{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:13:20Z","timestamp":1788909200694,"version":"build-2803163510"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1038\/s41380-025-03435-w","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T08:47:37Z","timestamp":1766566057000},"page":"2916-2926","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Common alterations of whole and subregion-specific amygdala intrinsic functional connectivity across psychiatric disorders: a meta-analysis"],"prefix":"10.1038","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4220-4285","authenticated-orcid":false,"given":"Lingxiao","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5238-2448","authenticated-orcid":false,"given":"Somayeh","family":"Maleki Balajoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5912-4871","authenticated-orcid":false,"given":"Qiyong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7087-7882","authenticated-orcid":false,"given":"Sarah","family":"Genon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8686-5010","authenticated-orcid":false,"given":"Xiaoqi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"3435_CR1","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1126\/science.aab2358","volume":"348","author":"TR Insel","year":"2015","unstructured":"Insel TR, Cuthbert BN. Medicine. Brain disorders? Precisely. Science. 2015;348:499\u2013500.","journal-title":"Science"},{"key":"3435_CR2","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1017\/S0033291703001399","volume":"34","author":"F Jacobi","year":"2004","unstructured":"Jacobi F, Wittchen HU, Holting C, H\u00f6fler M, Pfister H, M\u00fcller N, et al. Prevalence, co-morbidity and correlates of mental disorders in the general population: results from the German Health Interview and Examination Survey (GHS). Psychol Med. 2004;34:597\u2013611.","journal-title":"Psychol Med"},{"key":"3435_CR3","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1001\/jamapsychiatry.2014.2206","volume":"72","author":"M Goodkind","year":"2015","unstructured":"Goodkind M, Eickhoff SB, Oathes DJ, Jiang Y, Chang A, Jones-Hagata LB, et al. Identification of a common neurobiological substrate for mental illness. JAMA Psychiatry. 2015;72:305\u201315.","journal-title":"JAMA Psychiatry"},{"key":"3435_CR4","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1176\/appi.ajp.2019.18111271","volume":"177","author":"LM McTeague","year":"2020","unstructured":"McTeague LM, Rosenberg BM, Lopez JW, Carreon DM, Huemer J, Jiang Y, et al. Identification of Common Neural Circuit Disruptions in Emotional Processing Across Psychiatric Disorders. Am J Psychiatry. 2020;177:411\u201321.","journal-title":"Am J Psychiatry"},{"key":"3435_CR5","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1038\/ng.2711","volume":"45","author":"SH Lee","year":"2013","unstructured":"Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, et al. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet. 2013;45:984\u201394.","journal-title":"Nat Genet"},{"key":"3435_CR6","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1176\/appi.ajp.20240941","volume":"181","author":"AS Fox","year":"2024","unstructured":"Fox AS, Shackman AJ. An Honest Reckoning With the Amygdala and Mental Illness. Am J Psychiatry. 2024;181:1059\u201375.","journal-title":"Am J Psychiatry"},{"key":"3435_CR7","doi-asserted-by":"publisher","first-page":"3808","DOI":"10.1073\/pnas.1910842117","volume":"117","author":"CM Sylvester","year":"2020","unstructured":"Sylvester CM, Yu Q, Srivastava AB, Marek S, Zheng A, Alexopoulos D, et al. Individual-specific functional connectivity of the amygdala: A substrate for precision psychiatry. Proc Natl Acad Sci USA. 2020;117:3808\u201318.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3435_CR8","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1038\/s41562-022-01434-3","volume":"6","author":"MC Klein-Fl\u00fcgge","year":"2022","unstructured":"Klein-Fl\u00fcgge MC, Jensen DEA, Takagi Y, Priestley L, Verhagen L, Smith SM, et al. Relationship between nuclei-specific amygdala connectivity and mental health dimensions in humans. Nat Hum Behav. 2022;6:1705\u201322.","journal-title":"Nat Hum Behav"},{"key":"3435_CR9","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/sj.mp.4000812","volume":"6","author":"M Davis","year":"2001","unstructured":"Davis M, Whalen PJ. The amygdala: vigilance and emotion. Mol Psychiatry. 2001;6:13\u201334.","journal-title":"Mol Psychiatry"},{"key":"3435_CR10","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1146\/annurev.neuro.23.1.155","volume":"23","author":"JE LeDoux","year":"2000","unstructured":"LeDoux JE. Emotion circuits in the brain. Annu Rev Neurosci. 2000;23:155\u201384.","journal-title":"Annu Rev Neurosci"},{"key":"3435_CR11","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/nature14188","volume":"517","author":"PH Janak","year":"2015","unstructured":"Janak PH, Tye KM. From circuits to behaviour in the amygdala. Nature. 2015;517:284\u201392.","journal-title":"Nature"},{"key":"3435_CR12","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1002\/da.22901","volume":"36","author":"S Tang","year":"2019","unstructured":"Tang S, Li H, Lu L, Wang Y, Zhang L, Hu X, et al. Anomalous functional connectivity of amygdala subregional networks in major depressive disorder. Depress Anxiety. 2019;36:712\u201322.","journal-title":"Depress Anxiety"},{"key":"3435_CR13","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.neubiorev.2018.11.005","volume":"96","author":"J Xu","year":"2019","unstructured":"Xu J, Van Dam NT, Feng C, Luo Y, Ai H, Gu R, et al. Anxious brain networks: A coordinate-based activation likelihood estimation meta-analysis of resting-state functional connectivity studies in anxiety. Neurosci Biobehav Rev. 2019;96:21\u201330.","journal-title":"Neurosci Biobehav Rev"},{"key":"3435_CR14","doi-asserted-by":"publisher","first-page":"3581","DOI":"10.1038\/s41380-023-02291-w","volume":"28","author":"EM Haris","year":"2023","unstructured":"Haris EM, Bryant RA, Williamson T, Korgaonkar MS. Functional connectivity of amygdala subnuclei in PTSD: a narrative review. Mol Psychiatry. 2023;28:3581\u201394.","journal-title":"Mol Psychiatry"},{"key":"3435_CR15","doi-asserted-by":"publisher","first-page":"R868","DOI":"10.1016\/j.cub.2007.08.005","volume":"17","author":"J LeDoux","year":"2007","unstructured":"LeDoux J. The amygdala. Curr Biol. 2007;17:R868\u201374.","journal-title":"Curr Biol"},{"key":"3435_CR16","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s00429-005-0025-5","volume":"210","author":"K Amunts","year":"2005","unstructured":"Amunts K, Kedo O, Kindler M, Pieperhoff P, Mohlberg H, Shah NJ, et al. Cytoarchitectonic mapping of the human amygdala, hippocampal region and entorhinal cortex: intersubject variability and probability maps. Anat Embryol (Berl). 2005;210:343\u201352.","journal-title":"Anat Embryol (Berl)"},{"key":"3435_CR17","first-page":"1","volume":"26","author":"AJ McDonald","year":"2020","unstructured":"McDonald AJ. Functional neuroanatomy of the basolateral amygdala: Neurons, neurotransmitters, and circuits. Handb Behav Neurosci. 2020;26:1\u201338.","journal-title":"Handb Behav Neurosci"},{"key":"3435_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07679-9","volume":"9","author":"X Zhang","year":"2018","unstructured":"Zhang X, Li B. Population coding of valence in the basolateral amygdala. Nat Commun. 2018;9:5195.","journal-title":"Nat Commun"},{"key":"3435_CR19","doi-asserted-by":"publisher","first-page":"8699","DOI":"10.1523\/JNEUROSCI.1176-14.2014","volume":"34","author":"S Keshavarzi","year":"2014","unstructured":"Keshavarzi S, Sullivan RK, Ianno DJ, Sah P. Functional properties and projections of neurons in the medial amygdala. J Neurosci. 2014;34:8699\u2013715.","journal-title":"J Neurosci"},{"key":"3435_CR20","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.conb.2012.02.014","volume":"22","author":"D Pare","year":"2012","unstructured":"Pare D, Duvarci S. Amygdala microcircuits mediating fear expression and extinction. Curr Opin Neurobiol. 2012;22:717\u201323.","journal-title":"Curr Opin Neurobiol"},{"key":"3435_CR21","doi-asserted-by":"publisher","first-page":"3332","DOI":"10.1002\/hbm.20755","volume":"30","author":"L Goossens","year":"2009","unstructured":"Goossens L, Kukolja J, Onur OA, Fink GR, Maier W, Griez E, et al. Selective processing of social stimuli in the superficial amygdala. Hum Brain Mapp. 2009;30:3332\u20138.","journal-title":"Hum Brain Mapp"},{"key":"3435_CR22","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1001\/archgenpsychiatry.2009.104","volume":"66","author":"A Etkin","year":"2009","unstructured":"Etkin A, Prater KE, Schatzberg AF, Menon V, Greicius MD. Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder. Arch Gen Psychiatry. 2009;66:1361\u201372.","journal-title":"Arch Gen Psychiatry"},{"key":"3435_CR23","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1038\/s42003-022-04115-z","volume":"5","author":"L Cao","year":"2022","unstructured":"Cao L, Li H, Liu J, Jiang J, Li B, Li X, et al. Disorganized functional architecture of amygdala subregional networks in obsessive-compulsive disorder. Commun Biol. 2022;5:1184.","journal-title":"Commun Biol"},{"key":"3435_CR24","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1176\/appi.ajp.2017.16040400","volume":"174","author":"LM McTeague","year":"2017","unstructured":"McTeague LM, Huemer J, Carreon DM, Jiang Y, Eickhoff SB, Etkin A. Identification of Common Neural Circuit Disruptions in Cognitive Control Across Psychiatric Disorders. Am J Psychiatry. 2017;174:676\u201385.","journal-title":"Am J Psychiatry"},{"key":"3435_CR25","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Bmj. 2021;372:n71.","journal-title":"Bmj"},{"key":"3435_CR26","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1001\/jamapsychiatry.2022.0799","volume":"79","author":"Y Zhao","year":"2022","unstructured":"Zhao Y, Zhang Q, Shah C, Li Q, Sweeney JA, Li F, et al. Cortical Thickness Abnormalities at Different Stages of the Illness Course in Schizophrenia: A Systematic Review and Meta-analysis. JAMA Psychiatry. 2022;79:560\u201370.","journal-title":"JAMA Psychiatry"},{"key":"3435_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104574","volume":"135","author":"J Liu","year":"2022","unstructured":"Liu J, Cao L, Li H, Gao Y, Bu X, Liang K, et al. Abnormal resting-state functional connectivity in patients with obsessive-compulsive disorder: A systematic review and meta-analysis. Neurosci Biobehav Rev. 2022;135:104574.","journal-title":"Neurosci Biobehav Rev"},{"key":"3435_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2024.105583","volume":"159","author":"Z Zhou","year":"2024","unstructured":"Zhou Z, Gao Y, Bao W, Liang K, Cao L, Tang M, et al. Distinctive intrinsic functional connectivity alterations of anterior cingulate cortex subdivisions in major depressive disorder: A systematic review and meta-analysis. Neurosci Biobehav Rev. 2024;159:105583.","journal-title":"Neurosci Biobehav Rev"},{"key":"3435_CR29","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1192\/bjp.bp.108.055046","volume":"195","author":"J Radua","year":"2009","unstructured":"Radua J, Mataix-Cols D. Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder. Br J Psychiatry. 2009;195:393\u2013402.","journal-title":"Br J Psychiatry"},{"key":"3435_CR30","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.eurpsy.2011.04.001","volume":"27","author":"J Radua","year":"2012","unstructured":"Radua J, Mataix-Cols D, Phillips ML, El-Hage W, Kronhaus DM, Cardoner N, et al. A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps. Eur Psychiatry. 2012;27:605\u201311.","journal-title":"Eur Psychiatry"},{"key":"3435_CR31","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.neubiorev.2017.11.012","volume":"84","author":"VI M\u00fcller","year":"2018","unstructured":"M\u00fcller VI, Cieslik EC, Laird AR, Fox PT, Radua J, Mataix-Cols D, et al. Ten simple rules for neuroimaging meta-analysis. Neurosci Biobehav Rev. 2018;84:151\u201361.","journal-title":"Neurosci Biobehav Rev"},{"key":"3435_CR32","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.ebiom.2018.09.010","volume":"36","author":"S Tang","year":"2018","unstructured":"Tang S, Lu L, Zhang L, Hu X, Bu X, Li H, et al. Abnormal amygdala resting-state functional connectivity in adults and adolescents with major depressive disorder: A comparative meta-analysis. EBioMedicine. 2018;36:436\u201345.","journal-title":"EBioMedicine"},{"key":"3435_CR33","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/hbm.20141","volume":"25","author":"PT Fox","year":"2005","unstructured":"Fox PT, Laird AR, Fox SP, Fox PM, Uecker AM, Crank M, et al. BrainMap taxonomy of experimental design: description and evaluation. Hum Brain Mapp. 2005;25:185\u201398.","journal-title":"Hum Brain Mapp"},{"key":"3435_CR34","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/nrn789","volume":"3","author":"PT Fox","year":"2002","unstructured":"Fox PT, Lancaster JL. Opinion: Mapping context and content: the BrainMap model. Nat Rev Neurosci. 2002;3:319\u201321.","journal-title":"Nat Rev Neurosci"},{"key":"3435_CR35","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.tics.2018.01.010","volume":"22","author":"S Genon","year":"2018","unstructured":"Genon S, Reid A, Langner R, Amunts K, Eickhoff SB. How to Characterize the Function of a Brain Region. Trends Cogn Sci. 2018;22:350\u201364.","journal-title":"Trends Cogn Sci"},{"key":"3435_CR36","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1097\/PSY.0000000000000697","volume":"81","author":"M Zu","year":"2019","unstructured":"Zu M, Wang A, Bai T, Xie W, Guan J, Tian Y, et al. Resting-State Functional Connectivity Between Centromedial Amygdala and Insula as Related to Somatic Symptoms in Depressed Patients: A Preliminary Study. Psychosom Med. 2019;81:434\u201340.","journal-title":"Psychosom Med"},{"key":"3435_CR37","doi-asserted-by":"publisher","first-page":"3247","DOI":"10.1002\/hbm.22138","volume":"34","author":"D Bzdok","year":"2013","unstructured":"Bzdok D, Laird AR, Zilles K, Fox PT, Eickhoff SB. An investigation of the structural, connectional, and functional subspecialization in the human amygdala. Hum Brain Mapp. 2013;34:3247\u201366.","journal-title":"Hum Brain Mapp"},{"key":"3435_CR38","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/S0306-4522(02)00446-3","volume":"115","author":"HT Ghashghaei","year":"2002","unstructured":"Ghashghaei HT, Barbas H. Pathways for emotion: interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey. Neuroscience. 2002;115:1261\u201379.","journal-title":"Neuroscience"},{"key":"3435_CR39","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.neuroscience.2012.03.040","volume":"212","author":"JL Fudge","year":"2012","unstructured":"Fudge JL, deCampo DM, Becoats KT. Revisiting the hippocampal-amygdala pathway in primates: association with immature-appearing neurons. Neuroscience. 2012;212:104\u201319.","journal-title":"Neuroscience"},{"key":"3435_CR40","doi-asserted-by":"publisher","first-page":"14017","DOI":"10.1523\/JNEUROSCI.0170-13.2013","volume":"33","author":"YT Cho","year":"2013","unstructured":"Cho YT, Ernst M, Fudge JL. Cortico-amygdala-striatal circuits are organized as hierarchical subsystems through the primate amygdala. J Neurosci. 2013;33:14017\u201330.","journal-title":"J Neurosci"},{"key":"3435_CR41","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1523\/JNEUROSCI.0970-21.2021","volume":"42","author":"AC McHale","year":"2022","unstructured":"McHale AC, Cho YT, Fudge JL. Cortical Granularity Shapes the Organization of Afferent Paths to the Amygdala and Its Striatal Targets in Nonhuman Primate. J Neurosci. 2022;42:1436\u201353.","journal-title":"J Neurosci"},{"key":"3435_CR42","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1038\/s41593-021-00856-y","volume":"24","author":"BA Silva","year":"2021","unstructured":"Silva BA, Astori S, Burns AM, Heiser H, van den Heuvel L, Santoni G, et al. A thalamo-amygdalar circuit underlying the extinction of remote fear memories. Nat Neurosci. 2021;24:964\u201374.","journal-title":"Nat Neurosci"},{"key":"3435_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2024.110950","volume":"131","author":"S Grot","year":"2024","unstructured":"Grot S, Smine S, Potvin S, Darcey M, Pavlov V, Genon S, et al. Label-based meta-analysis of functional brain dysconnectivity across mood and psychotic disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2024;131:110950.","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"3435_CR44","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1176\/appi.ajp.2020.20030243","volume":"177","author":"DM Barch","year":"2020","unstructured":"Barch DM. What Does It Mean to Be Transdiagnostic and How Would We Know? Am J Psychiatry. 2020;177:370\u20132.","journal-title":"Am J Psychiatry"},{"key":"3435_CR45","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1111\/j.1399-5618.2012.01021.x","volume":"14","author":"J Townsend","year":"2012","unstructured":"Townsend J, Altshuler LL. Emotion processing and regulation in bipolar disorder: a review. Bipolar Disord. 2012;14:326\u201339.","journal-title":"Bipolar Disord"},{"key":"3435_CR46","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.jad.2017.06.047","volume":"225","author":"M Altinay","year":"2018","unstructured":"Altinay M, Karne H, Anand A. Lithium monotherapy associated clinical improvement effects on amygdala-ventromedial prefrontal cortex resting state connectivity in bipolar disorder. J Affect Disord. 2018;225:4\u201312.","journal-title":"J Affect Disord"},{"key":"3435_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2022.102283","volume":"214","author":"S Ocklenburg","year":"2022","unstructured":"Ocklenburg S, Peterburs J, Mundorf A. Hemispheric asymmetries in the amygdala: A comparative primer. Prog Neurobiol. 2022;214:102283.","journal-title":"Prog Neurobiol"},{"key":"3435_CR48","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.biopsych.2018.12.003","volume":"85","author":"F Brandl","year":"2019","unstructured":"Brandl F, Avram M, Weise B, Shang J, Sim\u00f5es B, Bertram T, et al. Specific Substantial Dysconnectivity in Schizophrenia: A Transdiagnostic Multimodal Meta-analysis of Resting-State Functional and Structural Magnetic Resonance Imaging Studies. Biol Psychiatry. 2019;85:573\u201383.","journal-title":"Biol Psychiatry"},{"key":"3435_CR49","doi-asserted-by":"publisher","first-page":"459","DOI":"10.12659\/MSM.893373","volume":"21","author":"WJ Liu","year":"2015","unstructured":"Liu WJ, Yin DZ, Cheng WH, Fan MX, You MN, Men WW, et al. Abnormal functional connectivity of the amygdala-based network in resting-state FMRI in adolescents with generalized anxiety disorder. Med Sci Monit. 2015;21:459\u201367.","journal-title":"Med Sci Monit"},{"key":"3435_CR50","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1001\/jamapsychiatry.2019.3351","volume":"77","author":"D Janiri","year":"2020","unstructured":"Janiri D, Moser DA, Doucet GE, Luber MJ, Rasgon A, Lee WH, et al. Shared Neural Phenotypes for Mood and Anxiety Disorders: A Meta-analysis of 226 Task-Related Functional Imaging Studies. JAMA Psychiatry. 2020;77:172\u20139.","journal-title":"JAMA Psychiatry"},{"key":"3435_CR51","doi-asserted-by":"publisher","DOI":"10.1186\/s12991-022-00402-5","volume":"21","author":"V Pugliese","year":"2022","unstructured":"Pugliese V, de Filippis R, Aloi M, Rotella P, Carbone EA, Gaetano R, et al. Aberrant salience correlates with psychotic dimensions in outpatients with schizophrenia spectrum disorders. Ann Gen Psychiatry. 2022;21:25.","journal-title":"Ann Gen Psychiatry"},{"key":"3435_CR52","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/da.20733","volume":"28","author":"JC Britton","year":"2011","unstructured":"Britton JC, Lissek S, Grillon C, Norcross MA, Pine DS. Development of anxiety: the role of threat appraisal and fear learning. Depress Anxiety. 2011;28:5\u201317.","journal-title":"Depress Anxiety"},{"key":"3435_CR53","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1038\/npp.2016.1","volume":"41","author":"SB Koch","year":"2016","unstructured":"Koch SB, van Zuiden M, Nawijn L, Frijling JL, Veltman DJ, Olff M. Intranasal Oxytocin Normalizes Amygdala Functional Connectivity in Posttraumatic Stress Disorder. Neuropsychopharmacology. 2016;41:2041\u201351.","journal-title":"Neuropsychopharmacology"},{"key":"3435_CR54","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2023.111777","volume":"338","author":"VK Tassone","year":"2024","unstructured":"Tassone VK, Gholamali Nezhad F, Demchenko I, Rueda A, Bhat V. Amygdala biomarkers of treatment response in major depressive disorder: An fMRI systematic review of SSRI antidepressants. Psychiatry Research: Neuroimaging. 2024;338:111777.","journal-title":"Psychiatry Research: Neuroimaging"},{"key":"3435_CR55","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.neuroimage.2018.07.013","volume":"181","author":"TRA Kral","year":"2018","unstructured":"Kral TRA, Schuyler BS, Mumford JA, Rosenkranz MA, Lutz A, Davidson RJ. Impact of short- and long-term mindfulness meditation training on amygdala reactivity to emotional stimuli. Neuroimage. 2018;181:301\u201313.","journal-title":"Neuroimage"},{"key":"3435_CR56","doi-asserted-by":"publisher","first-page":"S192","DOI":"10.1016\/j.biopsych.2021.02.487","volume":"89","author":"V Sydnor","year":"2021","unstructured":"Sydnor V, Cieslak M, Duprat R, Long H, Flounders M, Deluisi J, et al. Amygdala TMS-fMRI Evoked Response is Influenced by Prefrontal-Amygdala White Matter Pathway Fiber Density. Biol Psychiatry. 2021;89:S192.","journal-title":"Biol Psychiatry"},{"key":"3435_CR57","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn5803","volume":"8","author":"VJ Sydnor","year":"2022","unstructured":"Sydnor VJ, Cieslak M, Duprat R, Deluisi J, Flounders MW, Long H, et al. Cortical-subcortical structural connections support transcranial magnetic stimulation engagement of the amygdala. Sci Adv. 2022;8:eabn5803.","journal-title":"Sci Adv"},{"key":"3435_CR58","doi-asserted-by":"publisher","first-page":"kkaf024","DOI":"10.1093\/psyrad\/kkaf024","volume":"5","author":"Q-L Gao","year":"2025","unstructured":"Gao Q-L, Chen X, Castellanos FX, Lu B, Yan C-G. Towards closed-loop precision psychiatry: Integrating MRI biomarkers for individualized care of major depressive disorder. Psychoradiology. 2025;5:kkaf024.","journal-title":"Psychoradiology"},{"key":"3435_CR59","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s00213-003-1423-0","volume":"167","author":"BM Cohen","year":"2003","unstructured":"Cohen BM, Cherkerzian S, Ma J, Ye N, Wager C, Lange N. Cells in midline thalamus, central amygdala, and nucleus accumbens responding specifically to antipsychotic drugs. Psychopharmacology. 2003;167:403\u201310.","journal-title":"Psychopharmacology"},{"key":"3435_CR60","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.neuroimage.2008.11.030","volume":"45","author":"AK Roy","year":"2009","unstructured":"Roy AK, Shehzad Z, Margulies DS, Kelly AM, Uddin LQ, Gotimer K, et al. Functional connectivity of the human amygdala using resting state fMRI. Neuroimage. 2009;45:614\u201326.","journal-title":"Neuroimage"},{"key":"3435_CR61","doi-asserted-by":"publisher","first-page":"7941","DOI":"10.1073\/pnas.1120408109","volume":"109","author":"S Qin","year":"2012","unstructured":"Qin S, Young CB, Supekar K, Uddin LQ, Menon V. Immature integration and segregation of emotion-related brain circuitry in young children. Proc Natl Acad Sci USA. 2012;109:7941\u20136.","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41380-025-03435-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-025-03435-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-025-03435-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T09:02:44Z","timestamp":1776762164000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-025-03435-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":61,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["3435"],"URL":"https:\/\/doi.org\/10.1038\/s41380-025-03435-w","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,24]]},"assertion":[{"value":"6 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Ethics approval and consent to participate were not sought or required as this study was based on secondary data from previously published, publicly available data. The data used for analysis includes fully anonymized information.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}