraub D, Bamford C, et al. New evidence on the management of lewy body dementia. The Lancet Neurology. 2020;19:157\u201369.","journal-title":"The Lancet Neurology"},{"key":"3400_CR4","doi-asserted-by":"publisher","first-page":"5757","DOI":"10.1002\/alz.14039","volume":"20","author":"S Baiardi","year":"2024","unstructured":"Baiardi S, Hansson O, Levin J, Parchi P. In vivo detection of Alzheimer\u2019s and Lewy body disease concurrence: Clinical implications and future perspectives. Alzheimer\u2019s & Dementia. 2024;20:5757\u201370.","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"3400_CR5","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1038\/s41591-023-02449-7","volume":"29","author":"C Quadalti","year":"2023","unstructured":"Quadalti C, Palmqvist S, Hall S, Rossi M, Mammana A, Janelidze S, et al. Clinical effects of lewy body pathology in cognitively impaired individuals. Nature Medicine. 2023;29:1964\u201370.","journal-title":"Nature Medicine"},{"key":"3400_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52299-1","volume":"15","author":"LE Collij","year":"2024","unstructured":"Collij LE, Mastenbroek SE, Mattsson-Carlgren N, Strandberg O, Smith R, Janelidze S, et al. Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer\u2019s disease. Nat Commun. 2024;15:8061.","journal-title":"Nat Commun"},{"key":"3400_CR7","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1212\/WNL.46.1.130","volume":"46","author":"MS Mega","year":"1996","unstructured":"Mega MS, Cummings JL, Fiorello T, Gornbein J. The spectrum of behavioral changes in Alzheimer\u2019s disease. Neurology. 1996;46:130\u20135.","journal-title":"Neurology"},{"key":"3400_CR8","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1176\/appi.ajp.157.5.708","volume":"157","author":"CG Lyketsos","year":"2000","unstructured":"Lyketsos CG, Steinberg M, Tschanz JT, Norton MC, Steffens DC, Breitner JC. Mental and behavioral disturbances in dementia: findings from the cache county study on memory in aging. Am J Psychiatry. 2000;157:708\u201314.","journal-title":"Am J Psychiatry"},{"key":"3400_CR9","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1001\/jama.288.12.1475","volume":"288","author":"CG Lyketsos","year":"2002","unstructured":"Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, DeKosky S. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. Jama. 2002;288:1475\u201383.","journal-title":"Jama"},{"key":"3400_CR10","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1111\/j.1532-5415.2004.52356.x","volume":"52","author":"KM Sink","year":"2004","unstructured":"Sink KM, Covinsky KE, Newcomer R, Yaffe K. Ethnic differences in the prevalence and pattern of dementia-related behaviors. J Am Geriatr Soc. 2004;52:1277\u201383.","journal-title":"J Am Geriatr Soc"},{"key":"3400_CR11","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.neurobiolaging.2024.09.009","volume":"144","author":"AC Macedo","year":"2024","unstructured":"Macedo AC, Therriault J, Tissot C, Aumont \u00c9, Servaes S, Rahmouni N, et al. Modeling the progression of neuropsychiatric symptoms in Alzheimer\u2019s disease with PET-based Braak staging. Neurobiol Aging. 2024;144:127\u201337.","journal-title":"Neurobiol Aging"},{"key":"3400_CR12","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1001\/archneur.64.12.1755","volume":"64","author":"N Scarmeas","year":"2007","unstructured":"Scarmeas N, Brandt J, Blacker D, Albert M, Hadjigeorgiou G, Dubois B, et al. Disruptive behavior as a predictor in Alzheimer disease. Arch Neurol. 2007;64:1755\u201361.","journal-title":"Arch Neurol"},{"key":"3400_CR13","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1001\/archneur.62.10.1601","volume":"62","author":"N Scarmeas","year":"2005","unstructured":"Scarmeas N, Brandt J, Albert M, Hadjigeorgiou G, Papadimitriou A, Dubois B, et al. Delusions and hallucinations are associated with worse outcome in Alzheimer disease. Arch Neurol. 2005;62:1601\u20138.","journal-title":"Arch Neurol"},{"key":"3400_CR14","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1111\/j.1532-5415.1992.tb01853.x","volume":"40","author":"D Gallagher-Thompson","year":"1992","unstructured":"Gallagher-Thompson D, Brooks JO III, Bliwise D, Leader J, Yesavage JA. The relations among caregiver stress, \u201csundowning\u201d symptoms, and cognitive decline in Alzheimer\u2019s disease. J Am Geriatr Soc. 1992;40:807\u201310.","journal-title":"J Am Geriatr Soc"},{"key":"3400_CR15","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1001\/jamaneurol.2015.0606","volume":"72","author":"EJ Chung","year":"2015","unstructured":"Chung EJ, Babulal GM, Monsell SE, Cairns NJ, Roe CM, Morris JC. Clinical features of alzheimer disease with and without lewy bodies. JAMA Neurology. 2015;72:789\u201396.","journal-title":"JAMA Neurology"},{"key":"3400_CR16","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1001\/jamapsychiatry.2021.4363","volume":"79","author":"DP Devanand","year":"2022","unstructured":"Devanand DP, Lee S, Huey ED, Goldberg TE. Associations between neuropsychiatric symptoms and neuropathological diagnoses of alzheimer disease and related dementias. JAMA Psychiatry. 2022;79:359\u201367.","journal-title":"JAMA Psychiatry"},{"key":"3400_CR17","doi-asserted-by":"publisher","first-page":"953","DOI":"10.3233\/JAD-181285","volume":"69","author":"E Bayram","year":"2019","unstructured":"Bayram E, Shan G, Cummings JL. Associations between comorbid TDP-43, lewy body pathology, and neuropsychiatric symptoms in Alzheimer\u2019s disease. Journal of Alzheimer\u2019s Disease. 2019;69:953\u201361.","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"3400_CR18","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1002\/alz.12765","volume":"19","author":"LL Gibson","year":"2023","unstructured":"Gibson LL, Grinberg LT, Ffytche D, Leite REP, Rodriguez RD, Ferretti-Rebustini REL, et al. Neuropathological correlates of neuropsychiatric symptoms in dementia. Alzheimer\u2019s & Dementia. 2023;19:1372\u201382.","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"3400_CR19","doi-asserted-by":"publisher","first-page":"5114","DOI":"10.1002\/alz.13858","volume":"20","author":"D Tosun","year":"2024","unstructured":"Tosun D, Hausle Z, Iwaki H, Thropp P, Lamoureux J, Lee EB, et al. A cross-sectional study of \u03b1-synuclein seed amplification assay in Alzheimer\u2019s disease neuroimaging initiative: prevalence and associations with Alzheimer\u2019s disease biomarkers and cognitive function. Alzheimer\u2019s & Dementia. 2024;20:5114\u201331.","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"3400_CR20","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1212\/WNL.0b013e3181cb3e25","volume":"74","author":"RC Petersen","year":"2010","unstructured":"Petersen RC, Aisen PS, Beckett LA, Donohue MC, Gamst AC, Harvey DJ, et al. Alzheimer\u2019s disease neuroimaging initiative (ADNI): clinical characterization. Neurology. 2010;74:201\u20139.","journal-title":"Neurology"},{"key":"3400_CR21","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1176\/jnp.12.2.233","volume":"12","author":"DI Kaufer","year":"2000","unstructured":"Kaufer DI, Cummings JL, Ketchel P, Smith V, MacMillan A, Shelley T, et al. Validation of the NPI-Q, a brief clinical form of the neuropsychiatric inventory. J Neuropsychiatry Clin Neurosci. 2000;12:233\u20139.","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"3400_CR22","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1038\/s41596-022-00787-3","volume":"18","author":"L Concha-Marambio","year":"2023","unstructured":"Concha-Marambio L, Pritzkow S, Shahnawaz M, Farris CM, Soto C. Seed amplification assay for the detection of pathologic alpha-synuclein aggregates in cerebrospinal fluid. Nat Protoc. 2023;18:1179\u201396.","journal-title":"Nat Protoc"},{"key":"3400_CR23","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1016\/j.jalz.2018.01.010","volume":"14","author":"O Hansson","year":"2018","unstructured":"Hansson O, Seibyl J, Stomrud E, Zetterberg H, Trojanowski JQ, Bittner T, et al. CSF biomarkers of Alzheimer\u2019s disease concord with amyloid-\u03b2 PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts. Alzheimers Dement. 2018;14:1470\u201381.","journal-title":"Alzheimers Dement"},{"key":"3400_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54204-z","volume":"9","author":"K Blennow","year":"2019","unstructured":"Blennow K, Shaw LM, Stomrud E, Mattsson N, Toledo JB, Buck K, et al. Predicting clinical decline and conversion to Alzheimer\u2019s disease or dementia using novel Elecsys A\u03b2(1-42), pTau and tTau CSF immunoassays. Sci Rep. 2019;9:19024.","journal-title":"Sci Rep"},{"key":"3400_CR25","doi-asserted-by":"crossref","unstructured":"Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B (Methodological). 1995;57:289\u2013300.","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"3400_CR26","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s40266-013-0092-x","volume":"30","author":"C Ballard","year":"2013","unstructured":"Ballard C, Aarsland D, Francis P, Corbett A. Neuropsychiatric symptoms in patients with dementias associated with cortical lewy bodies: pathophysiology, clinical features, and pharmacological management. Drugs & Aging. 2013;30:603\u201311.","journal-title":"Drugs & Aging"},{"key":"3400_CR27","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1176\/ajp.156.7.1039","volume":"156","author":"C Ballard","year":"1999","unstructured":"Ballard C, Holmes C, McKeith I, Neill D, O\u2019Brien J, Cairns N, et al. Psychiatric morbidity in dementia with lewy bodies: a prospective clinical and neuropathological comparative study with Alzheimer\u2019s disease. American Journal of Psychiatry. 1999;156:1039\u201345.","journal-title":"American Journal of Psychiatry"},{"key":"3400_CR28","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/psyg.12490","volume":"20","author":"K Segers","year":"2020","unstructured":"Segers K, Benoit F, Meyts JM, Surquin M. Anxiety symptoms are quantitatively and qualitatively different in dementia with lewy bodies than in Alzheimer\u2019s disease in the years preceding clinical diagnosis. Psychogeriatrics. 2020;20:242\u20136.","journal-title":"Psychogeriatrics"},{"key":"3400_CR29","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.archger.2007.03.003","volume":"46","author":"B Borroni","year":"2008","unstructured":"Borroni B, Agosti C, Padovani A. Behavioral and psychological symptoms in dementia with Lewy-bodies (DLB): frequency and relationship with disease severity and motor impairment. Arch Gerontol Geriatr. 2008;46:101\u20136.","journal-title":"Arch Gerontol Geriatr"},{"key":"3400_CR30","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1136\/jnnp.2005.083113","volume":"78","author":"D Aarsland","year":"2007","unstructured":"Aarsland D, Br\u00f8nnick K, Ehrt U, De Deyn PP, Tekin S, Emre M, et al. Neuropsychiatric symptoms in patients with Parkinson\u2019s disease and dementia: frequency, profile and associated care giver stress. J Neurol Neurosurg Psychiatry. 2007;78:36\u201342.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"3400_CR31","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.3233\/JAD-215198","volume":"87","author":"E Schwertner","year":"2022","unstructured":"Schwertner E, Pereira JB, Xu H, Secnik J, Winblad B, Eriksdotter M, et al. Behavioral and psychological symptoms of dementia in different dementia disorders: a large-scale study of 10,000 individuals. Journal of Alzheimer\u2019s Disease. 2022;87:1307\u201318.","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"3400_CR32","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00401-020-02160-8","volume":"140","author":"M Rossi","year":"2020","unstructured":"Rossi M, Candelise N, Baiardi S, Capellari S, Giannini G, Orr\u00f9 CD, et al. Ultrasensitive RT-QuIC assay with high sensitivity and specificity for lewy body-associated synucleinopathies. Acta Neuropathol. 2020;140:49\u201362.","journal-title":"Acta Neuropathol"},{"key":"3400_CR33","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1176\/appi.ajp.2017.17040442","volume":"175","author":"NJ Donovan","year":"2018","unstructured":"Donovan NJ, Locascio JJ, Marshall GA, Gatchel J, Hanseeuw BJ, Rentz DM, et al. Longitudinal association of amyloid beta and anxious-depressive symptoms in cognitively normal older adults. Am J Psychiatry. 2018;175:530\u20137.","journal-title":"Am J Psychiatry"},{"key":"3400_CR34","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.jagp.2016.04.004","volume":"24","author":"GM Babulal","year":"2016","unstructured":"Babulal GM, Ghoshal N, Head D, Vernon EK, Holtzman DM, Benzinger TLS, et al. Mood changes in cognitively normal older adults are linked to alzheimer disease biomarker levels. Am J Geriatr Psychiatry. 2016;24:1095\u2013104.","journal-title":"Am J Geriatr Psychiatry"},{"key":"3400_CR35","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1176\/appi.ajp.161.5.843","volume":"161","author":"CG Ballard","year":"2004","unstructured":"Ballard CG, Jacoby R, Ser TD, Khan MN, Munoz DG, Holmes C, et al. Neuropathological substrates of psychiatric symptoms in prospectively studied patients with autopsy-confirmed dementia with lewy bodies. American Journal of Psychiatry. 2004;161:843\u20139.","journal-title":"American Journal of Psychiatry"},{"key":"3400_CR36","doi-asserted-by":"publisher","first-page":"8444","DOI":"10.1002\/alz.14276","volume":"20","author":"D Tosun","year":"2024","unstructured":"Tosun D, Hausle Z, Thropp P, Concha-Marambio L, Lamoureux J, Lebovitz R, et al. Association of CSF \u03b1-synuclein seed amplification assay positivity with disease progression and cognitive decline: A longitudinal Alzheimer\u2019s disease neuroimaging initiative study. Alzheimer\u2019s & Dementia. 2024;20:8444\u201360.","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"3400_CR37","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1093\/brain\/awaf037","volume":"148","author":"J Silva-Rodr\u00edguez","year":"2025","unstructured":"Silva-Rodr\u00edguez J, Labrador-Espinosa MA, Zhang L, Castro-Labrador S, L\u00f3pez-Gonz\u00e1lez FJ, Moscoso A, et al. The effect of Lewy body (co-)pathology on the clinical and imaging phenotype of amnestic patients. Brain. 2025;148:2441\u201352.","journal-title":"Brain"},{"key":"3400_CR38","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14571","volume":"21","author":"E Mak","year":"2025","unstructured":"Mak E, Przybelski SA, Wiste HJ, Fought AJ, Schwarz CG, Senjem ML, et al. Influence of alpha-synuclein on glucose metabolism in Alzheimer\u2019s disease continuum: Analyses of \u03b1-synuclein seed amplification assay and FDG-PET. Alzheimer\u2019s & Dementia. 2025;21:e14571.","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"3400_CR39","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13024-025-00822-3","volume":"20","author":"N Franzmeier","year":"2025","unstructured":"Franzmeier N, Roemer-Cassiano SN, Bernhardt AM, Dehsarvi A, Dewenter A, Steward A, et al. Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer\u2019s disease. Mol Neurodegener. 2025;20:31.","journal-title":"Mol Neurodegener"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41380-025-03400-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-025-03400-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-025-03400-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T07:58:40Z","timestamp":1776758320000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-025-03400-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,14]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["3400"],"URL":"https:\/\/doi.org\/10.1038\/s41380-025-03400-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6270682\/v1","asserted-by":"object"}]},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,14]]},"assertion":[{"value":"20 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"J.T. has served as a paid consultant for Neurotorium and Alzheon Inc, outside of the scope of the current work. E.R.Z. has served on the scientific advisory board or as a consultant for Nintx, Novo Nordisk, Magdalena Biosciences and Masima. He is also a co-founder and minority shareholder of Masima.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Institutional Review Boards of all participating sites approved the ADNI study, and all research participants or their authorized representatives provided written informed consent. All methods were performed in accordance with the relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}