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This prevailing concept is challenged by more recent findings, unveiling the role of PARP1 activity in synaptic long-term potentiation, synaptic plasticity and long-term memory. So, PARP1 inhibition, though intended to prevent memory deterioration, actually interferes with stimulation-induced synaptic plasticity and long-term memory. On the other hand, PARP inhibitors could be useful for preventing mental disorders associated with memory retrieval.<\/jats:p>","DOI":"10.1038\/s41380-025-03426-x","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:43:57Z","timestamp":1767660237000},"page":"1837-1843","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synaptic potentiation requires PARP1 activation: prevailing concepts are revisited"],"prefix":"10.1038","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1021-7564","authenticated-orcid":false,"given":"Malka","family":"Cohen-Armon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7592-0408","authenticated-orcid":false,"given":"Menahem","family":"Segal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"3426_CR1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0968-0004(00)89089-1","volume":"20","author":"T Lindahl","year":"1995","unstructured":"Lindahl T, Satoh MS, Poirier GG, KIungland A. 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