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M.C.J. and B.D.P. are inventors of a gene therapy for Angelman syndrome. This intellectual property has been filed, and a patent is pending (WO 2020\/237130). B.D.P. is a consultant for Astellas Gene Therapies. These relationships have been disclosed to, and are under management by, the University of North Carolina at Chapel Hill. Y.E. is a consultant for Astellas Gene Therapies and for Innoser.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All experiments in this study were strictly compliant and in accordance with the Institutional Animal Care and Use Committee (IACUC ID: 23-138.0 C) of the University of North Carolina at Chapel Hill and with the European Commission Council Directive 2010\/63\/EU (CCD approval AVD10100202216352) at Erasmus MC, Rotterdam. No human participants or data were used in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}