{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:53:08Z","timestamp":1781513588300,"version":"3.54.1"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101585"],"award-info":[{"award-number":["82101585"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471541"],"award-info":[{"award-number":["82471541"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460280"],"award-info":[{"award-number":["82460280"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171201"],"award-info":[{"award-number":["82171201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460280"],"award-info":[{"award-number":["82460280"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1038\/s41380-026-03516-4","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T13:19:38Z","timestamp":1772025578000},"page":"3758-3774","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual regulatory roles of CPT1C in chronic stress-induced depression-related outcomes"],"prefix":"10.1038","volume":"31","author":[{"given":"Dan","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Xuan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Ling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Jie","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Kai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Yan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Hua","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2577-8161","authenticated-orcid":false,"given":"Wu-Cheng","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Xiao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Meng","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5165-0391","authenticated-orcid":false,"given":"Shuang-Qi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4206-0928","authenticated-orcid":false,"given":"Zu-Cheng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"3516_CR1","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s40273-021-01040-7","volume":"39","author":"D Proudman","year":"2021","unstructured":"Proudman D, Greenberg P, Nellesen D. The growing burden of major depressive disorders (MDD): implications for researchers and policy makers. Pharmacoeconomics. 2021;39:619\u201325.","journal-title":"Pharmacoeconomics"},{"key":"3516_CR2","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1586\/ern.12.96","volume":"12","author":"L Musazzi","year":"2012","unstructured":"Musazzi L, Treccani G, Popoli M. Glutamate hypothesis of depression and its consequences for antidepressant treatments. Expert Rev Neurother. 2012;12:1169\u201372.","journal-title":"Expert Rev Neurother"},{"key":"3516_CR3","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.neuropharm.2011.07.036","volume":"62","author":"G Sanacora","year":"2012","unstructured":"Sanacora G, Treccani G, Popoli M. Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders. Neuropharmacology. 2012;62:63\u201377.","journal-title":"Neuropharmacology"},{"key":"3516_CR4","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/S0166-2236(00)01959-7","volume":"24","author":"C L\u00fcscher","year":"2001","unstructured":"L\u00fcscher C, Frerking M. Restless AMPA receptors: implications for synaptic transmission and plasticity. Trends Neurosci. 2001;24:665\u201370.","journal-title":"Trends Neurosci"},{"key":"3516_CR5","doi-asserted-by":"publisher","first-page":"15669","DOI":"10.1523\/JNEUROSCI.2588-13.2013","volume":"33","author":"AJ Kallarackal","year":"2013","unstructured":"Kallarackal AJ, Kvarta MD, Cammarata E, Jaberi L, Cai X, Bailey AM, et al. Chronic stress induces a selective decrease in AMPA receptor-mediated synaptic excitation at hippocampal temporoammonic-CA1 synapses. J Neurosci. 2013;33:15669\u201374.","journal-title":"J Neurosci"},{"key":"3516_CR6","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.neuron.2011.12.033","volume":"73","author":"EY Yuen","year":"2012","unstructured":"Yuen EY, Wei J, Liu W, Zhong P, Li X, Yan Z. Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex. Neuron. 2012;73:962\u201377.","journal-title":"Neuron"},{"key":"3516_CR7","doi-asserted-by":"publisher","first-page":"3192","DOI":"10.1152\/jn.91111.2008","volume":"101","author":"MR Campioni","year":"2009","unstructured":"Campioni MR, Xu M, McGehee DS. Stress-induced changes in nucleus accumbens glutamate synaptic plasticity. J Neurophysiol. 2009;101:3192\u20138.","journal-title":"J Neurophysiol"},{"key":"3516_CR8","doi-asserted-by":"publisher","first-page":"ra123","DOI":"10.1126\/scisignal.aai7884","volume":"9","author":"K Zhang","year":"2016","unstructured":"Zhang K, Xu T, Yuan Z, Wei Z, Yamaki VN, Huang M, et al. Essential roles of AMPA receptor GluA1 phosphorylation and presynaptic HCN channels in fast-acting antidepressant responses of ketamine. Sci Signal. 2016;9:ra123.","journal-title":"Sci Signal"},{"key":"3516_CR9","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1038\/s41380-019-0400-x","volume":"24","author":"RS Duman","year":"2019","unstructured":"Duman RS, Shinohara R, Foga\u00e7a MV, Hare B. Neurobiology of rapid-acting antidepressants: convergent effects on GluA1-synaptic function. Mol Psychiatry. 2019;24:1816\u201332.","journal-title":"Mol Psychiatry"},{"key":"3516_CR10","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/nature11160","volume":"487","author":"BK Lim","year":"2012","unstructured":"Lim BK, Huang KW, Grueter BA, Rothwell PE, Malenka RC. Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens. Nature. 2012;487:183\u20139.","journal-title":"Nature"},{"key":"3516_CR11","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.neuron.2013.05.014","volume":"79","author":"NR Wall","year":"2013","unstructured":"Wall NR, De La Parra M, Callaway EM, Kreitzer AC. Differential innervation of direct- and indirect-pathway striatal projection neurons. Neuron. 2013;79:347\u201360.","journal-title":"Neuron"},{"key":"3516_CR12","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.biopsych.2014.07.021","volume":"77","author":"TC Francis","year":"2015","unstructured":"Francis TC, Chandra R, Friend DM, Finkel E, Dayrit G, Miranda J, et al. Nucleus accumbens medium spiny neuron subtypes mediate depression-related outcomes to social defeat stress. Biol Psychiatry. 2015;77:212\u201322.","journal-title":"Biol Psychiatry"},{"key":"3516_CR13","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/nn.2551","volume":"13","author":"V Vialou","year":"2010","unstructured":"Vialou V, Robison AJ, Laplant QC, Covington HE III, Dietz DM, et al. DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nat Neurosci. 2010;13:745\u201352.","journal-title":"Nat Neurosci"},{"key":"3516_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-015-0140-z","volume":"8","author":"C Su","year":"2015","unstructured":"Su C, D\u2019Amour J, Lee M, Lin HY, Manders T, Xu D, et al. Persistent pain alters AMPA receptor subunit levels in the nucleus accumbens. Mol Brain. 2015;8:46.","journal-title":"Mol Brain"},{"key":"3516_CR15","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1016\/j.bbamem.2011.07.009","volume":"1808","author":"C Aicart-Ramos","year":"2011","unstructured":"Aicart-Ramos C, Valero RA, Rodriguez-Crespo I. Protein palmitoylation and subcellular trafficking. Biochim Biophys Acta. 2011;1808:2981\u201394.","journal-title":"Biochim Biophys Acta"},{"key":"3516_CR16","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.neuron.2005.06.035","volume":"47","author":"T Hayashi","year":"2005","unstructured":"Hayashi T, Rumbaugh G, Huganir RL. Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites. Neuron. 2005;47:709\u201323.","journal-title":"Neuron"},{"key":"3516_CR17","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3389\/fnmol.2018.00275","volume":"11","author":"E Gratac\u00f2s-Batlle","year":"2018","unstructured":"Gratac\u00f2s-Batlle E, Olivella M, S\u00e1nchez-Fern\u00e1ndez N, Yefimenko N, Miguez-Cabello F, Fad\u00f3 R, et al. Mechanisms of CPT1C-dependent AMPAR trafficking enhancement. Front Mol Neurosci. 2018;11:275.","journal-title":"Front Mol Neurosci"},{"key":"3516_CR18","doi-asserted-by":"publisher","first-page":"10220","DOI":"10.1523\/JNEUROSCI.1590-18.2018","volume":"38","author":"M Itoh","year":"2018","unstructured":"Itoh M, Yamashita M, Kaneko M, Okuno H, Abe M, Yamazaki M, et al. Deficiency of AMPAR-palmitoylation aggravates seizure susceptibility. J Neurosci. 2018;38:10220\u201335.","journal-title":"J Neurosci"},{"key":"3516_CR19","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1038\/s41386-022-01347-9","volume":"47","author":"A Oota-Ishigaki","year":"2022","unstructured":"Oota-Ishigaki A, Takao K, Yamada D, Sekiguchi M, Itoh M, Koshidata Y, et al. Prolonged contextual fear memory in AMPA receptor palmitoylation-deficient mice. Neuropsychopharmacology. 2022;47:2150\u20139.","journal-title":"Neuropsychopharmacology"},{"key":"3516_CR20","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.biopsych.2018.05.007","volume":"84","author":"C Yang","year":"2018","unstructured":"Yang C, Kobayashi S, Nakao K, Dong C, Han M, Qu Y, et al. AMPA receptor activation-independent antidepressant actions of ketamine metabolite (S)-norketamine. Biol Psychiatry. 2018;84:591\u2013600.","journal-title":"Biol Psychiatry"},{"key":"3516_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42780-8","volume":"14","author":"SG Xue","year":"2023","unstructured":"Xue SG, He JG, Lu LL, Song SJ, Chen MM, Wang F, et al. Enhanced TARP-\u03b38-PSD-95 coupling in excitatory neurons contributes to the rapid antidepressant-like action of ketamine in male mice. Nat Commun. 2023;14:7971.","journal-title":"Nat Commun"},{"key":"3516_CR22","doi-asserted-by":"crossref","unstructured":"Hatano M, Nakajima W, Tani H, Uchida H, Miyazaki T, Arisawa T, et al. Characterization of patients with major psychiatric disorders with AMPA receptor positron emission tomography. Mol Psychiatry. 2025;30:1780\u201390.","DOI":"10.1038\/s41380-024-02785-1"},{"key":"3516_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.apsb.2014.12.002","volume":"5","author":"J Han","year":"2015","unstructured":"Han J, Wu P, Wang F, Chen J. S-palmitoylation regulates AMPA receptors trafficking and function: a novel insight into synaptic regulation and therapeutics. Acta Pharm Sin B. 2015;5:1\u20137.","journal-title":"Acta Pharm Sin B"},{"key":"3516_CR24","doi-asserted-by":"publisher","first-page":"4007","DOI":"10.1242\/jcs.059287","volume":"123","author":"E Conibear","year":"2010","unstructured":"Conibear E, Davis NG. Palmitoylation and depalmitoylation dynamics at a glance. J Cell Sci. 2010;123:4007\u201310.","journal-title":"J Cell Sci"},{"key":"3516_CR25","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/s41556-024-01397-9","volume":"26","author":"N Zhang","year":"2024","unstructured":"Zhang N, Zhang J, Yang Y, Shan H, Hou S, Fang H, et al. A palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis. Nat Cell Biol. 2024;26:757\u201369.","journal-title":"Nat Cell Biol"},{"key":"3516_CR26","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.1038\/s41380-019-0484-3","volume":"25","author":"C Soares-Cunha","year":"2020","unstructured":"Soares-Cunha C, de Vasconcelos NAP, Coimbra B, Domingues AV, Silva JM, Loureiro-Campos E, et al. Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion. Mol Psychiatry. 2020;25:3241\u201355.","journal-title":"Mol Psychiatry"},{"key":"3516_CR27","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.biopsych.2016.09.007","volume":"81","author":"TC Francis","year":"2017","unstructured":"Francis TC, Lobo MK. Emerging role for nucleus accumbens medium spiny neuron subtypes in depression. Biol Psychiatry. 2017;81:645\u201353.","journal-title":"Biol Psychiatry"},{"key":"3516_CR28","doi-asserted-by":"publisher","first-page":"8127","DOI":"10.1523\/JNEUROSCI.6034-11.2012","volume":"32","author":"DA Fortin","year":"2012","unstructured":"Fortin DA, Srivastava T, Dwarakanath D, Pierre P, Nygaard S, Derkach VA, et al. Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors. J Neurosci. 2012;32:8127\u201337.","journal-title":"J Neurosci"},{"key":"3516_CR29","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ccr.2004.06.007","volume":"6","author":"RJ Shaw","year":"2004","unstructured":"Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell. 2004;6:91\u201399.","journal-title":"Cancer Cell"},{"key":"3516_CR30","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.neuropharm.2015.03.003","volume":"95","author":"G Wang","year":"2015","unstructured":"Wang G, Amato S, Gilbert J, Man HY. Resveratrol up-regulates AMPA receptor expression via AMP-activated protein kinase-mediated protein translation. Neuropharmacology. 2015;95:144\u201353.","journal-title":"Neuropharmacology"},{"key":"3516_CR31","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1101\/gad.1110003","volume":"17","author":"K Inoki","year":"2003","unstructured":"Inoki K, Li Y, Xu T, Guan KL. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 2003;17:1829\u201334.","journal-title":"Genes Dev"},{"key":"3516_CR32","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1042\/BJ20080281","volume":"412","author":"J Huang","year":"2008","unstructured":"Huang J, Manning BD. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J. 2008;412:179\u201390.","journal-title":"Biochem J"},{"key":"3516_CR33","doi-asserted-by":"publisher","first-page":"13771","DOI":"10.1073\/pnas.2000258117","volume":"117","author":"A Porcu","year":"2020","unstructured":"Porcu A, Vaughan M, Nilsson A, Arimoto N, Lamia K, Welsh DK. Vulnerability to helpless behavior is regulated by the circadian clock component CRYPTOCHROME in the mouse nucleus accumbens. Proc Natl Acad Sci USA. 2020;117:13771\u201382.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3516_CR34","doi-asserted-by":"publisher","first-page":"18381","DOI":"10.1523\/JNEUROSCI.1875-13.2013","volume":"33","author":"MK Lobo","year":"2013","unstructured":"Lobo MK, Zaman S, Damez-Werno DM, Koo JW, Bagot RC, DiNieri JA, et al. \u0394FosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli. J Neurosci. 2013;33:18381\u201395.","journal-title":"J Neurosci"},{"key":"3516_CR35","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.apsb.2023.12.005","volume":"14","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Gao J, Li N, Xu P, Qu S, Cheng J, et al. Targeting cAMP in D1-MSNs in the nucleus accumbens, a new rapid antidepressant strategy. Acta Pharm Sin B. 2024;14:667\u201381.","journal-title":"Acta Pharm Sin B"},{"key":"3516_CR36","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1146\/annurev.cellbio.23.090506.123516","volume":"23","author":"JD Shepherd","year":"2007","unstructured":"Shepherd JD, Huganir RL. The cell biology of synaptic plasticity: AMPA receptor trafficking. Annu Rev Cell Dev Biol. 2007;23:613\u201343.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"3516_CR37","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/nn1270","volume":"7","author":"L Groc","year":"2004","unstructured":"Groc L, Heine M, Cognet L, Brickley K, Stephenson FA, Lounis B, et al. Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors. Nat Neurosci. 2004;7:695\u20136.","journal-title":"Nat Neurosci"},{"key":"3516_CR38","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.neuron.2007.01.030","volume":"53","author":"C Bats","year":"2007","unstructured":"Bats C, Groc L, Choquet D. The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking. Neuron. 2007;53:719\u201334.","journal-title":"Neuron"},{"key":"3516_CR39","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.1523\/JNEUROSCI.2362-17.2018","volume":"38","author":"JL Sanderson","year":"2018","unstructured":"Sanderson JL, Scott JD, Dell\u2019Acqua ML. Control of homeostatic synaptic plasticity by AKAP-anchored kinase and phosphatase regulation of Ca(2+)-permeable AMPA receptors. J Neurosci. 2018;38:2863\u201376.","journal-title":"J Neurosci"},{"key":"3516_CR40","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/S0092-8674(02)00683-9","volume":"108","author":"AD El-Husseini","year":"2002","unstructured":"El-Husseini AD, Schnell E, Dakoji S, Sweeney N, Zhou Q, Prange O, et al. Synaptic strength regulated by palmitate cycling on PSD-95. Cell. 2002;108:849\u201363.","journal-title":"Cell"},{"key":"3516_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107561","volume":"26","author":"MD Li","year":"2023","unstructured":"Li MD, Wang L, Zheng YQ, Huang DH, Xia ZX, Liu JM, et al. DHHC2 regulates fear memory formation, LTP, and AKAP150 signaling in the hippocampus. iScience. 2023;26:107561.","journal-title":"iScience"},{"key":"3516_CR42","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1111\/bph.16318","volume":"181","author":"SY Wang","year":"2024","unstructured":"Wang SY, Xia ZX, Yang SW, Chen WK, Zhao YL, Li MD, et al. Regulation of depressive-like behaviours by palmitoylation: Role of AKAP150 in the basolateral amygdala. Br J Pharmacol. 2024;181:1897\u2013915.","journal-title":"Br J Pharmacol"},{"key":"3516_CR43","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/nn.2351","volume":"12","author":"DT Lin","year":"2009","unstructured":"Lin DT, Makino Y, Sharma K, Hayashi T, Neve R, Takamiya K, et al. Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation. Nat Neurosci. 2009;12:879\u201387.","journal-title":"Nat Neurosci"},{"key":"3516_CR44","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.biopsych.2010.11.025","volume":"69","author":"DK Van Dolah","year":"2011","unstructured":"Van Dolah DK, Mao LM, Shaffer C, Guo ML, Fibuch EE, Chu XP, et al. Reversible palmitoylation regulates surface stability of AMPA receptors in the nucleus accumbens in response to cocaine in vivo. Biol Psychiatry. 2011;69:1035\u201342.","journal-title":"Biol Psychiatry"},{"key":"3516_CR45","first-page":"469","volume":"8","author":"E Gratac\u00f2s-Batlle","year":"2014","unstructured":"Gratac\u00f2s-Batlle E, Yefimenko N, Cascos-Garc\u00eda H, Soto D. AMPAR interacting protein CPT1C enhances surface expression of GluA1-containing receptors. Front Cell Neurosci. 2014;8:469.","journal-title":"Front Cell Neurosci"},{"key":"3516_CR46","doi-asserted-by":"publisher","first-page":"e201912045","DOI":"10.1083\/jcb.201912045","volume":"219","author":"M Casas","year":"2020","unstructured":"Casas M, Fad\u00f3 R, Dom\u00ednguez JL, Roig A, Kaku M, Chohnan S, et al. Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking. J Cell Biol. 2020;219:e201912045.","journal-title":"J Cell Biol"},{"key":"3516_CR47","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.plipres.2015.11.004","volume":"61","author":"N Casals","year":"2016","unstructured":"Casals N, Zammit V, Herrero L, Fad\u00f3 R, Rodr\u00edguez-Rodr\u00edguez R, Serra D. Carnitine palmitoyltransferase 1C: From cognition to cancer. Prog Lipid Res. 2016;61:134\u201348.","journal-title":"Prog Lipid Res"},{"key":"3516_CR48","doi-asserted-by":"publisher","first-page":"21224","DOI":"10.1074\/jbc.M111.337493","volume":"287","author":"P Carrasco","year":"2012","unstructured":"Carrasco P, Sah\u00fan I, McDonald J, Ram\u00edrez S, Jacas J, Gratac\u00f3s E, et al. Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition. J Biol Chem. 2012;287:21224\u201332.","journal-title":"J Biol Chem"},{"key":"3516_CR49","doi-asserted-by":"publisher","first-page":"3533","DOI":"10.1113\/JP284248","volume":"601","author":"G Iborra-L\u00e1zaro","year":"2023","unstructured":"Iborra-L\u00e1zaro G, Djebari S, S\u00e1nchez-Rodr\u00edguez I, Gratac\u00f2s-Batlle E, S\u00e1nchez-Fern\u00e1ndez N, Rado\u0161evi\u0107 M, et al. CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative and non-associative learning. J Physiol. 2023;601:3533\u201356.","journal-title":"J Physiol"},{"key":"3516_CR50","first-page":"228","volume":"20","author":"C Dong","year":"2017","unstructured":"Dong C, Zhang JC, Yao W, Ren Q, Ma M, Yang C, et al. Rapid and sustained antidepressant action of the mGlu2\/3 receptor antagonist MGS0039 in the social defeat stress model: comparison with ketamine. Int J Neuropsychopharmacol. 2017;20:228\u201336.","journal-title":"Int J Neuropsychopharmacol"},{"key":"3516_CR51","doi-asserted-by":"publisher","first-page":"25548","DOI":"10.1074\/jbc.M115.681064","volume":"290","author":"R Fad\u00f3","year":"2015","unstructured":"Fad\u00f3 R, Soto D, Mi\u00f1ano-Molina AJ, Pozo M, Carrasco P, Yefimenko N, et al. Novel regulation of the synthesis of \u03b1-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) receptor subunit GluA1 by carnitine palmitoyltransferase 1C (CPT1C) in the hippocampus. J Biol Chem. 2015;290:25548\u201360.","journal-title":"J Biol Chem"},{"key":"3516_CR52","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.tcb.2015.06.002","volume":"25","author":"CC Dibble","year":"2015","unstructured":"Dibble CC, Cantley LC. Regulation of mTORC1 by PI3K signaling. Trends Cell Biol. 2015;25:545\u201355.","journal-title":"Trends Cell Biol"},{"key":"3516_CR53","doi-asserted-by":"publisher","first-page":"1354062","DOI":"10.3389\/fneur.2024.1354062","volume":"15","author":"W Weiliang","year":"2024","unstructured":"Weiliang W, Yinghao R, Weiliang H, Xiaobin Z, Chenglong Y, Weimiao A, et al. Identification of hub genes significantly linked to tuberous sclerosis related-epilepsy and lipid metabolism via bioinformatics analysis. Front Neurol. 2024;15:1354062.","journal-title":"Front Neurol"},{"key":"3516_CR54","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.biopsych.2019.03.967","volume":"86","author":"HY Zhou","year":"2019","unstructured":"Zhou HY, He JG, Hu ZL, Xue SG, Xu JF, Cui QQ, et al. A-kinase anchoring protein 150 and protein kinase a complex in the basolateral amygdala contributes to depressive-like behaviors induced by chronic restraint stress. Biol Psychiatry. 2019;86:131\u201342.","journal-title":"Biol Psychiatry"},{"key":"3516_CR55","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/mp.2017.76","volume":"23","author":"MX Li","year":"2018","unstructured":"Li MX, Zheng HL, Luo Y, He JG, Wang W, Han J, et al. Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs. Mol Psychiatry. 2018;23:556\u201368.","journal-title":"Mol Psychiatry"},{"key":"3516_CR56","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.801234","volume":"12","author":"YF Luo","year":"2021","unstructured":"Luo YF, Ye XX, Fang YZ, Li MD, Xia ZX, Liu JM, et al. mTORC1 signaling pathway mediates chronic stress-induced synapse loss in the hippocampus. Front Pharmacol. 2021;12:801234.","journal-title":"Front Pharmacol"},{"key":"3516_CR57","doi-asserted-by":"publisher","first-page":"988","DOI":"10.2527\/jas1967.265988x","volume":"26","author":"RG Beilharz","year":"1967","unstructured":"Beilharz RG, Cox DF. Genetic analysis of open field behavior in swine. J Anim Sci. 1967;26:988\u201390.","journal-title":"J Anim Sci"},{"key":"3516_CR58","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.biopsych.2018.09.024","volume":"85","author":"ZC Shen","year":"2019","unstructured":"Shen ZC, Wu PF, Wang F, Xia ZX, Deng Q, Nie TL, et al. Gephyrin palmitoylation in basolateral amygdala mediates the anxiolytic action of benzodiazepine. Biol Psychiatry. 2019;85:202\u201313.","journal-title":"Biol Psychiatry"},{"key":"3516_CR59","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/BF00428203","volume":"85","author":"L Steru","year":"1985","unstructured":"Steru L, Chermat R, Thierry B, Simon P. The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl). 1985;85:367\u201370.","journal-title":"Psychopharmacology (Berl)"},{"key":"3516_CR60","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202406269","volume":"11","author":"T Cao","year":"2024","unstructured":"Cao T, Tian D, Wang SY, Pan Y, Xia ZX, Chen WK, et al. Microglial DBP signaling mediates behavioral abnormality induced by chronic periodontitis in mice. Adv Sci (Weinh). 2024;11:e2406269.","journal-title":"Adv Sci (Weinh)"},{"key":"3516_CR61","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.biopsych.2018.07.026","volume":"85","author":"K Li","year":"2019","unstructured":"Li K, Chen HS, Li D, Li HH, Wang J, Jia L, et al. SAR405, a highly specific VPS34 inhibitor, disrupts auditory fear memory consolidation of mice via facilitation of inhibitory neurotransmission in basolateral amygdala. Biol Psychiatry. 2019;85:214\u201325.","journal-title":"Biol Psychiatry"},{"key":"3516_CR62","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/s41392-023-01699-8","volume":"8","author":"H Chen","year":"2023","unstructured":"Chen H, Fu S, Li X, Shi M, Qian J, Zhao S, et al. Microglial glutaminase 1 mediates chronic restraint stress-induced depression-like behaviors and synaptic damages. Signal Transduct Target Ther. 2023;8:452.","journal-title":"Signal Transduct Target Ther"},{"key":"3516_CR63","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.biopsych.2016.10.024","volume":"81","author":"R Chandra","year":"2017","unstructured":"Chandra R, Engeln M, Francis TC, Konkalmatt P, Patel D, Lobo MK. A role for peroxisome proliferator-activated receptor gamma coactivator-1\u03b1 in nucleus accumbens neuron subtypes in cocaine action. Biol Psychiatry. 2017;81:564\u201372.","journal-title":"Biol Psychiatry"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41380-026-03516-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-026-03516-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41380-026-03516-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:03:30Z","timestamp":1781510610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-026-03516-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":63,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["3516"],"URL":"https:\/\/doi.org\/10.1038\/s41380-026-03516-4","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]},"assertion":[{"value":"27 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}